USA (Ed) Isotope labeling in Animal Models of Eating … · 2012. 6. 22. · Biomolecular NMR NMR spectroscopy has undergone a revolution in recent years with the advent of several

News 7/2012 Biomedicine

13

M. E. Abood, School of Medicine, Temple University, Philadelphia, PA, USA; R. G. Sorensen, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA; N. Stella, University of Washington, Seattle, WA, USA (Eds)

endoCANNABINOIDSActions at Non-CB1/CB2 Cannabinoid Receptors

Features 7 Research provided by leading scien-tists 7 Complement recent texts that describe cannabinoids, the endocannabinoid system, the physiological roles of cannabinoids as mediated through their actions at cannabinoid receptors, and the therapeutic potential of compounds that modulate CB1 and CB2 receptor function 7 Cut-ting-edge research presented in accessible manner

Contents Overview of Non-Cannabinoid Receptors.Overview of Non-Classical Cannabinoid Recep-tors.Overview of Non-Cannabinoid Receptors: Chemistry and Modeling.- G-Protein Coupled Receptors.GPR55 in the CNS.The Role of GPR55 in Bone Biology.The Role of GPR55 in Cancer.GPR18 and NAGly signaling: New members of the endocannabinoid family or distant cousins?.Cannabinoid Signaling Through Non CB1/Non CB2 GPCR Targets in Microglia.- Ion Channels.Temperature-Sensitive Transient Receptor Potenti-al Channels as Ionotropic Cannabinoid Receptors.Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors.- Transcription Factors.Peroxisome proliferator-activated receptors and inflammation.Peroxisome proliferator-activated nuclear receptors (PPAR) and drug addiction.- Conclusions/Therapeutic Potential.Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors.

Fields of interestsNeurosciences; Human Physiology; Receptors

Target groupsResearch

Discount groupProfessional Non-Medical

Due September 2012

2012. 416 p. 34 illus., 17 in color. (The Receptors, Volume 24) Hardcover7 approx. $209.00ISBN 978-1-4614-4668-2

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H. S. Atreya, Indian Institute of Science, Bangalore, India (Ed)

Isotope labeling in Biomolecular NMRNMR spectroscopy has undergone a revolution in recent years with the advent of several new me-thods overcoming the problems of sensitivity and resolution. Recent developments in biotechnology have made it easier and economical to introduce 13C, 15N and 2H into proteins and nucleic acids. At the same time, there has been an explosion in the number of NMR experiments that utilize such isotope labeled samples.

Features 7 Includes step-by-step procedures and practical tips for different isotope labeling methods 7 Co-vers the entire gamut of biomolecular NMR spectroscopy 7 Includes emerging areas such as structure/dynamics of large proteins, metabolo-mics and solid state NMR

Contents 1. Isotope labeling methods for large systems. - 2. Segmental labeling to study multidomain proteins. - 3. Isotope Labeling for Solution and Solid-State NMR Spectroscopy of Membrane Proteins. - 4. Isotope labeling methods for relaxation measure-ments. - 5. Stereo-array isotope labeling method for studying protein structure and dynamics. - 6. Amino acid selective labeling and unlabeling for protein resonance assignments. - 7. Isotope labeling and segmental labeling of larger RNAs for NMR structural studies. - 8. Isotope Enhanced Approaches in Metabolomics. - 9. Cell-free protein synthesis using E. coli cell extract for NMR studies. - 10. Isotope labeling in insect cells. - 11. Mamma-lian Expression of Isotopically Labeled Proteins for NMR Spectroscopy.

Fields of interestsBiomedicine general; Spectroscopy/Spectrometry; Biotechnology



Available

2012. XV, 235 p. 80 illus., 40 in color. (Advances in Experimental Medicine and Biology, Volume 992) Hardcover7 approx. $189.00ISBN 978-94-007-4953-5

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N. M. Avena, University of Florida, Gainesville, FL, USA (Ed)

Animal Models of Eating DisordersContents Introduction: Binge Eating, Bulimia Nervosa, and Hedonic Overeating.- Binge-Prone vs. Binge-Resistant Rats and Their Concomitant Behavioral Profiles.- Binge Eating in Female Rats Induced by Yo-Yo Dieting and Stress.- Binge-Type Eating In-duced by Limited Access to Optional Foods.- As-sessment of Stress-Independent Binge-Like Eating Behavior in Mice.- Predicting and Classifying Rats Prone to Overeating Fat.- Modeling Binge Eating in Non-Human Primates.- Psychosocial Stress and Diet History Promote Emotional Feeding in Female Rhesus Monkeys.- Stressful Experiences in Early Life and Subsequent Food Intake.- Sham Feeding in Rats Translates Into Modified Sham Feeding in Women with Bulimia Nervosa and Purging.- Animal Models of Binge Eating Palatab-le Foods: Emergence of Addiction-Like Behavi-ors and Brain Changes in the Rat.- Deep Brain Stimulation for the Treatment of Binge Eating: Mechanisms and Preclinical Models.- Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse.- Food Seeking in Spite of Harmful Consequences.- Introduction: Anorexia and Undereating.- Food Restriction and Reward in Rats.- Activity-Based Anorexia in the Rat.- Food-Anticipatory Activity: Rat Models and Underlying Mechanisms.- Anorexia and Drugs of Abuse Abnormally Suppress Appetite, the Result of a Shared Molecular Signal Foul-Up.- The Anorectic Phenotype of the Anx/anx Mouse is Related to Hypothalamic Dysfunction.- Functional Magnetic Resonance Imaging in Awake Rats: Studies Rele-vant to Addiction and the Reward Circuitry.

