University of Washington February 4, 2016 School of ...€¦ · Curriculum Vitae – Monica S. Vavilala, M.D. Page 2 2013-2014 Interim Director, UW Harborview Injury Prevention and

University of Washington February 4, 2016 School of Medicine Curriculum Vitae

Personal Data: Name Monica S. Vavilala, MD

Address (work) Department of Anesthesiology & Pain Medicine

Harborview Medical Center 325 Ninth Avenue, Box 359724, Seattle, WA 98104

Telephone (206) 744-3210 (office)Fax (206) 744-8090 (fax)Email [email protected] USA

Education:

1984-1987 University of Houston, Houston, TX B.S. 1987-1991 University of Texas Medical School, Houston, TX M.D.

Postgraduate Training:

1991-1994 University of Texas, Houston, TX Residency Pediatrics 1994-1997 University of Washington, Seattle, WA Residency Anesthesiology 2012-2013 Certificate Course in Health Economics University of Washington

Faculty Positions Held:

1997-2000 Acting Assistant Professor, Departments of Anesthesiology and Pediatrics, University of Washington School of Medicine, Seattle, WA

2000- Assistant Professor, Departments of Anesthesiology and Pediatrics, University of Washington School of Medicine, Seattle, WA

2003- Core Faculty. Harborview Injury Prevention and Research Center, Seattle, WA 2004- Associate Professor. Departments of Anesthesiology and Pediatrics. University of

Washington School of Medicine, Seattle, WA 2004- Adjunct Associate Professor. Department of Neurological Surgery. University of

Washington. Seattle, WA. 2008- Associate Director, Harborview Injury Prevention and Research Center. Seattle, WA. 2010-2011 Director, Harborview Anesthesia Research Center 2010- Adjunct Associate Professor. Department of Radiology. University of Washington. Seattle,

WA. 2011- Professor. Departments of Anesthesiology and Pediatrics. University of Washington. Seattle,

WA. 2011- Adjunct Professor. Departments of Neurological Surgery and Radiology. University of

Washington. Seattle, WA. 2012-2013 Interim Vice-Chair for Clinical Research, Department of Anesthesiology and Pain Medicine

Curriculum Vitae – Monica S. Vavilala, M.D. Page 2

2013-2014 Interim Director, UW Harborview Injury Prevention and Research Center 2014- Director, UW Harborview Injury Prevention and Research Center Hospital Positions Held: 1992-1994 Attending Pediatrician, Mac Gregor Medical Association. Houston, TX 1992-1994 Flight Physician, Life Flight, Houston, TX 1994-2005 Attending Pediatrician, Emergency Department, Children’s Hospital and Regional Medical

Center, Seattle, WA 2005-2006 Attending Anesthesiologist, Seattle Children’s Hospital, Seattle, WA 1997- Attending Anesthesiologist, Harborview Medical Center, Seattle, WA Academic and Professional Honors: 1983 Dr. Michael E. De Bakey Summer Research Fellowship 1984 Dr. Michael E. De Bakey Summer Research Fellowship 1986 Southwestern Sociological Association Writing Award 1990 American Cancer Society Fellowship 1992 Outstanding Medical Student Educator 1992 Pediatrics Resident of the Year 2005 EuroNeuro2005 Anesthesiology Poster Presentation Prize 2005 University of Washington Department of Anesthesiology B. Raymond Fink Award for

Research 2012 Best Doctor in Anesthesiology, Seattle Metropolitan Magazine 2012 Foundation for Anesthesia Education and Research Academy of Mentors

Board Certification: 1994 Diplomate, American Board of Pediatrics 1997 Diplomate, American Board of Anesthesiologists 2000 Recertification in Pediatrics Certifications: 1997- Advanced Trauma Life Support, Advanced Cardiac Life Support, Pediatric Advanced Life

Support, Advanced Life Support 2012 Certificate in Health Economics and Outcomes, University of Washington License to Practice: 1992 Texas 1994- Washington


Professional Organizations: 1987-1994 Harris County Medical Society 1991-2002 American Medical Association 1991-2002 American Academy of Pediatrics 1994- Washington State Society of Anesthesia 1995- American Society of Anesthesiologists 1999- Society for Pediatric Anesthesia 1999- Society for Neuroscience in Anesthesiology and Critical Care 2003- Society for Pediatric Research 2005- Association of University Anesthesiologists 2008- National Neurotrauma Society 2010- Pediatric Neurocritical Care Research Group Ethics Training

2003, 2005, 2007, 2010, 2012, 2013 University of Washington IRB Ethics Modules Certification Developing World Experience

1986-1988 Medical student volunteer, Rural India. World health Organization June-August 1986, June –August 1988

Formal Teaching Responsibilities: 1997-1999 University of Washington, Department of Anesthesiology, R2 Lectures, Inhalational

Anesthetics, Seattle, WA 1997-1999 University of Washington, Department of Pediatrics, PICU Fellow Lectures, Pediatric

