cellular effect

Ca2+

Ca2+ Ca2+

Ca2+ G Protein

Robert-Rössle-Str. 1013125 Berlin-Buch

The MDC.C is an international gathering place for scientific dialogue has been established in the center of the campus Berlin-Buch, which focuses on the elucidation of mole-cular mechanisms underlying cardiovascular and neurode-generative diseases, cancer, patient-oriented clinical research and the development of innovative therapies.

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MDC Communications Center

Registration and Abstract SubmissionVenue

Receptors, G Proteins and Integration of Ca2+ Signaling in the Cardiovascular System

International DZHK-Symposium20th-22nd November 2014

Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+

info@dzhk.de www.dzhk.de

Christine Vollgraf, DZHK main office phone: +49 30 4593 7102 christine.vollgraf@dzhk.de

ContactThomas Gudermann, Munich phone: +49 89 2180 75700/2 Thomas.Gudermann@lrz.uni-muenchen.de

Enno Klussmann, Berlin phone: +49 30 9406 2596 enno.klussmann@mdc-berlin.de

Scientific organizer:

Local organizer:

Contact for questions concerning the online registration:

Editor: DZHK e.V. • Oudenarder Straße 16 • D-13347 Berlin info@dzhk.de • www.dzhk.de

353Bernau or Buch BuchLindenberger Weg /Stadtgrenze Campus Buch

A2Hannover

A9Leipzig

A13Dresden

SchönefeldA12

Frankfurt/Oder

A11 Prenzlau

A10Berliner Ring

A24Hamburg

Deadline: The deadline for registration and abstract submission is November 1st.To encourage scientific discussions and social interactions, the number of participants is limited. Delegates will be accepted on a first come / first serve basis.

Registration fee: For symposium registration you need to pay 50 € registration fee. For members of the DZHK registration is free of charge.

Conference dinner fee: If you wish to join the conference dinner on Friday night, Nov 21st 2014, you need to pay 50 € conference dinner fee (also members of the DZHK).

Please register and submit your abstract online: http://dzhk.de/symposium/registration-and-abstracts/

MDC Communications Center Berlin-Buch, Germany

Organizers Thomas Gudermann (Munich)Michael Bader (Berlin)Marc Freichel (Heidelberg)Stefan Offermanns (Bad Nauheim)

Local OrganizerEnno Klussmann (MDC)

The scientific aim of this symposium is to bring together the receptor/cyclic nucleotide and calcium signaling communities with an explicit focus on the cardiovascular system. Receptors, G proteins and calcium permeable ion channels are central signaling modules orchestrating cardiovascular functions. In the recent past novel bio-physical, genetic and pharmacological approaches have granted deeper insight into single components of complex signaling cascades.

However, the functional interplay of defined signaling mo-dules still remains ill understood. The symposium focuses on the integration of receptor-, G protein-, cyclic nucle-otide- and calcium-mediated cellular signals underlying complex cellular functions in the cardiovascular system. The synoptic approach chosen will lead to a deeper mechanistic understanding of physiological regulation and pathologic dysregulation and will highlight novel pharma-cological intervention strategies.

Program18:15 B. Nilius

LeuvenIntroduction: The mysteries of VRAC

18:30 T. J. Jentsch Berlin

Molecular basis of cellular volume regulation

20:30 Congress dinner and Evening LectureW. Rosenthal Jena

N not G

F. Hofmann Munich

Cyclic nucleotides, kinases and calcium signaling: Paradigm shifts over the years

Saturday, November 22, 2014

08:30 Arrival

Receptors, G proteins and Ca2+ signaling: Integrative cellular functionsChair: K. Groschner, Graz

09:00 D. W. Putney NIH

SOCE: From initial concepts to molecules

09:30 R. Penner Honolulu

ICRAC – Why do we care about it?

10:00 I. S. Ambudkar NIH

Contribution of TRPC channels to SOCE

10:30 S. Feske New York

Role of SOCE in immunity, hemostasis and cancer

11:00 Coffee break

Chair: V. Flockerzi, Homburg

11:30 A. Konnerth Munich

TRPC3-dependent synaptic transmis-sion in central mammalian neurons

12:00 U. Rudolph Boston

Genetic dissection of a ligand- gated ion channel: Neuronal, cardiac and respiratory functions of GABAA receptors

12:30 B. Nürnberg Tübingen

PI3Ks – where RTKs and GPCRs meet

13:00 R. Iyengar New York

Decoding information in cellular signaling

13:30 Lunch and poster session 2

PerspectivesChair: G. Schultz, Berlin

14:30 M. Freissmuth Vienna

Receptor/G protein signaling: The past and the future

15:00 M. X. Zhu Houston

TRPs, TPCs and what else to come?

15:30 L. Birnbaumer NIH

Half a century of cell signaling: What did we learn?

16:30 W. Rosenthal Jena

Summary and closing remarks

17:00 End of symposium

Thursday, November 20, 2014

Arrival and check-in at hotel

20:00 - 22:00 Speakers’ Dinner

Friday, November 21, 2014

08:15 Registration and welcome08:45 T. Gudermann

MunichIntroduction

Receptors, G proteins, cyclic nucleotides and Ca2+ signaling in cardiovascular (patho)physiologyChair: W. Rosenthal, Jena

09:00 M. J. Lohse Würzburg

The ins and outs of adrenergic signaling

09:30 M. Bader Berlin

Emerging complexities of the renin- angiotensin system

10:00 F. O. Levy Oslo

Serotonin receptors and heart failure

10:30 T. Gudermann Munich

Integration of vascular mechanotransduction by GPCRs

11:00 Coffee break

Chair: M. Freissmuth, Vienna

11:30 S. Offermanns Bad Nauheim

GPCR signaling and endothelial fluid shear stress response

12:00 C. Weber Munich

Chemokines and their receptors in atherosclerosis

12:30 S. Engelhardt Munich

Paracrine actions of secreted cAMP

13:00 E. Klussmann Berlin

Targeting AKAP-dependent protein- protein interactions

13:30 Lunch and poster session 1

Chair: F. Hofmann, Munich

14:30 K. Groschner Graz

From lipid sensing by TRPCs to cardiovascular remodeling

15:00 M. Freichel Heidelberg

Role of TRPCs in cardiac function

15:30 A. Dietrich Munich

TRPCs in the cardiopulmonary system

16:00 Coffee break

Chair: M. Birnbaumer, NIH

16:30 V. Flockerzi Homburg

Novel function of Ca2+ channel beta3 sub-unit in fibroblasts

17:00 M. Biel Munich

Cyclic nucleotide-modulated channels and cardiac rhythmicity

17:30 T. Eschenhagen Hamburg

Human iPSC-derived engineered heart tissue as a test bed for signaling in a human context

Short break

Keynote Lecture: Cellular volume control

Chair: B. Nilius, Leuven

Receptors, G Proteins and Integration of Ca2+ Signaling in the Cardiovascular System

International DZHK-Symposium20th-22nd November 2014