Fields of interestsNeurosciences; Psychiatry; Animal Models

Target groupsProfessional/practitioner


Due September 2012

2012. XI, 595 p. 80 illus., 11 in color. (Neuromethods, Volume 74) Hardcover7 $139.00ISBN 978-1-62703-103-5

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www.springer.com/978-1-4614-4668-2



Biomedicine springer.com/NEWSonline

14

A. S. Azmi, Wayne State University, Detroit, MI, USA (Ed)

Systems Biology in Cancer Research and Drug DiscoveryContents Preface. I Systems Biology in Cancer.-1 Systems Biology Approach to Metabolomics in Cancer Stu-dies.-2 System Biology Approach to Study Cancer Related Pathway.-3 Modeling Oncogenic Signaling Networks from Gene Expression Dynamics.-4 An Integrated Systems Approach to the Study of Pancreatic Cancer.-5 Protein Microarray: an Ideal Platform for Systems Biology.-6 Systems Biology of Pancreatic Cancer: the Role of Tumor-Micro-environment communication in Development, Progression and Therapy Resistance.II Systems Approaches to understand cancer Progression.-7 Understanding Cancer Progression Using Protein Interaction Networks.-8 Understanding the Dy-namics of Tumor Angiogenesis: a Systems Biology Approach.-9 Applications of Network Bioinforma-tics to Cancer Angiogenesis.III Systems and Net-work Biology in decoding miRNA complexity.-10 Human MicroRNA Targetome Indicates a Specia-lized Role of MicroRNAs in Regulation of Onco-genesis.-11 Novel and Alternative Bioinformatics Approaches to understand miRNA- mRNA Interactome in Cancer Research.-12 Prioritizing Candidate Disease miRNAs by Topological Fea-tures in the miRNA-target Dysregulated Network.IV Network Modeling in Cancer Drug Discovery and clinical trials.-13 Development and Clinical Implementation of Reverse Phase Protein Mic-roarrays for Protein Network Activation Mapping: Personalized Cancer Therapy.-14 The Principle of Rational Design of Drug Combination and Perso-nalized Therapy Based on Network Pharmacolo-gy.-15 Relevance of Network Hierarchy in Cancer Drug-Target Selection. [...]

Fields of interestsBiomedicine general; Cancer Research; Systems Biology



Available

2012. X, 431 p. 78 illus., 60 in color. Hardcover7 $209.00ISBN 978-94-007-4818-7

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S. Chatterjee, Kolkata, India; K. Chaudhuri, Indian Institute of Chemical Biology, Kolkata, India

Outer Membrane Vesicles of BacteriaThis book provides a detailed account of the physico-chemical properties and biological func-tions of the outer membrane vesicles (OMVs) of different pathogenic and non-pathogenic Gram-negative bacteria. It also includes an authentic record of the first systematic study that discovered the mechanism of OMV formation by a pathogen, Vibrio cholerae, and proposed that the process represented a novel secretory activity of bacteria. Furthermore, the authors present clinical and laboratory data on the use of OMVs as immu-nogens, as effective and licensed vaccines against Neisseria meningitidis serogroup B infections and on the development of more effective vaccines against other human and animal pathogens including Vibrio cholerae. This volume thus bears witness to the emerging revolution in the field of vaccines against pathogens and closes with a discussion of open questions and future research on OMVs.

Contents Discovery of outer membrane vesicles: A revisit to the contemporary works.- Gram-negative bacteria: The cell membranes and the outer membrane vesicles.- Factors affecting production of outer membrane vesicles.- Outer membrane vesicles as carriers of biomaterials.- Outer membrane vesicles and the biofilm formation.- Outer membrane vesicles: Interaction with prokaryotes and euka-ryotes.- Biogenesis of outer membrane vesicles.- Release of outer membrane vesicles: Is it a novel secretion mechanism ?- Outer membrane vesicles: Physiological and medical applications.- Conclu-ding notes.

Fields of interestsMedical Microbiology; Immunology; Bacteriology



Available

2012. IX, 137 p. 29 illus., 10 in color. (SpringerBriefs in Microbiology) Softcover7 $49.95ISBN 978-3-642-30525-2

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G. G. Chen, B. P. Lai, The Chinese University of Hong Kong, PR China (Eds)

Novel Apoptotic Regulators in CarcinogenesisOur recent understanding of the cellular and mo-lecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally desi-gned anticancer strategies and the development of novel agents that regulates apoptosis.

Features 7 Description of a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment 7 11 chapters written by established leaders in the world 7 Valuable tools for academics working in the field of cancer research and apoptosis as well as pharmaceutical and pharmacological industries

Contents Preface.-1 Apoptosis Inducer from Streblus asper Extracts for Cancer Chemoprevention.- 2 Apop-tosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Sig-naling Networks.- 3 Heterocyclics as inducers of apoptosis.- 4 Anthocyanins as Apoptotic Agents.- 5 Apoptosis as a mechanism involved in the anticancer effect of dietary n-3 polyunsaturated fatty acids.- 6 Apoptotic Pathways Upon Arsenite Treatment.- 7 Flavokawains in Cancer Prevention and Treatment: Potentials and Challenges.- 8 Pro-gesterone Receptor Modulators Induce Apoptosis in Mammary Tumors and Uterine Leiomyomas.- 9 Apoptotic regulators and its clinical implication in mammary carcinoma.- 10 Curcumin analogs as inhibitors of the Jak-STAT signal transduction pathway.- 11 Targeting cancer by betulin and betu-linic acid. Abbreviations. Subject index.

