VasopressinAntidiuretic hormone (ADH)

Cameron Wolf

VasopressinO Vasopressin, also known as arginine

vasopressin, is produced in the posterior pituitary gland.

O Within hypothalamic neurons the hormone is packed in secretory vesicles with a the carrier protein neurophysin. Both of these are released from the secretory vesicles upon hormone secretion

Target Cell of VasopressinO Vasopressin primarily targets the

KidneyO By increasing the water permeability

and collecting duct cells in the kidney it allows us to retain more water and excretion of more concentrated urine.

When is it released? Typical amounts?

O Vasopressin is released when the sensitive osmoreceptors in the hypothalamus detect very small increases in extracellular fluid osmolality

O Typical amounts of vasopressin range from 1 to 5 pg/mL (picograms per milliliter)

What does it look like?

What does ADH do for the Body?

O Vasopressin helps the body maintain water levels. It also helps keep the concentration of urine and blood in check.

Too Little?O Hypothalamic diabetes insipidus- in

inadequate fluids are consumed, the large amount of water lost in the urnie may cause dehydration and high sodium levels in the blood

Too Much?O Nephrogenic diabetes insipidus (NDI)

- a defect in the small tubes in the kidneys causes a person to pass a large amount of urine

O This disease occurs when the kidney tubules do not respond to ADH-the kidneys release an excessive amount of water into the urnie, producing a large quantity of very dilute urine.

How is NDI treated?O They need to consume enough fluids

to equal the amount of urine produced.

O Low-salt and low-protein diet