ANNEX 15

fi~[~rjJ~Jfl~ COMPARISON OF TESTRESULTS AND PREDICTIONS

Chum. JNo.

—

4

MPD resultInvitro

MPD result SAXinvivo j

Agreement?-__I__________

.7nd- nd 0

6 Sal -ye mnuc -ye 0 Yes

16 Sal-vs -nd 0 NoSARlowMCUM+ve

17 Sal +ve nd 0 NoSARIowMCGM -vs

21 Sal-vs mnuc -vs 0 Yes

23. Sal-vs - ronuc-ve 0 Yes

24 Sal-vn mnuc-ve 0 Yes

26 Sal-vs • mnuc-vs 0 • Yes

37 Sal -ye mnuc -ye L-M No EC low

44 Sal-vs mnuc-ve 0 Yes-

47 Sal-vs mnuc-ve 0 Yes

49 Sal-vs nd 0 YesMCGM -vs -

50 Sal-vs nd 0 Yes• NC-vs

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CiNo.

MPD resultvitro

MPD resultin vivo

SAR Agreement?I___________

0 YesSal-vs mnuc-vs

54 Sal weak +vsMCGM -vs

SCE -vsNA -vs

equivocal Yes

61 Sal-vs. nd 0 YesNC -vs

68 Sal-vs nd 0 YesNC -vs

69 Sal-vsE Coli -vs

mnuc-vs 0 Ye~

70 Sal-vs ronuc-ve 0 Yes

76 5a1 -vs mnuc -vs 0 YesUDS -vs

78 Sal -vs mnuc -vs 0 Yes

79 Sal -vs mnuc -vs 0 YesE Coli -vs

87 - Sal-vs nd 0 YesNC -vs

96 - Sal -vs mnuc -vs L-M No EC lowEColi-ve

99 Sal-vs mnuc-vs 0 YesIVC -vs

101 Sal -vs mnuc -vs L-M No EC low

C

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MPD resultin vitro

SAX Agreement?Chum.No.j

MPD resultin vivo ~• I___________

mnuc-ve L-M NoEClowVa

102 Sal-vs..

106 Sal -vsE Coli -vs

mnuc -vs 0 Yes

107 nd nd 0 7

108 Sal-vs mouc -vs 0 Yes

110 Sal-vsMCGM -vsNC -vs

mnuc-vs 0 Yes

11.3 Sal -vs mnuc-vs 0 Yes

118 Sal-vs NA-vsmnuc -vs

0 Yes

124 Sal-vs mnuc-vs 0 Yes

128 Sal-vs CA-vs 0 Yes

133 Sal-vs mnuc-vs 0 Yes

144-MCGM

-•

Sal-vs-vs

, IVC -vs

nd 0 Yes

148 Sal-vs mnuc-vs 0 -. Yes

151 Sal-vsMCGM -vs

C NC-vs

nd 0 - - Yes

*

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SAXChum.No.

MPD resultIn vitro

MPD resultinvivo J___________

mnuc-ve 0 •

Agreement? -

155 • Sal-v. Yes

156 Sal -vs tunuc -vs 0 Yes

164 Sal -vsSCE -vs

mnuc -vs 0 Yes

170 Sal +vs• mnuc -vs 0 No SAllow

173 Sal -vs mnuc-vs 0 Yps

176 - Sal -vs mnuc-ve 0 Yes

182 Sal-vsMCGM -vs

mnuc-ve 0 Yes

186 Sal-vs mnuc-vs 0 Yes

192 Sal -vsE Coli -vs

mnuc -vs 0 Yes

194 nd nd 0 Yes

196 Sal -vsIVC weak +vs

mauc -vs L-M Yes

197 Salwsak+veE Coli -vsP/C -vs

ud L-M Yes

200 Sal-vsNC-vs

• C

ud 0 Yes

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*

No.MPD result

InvitroMPD result

InvivoSAX

aAgreement?

204 Sal-v. mnuc-vs 0 Yes

214 - Sal-vs esnuc-ve 0 Yes

216 Sal weak +veMCGM -vs

P/C -vs

NA -vsmauc -vs

0 No SAX low

217 Sal-vs mnuc-vs 0 Yes

218 Sal~vsE Coli -vsP/C -vs

ud 0 Yes

219 Sal +veMCGM -vs

mnuc -vs L-M Yes

222 Sal -ye mnuc -vs L-M No EC low

- 224 Sal -vs mnuc -vs L-M No EC low

235 Sal-vs. ~uc-vs 0 Yes

237 Sal-vsP/C -vs

nd 0 Yes

239 . Sal-vs

IVC -vs

nd 0 Yes

240 Sal -vs mnuc -vs 0 Yes

241•

Sal-vsIVC -vs

C

nd 0 • Yes

a

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—.Chum.

No.MPD resultinvitro MPD resultinvivo SAX Agreement?I___________

0 Yes242 • Sal-vs

P/C -vs

nd

253 Sal-vs mnuc-ve 0 Yes

256 Sal -vs innuc -vs 0 Yes

263 Sal +vs mnuc -vs L-M YesP/C -vs

265 Sal-vsP/C -vs

nd 0 Yes

267 • ud nd 0 Yes

268 Sal -vs mnuc -vs 0 Yes

269 Sal weak +veMCGM -vs

mnuc -vs L-M Yes

P/C -vs

270 - Sal--vs mnuc-vs 0 Yes

271 Sal -vs• IVC -vs

nd 0 Yes

275 Sal +ve mnuc -vs L-M YesIVC -vs

278 - Sal-vs

SCE weak +vs?

mnuc-vs 0 Yes

281 Sal-vs mnuc -vs L YesC

a

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C

Chum. j

No.j

MPD result

invitro

MPD result

invivo

SAX Agreement?

