USP Purified Water with Endotoxin Removal

Two-BedDeionization

or ReverseOsmosis

UltravioletSterilization

Mixed-BedDeionization

UltravioletSterilization

Submicron FiltrationSubmicron Particle

RetentionFinal Filter Protection

UltrafiltrationMolecular WeightCutoff Membrane

Continuous flow loop to maintain high purity water

IncomingCity Water

Continuous flow loop to maintain high purity and eliminate “Dead-legs”

USP Purified - US Pharmacopeia / European Pharmacopeia

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USP Purified Water with Endotoxin Removal

Removes dissolvedminerals from incoming

water

ResistivityMonitor 1

Mohm minimum

185/254 nm UVTOC (Total Organic Carbon)

reduction &initial disinfection dose

Further removal ofdissolved minerals

& CO2

185/254 nm UVFurther TOC reduction &additive disinfection dose

Removal of suspendedsolids & larger bacteria

Retention of endotoxin,bacteria & particulate

ResistivityMonitor 200

Kohm minimum

High purity piping: polypro, PVDF or Teflon™Clean use point design

Final product water topoints-of-use in the plant

USP

EP

<500 ppb

TOC (ppm)

<500 ppb

>0.77

Conductivity(megohm/cm)

>0.23

<100 CFU/ml

Bacteria(CFU/ml)

<100 CFU/ml

ns

Nitrates(ppm)

ns

<0.1

Heavy Metals(ppm)

<0.25

<0.25

Endotoxin(Eu/ml)

<0.2