Upload
many87
View
424
Download
2
Tags:
Embed Size (px)
Citation preview
1
PEER REVIEW ADVISORY COMMITTEEUpdate on New CSR Realignments
Basic Oncology and Bioengineering
Don Schneider
National Institutes of HealthU.S. Department of Health and Human Services
February 1, 2010
Continuous evolution/alignment of study sections is necessary
• Science changes
• CSR is committed to assessment
• Study section size matters –
too small/too large
[Fewer than 50 applications
Is a problem]
2
Three goals to consider
• Look at recent reorganizations
• Examine proposed guideline adjustments for Oncology 1 – Basic Translational (OBT) IRG
• Re-examine Microscopic Imaging study section
3
Cell Biology merged study sections
2009/05 2010/05
Cell Structure Nuclear & Cytoplasmic
& Function 41 Struct, Functn, & Dynam
Nuclear Dynam 67
& Transport 45
Cellular Signaling Cellular Signaling
& Regulatory & Regulatory
Systems58 Systems 84
Subtotal144 151 applctns4
Digestv, Kidney, & Urologcl Sys merged study sections
2009/05 2010/05
Gastrointestinal
Cell & Molecular
Biology 41
Gastrointestinal Gastrointestinal
Mucosal Mucosal
Pathobiology 53 Pathobiology 56
Hepatobiliary Hepatobiliary
Pathophysiology 64 Pathophysiology 78
Clinical & Clinical,
Integrative Integrative
Gastrointestinal & Molecular
Pathobiology 46 Gastroenterology 68
Subtotal 204 202 5
Bioengineering merged panels2009/05 2010/05
Biodata Management Biodata Management
& Analysis 40 & Analysis 88
SEP 28
Modeling & Analysis Modeling & Analysis
Of Biological Of Biological
Systems 39 Systems 72
Microscopic Microscopic
Imaging 20 Imaging 27
Subtotal 127 187
6
Interim analysis of realignments is positive
• Workloads improve (except Micros Imaging)• Science and fairness of review are probably
better• CSR needs metric/tool to measure scientific
impact
7
Translational and Clinical Sciences
Cardiovascular and Respiratory Sciences
Surgical Sciences, Biomedical
Imaging and Bioengineering
Musculoskeletal, Oral & Skin Sciences
Oncology: Translational Clinical
Vascular and Hematology
Physiological and Pathological Sciences
Endocrinology, Metabolism, Nutrition & Reproductive Sciences
Immunology
Infectious Diseases& Microbiology
Digestive, Kidney &Urological Systems
Neuroscience, Development and Aging
Brain Disorders &Clinical Neuroscience
Molecular, Cellular &Developmental Neuroscience
Integrative, Functional & Cognitive Neuroscience
Emerging Technologies &Training in Neuroscience
Biology of Development & Aging
Biobehavioral & Behavioral Processes
Risk, Prevention& Health Behavior
Population Sciences & Epidemiology
Healthcare Delivery & Methodologies
AIDS & AIDSRelated Research
AIDS, Behavioral and Population Sciences
Basic and Integrative Biological Sciences
Biological Chemistry & Macromolecular
Biophysics
Bioengineering Sciences& Technologies
Genes, Genomes & Genetics
Oncology: Basic Translational
Cell Biology
Interdisciplinary Molecular Sciences
& Training
CSR formed five review divisions, January 2009
Oncology 1 – Basic & Translational IRG was established and reviewed
• Split ONC to form OBT & OTC January 2009
• Collected feedback from reviewers two cycles (October and February meetings)
• Discussed feedback with Chairs (Chief and DD)
• Reviewed by CSR Director et al September 23, 2009
[Chief – Cathleen Cooper]9
Realignments are proposed for OBT study sections
For emerging trends, clarity of scientific scope, and workload balance, guideline adjustments are proposed:
• Cancer Molecular Pathology study section (CAMP) –about 110 applications a cycle; focuses on oncogenes and tumor suppressors; move telomeres and epigenomics
• Cancer Genetics study section (CG) – about 75 applications a cycle; focuses on chromosomal integrity and stability; add telomeres and epigenomics (would fit well)
• Cancer Etiology study section (CE) – about 90 applications a cycle; focuses on DNA repair and environmental carcinogenesis; move epigenomics unless focus is environmental
• Estimated result: about 95, 90, and 90 applications10
Bioengineering Sciences and Technologies IRG was formed in 2004
Regular Study Sections• Biodata Management and Analysis (BDMA)• Biomaterials and Biointerfaces (BMBI)• Gene and Drug Delivery Systems (GDD)• Instrumentation Systems and Development (ISD)• Modeling and Analysis of Biological Systems
(MABS)• Microscopic Imaging (MI)• Nanotechnology (NANO)
[Chief – George Chacko]
11
Steps to realign were taken a year ago
• Original study sections were hybrids in that R01s and R43s were reviewed together – no longer possible
• BDMA & MI were small, about 50 applications each• Via Working Group and PRAC, BDMA was
combined with a software SEP and scope of MI was expanded
12
2009 Realignment worked for BDMA, not for MI
13
Microscopic Imaging and Spectroscopy
The study section focuses on review of applications on techniques and instrumentation for microscopic visualization of molecules, organelles, and model systems
• Development and improvement of microscopic imaging and spectroscopy
• Development of imaging tools/software• Image acquisition and analysis, including single
particle
14
Instrumentation Systems and Development shares interests with Microscopic Imaging
• Optical and spectroscopic instrumentation• Microfabrication• Automation and integration• Sensing of single cells
15
MIS, ISD, & EBT share interests
• Microscopic Imaging and Spectroscopy, in BST, focus is to develop techniques to visualize molecules, organelles, and cells
• Instrumentation and Systems Development, in BST, focus is to develop instrumentation for biological research
• Enabling Bioanalytical and Biophysical Technologies, in BCMB, focus is development of bioanalytical tools to probe molecules
16
Options presented to Working Group
[Working within the Bioengineering IRG]
• Terminate MIS
• Merge MIS with ISD
• Expand the scope of MIS
17
Bioengineering Working Group #2 met January 2010
ROSTER
• Wah Chiu, PhD (Baylor College of Medicine)
• Robert M Dickson, PhD (Georgia Institute of Technology)
• Michael Gilson, MD, PhD (University of Maryland)
• Enrico Gratton, PhD (University of California Irvine)
• Jerome Mertz, PhD (Boston University)
• Stephen C Miller, PhD (University of Massachusetts Worcester)
• Amy Palmer, PhD (University of Colorado Boulder)
• Peter Sorger, PhD (Massachusetts Institute of Technology)
• Shankar Subramaniam, PhD (University of California San Diego)
• Stephen Wong, PhD (Cornell University Weill)
• Xiaowei Zhuang, PhD (Harvard University)
• NIH: James Deatherage, PhD (NIGMS); Catherine Lewis, PhD (NIGMS); George Chacko, PhD (CSR); Don Schneider, PhD (CSR)
18
Working Group Expressed Preferences
• Terminate Microscopic Imaging - WG least enthusiasm, integrated basic imaging panel has value, will grow
• Merge MIS, principally with Instrumentation and Systems Development - WG medium enthusiasm
• Expand scope and continue Microscopic Imaging - WG considerable enthusiasm
19
Should MI be continued?
• Element of “Been there, done that”• Related issues
- EBT study section
- IMST IRG
20
CSR created Interdisciplinary Molecular Sciences & Training IRG January 2009
• IMST uses SEPs to review all fellowship and small business applications for Basic & Integrative Biological Sciences (basic oncology, bio-chemistry/biophysics, bioengineering, cell biology, and genetics)
• IMST uses SEPs to review interdisciplinary special applications, e.g., some P01s, P41s, and S10s
• IMST was recently chartered, with understanding that it would form a regular, chartered study section
[Chief – Ross Shonat] 21
Taking a bolder, broader view
• EBT averages about 60 applications a round• MI averages about 25 applications a round• EBT and MI have complementary interests• IMST IRG needs a chartered study section• 25 + 60 = 85, close to ideal• Create EBIT, Enabling Bioanalytical and
Imaging Technologies
22
PRAC input sought
Oncology 1 – Basic Translational IRG (OBT)• Move telomeres and epigenomics from Cancer
Molecular Pathology to Cancer Genetics• Move some epigenomics from Cancer Etiology to
Cancer Genetics
Microscopic Imaging and Spectroscopy• Allow more time for growth, OR• Merge with Enabling Bioanalytical and Biophysical
Technologies and move to Interdisciplinary Molecular Sciences and Training IRG
23
Discussion