Fields of interestsBiomedicine general; Medicine/Public Health, general; Entomology



Available

2012. XX, 314 p. 83 illus., 19 in color. Hardcover7 approx. $189.00ISBN 978-94-007-4916-0

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15

C. Y. Cheng, Center for Biomedical Research, Population Council, NY, USA (Ed)

Biology and Regulation of Blood‑Tissue BarriersContents Regulation of Permeability Across the Blood-Brain Barrier.- Drug Transporters at Brain Barriers: Expression and Regulation by Neurological Disor-ders.- The Blood-Retina Barrier: Tight Junctions and Barrier Modulation.- The Inner Blood-Retinal Barrier: Molecular Structure and Transport Bio-logy.- Endothelial and Epithelial Barriers in Graft-Versus-Host Disease.- Structure and Regulation of Intestinal Epithelial Tight Junctions: Current Concepts and Unanswered Questions.- Polarity Protein Complex Scribble/Lgl/Dlg and Epithelial Cell Barriers.- The Blood-Biliary Barrier, Tight Junctions and Human Liver Diseases.- The Blood-Follicle Barrier (Bfb) in Disease and in Ovarian Function.- Physiology and Pathophy-siology of the Epithelial Barrier of the Female Reproductive Tract: Role of Ion Channels.- The Blood-Epididymis Barrier and Human Male Fer-tility.- Blood-Tissue Barriers: Morphofunctional and Immunological Aspects of the Blood-Testis and Blood-Epididymal Barriers.- Gap Junctions and Blood-Tissue Barriers.- Transcriptional Regu-lation of Cell Adhesion at the Blood-Testis Barrier and Spermatogenesis in the Testis.- c-Src and c-Yes are Two Unlikely Partners of Spermatogene-sis and Their Roles in Blood-Testis Barrier Dyna-mics.- Role of P-Glycoprotein at the Blood-Testis Barrier on Adjudin Distribution in the Testis: a Revisit of Recent Data.- The Apical Ectoplasmic Specialization-Blood-Testis Barrier Functional Axis is a Novel Target for Male Contraception.

Fields of interestsMolecular Medicine; Biomedicine general



Due September 2012

2012. XX, 360 p. 60 illus., 1 in color. (Advances in Experimental Medicine and Biology, Volume 763) Hardcover7 approx. $209.00ISBN 978-1-4614-4710-8

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G. L. Conn, Emory University, Atlanta, GA, USA (Ed)

Recombinant and In Vitro RNA synthesisMethods and Protocols

Contents Purification of RNA Expressed in vivo Inserted in a tRNA Scaffold.-Selective RNase H Cleavage of Target RNAs from a tRNA Scaffold.- Preparation of Long Templates for RNA in vitro Transcrip-tion by Recursive PCR.- General Protocols for Preparation of Plasmid DNA Template, RNA in vitro Transcription and RNA Purification by Denaturing PAGE.- Preparation of Short RNA by in vitro Transcription.- Native RNA Purification by Gel Filtration Chromatography.- Cis-acting Ribozymes for the Production of RNA in vitro Transcripts with Defined 5’ and 3’ Ends.- Trans-acting Antigenomic HDV Ribozyme for Produc-tion of in vitro Transcripts with Homogenous 3‘ Ends.- Rapid Preparation of RNA Samples using DNA-affinity Chromatography and DNAzyme Methods.-Preparation of lN-GST Fusion Protein for Affinity Immobilization of RNA.- Affinity Purification of RNA using an ARiBo Tag.- Plasmid Template Design and in vitro Transcription of Short RNAs within a ‘Structure Cassette’ for Struc-ture Probing Experiments.- In Vitro Transcription of Modified RNAs.- End-Labeling Oligonucleo-tides with Chemical Tags After Synthesis.- High-Purity Enzymatic Synthesis of Site-Specifically Modified tRNA.- Se-derivatized RNAs for X-ray Crystallography.- Biosynthetic Preparation of 13C/15N-labelled rNTPs for High-resolution NMR Studies of RNAs.- Preparative Separation of Ribonucleoside Monophosphates by Ion-Pair Reverse-Phase HPLC.- Splint Ligation of RNA with T4 DNA Ligase.

Fields of interestsHuman Genetics; Nucleic Acid Chemistry



Due October 2012

2013. 255 p. 56 illus. (Methods in Molecular Biology, Volume 941) Hardcover7 $119.00ISBN 978-1-62703-112-7

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Current Topics in Microbiology and ImmunologyEditors: R. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Gleba, B. Malissen, K. Aktories

Volume 360

F. Radtke, University of Lausanne, Switzerland (Ed)

Notch Regulation of the Immune SystemNotch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regu-lation of immune responses. This special issue on Notch regulation of the immune system summa-rizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte develop-ment and function as well as in T cell leukemia.

Fields of interestImmunology



Available

2012. X, 200 p. 26 illus., 24 in color. Hardcover7 approx. $189.00ISBN 978-3-642-24293-9

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16

Current Topics in Microbiology and ImmunologyEditors: R. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers, Series editors: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Gleba, B. Malissen, K. Aktories

Volume 361

K. Aktories, J. H. Orth, University of Freiburg, Germany; B. Adler, Monash University, Melbourne, Australia (Eds)

Pasteurella multocidaMolecular Biology, Toxins and Infection

This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, patho-genic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host tissues, cells, immune system, and signalling pathways.