Trauma, Seattle, WA 1997-2002 Harborview Medical Center, Department of Anesthesiology, Resident Weekly Case

Conference Coordinator, Seattle, WA 1997- University of Washington, Department of Pediatrics, R2, R3 Lectures, Trauma Resuscitation,

Seattle, 1998 University of Washington, Department of Anesthesiology, R4 Lectures, Oral Board Review,

Seattle, WA 1999- Harborview Medical Center, Departments of Nursing and Respiratory Therapy, Newborn and

Pediatric Resuscitation, Seattle, WA 1999- Harborview Medical Center, Departments of Anesthesiology, Anesthesia Technician Lecture,

Newborn and Pediatric Resuscitation, Seattle, WA 2000-2004 American Society of Anesthesiologists Annual Meeting Problem Based Learning Discussion

Sessions 2002- University of Washington, Department of Anesthesiology, Annual R4 Seminar, Newborn

Resuscitation, Seattle, WA 2006- University of Washington, Department of Pediatrics, Quarterly Pain Conference, Seattle, WA 2011 Graduate Nursing Seminar, University of Washington, Seattle, WA


Invited Speaker/ Lectures and Visiting Professorships:

1. Invited Speaker. “Pediatric Trauma.” Washington State Society of Anesthesia, Seattle, WA 1998. 2. Invited Speaker.“Pediatric Trauma Resuscitation.” Annual WWAMI HMC Trauma Conference,

Seattle, WA 2000, 2001. 3. Invited Speaker. “Cerebral Autoregulation.” Annual WWAMI HMC Trauma Conference, Seattle, WA

2000. 4. Invited Speaker. “Should We Use Ketamine in The ED?” Annual WWAMI HMC Trauma Conference,

Seattle, WA 2001. 5. Invited Speaker.“Airway Management in Pediatric Trauma: CNS Implications.” Washington State

Society of Anesthesiologists, Seattle, WA 2000. 6. Invited Speaker. “Pediatric Trauma.” American Society of Anesthesia Technicians, Seattle, WA 2000. 7. Invited Speaker. “Anesthesia for Head Injury.” St. Joseph’s Hospital, Tacoma, WA 2000. 8. Invited Speaker. “Pediatric Trauma.” Providence Hospital, Everett, WA 2000. 9. Invited Speaker. “Pediatric Sedation and Rapid Sequence Intubation.” Providence Hospital, Everett,

WA 2001. 10. Visiting Professor. “Hemodynamic Management in Pediatric Traumatic Brain Injury.” University of

Texas Medical School at Houston, Houston, TX 2003. 11. Visiting Professor. “Cerebral Blood Flow and Autoregulation in Pediatric Diabetic Ketoacidosis”

Loyola University Medical Center, Chicago, IL 2003. 12. Visiting Professor “Hemodynamics in Pediatric Traumatic Brain Injury” Loyola University Medical

Center, Chicago, IL 2003. 13. Invited Speaker “Factors Governing Hemodynamic Management in Pediatric Traumatic Brain Injury.”

Children’s Hospital and Regional Medical Center, Seattle, WA 2003. 14. Visiting Professor “Hemodynamics and Outcome in Severe Pediatric Traumatic Brain Injury.”

Vanderbilt University, Nashville, TN 2004. 15. Visiting Professor “Blood Pressure Management in Severe Pediatric Traumatic Brain Injury.”

Children’s Hospital of Philadelphia, Philadelphia, PA 2005. 16. Invited Speaker.“Pediatric Trauma”. European Society of Anesthesiologists, Munich, Germany 2005. 17. Invited Speaker “Management of Intracranial Pressure”. Thai Society of Anesthesiologists. Bangkok,

Thailand, 2005 18. Invited Speaker “Monitoring in Traumatic Brain Injury”. Thai Society of Anesthesiologists. Bangkok,

Thailand. 2005 19. Visiting Professor “Blood Pressure Management in Severe Pediatric Traumatic Brain Injury.” SAFAR

Institute, Pittsburgh, PA 2005. 20. Invited Speaker "Blood Pressure and Cerebral Autoregulation in Pediatric Traumatic Brain Injury.

Canadian Critical Care Conference, Whistler, CA 2006. 21. Visiting Professor “Blood Pressure Management in Severe Pediatric Traumatic Brain Injury.”

University of Alabama, Birmingham, AL. 2006. 22. Visiting Professor “Pediatric Traumatic Brain Injury”. University of Pittsburgh. 2009. 23. Visiting Professor “How I Got here” University of Washington Minorities in Health Care presentation.

2009 24. Invited Speaker “Cerebral Blood Flow Monitoring”. National Neurotrauma Society Meeting. 2009. 25. Invited Speaker “ Blood Pressure Management in Traumatic Brain Injury”, Nizam’s Institute of Medical

Sciences. Hyderabad, India. 2009.


