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PharmacoEconomics & Outcomes News 585 - 22 Aug 2009 Untapped markets offer large rewards Current markets for arthritis, prostate cancer and drug device combinations are expected to grow while the dyslipidemia market shrinks, according to recently released reports from Decision Resources, and Research and Markets. Proportionally, the arthritis treatment drug market in Brazil is poised to be the largest winner, with a projected growth of over 55% between 2008 and 2013, bringing total market value to more than $US315 million. 1 The 2008 market was led by tumour necrosis factor-alpha inhibitors Humira [adalimumab] and Remicade [infliximab], despite holding a combined patient share of 2%. Drug device combinations (a vendible combination of drugs and medical devices) are further projected to show compound annual market growth of 11.8% over the next five years, primarily due to untapped market potential. 2 Similarly, the significant unmet need for therapies which target hormone-refractory metastases from prostate cancer is expected to be filled by 2018, capturing more than one third of the overall prostate cancer market in France, Germany, Italy, Japan, Spain, the UK, and the US. 3 Several agents, including the therapeutic cancer vaccine sipuleucel-T [Provenge], are expected to fuel this $US2 billion growth. During the very same time frame the dyslipidemia drug market in these countries is expected to shrink by $US4 billion, due to generic erosion of key statins such as atorvastatin and rosuvastatin, whose US patents expire in 2010 and 2016, respectively. 4 Opportunity still exists in this market to develop treatments for the growing number of mixed dyslipidemia cases. 1. Decision Resources. Brazil’s Rheumatoid Arthritis Drug Market Will Grow $115 Million by 2013. Media Release : 20 Jul 2009. Available from: URL: http://www.decisionresources.com. 2. Research and Markets. Research and Markets: Drug and Device Combination 2009-2014 - Current Market Has a Potential of US$10.6 Billion, a Growth of 15% CAGR over the Past Two Years. Media Release : 14 Jul 2009. Available from: URL: http://www.researchandmarkets.com. 3. Decision Resources Inc. Driven by Launch of Emerging Therapies, Overall Prostate Cancer Drug Market Will Increase by $2 Billion Through 2018. Media Release : 27 Jul 2009. Available from: URL: http://www.decisionresources.com. 4. Decision Resources Inc. Through 2018, Generic Erosion of Key Statins Such as Lipitor and Crestor Will Reduce the Dyslipidemia Drug Market by $4 Billion. Media Release : 21 Jul 2009. Available from: URL: http:// www.decisionresources.com. 801108569 1 PharmacoEconomics & Outcomes News 22 Aug 2009 No. 585 1173-5503/10/0585-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Untapped markets offer large rewards

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PharmacoEconomics & Outcomes News 585 - 22 Aug 2009

Untapped markets offer largerewards

Current markets for arthritis, prostate cancer and drugdevice combinations are expected to grow while thedyslipidemia market shrinks, according to recentlyreleased reports from Decision Resources, and Researchand Markets.

Proportionally, the arthritis treatment drug market inBrazil is poised to be the largest winner, with a projectedgrowth of over 55% between 2008 and 2013, bringingtotal market value to more than $US315 million.1 The2008 market was led by tumour necrosis factor-alphainhibitors Humira [adalimumab] and Remicade[infliximab], despite holding a combined patient share of2%.

Drug device combinations (a vendible combination ofdrugs and medical devices) are further projected toshow compound annual market growth of 11.8% overthe next five years, primarily due to untapped marketpotential.2 Similarly, the significant unmet need fortherapies which target hormone-refractory metastasesfrom prostate cancer is expected to be filled by 2018,capturing more than one third of the overall prostatecancer market in France, Germany, Italy, Japan, Spain,the UK, and the US.3 Several agents, including thetherapeutic cancer vaccine sipuleucel-T [Provenge], areexpected to fuel this $US2 billion growth.

During the very same time frame the dyslipidemiadrug market in these countries is expected to shrink by$US4 billion, due to generic erosion of key statins suchas atorvastatin and rosuvastatin, whose US patentsexpire in 2010 and 2016, respectively.4 Opportunity stillexists in this market to develop treatments for thegrowing number of mixed dyslipidemia cases.1. Decision Resources. Brazil’s Rheumatoid Arthritis Drug Market Will Grow

$115 Million by 2013. Media Release : 20 Jul 2009. Available from: URL:http://www.decisionresources.com.

2. Research and Markets. Research and Markets: Drug and Device Combination2009-2014 - Current Market Has a Potential of US$10.6 Billion, a Growth of15% CAGR over the Past Two Years. Media Release : 14 Jul 2009. Availablefrom: URL: http://www.researchandmarkets.com.

3. Decision Resources Inc. Driven by Launch of Emerging Therapies, OverallProstate Cancer Drug Market Will Increase by $2 Billion Through 2018. MediaRelease : 27 Jul 2009. Available from: URL: http://www.decisionresources.com.

4. Decision Resources Inc. Through 2018, Generic Erosion of Key Statins Such asLipitor and Crestor Will Reduce the Dyslipidemia Drug Market by $4 Billion.Media Release : 21 Jul 2009. Available from: URL: http://www.decisionresources.com.

801108569

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PharmacoEconomics & Outcomes News 22 Aug 2009 No. 5851173-5503/10/0585-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved