Vector Ecology & ManagementWHO Neglected Tropical Diseases

UPDATES: VEM / NTD & STAG 2019

RAMAN VELAYUDHAN, VEM/NTDVCAG MEETING, 13 MAY 2019

GENEVA, SWITZERLAND

2Vector Ecology & Management

WHO Neglected Tropical Diseases

5 CORE STRATEGIES FOR CONTROL, ELIMINATION AND ERADICATION OF NTDs…

Preventive chemotherapy (1. 2017)1.762 – billion treatments delivered; 1.036 billion in need treated for at least one disease

Innovative and intensified disease management2.> – 462 000 people diagnosed and treated (2017)Roll– -out of WHO information System to Control and Eliminate NTDs (WISCENTD) Scale– -up of the integrated skin-NTD approach

Vector ecology and management3.Updating normative guidance and supporting implementation of GVCR – 2017 ̶2030Preventing and controlling dengue/chikungunya and other – Aedes-borne diseasesInvestigating new tools for prevention and control of VBDs–

Veterinary public health and One Health approaches4.Reinforcing coordination with FAO, OIE and veterinary and food safety authorities–

authorities

Water, sanitation and hygiene5.Toolkit on WASH and Neglected Tropical Diseases released in – 2019

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WHO Neglected Tropical Diseases

9 Neglected Tropical Diseases (NTDs) involve vector transmission:

➢dengue, chikungunya, Zika virus disease, leishmaniasis, lymphatic filariasis, human African trypanosomiasis, Chagas disease, onchocerciasis, and schistosomiasis

600M annual cases among world's poorest populations

Aedes-borne disease outbreaks show the growing threat vector-borne NTDs pose to societies

VEM WORKS TO STOP NTDs SPREAD BY MOSQUITOES, FLIES (SAND-, BLACK-, TSETSE-),

BUGS, TICKS, AND OTHER VECTORS

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SUPPORT EMERGENCYRESPONSE

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• Core capacities for vector control at PoE

• Vector Identification at PoE• Aircraft disinsection methods

and procedures

INNOVATION & VECTOR CONTROL

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• New Vector Control Tools for NTDs – VCAG

• M&E of Wolbachia-Aedespilots (PAHO) & Safety of Wolbachia-Aedes

• Horizon scanning for VC tools

BUILD CAPACITY FOR RESEARCH & SURVEILLANCE

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• Capacity building for GLP certification of labs (i2i)

• Global arbovirus laboratory proficiency testing (IHR)

• Collaborating institutions

SUPPORT COUNTRIES

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9 • Neglected Tropical Diseases Pesticide •management (IPCS)Ethics and Vector •borne diseases Guidance Framework for SIT-Aedes (IAEA / TDR)

GLOBAL POLICIES1

• Global vector control response 2017–2030: “World free of human suffering from vector-borne diseases”

• Reduce the burden and threat of dengue globally

UPDATE ON VEM PROJECTS & COLLABORATIONS

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WHO Neglected Tropical Diseases

Supporting countries in Aedes-borne diseasesProgress

• >50% case decline (2017 ̶ 2018) in the Americas post-Zika outbreak

Global decline in case fatality rate•

Burden estimation toolkit developed; •10 countries assessed

Challenges

128 • endemic countries, 3.6 billion at risk of infection, 50 ̶ 100 M cases/year

Rise in number and size of urban areas•

Opportunities

New vector control tools, potential •vaccines, integrated & intersectoral approach

Regional plans and country activities •based on GVCR

Vector surveillance and M&E•

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WHO Neglected Tropical Diseases

New Vector Control Tools for NTDs

POLICYFOR INNOVATION

& VECTOR CONTROL

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SUPPORTCOUNTRIES

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Intervention Disease target Prototype / product Status

Spatial Repellents Dengue /arboviral Transfluthrin passive emanator Epi

Peridomestic residual spray Dengue /arboviral Spaying of exterior walls and boundary fences of dwellings with residual insecticide formulations

Epi

Vector traps for disease management

Dengue /arboviral Vector traps including AGO trap and Trap-N-kill ® trap

Epi

Dengue /arboviral In2Care® Mosquito Trap Epi

Genetic manipulation of vectors for disease control

Dengue /arboviral Next generation product ---

Sterile insect technique with microbial infection

Dengue /arboviral Sterilized male Ae. aegypti and Ae. albopictus infected with Wolbachia

Epi

Microbial control of human pathogens in adult vectors

Dengue /arboviral wMel strain Wolbachia in Aedesaegypti

Epi

Systemic insecticides and endectocides

Leishmaniasis / sandfly Fipronil bolus Epi

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WHO Neglected Tropical Diseases

Two overarching goals ̶ disease-specific targets ̶ cross-cutting indicators

OUTCOMES OF STAG 2019TOWARDS 2030: NEW NTD ROADMAP

The new NTD Roadmap 2021 ̶ 2030 will be:the outcome of a wide consultative process–

country– -centric

focused towards – 2030 while building on progress of the 2020 NTD Roadmap

aligned with the UN Sustainable Development Goals and WHO– ’s GPW13

cross– -cutting

launched in October – 2020

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–UN Sustainable Development Goals–GPW 13

–NTD Road map

2018

2019

2020

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

–“The triple billion”

NTDs in the development context

New NTD Road map–

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Revision and updates

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WHO Neglected Tropical Diseases

OUTCOMES OF STAG 2019: Vector-borne diseases

Urban environments (especially informal settlements) facilitate the spread of A. aegypti and associated arboviral infections, and the NTD department should facilitate cross-sectoral action, working with appropriate actors.

The NTD Department should work closely with appropriate actors to address the issues of NTD medicine and insecticide resistance.

Technical WGs that report to the Director NTDs to include dengue and arbovirus control

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Thank you

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