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Uses of Ionic Liquids in

Pharmaceutical industry

 Muhammad Faisal Jamil 

Chem-431

12-10006 Forman Christian College

Lahore

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Properties of [bmim][PF6] and [bdmim][PF6]

1-Butyl-3-methylimidazoliumhexafluorophosphate, also known as

BMIM-PF6, is

viscous

colourless

hydrophobic

density: 1.38 g/mL at 20°C (lit.)

mp: 6.5°C

1-Butyl-2,3-dimethylimidazoliumhexafluorophosphate, also known as

BDMIM-PF6, is

dark brown liquid

density: 1.345 g/mL at 20°C (lit.)

mp: 50°C

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Viscosities of [bmim][PF6] and [bdmim][PF6]

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Seddon/QUILL: [bmim][PF6]/pravadolineM.J.Earle et al.,Green Chem., 2000, 2, 261

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Central Glass: [Bu3P(CH2)2C8F17)]OTf 

Chiral synthesisA. Winkel et al., Synthesis, 2008, 999

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Liquid active pharmaceutical ingredients (API)

³ API, Active Pharmaceutical Ingredients are portions of any drug, which are active.´

[Source: http://www.pharma-ingredients.com/active_pharmaceutical_ingredients]

³One of the major strengths of ionic liquids resides in their internal plural nature: since at least

one kind of cation and one kind of anion have to be present, the properties of the resulting

 products can be tuned by judicious choice of cation(s) and anion(s). Any two ionic liquids,

even with one ion in common, can range from hydrophilic to hydrophobic, or their melting

 points can differ by over 100°C. The possible combinations of ions which could form an ionic

liquid are practically countless, as are the physical, chemical, and biological property sets thatcan be obtained by ³designer salts´.´

[Source: Ionic Liquid Technology: A Potential New Platform for the Pharmaceutical Industry. Héctor

Rodríguez1, Katharina Bica1 and Robin D Rogers1

1T he QU  ILL Research Centre and School of Chemistry and Chemical Engineering  , T he Queen¶s University of 

 Belfast  , Belfast  , Northern  I reland  , United Kingdom , BT9 5 AG

2Center for Green Manufacturing and Department of Chemistry , T he University of  Alabama , T uscaloosa ,  AL 35401

Tropical J ournal of Phar maceutical Resear ch, Se ptember 2008; 7(3): 1011-1012

R etrieved from, http://www.tjpr.org/vol7_no3/731_editorial.php]

 

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Delivery by controlled release: [rmim]PF6(r = C4, C6; C8)V. Jaitely et al., Int. J. Pharm., 2008, 354, 168

Many pharmaceuticals are salts: Na[A]; [B]Cl

Sodium ibuprofenate (anti-inflammatory)

Lidocaine hydrochloride (pain relief)