Fields of interestsPharmacology/Toxicology; Medical Microbiology



Available


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I. Fong, Saint Michael‘s Hospital, Toronto, ON, Canada (Ed)

Challenges in Infectious DiseasesThis next volume in the series will provide up to date Information and discussion on future approach to control several challenging Infectious Disease worldwide. The past decade has been highlighted by numerous advances in research of medical scientific knowledge. medical technology and the biological and diagnostic techniques-but somewhat less dramatic changes or improvement in management of medical conditions. This volu-me will address some of the emerging issues, chal-lenges, and controversies in Infectious Diseases.

Features 7 Features cutting-edge research 7 Explores current demands as well as pending challenges of infectious disease outbreaks 7 Provides state-of-the-art reviews on epidemiology, biology, clinical aspects, prevention, current approaches to control and prevention such as new vaccines

Contents Preface.- HIV Epidemic.- Multidrug-resistant Bac-teria: The Emerging Crisis.- Multidrug-Resistant Tuberculosis: A Global Challenge.- Urbanization and Infectious Diseases: General Principles, Histo-rical Perspectives, and Contemporary Challenges.- Challenges in enteric epidemics from Cholera to malnutrition and cognitive development: barome-ters of inadequate water sanitation.- Challenges in control and eradication of malaria.- Lymphatic filariasis: progress and challenges in the move toward elimination.- Leishmaniasis: Challenges in the control and eradication.- Challenges in cont-rolling and eliminating Schistosomiasis.- Dengue Infections.- Index.

Fields of interestsImmunology; Antibodies; Drug Resistance



Due September 2012

2012. XVIII, 312 p. 30 illus., 22 in color. (Emerging Infectious Diseases of the 21st Century) Hardcover7 $189.00ISBN 978-1-4614-4495-4

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S. L. Gersen, AmeriPath Northeast, Shelton, CT, USA; M. B. Keagle, University of Connecticut, Storrs, CT, USA (Eds)

The Principles of Clinical CytogeneticsIn this thoroughly revised and expanded third edi-tion of the highly praised classic, The Principles of Clinical Cytogenetics, a panel of hands-on experts update their descriptions of the basic concepts and interpretations involved in chromosome analysis to include the many advances that have occurred in the field.

Features 7 Covers advances in chromosome microar-ray 7 Up-to-date survey of chromosome analysis for physicians and students 7 Coverage of cancer cytogenetics 7 Essential reference for all health care providers using chromosome analysis

Contents History of Clinical Cytogenetics.- DNA, Chromo-somes, and Cell Division.- Human Chromosome Nomenclature: An Overview and Definition of Terms.- Basic Cytogenetics Laboratory Procedu-res.- The Essentials of Light Microscopy.- Quality Control & Quality Assurance.- Instrumentation in the Cytogenetics Laboratory.- Autosomal Aneuploidy.- Structural Chromosome Rearrange-ments.- Sex Chromosomes, Sex Chromosome Dis-orders, and Disorders of Sex Development.- The Cytogenetics of Infertility.- Prenatal Cytogene-tics.- The Cytogenetics of Spontaneous Aborti-on.- Chromosome Instability.- The Cytogenetics of Hematologic Neoplasms.- The Cytogenetics of Solid Tumors.- Fluorescence in situ Hybridization (FISH).- Microarray-Based Cytogenetics.- Fragile X: A Family of Disorders: Changing Phenotype and Molecular Genetics.- Genomic Imprinting and Uniparental Disomy.- Genetic Counseling.

Fields of interestsCytogenetics; Human Genetics; Pathology


Discount groupMedical Clinical

Due September 2012

3rd ed. 2012. XXX, 1555 p. 209 illus., 108 in color. Hardcover7 approx. $189.00ISBN 978-1-4419-1687-7

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17

M. Hayat, Kean University, NJ, USA (Ed)

Stem Cells and Cancer Stem Cells, Volume 8Therapeutic Applications in Disease and Injury

Contents Preface. I. Stem cell culture.-1 Stem cell culture: optimizing amidst the complexity.-2 Development of defined culture conditions for expansion of human mesenchymal stromal cells for clinical applications.-3 Retention of stem cell properties post-expansion in myosphere culture.II. Bone marrow stem cells.-4 Role of reactive oxygen species formation form oxidized low density lipoprotein in bone marrow stem cells.-5 The role of bone marrow-derived progenitor cells in tumor growth and angiogenesis.-6 Myelodysplastic stem cells: gene expression profiling.III. Mesenchymal stem cells.-7 Human mesenchymal stem cell transdifferentiation to neural cells: role of tumor necrosis factor alpha.-8 Role of mesenchymal stem cells (msc) in hiv-1 associated bone and lipid toxicities.-9 Mesenchymal stem cell therapy: immunomodulation and homing mechanisms.-10 Mesenchymal stem cells: the role of endothelial cells and the vasculature.-11 Use of cancer/testis antigens in immunotherapy: potential effect on mesenchymal stem cells.IV. Reprogramming and differentiation of stem cells.-12 Regulation of self-renewal and pluripotency of embryonic stem cells: role of natriuretic peptide receptor.-13 Reprogramming and pluripotency of epiblast stem cells.-14 Epigenetic modifiers and stem cell differentiation.-15 Enrichment and selection of stem cell-derived tissue-specific precursors.-16 Differentiation of pluripotent stem cells into stero-idogenic cells: role of sf-1 regulator. [...]