2831429

Sal -vs mnuc-vs 0 Y

286 Sal -vs mnuc -vs 0 Yes

287 Sal -vs mnuc -vs 0 Yes

289 Sal +vsP/C -vs

mnuc -vs L-M Yes

291 Sal -vs mnuc -vs L Yes

292-

Sal-vsP/C-vs

nd 0 Yes

300 Sal-vs mnuc-vs 0 Yes

307 Sal +vsE~oli -vs

mnuc -vs L-M Yes

309 Sal -vs mnuc -vs 0 Yes

312•

Sal +veMCGM -vs

mnuc-vs L-M Yes-

•318 Sal-vs mnuc -vs 0 Yes:

320 Sal -vs mnuc -vs 0 Yes

• 321 Sal-vs mnuc-vs M NoEClowC

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Chin.

No.

MPD resultin vitro

MPD resultIn vivo

SAX ~ Agreement?- I___________

L-M • No330 Sal -vs mnuc -vs

335 Sal +veMCGM -vs

mnuc -vs L-M Yes

336 Sal-vs mnuc-vs 0 Yes

337 Sal -vs •MCGM -vs

nd L-M No EC low

P/C -vs

340 Sal-yeP/C +vs

mnuc-ve 0 NoSAXIow

341 Sal-vs mnuc-vs 0 Yes

342 - Sal-vs mnuc-vs 0 YesP/C -vs

344 Sal-vs ronuc-ve • 0 Yes

348 Sal-vs mnuc-vs 0 Yes

349 Sal-vs mnuc-vs 0 Yes

354• Sal -vs- P/C-vs

mnuc-vs 0 Yes

SCE -vs

355 Sal-vs mnuc-vs 0 Yes

360 Sal-vsP/C-vs -

nd 0 Yes

C

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Agreement?Chum. MPD result MPD resultin vivo

SAXi________

0 Yes

a

ud

362 Sal weak +vs mnuc -vs L-M Yes

364 Sal-vsP/C +vs

mnuc-vs 0 NoSARIow

366 Sal-vs- E Coli -vs

mnuc-vs 0 Yes

P/C -vsnd 0 Yes

P/C +vs (art)mnuc -vs 0 Yes

370 Sal-vs mnuc-vs 0 Yes

mnuc -vs 0 Yes

376 Sal-vsIVC -vs

nd 0 Yes

379 Sal -vsIVC -vs

nd L-M No EC low

381 Sal-vs mnuc -vs 0 Yes

383 Sal-vs mnuc-vs 0 Yes

386•

Sal-vsEColi -vsP/C-vs

mnuc-vs 0 Yes

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S

CChum. MPD resultNo.1 In vitro

MPD resultinvivo

SAX j Agreement?SI___________

0 Yes393 Sal-vs CA-vs

394 Sal-vs ad 0 YesP/C -vs

396 Sal-vs mnuc-vs 0 Yes

398 Sal-vs mnuc-vs 0 Yes

401 Sal-vs nd 0 YesP/C v.wsak +ve

406 • Sal-vs ad L-M NoEClowP/C -vs

411 Sal-vs mauc-ve 0 YesPrival -vs

413 Sal-vs mnuc-vs 0 Yes

414 Sal-vs mauc-ve 0 Yes

415 Sal-vs innuc-ve -0 Yes

416 • Sal -vs mnuc-ve 0 . Yes

417 Sal-vs umuc-vs 0 Yes

420 Sal-vs nd 0 • YesEColi-ve4VC -vs

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Chum. MPD result MPD result

2. I ~ [ m:’~

SAX

Agreement?Yes

425 -Sal-vsP/C-vs

ad 0 Yes

431-

Sal-vsP/C-vs

ad 0 Yes

436 Sal-vs . CA-vs 0 Yes

437 Sal -vsP/C -vs

mnuc -vs 0 Yes

439 Sal-vsP/C -vs

ad 0 Yes

441 Sal -vsE Coli -vsP/C -vs

nd L-M No EC low

442 Sal -vsP/C +ve

nd L-M Yes

443 Sal-vs . mnuc-vs 0 • Yes

444 Sal -vs mnuc -vs L-M No EC low

445 ud nd 0 Yes

446 Sal-vsEColi -vs

mauc-ve 0 • Yes

451 • Sal-vs

EColi -vs

IVC -vs

mnuc -vs 0 Yes

472 C~ Sal -vs ronuc -vs 0 Yes

AIS-11

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- *

Abbreviations: Sal = Salmonella (Ames) gene mutation testmnuc = micronucleus testMCGM = any mammalian cell gene mutation testP/C = in~iim chromosome aberration testSCE = sister chromatid exchange testUDS = unscheduled DNA synthesis testNA = nuclearanomaly testCA = chromosomeaberrationtestE coli = E coli gene mutation testart = artefactad = not dons -

o or L = SAX prediction of low concernL-M = SAR prediction of low to moderata concernM m SAX prediction of moderate concern+vs = positive.-vs = negative 9

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