26. Visiting Professor “Hemodynamic Management in Pediatric Traumatic Brain Injury”. New York University. May 2010 .

27. Invited Speaker “Advances in Neuroanesthesia”. 120th Anniversary Mahidol University. Bangkok, Thailand. August 2010.

28. Invited Speaker “Asian Society of Neuroanesthesia.” New Delhi, India. February 2011. 29. Invited Speaker “Society for Critical Care Medicine ipodCast on Published Study on Pediatric Diabetic

Ketoacidosis. 30. Invited Speaker “ Brain Trauma Foundation National Webinar Broadcast. Hemodynamics in Pediatric

Traumatic Brain Injury.” June 23, 2010. 31. Invited Speaker “The Head Injured Child”. American Society of Anesthesiologists Annual Meeting.

October 17,2010. 32. Invited Speaker “Cerebrovascular Changes in Pediatric Traumatic Brain Injury. Brain Research

Meeting. January 22, 2011. 33. Invited Speaker “Pediatric Traumatic Brain Injury”. American Society of Anesthesiologists Refresher

Course. October 18,2011 34. Visiting Professor, “Translational Approach to Pediatric Traumatic Brain Injury Research”. Oregon

Health Sciences University, Portland, OR. April 30, 2012. 35. Visiting Professor, “Translational Approach to Pediatric Traumatic Brain Injury Research”.

Downstate New York. May 30, 2012. 36. Visiting Professor, “Management of the Child with Head Injury.” Toronto Sick Kids. Nov 8, 2013. 37. Visiting Professor, “Pediatric Guideline and Adherence and Outcomes” in Traumatic Brain Injury.”

Columbus Children’s Hospital. June 14, 2015. Research Mentorship: 2001 Jake Kleven, M.D. Use of Epidural Anesthesia During Pediatric Latissiumus Dorsi Free Flap

Procedure, Western Anesthesia Resident Conference Poster Presentation 2002 Joshua C. Uffman, M.D. Blood Pressure and Outcome Following Severe Pediatric Traumatic

Brain Injury. Published J Trauma, 2003. 2003 Sean Kincaid, M.D. Feeding Intolerance Due to Jejuno-jejunal Intussuception in a Child with

Severe Burns. Western Anesthesia Resident Conference Poster Presentation. Published AJBCR. 2004.

2003 Cecelia Roscigno, R.N.,M.N. Independent Study towards PhD. Pediatric Head Injury Physiology

2003-2005 Pilar Suz, M.D. Fever Following Severe Pediatric Traumatic Brain Injury. Published J Neurosurg Anesthesiol. 2004.

2003-2005 Bria Coates, M.S. III. Pre-Hospital Hypotension and Outcome Following Pediatric Traumatic Brain Injury. Published Crit Care Med. 2005.

2003-2005 Nathalia Jimenez, M.D. Pediatric Anesthesiology Fellow. Cerebral Blood Flow and Autoregulation in Pediatric Craniosynostosis.

2003-2005 Sean Kincaid, M.D. Cerebral Autoregulation Testing in Healthy Children Using Tilt Test Methodology. Published Pediatr Res 2005.

2003-2005 Saipin Muangman, M.D. Anesthesiologist. Research Fellow from Thailand. Please see manuscripts.


2005 Joshua Uffman, MD. Pediatric Anesthesiology Faculty. Pediatric Trauma. International Anesthesia Clinics (in press).

2005 Uma Samant, MD. Medical Student. FAER Award Winner. Hypotension Timing and Outcome Following Severe Pediatric Traumatic Brain Injury.

2005 Alan Kirsch. Student. Hypotension Burden and Outcome in Adult Traumatic Brain Injury. 2005 Nuj Tontisirin, MD. Anesthesiologist. Research Fellow from Thailand. Gender Differences in

Cerebral Blood Flow and Autoregulation in Healthy Children. Pediatrics (in-press). 2006-2007 Yuthana Udomphorn. Harborview Anesthesiology Research Center Fellow. Cerebral

Autoregulation and Pediatric Quality of Life. 2007-2008 Onuma Chaiwat. Harborview Anesthesiolgoy Research Fellow. Cerebral Autoregulation in

Pediatric Traumatic Brain Injury. 2008- Deepak Sharma, MD. Neuroanesthesia Fellow. Perioperative Hyperglycemia in Pediatric

Traumatic Brain Injury. Anesth & Analg (in-press) 2008- Lin DiGenarro, MD. PICU Fellow. Vasopressor Effectiveness in Pediatric Traumatic Brain

Injury 2008-2009 Amin Malakouti, MD. Harborview Anesthesiology Research Fellow. Nutrition in Pediatric

Traumatic Brain Injury. 2008-2009 Kristina Deeter, MD. PICU Fellow. Hypertension in Pediatric Diabetic Ketoacidosis. 2008-2009 Shaji Philip, MD. Harborview Anesthesiology Center Research Fellow. Variation in Cerebral

Blood Flow Velocity with Cerebral Perfusion Pressure > 40mmHg. 2008- Kalpana Kanal, MD. Assistant Professor. Radiology. Variations in head CT Utilization in

WA State. 2008 - Marco Palla, MD. Pediatric Anesthesia Fellow. Vasopressor Efficiency in Pediatric TBI.