Fields of interestsMolecular Medicine; Cancer Research; Medicine/Public Health, general

Target groupsGraduate


Available

2012. XVII, 551 p. 25 illus., 10 in color. (Stem Cells and Cancer Stem Cells, Volume 8) Hardcover7 $209.00ISBN 978-94-007-4797-5

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P. Humphries, M. M. Humphries, L. C. Tam, G. J. Farrar, P. F. Kenna, M. Campbell, A.-S. Kiang, University of Dublin, Ireland

Hereditary RetinopathiesProgress in Development of Genetic and Molecular Therapies

The hereditary retinopathy, retinitis pigmentosa (RP), which affects 1 in 3,500 people worldwide, is the most common cause of registered visual handicap among those of the working age in de-veloped countries. RP is a highly variable disorder where patients may develop symptomatic visual loss in early childhood, while others may remain asymptomatic until mid-adulthood. Most cases of RP segregate in autosomal dominant, recessive or X-linked recessive modes, with approximately 41 genes being implicated in disease pathology to date (RetNet). The extensive genetic heterogeneity associated with autosomal dominant RP (adRP) is an undisputed hindrance to the development of genetically based therapeutics.

Features 7 Provides a snap-shot of current gene and drug-based therapies for hereditary retinal dis-orders 7 The authors explore emerging topics such as novel gene or drug delivery methods to the retina and retinal diseases caused by protein misfolding and aggregation 7 Describes current developments and future prospects for the applica-tion of gene therapy

Contents Preface.- Introduction.- Gene-based Medicines directly targeting genetic defects and molecu-lar pathologies common to multiple forms of disease.- Molecular Medicines.

Fields of interestsHuman Genetics; Gene Therapy; Ophthalmology



Due July 2012

2012. V, 45 p. 8 illus., 5 in color. (SpringerBriefs in Genetics) Softcover7 $49.95ISBN 978-1-4614-4498-5

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W. G. Jiang, Cardiff University, UK (Ed)

Electric Cell‑Substrate Impedance Sensing and Cancer MetastasisContents Preface.-1 Electric Cell-substrate Impedance Sensing Concept to Commercialisation.-2 Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impe-dance.-3 ECIS as a tool in the study of metasta-sis suppressor genes: Epithelial Protein Lost In Neoplasm (EPLIN).-4 Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Trans-formation, Migration, Invasion, and Anticancer Compound Screening.-5 Epithelial-mesenchymal transition and the use of ECIS.-6 Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing.-7 Tight Junctions in Cancer Metastasis and their investigation using ECIS (Electric Cell-substrate Impedance Sensing).-8 Epithelial wound healing and the effects of cyto-kines investigated by ECIS.-9 Tumour-endothelial and tumour-mesothelial interactions investigated by impedance sensing based cell analyses.-10 Application of Electric Cell-Substrate Impedance Sensing in evaluation of traditional medicine on the cellular functions of gastric and colorecctal cancer cells.-11 Electric cell-substrate impedance sensing as a screening tool for wound healing agents.-12 ECIS, cellular adhesion and migration in keratinocytes.-13 Current and future applica-tion of ECIS models to study bone metastasis.Index.

Fields of interestsCancer Research; Biomedicine general; Molecular Medicine



Available

2012. VIII, 284 p. 71 illus., 59 in color. (Cancer Metastasis - Biology and Treatment, Volume 17) Hardcover7 approx. $189.00ISBN 978-94-007-4926-9

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18

L. K. McLoon, University of Minnesota, Minneapolis, MN, USA; F. Andrade, University of Kentucky, Lexington, KY, USA (Eds)

Craniofacial MusclesA New Framework for Understanding the Effector Side of Craniofacial Muscle Control

Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofa-cial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipu-lation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic fea-tures that separate them from the skeletal muscle stereotype. This book is the most comprehensive reference to date on craniofacial muscle develop-ment, structure, function, and disease.

Features 7 Despite their critical importance, the majority of research on skeletal muscle basically has igno-red this collection of muscles 7 These muscles are complex, and therefore extremely difficult to study 7 This book highlights novel findings on the development of these muscles

Contents Craniofacial Muscles: An argument for unique-ness.- Development of craniofacial muscles.- Ext-raocular Muscle.- Masticatory Muscles.- Laryngeal and pharyngeal muscles.- Tongue Musculature.- Facial Muscles.- Innervation and Facial Palsies.- Facial Spasm Disorders.

Fields of interestsHuman Physiology; Anatomy; Neurosciences



Due September 2012

2012. XIV, 370 p. 65 illus., 44 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-4465-7

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M. Munir, S. Zohari, M. Berg, Swedish University of Agricultural Sciences, Uppsala, Sweden

Molecular Biology and Pathogenesis of Peste des Petits Ruminants VirusPeste de Petits Ruminants (PPR) is a highly con-tagious viral disease of domestic and wild small ruminants that can significantly affect economies. The authors are experts in the field and provide an up-to-date and comprehensive review covering all aspects of the disease. The book is divided into seven chapters highlighting genome organiza-tion, virus replication and the determinants of virulence, pathophysiology and clinical disease, immunology and immunopathogenesis, epide-miology, diagnostic assays and vaccines, and the challenges concerning global eradication. It is an invaluable reference work, presenting the latest information for virologists, microbiologists, im-munologists, veterinarians, and scientists working in PPR research.

