Slide 1

Vertebrate Embryonic Patterning 5 Neural Crest

Slide 2

Neural Crest Cells

Slide 3

Neural Crest Derivatives Two major divisions Cranial Trunk PNS Endocrine Melanocytes Facial Cartilage Connective Tissue

Slide 4

Trunk Neural Crest

Slide 5

Neural Crest Cells Stain Positive for ECM Protein HNK-1 RhoB HNK-1

Slide 6

Migratory Pathways of Neural Crest ephrins expressed in posterior compartment of somite

Slide 7

Ephrin Eph RTK Pathway Regulates NC Migration Through/Over Somites Eph RTKs and ephrins appear to regulate boundary formation and cell-cell interactions in many regions of the embryo

Slide 8

Ephrins Repulse Axon Growth

Slide 9

Signals from the Floorplate Induce Axon Migration

Slide 10

Netrin Induces Commissural Axon Growth

Slide 11

Semaphorins Repulse Axons

Slide 12

Axonal Guidance in Invertebrates

Slide 13

Eph RTK & Ephrins Regulate Retinotectal Patterning