University of Turin, Italy. 2009-2010 Arunotai Sirriswakkul, MD. Research Fellow. Postoperative Respiratory Failure After

Trauma. 2009-2010 Pimwan Sookplung. Neuroanesthesia Research Fellow. Vasopressor Effectiveness after

Traumatic Brain Injury. 2010- Lin DiGenarro, MD. Assistant Professor. Pediatrics. Inflammation in Pediatric Diabtic

ketoacidosis. 2010- Parichat Curry, MD. Research Fellow. Hyperglycemia in Traumatic Brain Injury. 2011 Yasuki Fujita, MD PhD. Research Fellow. Cerebrovascular Autoregulation in Stroke. 2011-2013 Jib Prathep, MD. Research Fellow. Biomarkers in Traumatic Brain Injury. 2011 Vijay Ramaiah, MD. Neuroanesthesiology Fellow, UW. PaO2 Thresholds in Pediatric

Traumatic Brain Injury. 2011 Shyamal Asher, BS. Neuroanesthesiology Fellow, UW. PaO2 Thresholds in Pediatric

Traumatic Brain Injury. 2012- Vijay Krishnamoorthy, MD. Assistant Professor. Cardiac Dysfunction in Traumatic Brain

Injury. 2012- Janessa M. Graves, PhD. HIPRC T32 Trainee. Cost Effectiveness of Adherence to Pediatric

Traumatic Brain Injury Care. 2010- Ericka Fink, MD. Assistant Professor, U Pittsburgh. Point Prevalence of Acute Neurological

Disease in Children (PANGEA Study funding Laerdal and U Pitt). 2012 Leslie Dervan, MD. PICU Fellow, SCH. Diffuse Tensor Imaging in Pediatric Diabetic

Ketoacidosis.


2012 Christy A. Ryan, MD. Assistant Professor. Perioperative Care of Elderly Traumatic Brain Injury Patient.

2012 Nicole O’Brien, MD. Assistant Professor, Columbus Children’s Hospital. Cerebral Ischemia During ECMO. AHA Award Preparation

2012- Nathalia Jimenez, MD, MPH. Assistant Professor. Health Care Disparities in Pediatric Traumatic Brain Injury. K23 Award Preparation and Manuscript submitted (Pediatrics).

2012 Fayeza Ahmed, PhD. Cerebrovascular Resistance Changes in Mild Traumatic brain injury. K23 Award preparation.

2013- Katy Flynn O’Brien. Craniotomy Rates in Washington State. T32 Fellow at Harborview Injury Prevention and Research Center.

2015- Cordelie Witt, MD. Surgery Resident & T32 Fellow in Pediatric Injury at Harborview Injury Prevention and Research Center

2015- Pratik V. Patel, MD. Spinal Cord Injury and Respiratory Failure. 2014- Megan Moore, PhD. Assistant Professor of Social Work. KL2 Scholar. Developing a Family

Centered Care Model for Traumatic Brain Injury. 2015- Lauren Rakes, MD. Pediatric Intensivist. Post Pathway Implementation Outcomes in

Pediatric Traumatic Brain Injury. 2013-2015 Nadav Sheffy, MD. Trauma Anesthesia Fellow. Geriatric Trauma Anesthesia Complications. 2015- Nithya Kannan, MBBS. MPH Student in Epidemiology. Nutrition and Outcomes in

Traumatic Brain Injury. Editorial Responsibilities: Ad Hoc Reviewer: 1999 Stroke 2000- Journal of Neurosurgical Anesthesiology 2001 Archives of Pediatrics and Adolescent Medicine 2002- Anesthesiology 2003 Anesthesia & Analgesia 2003 Pediatric Research 2003- Critical Care Medicine 2003- Pediatric Critical Care Medicine 2004 Pediatric Rehabilitation 2004- Canadian Medical Association Journal 2007 Neuroscience Letters 2007- Pediatric Emergency Care 2012- Lancet Neurology Editorial Board:

2006- Journal of Neurosurgical Anesthesiology 2011- Pediatric Critical Care Medicine


Special National and International Responsibilities: 2001 Instructor, Transcranial Doppler Ultrasonography Workshop, Society of Neurosurgical Anesthesiology and Critical Care Breakfast Panel at the American Society of

Anesthesiologists Meeting, Orlando, FL 2002 Moderator, Society of Neurosurgical Anesthesiology and Critical Care Breakfast Panel at the American Society of Anesthesiologists Meeting, New Orleans, LA 2002 Member, Society for Pediatric Anesthesia Research Committee 2003 Member, Pediatrics Committee of the American Society of Anesthesiologists 2005 Moderator, American Society of Anesthesiologists Neurotrack Workshop, Atlanta, GA 2006 Vice President. Society of Neurosurgical Anesthesiology and Critical Care. 2005-2006 Ad hoc Member Study Section, Pediatrics Subcommittee, NICHD, NIH October 2005,

