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UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM. Mochamad Fahlevi Rizal. Infeksi akibat biofilm. Perkembangan teori biofilm. Skema biofilm. Properti biofilm. Fungsi komponen saliva. Jalur metabolik spesifik dan mekanisme transport S. mutans. Salivary Mucin MG2. .5. .4. .3. .2. - PowerPoint PPT Presentation
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UPAYA PENCEGAHAN KARIES MELALUI PENELAAHAN BIOFILM
Mochamad Fahlevi Rizal
Infeksi akibat biofilm
Perkembangan teori biofilm
Skema biofilm
Properti biofilmGeneral property Dental plaque example
Open architecture Presence of channels and voids
Protection from host defences, desiccation etc.
Production of extracellular polymers to form a functional matrix
Enhanced resistance to antimicrobials
Increased resistance to chlorhexidine and antibiotics
Neutralization of inhibitors Β-lactamase production by neighbouring cells to protect sensitive organisms
Novel gene expression Synthesis of novel proteins; up-regulation of gtfBC
Co-ordinated gene responses Production of cell-cell signaling molecules (e.g. CSP, autoinducer 2)
Spatial and environmental heterogeneity
pH and O2 gradients; co-adhesion
Broader habitat range Obligate anaerobes in an overtly aerobic environment
More efficient metabolism Complete catabolism of complex host macromolecules (e.g. mucins) by consortia
Host•Saliva•Struktur Gigi•dll
Agent
•Bakteri
Fungsi komponen saliva
Jalur metabolik spesifik dan mekanisme transport S. mutans
Salivary Mucin MG2
deft
1614121086420-2
.5
.4
.3
.2
.1
0.0
-.1
Observed
Cubic
Terima Kasih