Contents Genome Organization of Peste des Petits Ruminants Virus.- Replication and Virulence Determinants of Peste des Petits Ruminants Virus.- Pathophysiology and Clinical Assessment of Peste des Petits Ruminants.- Immunology and Immunopathogenesis of Peste des Petits Rumi-nants Virus.- Epidemiology and Distribution of Peste des Petits Ruminants.- Current Advances in Molecular Diagnosis and Vaccines for Peste des Petits Ruminants.- Poverty Alleviation and Global Eradication of Peste des Petits Ruminants.

Fields of interestsVirology; Immunology; Fish & Wildlife Biology & Management



Available

2012. 120 p. (SpringerBriefs in Animal Sciences) Softcover7 $49.95ISBN 978-3-642-31450-6

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V. Regitz-Zagrosek, Institute of Gender in Medicine (GiM), University of Berlin, Germany (Ed)

Sex and Gender Differences in PharmacologyThis is the very first book to deal with sex and gender differences in drug therapy - an incre-asingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioecono-mic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug develop-ment, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Features 7 Very first book to deal with sex and gender differences in drug therapy - an increasingly reco-gnized medical need 7 Connection to large da-tabase on sex differences in drug effects 7 Clear key note messages by international experts

Contents From the contents.- Preface.- Part 1: Sex diffe-rences in mechanisms of disease.- Part 2: Sex differences in pharmaco kinetics, in drug develop-ment and use.- Part 3: Sex differences in different therapeutic areas.

Fields of interestsPharmacology/Toxicology; Molecular Medicine; Pharmaceutical Sciences/Technology



Available

2013. Approx. 510 p. 35 illus., 22 in color. (Handbook of Experimental Pharmacology, Volume 214) Hardcover7 $459.00ISBN 978-3-642-30725-6

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19

D. Ribatti, University of Bari Medical School, Italy

Morphofunctional Aspects of Tumor MicrocirculationBlood vessels of tumors display many structural and functional abnormalities. Their unusual lea-kiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvi-ronment. Like normal blood vessels, they consist of endothelial cells, mural cells and their envelo-ping basement membrane.

Features 7 Tumors depend on a vascular supply for their growth 7 Tumor vasculature is clearly different to normal vasculature 7 The phenotypic range of tumor endothelium is influenced by the specific tumor microenvironment and by epigenetic effects 7 Two approaches are available for targeting tumor vasculature: a) prevent new blood vessel formation; b) disrupt tumor vasculature

Contents List of abbreviations.- Introduction.- 1.1.Tumor endothelial cell features.- 1.2. Tumor pericy-tes.- 1.3. Tumor lymphatic vessels.- 2.1.Tumor angiogenesis.- 2.2.The role of inflammatory cells in tumor angiogenesis.- 2.3. Alternative mode of tumor vascular growth.- 2.4. The role of bone marrow stem cells in tumor angiogenesis.- 3.1. Anti-angiogenic therapy.- 3.2. Metronomic chemotherapy.- 3.3.Combinatorial approach.- 3.4.Vascular targeting to tumor vasculature.- 3.5. Tumor vascular normalization.- 3.6. Drawbacks of anti-angiogenesis therapies.- References.

Fields of interestsCancer Research; Oncology; Cell Biology



Available


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S. Schultz-Cherry, St Jude Children‘s Research Hospital, Memphis, TN, USA (Ed)

Astrovirus ResearchEssential Ideas, Everyday Impacts, Future Directions

Astroviruses were first identified in the feces of children in 1975. Since then, they have been found in ~ 3 to 20% of children with diarrhea. Given that serological studies have demonstrated that up to 90% of children have been exposed to at least one strain of astrovirus by age 9, the prevalence of infection may be much higher. Supporting this are studies demonstrating that as-troviruses can also be isolated in a subset of asym-ptomatic individuals, suggesting that a proportion of infected individuals shed the virus asympto-matically or for some time after the resolution of other symptoms of infection. Asymptomatic carriers may be a major reservoir for astroviruses in the environment and could contribute to disse-mination of the virus.

Features 7 First book of its kind 7 Would remain up-to-date for 3-5 years 7 Will be of great interest to professionals and researchers from many different fields, including public health and food safety experts, poultry specialists, microbiologists, virolo-gists, pediatricians, and veterinarians

Contents Preface.- Epidemiology of Human Astroviruses.- Replication Cycle of Astroviruses.- Astrovirus Structure and Assembly.- Astrovirus Pathogene-sis.- Immune Responses.- Astrovirus Taxonomy.- New Human Astroviruses.- Astrovirus Infections in Animal Mammalian Species.- Avian Astroviru-ses.- Index.