March 2006 2006-2010 Permanent Member Study Section, Pediatrics Subcommittee, NICHD, NIH 2008- Medical Advisory Board, Sarah Jane Foundation 2009- Working Group member, National Pediatric Guidelines for Management of Traumatic Brain

Injury in Infants and Children 2009 Ad-hoc Reviewer Medical Research Council UK 2009 Ad-hoc Reviewer Medical Research Council South Africa 2010 Ad-hoc member, Special Emphasis Review Panel, Emergency Medical Services for Children 2010 Ad-hoc member, NIH National Loan Repayment Program Review Panel 2010 Ad-hoc Reviewer ERANET PRIOMED, Netherlands 2010 Ad-hoc Reviewer NIH K-12 Career Development Award Applications 2010 Ad-hoc Reviewer NIH DIRH Study Section

2010 Reviewer for European Child Research Network Grant Cycle 2010- Working Group, Brain Trauma Foundation Traumatic Brain Injury Guidelines Committee 2011-2012 NINDS Common Data Elements Project Acute Care Workgroup Member

2010-2011 President, Society for Neuroscience in Anesthesiology and Critical Care 2011-2012 Executive Committee, Society for Neuroscience in Anesthesiology and Critical Care 2012-2013 Chair, Scientific Review Committee, Pediatric Neurocritical Care Research Group 2013 Reviewer, Canadian Institute of Health Research 2013 Ad Hoc member, Special Emphasis Panel ZRG SBIB V (82) 2013- Permanent member, NIH SAT Study Section

2014 Ad Hoc member, NINDS Clinical Trials SEP 2014/05 ZNS1 SRB-G (74) 2014- NIGMS Surgery, Anesthesia and Trauma Study Section, Permanent Member 2015 NIH Director’s Award 2015/05 ZRG1 MOSS-C (56) R 2015 NICHD 2015/05 CHHD-A Pediatrics Subcommittee

Special Local Responsibilities: 1997-2000 Instructor, Yearly Seattle Paramedic Education Program 1997 Pediatric Quality Assurance, Emergency Department, Harborview Medical Center, Seattle,

WA


1997- Member, Academic Affairs Committee, Department of Anesthesiology. University of Washington, Seattle, WA

1997- Residency Interviews, Department of Anesthesiology, University of Washington, Seattle, WA

1999- Member, Subcommittee Pre-hospital Pediatric Trauma Task Force, Department of Health, WA

1999- Member, Hospital Pediatrics Committee, Harborview Medical Center, Seattle, WA 1999 Member, Sabbatical Committee, Department of Anesthesiology, University of Washington,

Seattle, WA 1999 Member, Retreat Committee, Department of Anesthesiology, University of Washington,

Seattle, WA 1999- Planning Committee. Harborview WWAMI Adult and Pediatric Trauma Conference, Seattle,

WA 2000 Member Clinical Competence Committee, University of Washington, Seattle, WA 2001 WA State Governor’s Pediatric Trauma Task Force 2003- Core member, Pediatric anesthesia work group, Harborveiw Medical Center 2004 Member, Recruitment Committee, Harborview Medical Center. Department of

Anesthesiology, University of Washington, Seattle, WA 2004 Member, Search Committee. Harborview Medical Center Chief of Anesthesiology 2005 Member, Search Committee. Veteran’s Administration’s Chief of Anesthesiology 2004 - Coordinator, Department of Anesthesiology Grand Rounds 2005 - Core Faculty, Harborview Anesthesia Clinical Research Center 2006- Advisor, Washington State Department of health Pediatric Trauma Educational Curriculum 2006- Co-Chair, Emergency Airway Committee, Department of Anesthesiology, University of

Washington 2008- Chair, Interdisciplinary Task Force on Pediatric TBI Clinical Care Pathway 2009 Member, Harborview Falls Committee 2009- Co-Chair, Search Committee. Basic Science Chair for Department of Anesthesiology.

University of Washington. 2009- Member, Organizational Improvement Committee, Harborview Medical Center 2009- Member, Quality Data and Metrics Committee, Harborview Medical Center 2009- Steering Committee, T32 Award in Pediatric Injury Prevention. Harborview Injury

Prevention and Research Center 2010- Steering Committee and Core Research Leader, T32 Department of Anesthesiology and Pain

medicine, University of Washington. 2009- Advisor for Youth 180 and Upward Bound Community Programs to decrease urban violence

2010- Director, Harborview Anesthesia Research Center 2010 Chair, Committee to Develop Geriatric PACU Orderset 2010- Harborview Pediatric Education Requirements in Trauma Curriculum 2010 Development of Washington State Department of Health DVD on Teen Driving and TBI 2011 Member, UW Department of Anesthesiology Informatics Working Group 2011 Member, UW Anesthesiology ICU Handoffs Working Group

