Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells

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  • Slide 1
  • Vertebrate Embryonic Patterning 5 Neural Crest
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  • Neural Crest Cells
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  • Neural Crest Derivatives Two major divisions Cranial Trunk PNS Endocrine Melanocytes Facial Cartilage Connective Tissue
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  • Trunk Neural Crest
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  • Neural Crest Cells Stain Positive for ECM Protein HNK-1 RhoB HNK-1
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  • Migratory Pathways of Neural Crest ephrins expressed in posterior compartment of somite
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  • Ephrin Eph RTK Pathway Regulates NC Migration Through/Over Somites Eph RTKs and ephrins appear to regulate boundary formation and cell-cell interactions in many regions of the embryo
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  • Ephrins Repulse Axon Growth
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  • Signals from the Floorplate Induce Axon Migration
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  • Netrin Induces Commissural Axon Growth
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  • Semaphorins Repulse Axons
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  • Axonal Guidance in Invertebrates
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  • Eph RTK & Ephrins Regulate Retinotectal Patterning