Fields of interestsMedical Microbiology; Virology; Immunology



Due October 2012


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S. Sudowe, Ganzimmun Diagnostics AG, Mainz, Germany; A. B. Reske-Kunz, Johannes Gutenberg-University, Mainz, Germany (Eds)

Biolistic DNA DeliveryMethods and Protocols

Contents Comparison Between Agrobacterium-Mediated and Direct Gene Transfer Using the Gene Gun.- Transient Gene Expression in Epidermal Cells of Plant Leaves by Biolistic DNA Delivery.- Transfor-mation of Nuclear DNA in Meristematic and Em-bryogenic Tissues.- Biolistic DNA Delivery to Leaf Tissue of Plants with the Non-Vacuum Gene Gun (HandyGun).- HandGun-Mediated Inoculation of Plants with Viral Pathogens for Mechanistic Studies.- Biolistics-Based Gene Silencing in Plants Using a Modified Particle Inflow Gun.- Biolistic Transformation of Caenorhabditis elegans.- Improved Vectors for Selection of Transgenic Caenorhabditis elegans.- Biolistic Transformation of Brugia malayi.- Biolistic Transfection of Human Embryonic Kidney (HEK) 293 Cells.- Biolistic Transfection of Tumor Tissue Samples.- Biolistic Transfection of Freshly Isolated Adult Ventricu-lar Myocytes.- Biolistic Transfection of Neurons in Organotypic Brain Slices.- Biolistic DNA Delivery to Mice with the Low Pressure Gene Gun.- Chemokine Overexpression in the Skin by Biolistic DNA Delivery.- Enhancement of Gene Gun-Induced Vaccine-Specific Cytotoxic T Cell Response by Administration of Chemotherapeutic Drugs.- Dendritic Cell-Specific Biolistic Transfec-tion Using the Fascin Gene Promoter.- Particle-Mediated Administration of Plasmid DNA on Corneas of BALB/c Mice.- Optimizing Particle-Mediated Epidermal Delivery of an Influenza DNA Vaccine in Ferrets.- Methods for Monitoring Gene Gun-Induced HBV- and HCV-Specific Immune Responses in Mouse Models.- Gene Gun Immunization to Combat Malaria. [...]

Fields of interestsHuman Genetics; Genetic Engineering



Due September 2012

2013. 400 p. 80 illus., 27 in color. (Methods in Molecular Biology, Volume 940) Hardcover7 $139.00ISBN 978-1-62703-109-7

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A. Szallasi, Monmouth Medical Center, Long Branch, NJ, USA; T. Bíró, University of Debrecen, Hungary (Eds)

TRP Channels in Drug DiscoveryVolume II

Contents TRPs to Cardiovascular Disease.- Anemic Zebrafi-sh Models of Cardiomyopathy.- Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function.- Atherosclerosis Models with Cell-Mediated Calcification.- Models of Hypertension and Blood Pressure Recording.- Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling.- TRP Channels in the Brain.- Investigation of the Possible Role of TRP Channels in Schizophrenia.- Investigating Disea-ses of Dopaminergic Neurons and Melanocytes Using Zebrafish.- A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents.- Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory.- Chick Anxiety-Depression Screening Model.- A Clinically Relevant Throm-boembolic Stroke Model in the Aged Rat.- Use of Cell-Stretch System to Examine the Characteris-tics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies.- Methods in Neuronal Growth Cone Biology.- Transient Receptor Potential Channels and Pruritus.- Skin Sensitivity Studies.- Hair Follicle Culture.- Animal Models for Type 1 Diabetes.- Type 2 Diabetes Models.- Using Diet to Induce Metabolic Disease in Rodents.- Rodent Models to Evaluate Anti-Obesity Drugs.- Experimental Colitis Models.- Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis.- Methods to Study Thermonoci-ception in Rodents.- Methods for the Assessment of Heat Perception in Humans. [...]

Fields of interestsPharmacology/Toxicology; Proteomics



Due September 2012

2013. XX, 766 p. 75 illus., 55 in color. (Methods in Pharmacology and Toxicology, Volume 1) Hardcover7 approx. $139.00ISBN 978-1-62703-094-6

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Z. Trajanoski, Medical University Innsbruck, Austria (Ed)

Computational MedicineTools and Challenges

Contents 1. Bioinformatics tools for the search of disease-associated variations. Stefan Coassin, Anita Kloss-Brandstätter, Florian Kronenberg.- 2. Cloud computing: bringing computational power to me-dical genetics. Lukas Forer, Sebastian Schönherr, Hansi Weißensteiner, Günther Specht, Florian Kronenberg, Anita Kloss-Brandstätter.- 3. High-throughput characterization and comparison of microbial communities. Bettina Halwachs, Gregor Gorkiewicz, Gerhard G. Thallinger.- 4. Microar-ray Meta-Analysis: From Data to Expression to Biological Relationships. Julia Feichtinger, Gerhard G. Thallinger, Ramsay J. McFarlane, Lee Lar-combe.- 5. Analysis of labeled quantitative mass spectrometry proteomics data. Florian Breitwieser, Jacques Colinge.- 6. Lipidomics, Mass Spectro-metry and Bioinformatics. Jürgen Hartler, Harald C. Köfeler, Christopher J.O. Baker, Ravi Tharakan, Gerhard G. Thallinger.- 7. Protein sequence-structure-function-network links discoveries with the ANNOTATOR software suite: Application to ELYS/Mel-28analysis. Georg Schneider, Westley Sherman, Durga Kuchibhatla, Ooi Hong Sain, Fernanda L. Sirota, Sebastian Maurer-Stroh, Birgit Eisenhaber, Frank Eisenhaber.- 8. 3D structure and drug design. Kristina Djinovic-Carugo, Oliviero Carugo.- 9. Integrating biomolecular and clinical data for cancer research: concepts and challenges. Pornpimol Charoentong, Hubert Hackl, Bern-hard Mlecnik, Gabriela Bindea, Jerome Galon, Zlatko Trajanoski.- 10. Applied data mining: from biomarker discovery to decision support systems. Melanie Osl, Michael Netzer, S. Dreiseitl, Christian Baumgartner. [...]