2012- Interim Vice-Chair for Clinical Research, Department of Anesthesiology and Pain Medicine 2013- Member, Trauma Strategic Planning Committee, Harborview Medical Center 2014- School of Medicine, Appointments and Promotions Committee


Research Funding: PAST Harborview Injury Prevention & Research Center (PI: Vavilala, M.S.) 998-2001 Thromboelastography in Children with Head Injury. $ 20,000 Royalty Research Fund (PI: Vavilala, M.S.) 03/01/02-8/31/03 Cerebral Autoregulation Following Pediatric Traumatic Brain Injury $30,056 The specific aims of this proposal are to determine: 1) the effects of age on cerebral autoregulation in unanesthetized children without neurological injury, 2) whether Traumatic Brain Injury (TBI) induced impairment of cerebral autoregulation is age dependent, and 3) if impaired cerebral autoregulation is associated with poor outcome. The results of our study can help form practice guidelines for the hemodynamic management of children with TBI. AHA Beginning Grant In Aid (PI: Vavilala, M.S.) 07/01/02-06/30/04 Cerebral Autoregulation During Sevoflurane Anesthesia $80,000 The specific aims of this proposal are to determine the effects of age on cerebral autoregulation in healthy anesthetized children, whether Traumatic Brain Injury (TBI) impairs cerebral autoregulation in children during general anesthesia, if the incidence of TBI induced impairment of cerebral autoregulation is age dependent and if impaired cerebral autoregulation during general anesthesia is associated with poor outcome. Washington State Society of Anesthesiologists (PI: Vavilala, M.S.) 01/01/03-12/31/03 Cerebral Perfusion Pressure and Outcome in Traumatic Brain Injury $9,600 The goal of the proposed pilot study is to prospectively characterize cerebral hemodynamics following severe TBI and to determine the relationship between cerebral hemodynamics and outcome following severe pediatric TBI. Results from this study will provide important pilot data for a larger prospective study to determine the relationship between cerebral hemodynamics and outcome in children with severe TBI. Department Start up Fund (PI: Vavilala, M.S.) 01/01/02-12/31/03 Anesthesia Research & Training $8,640 Cerebral Autoregulation and Cerebral Oxygenation in Cerebral Edema due to Pediatric Diabetic Ketoacidosis The specific aims of this proposal are: 1) to examine the relationship between impaired cerebral autoregulation and cerebral edema associated with diabetic ketoacidosis (DKA), 2) to examine the relationship between middle cerebral artery flow velocity (Vmca) and cerebral edema in children with DKA, and 3) to examine the association between cerebral edema secondary to DKA and cerebral oxygen desaturation. Harborview Injury Prevention & Research Center (PI:Vavilala, M.S.) 08/01/2003 - 07/31/2004 Pre-hospital Hypotension and Outcome in Children with Traumatic Brain Injury $2,000 The overall goals of the proposed study are to: 1) characterize the incidence of pre-hospital hypotension following pediatric TBI and 2) determine the relationship between pre-hospital blood pressure and outcome following TBI in children. Results from this study will provide important pilot data for a larger prospective study to determine the relationship between pre-hospital blood pressure and outcome in children with TBI. The specific aim of this study is to investigate the relationship between pre-hospital hypotension and outcome following pediatric TBI.


Departmental RFA (PI: Vavilala, M.S.) 02/13/2004 Anesthesia Research & Training $34,972 Departmental RFA for shared equipment: Purchase of Research Equipment (Transcranial Doppler Ultrasonography) for Collaborative Departmental Use. NINR/NIH/R01 (PI: Mitchell, P) 04/01/2004 – 03/31/2008 National Institute of Nursing Research $1,295, 635 The purpose of this study is to evaluate the effect of CPP monitoring on Nursing Practice. NICHD/NIH/ K23 (PI: Vavilala, M.S) 09/01/2003- 08/31/2008 National Institute of Child Health and Human Development $638,000 The purpose of the study is to examine the: 1) relationship between cerebral perfusion pressure and outcome, 2) relationship between persistent impairment of cerebral autoregulation and outcome, and 3) the age-related incidence of hyperemia. We will also examine the relationship between hyperemia and impaired cerebral autoregulation and the relationship between persistent hyperemia and outcome following severe pediatric TBI. CDC/R49 CE000197-05 (PI Ebel, BE) 08/01/2004 – 07/31/2009 Center for Disease Control $ 4,500,000 “Harborview Injury Prevention & Research Center” The purpose is to examine trauma care delivery and outcome. Role: Co-investigator NICHD/NIH/R21 (PI: Vavilala, M.S.) 04/01/2005 – 03/31/2009 National Institute of Child Health and Human Development $275,000 (no-cost extension) The purpose of the study is to examine the relationship between cerebral blood flow velocity, cerebral autoregulation and cerebral oxygenation and the development of cerebral edema in children with diabetic ketoacidosis. Department of Health (PI: Vavilala, M.S.) 07/01/10-06/30/11 Curriculum for Radiation Dose Reduction in WA State $5,000 The aim of this project is to develop an educational curriculum for radiation dose reduction for pediatric head CT scans in WA state. Department of Health (PI: Vavilala, M.S) 07/01/10-06/30/11 First Responder Curriculum for Traumatic Brain Injury $60,000 The aim of this project is to develop a traumatic brain injury specific educational curriculum for first responders in WA State. CDC/R49 CE0010210-02 (PI: Rivara, F.P.) 09/01/2006 – 08/30/2011 Center for Disease Control $ 3,200,000 “Disability from Pediatric Trauma Brain Injury The purpose is to examine disability after pediatric traumatic brain injury. Role: Co-investigator


Department of Health and Human Services (PI: Vavilala, M.S) 07/01/12-06/30/13 Implementation of a TBI Quality Improvement Bundle $ 60,000 The aim of this project is to implement a traumatic brain injury specific quality improvement bundle for first responders in WA State. Laerdal Foundation (PI: Fink, University of Pittsburgh) 07/01/11-06/30/13 Prevalence of Acute Neurological Global Disease Project $100,000 The purpose of this project is to estimate the global burden of acute neurological diseases in children and its relationship with outcomes. 0006876A.UW (PI: Rousdari) 3/1/09-2/28/14 University of Texas/NIH $ 21,094 Resource Over-Utilization due to Serious Alcohol Related Injuries The study will estimate the extra-burden of injuries imposed by individuals with high blood alcohol concentrations in the ED and/or dependence to alcohol on emergency medical service (EMS) system and the hospital health care system. NIH/NINDS R21NS077444-01 (PI: Vavilala, M.S.) 09/30/11-08/31/14 Improving Indo-US Traumatic Brain Injury Outcomes $ 275,000 Our project goal is to develop and use a severe TBI adherence scorecard to quantify the prevalence and temporal profile of post TBI secondary insults (example hypoxia and hypotension), to test the association between adherence to evidence based guidelines and patient outcomes and to develop an interdisciplinary TBI care pathway that facilitates adherence, lessens secondary insults and improves patient outcomes after severe TBI. NIH/NINDS R03 NS077444-01 (PI: Rivara, F.P.) 04/01/14 – 03/31/15 Entering Legacy Pediatric Traumatic Brain Injury Data $ 100,000 Our project goal is contribute legacy Child Health after Head Injury Data to NINDS. Washington State Department of Social and Health Services (PI: Vavilala) 02/15/2015-06/30/2015 TBI School Transitions and Educator Needs $60,689 The goal is to develop a TBI Transitions Support program to meet the need for trained persons to support people with brain injury when returning to education. ACTIVE NIH /R01 NS072308-01 (PI: Vavilala, M.S.) 09/01/2010- 08/30/16 (NCE) Implementation Science and Pediatric Brain Injury Guidelines $ 3,297,345 The aim of this project is to develop a blueprint for increasing adherence to the Pediatric Guidelines for traumatic brain injury. NIH/R21 R21NS095321 (PI: Vavilala, M.S.) 09/30/2015-08/31/2017 Vasoactive Agents and Cerebral Outcomes in Brain Injury $275,000 This research will examine whether and how choice of vasoactive agent affects brain outcomes (cerebral hemodynamics, cerebral perfusion characteristics, and the neurovascular unit) in pediatric TBI by age and sex.

https://public.era.nih.gov/grantfolder/piAppDetails/genericStatus.do?encryptedParam=iTVCXSmHbtY.yE3bNEVdTNostmqX9XXTZ9yKyhRq70H85y761B7XwiE.


R01 NS090998 (PI: Armstead/UW PI: Vavilala) 09/01/2015-08/31/2020 Pressor Choice Influences Protection of Autoregulation in Brain Injury $ 3,296,454 This proposal leverages translational expertise in relation to children with TBI and fosters bi-directional translational research. NIH Center of Excellence in Pain Education (PI: Tauben, D) 06/15/15-08/31/17 Center of Excellence in Pain Education $ 61,687 This project will contribute to education in the area of pediatric trauma pain assessment and treatment. NIH/NINDS U01 (PI: Bell, MJ) 07/1/13-6/30/18 Children’s Hospital of Pittsburgh $5,466,789 Multiple Medical Therapies in Children with Severe Traumatic Brain Injury The current study will examine effectiveness of select therapies that hold promise in severe traumatic brain injury. NIH T32 Program (PI: Rivara) 05/05/10-04/30/15 Pediatric Injury Training Program $ 258,628 The purpose of the Training Program is to create and sustain a corps of interdisciplinary-trained investigators who will conduct rigorous research on ways to reduce the toll from injuries. Seattle Children’s Research Institute (UW PI: Vavilala) 08/01/2014 – 07/31/2016 Traumatic Brain Injury (TBI) Program $38,995 In collaboration with Seattle Children’s faculty, this study focuses on the rationale for and assessment of cerebral autoregulation among the subject population, adolescent soccer players. Seattle Children’s Research Institute (UW PI: Vavilala) 08/01/2014 – 07/31/2016 HOPE Study $38,995 In collaboration with Seattle Children’s faculty, this study focuses on the rationale for and assessment of cerebral autoregulation among the subject population, adolescent soccer players. Coulter Foundation (Multiple PI: Nair/Vavilala) 06/01/2015-05/31/2016 Smart Anesthesia Manager™ (SAM) for Real-time Decision Support $130,234 We propose to integrate Smart Anesthesia Manager™ (SAM) with two leading Anesthesia Information Management Systems (AIMS) – McKesson Anesthesia Care and Cerner Surginet. We also propose to demonstrate proof of concept evaluation of SAM showing its benefits at two hospitals. PENDING 1R24HD087154-01 (Multi PI: Vavilala/Buchwald) 04/01/2016-03/31/202 Native American Pediatric Motor Vehicle Injuries $ 3,768,983 The goal is to study the effect of the Return Home Safely Intervention to increase pediatric motor vehicle-related safety behaviors in Native American communities. 1R35NSXXXXX (PI: Vavilala) 04/01/2016-03/31/202 Pediatric Brain Injury Guidelines and Outcomes (PEGASUS) $ 6,000,000 The goal is to implement and evaluate the PEGASUS pathway