Fields of interestsMolecular Medicine; Bioinformatics; Cell Biology



Available

2013. 350 p. 50 illus. in color. Hardcover7 $209.00ISBN 978-3-7091-0946-5

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C. Ulrich, National Center for Tumor Diseases, Heidelberg, Germany; K. Steindorf, German Cancer Research Center, Heidelberg, Germany; N. A. Berger, Case Western Reserve University, Cleveland, OH, USA (Eds)

Exercise, Energy Balance, and CancerFeatures 7 Examines the effect of exercise in biological pathways in tumor development 7 Explores the impact of exercise and ROS, RNOS and pros-taglandin on tumor growth 7 Features up-to-date research on the relationship between physical activity and cancer

Contents Introduction.- Effect of Exercise in Biological Pa-thways in Tumor Development.- Impact of Exer-cise and ROS, RNOS and Prostaglandin on Tumor Growth.- Impact of Exercise on Hormones and Cytokines Mediated Tumor Growth in PEPCK-Cmus Mice.- Energy Balance, Obesity, Immune Regulation and Cancer.- Physical Activity and Pri-mary Cancer Prevention.- Benefits and Rationale for Exercise During Cancer Therapy.- Exercise During Acute Cancer Chemotherapy.- Exercise During Stem Cell Transplantation.- Exercise in Patients with Advanced Cancer.- Exercise in Pedi-atric Cancer Patients.- Exercise In Elderly Cancer Center.- Benefits of Aerobic and Resistance Exer-cise.- Motivation and Sustainability .- Index.

Fields of interestsCancer Research; Health Promotion and Disease Prevention



Due September 2012

2012. XII, 230 p. 9 illus., 6 in color. (Energy Balance and Cancer, Tentative volume 6) Hardcover7 $189.00ISBN 978-1-4614-4492-3

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21

D. N. Wheatley, BioMedES, Inverurie, Aberdeen, UK

BipolARTArt in Therapy for Bipolar Disorder

Written with disarming honesty by a long-term sufferer of bipolar disorder, with more than half a century’s experience of intervention and treatment, this highly personal volume traces the effectiveness of a therapy modality for mental illness that has gained much ground in the past two decades: art. The author began to use art, and in particular doodling, from 1998 as a way of externalizing his feelings. Its expressiveness, acces-sibility and energy-efficiency was ideally suited to the catatonia he experienced during the bouts of depression that are a feature of bipolar disorder, while as the low moods lifted and his energy sur-ged, he completed more ambitious and elaborate works. As well as being highly eclectic, Wheatley’s assembled oeuvre has afforded him both insights and therapeutic intervention into his condition, once deemed highly debilitating and taboo, but much more socially accepted now that well known sufferers such as Stephen Fry have recounted their experiences of the condition.

Features 7 Uniqueness 7 Combines science with art 7 Is relevant to therapy 7 Advances under-standing of brain activity during bipolar disorder

Contents 1. Prologue – by way of an Introduction. - 2. Doodles – from the beginning. - 3. Drawing – a simple art. - 4. Development of doodles. - 5. A biological journey. - 6. Reality – drawings from life. - 7. A short musical interlude. - 8. Abstraction – a mind roaming free. - 9. Humour - light relief in a small biological structure. - 10. Goaded by geometry. - 11. Epilogue.

Fields of interestsBiomedicine general; Psychiatry; Behavioral Therapy



Available

2012. X, 80 p. 40 illus., 20 in color. Hardcover7 $139.00ISBN 978-94-007-4871-2

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G. Witzany, Telos - Philosophische Praxis, Bürmoos, Austria (Ed)

Viruses: Essential Agents of LifeFeatures 7 Most recent empirical knowledge on viru-ses and their role in evolution and environ-ment 7 Assembles most leading experts in their field 7 Changes biology paradigm from cell first to virus first perspective

Contents Preface.- 1. Revolutionary struggle for existence: introduction to four intriguing puzzles in virus research.- 2. Quasispecies dynamics of RNA viruses.- 3. The origin of virions and virocells: the escape hypothesis revisited.- 4. Scratching the Surface of Biology‘s Dark Matter.- 5. Virus universe: can it be constructed from a limited number of viral architectures.- 6. The addiction module as a social force.- 7. Viral integration and consequences on host gene expression.- 8. Persistent plant viruses: molecular hitchhikers or epigenetic elements?.- 9. The concept of virus in the post-Megavirus era.- 10. Unpacking the baggage : Origin and Evolution of Giant Viruses.- 11. Megavirales composing a fourth domain of life: Mimiviridae and Marseilleviridae.- 12. On viruses, bats and men: a natural history of food-borne viral infections.- 13. LTR retroelement-derived protein-coding genes and vertebrate evolution.- 14. Koala retrovirus endogenisation in action.- 15. The evolutionary interplay between exogenous and endogenous sheep betaretroviruses.- 16. Endoge-nous retroviruses and the epigenome.- 17. From viruses to genes: syncytins.- 18. Hepatitis G Virus or GBV-C: A Natural Anti-HIV Interfering Virus.- 19. Salutary Contributions of Viruses to Medicine and Public Health.- 20. From Molecular Entities to Competent Agents: Viral Infection-Derived Consortia Act as Natural Genetic Engineers.

Fields of interestsVirology; Evolutionary Biology; Microbiology



Available

2012. Approx. 350 p. 50 illus., 32 in color. Hardcover7 approx. $209.00ISBN 978-94-007-4898-9

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