1R01NS095791-01 (Multi PIs: Bell/Vavilala) 04/01/2016-03/31/2021 South American Guideline Adherence (SAGA) study $ 3,365,834 The goal is to examine the generalizability of US based TBI Guidelines in South America. National Institute of Justice (PI: Rowhani) 01/01/2016- 12/31/2018 TBI in Female Survivors of Intimate Partner Violence $91,078 The goals of this project are to 1) determine the prevalence of TBI among female survivors of IPV who sought medical care; 2) examine the risk factors associated with TBI among female survivors of IPV; and 3) explore the consequences of TBI in female survivors of IPV and the role law enforcement officers play in their seeking medical care. Pac-12 Conference (PI: Vavilala) 01/01/2016-12/31/2016 Cerebral Blood Flow Changes in Head Trauma $462,519 This proposal will search for a link between cerebrovascular features and SRTBI symptoms, and may identify cerebrovascular reserve as a biomarker that informs the return to play of athletes after SRTBI. We expect that athletes who return to play (no clinical symptoms) will not necessarily have normal cerebrovascular outcomes but that athletes who do not return to play due to persistent clinical symptoms will have worse cerebrovascular reserve.


BIBLIOGRAPHY Manuscripts in Refereed Journals (170 peer reviewed published or in -press):

1. Sherman, N., Vavilala, M., Pollock, R., Romsdahl, M., Jaffe, N.: The Role of Radiotherapy in the Treatment of Alveolar Soft Part Sarcoma. Med Pediatr Oncol. 22:380-383, 1994.

2. Vavilala, M.S., O’Donnell, R.J., Conrad, E.U., Panos, A.L., Stephens, K.E., Cheney, F.W.: Paradoxical Air Embolism After Lower Limb Reconstruction. Anesth Analg. 83:654-655, 1996.

3. Vavilala, M.S., Geiduschek, J., Beck J.: Pneumococcal Epiglottitis- Laryngo-tracheitis. Pediatr Rev. 21(1):20-26, 2000.

4. Vavilala, M.S., Lam, A.M.: Intraoperative Intracranial Pressure Monitoring in Pneumococcal Meningitis. Anesth Analg. 90(1):107-108, 2000.

5. Vavilala, M.S., Bernards, C.M.: Urine Color As An Indicator of Urine Concentration in Surgical Patients. American J Anesthesiol. 27(6): 335-338, 2000.

6. Lam AM., Vavilala M.S.: Macroglossia-Compartment Syndrome of the Tongue? Anesthesiology. 92(6):1832-1835, 2000.

7. Vavilala, M.S., Dunbar, P.J., Lam, A.M., Rivara, F.P.: Coagulopathy Predicts Outcome in Head Injured Children. J Neurosurg Anesthesiol. 13:13-18, 2001.

8. Vavilala, M.S., Lee L.A., Lam, A.M.: Cerebral Autoregulation Before and After Blood Transfusion in A Child. J Neurosurg Anesthesiol.13:231-6, 2001.

9. Vavilala, M.S., Roberts J.O., Moore A.E., Newell, D.W., Lam A.M.: The Influence of Inhaled Nitric Oxide on Cerebral Blood Flow and Metabolism in a Child with Traumatic Brain Injury. Anesthesia & Analgesia 93:351-3, 2001.

10. Vavilala, M.S., Junger E., Douville C.A., Rivara, F.P.: Newell D., Lam A.M.: Dynamic Cerebral Autoregulation in Healthy Adolescents. Acta Scanda Anes 46:393-7, 2002.

11. Sharar, S.R., Carrougher, G.J., Selzer, K., O’Donnell, F., Vavilala, M.S., Lee, L.A.: A Comparison of Oral Transmucosal Fentanyl Citrate (OFTC) and Oral Oxycodone (OC) for Pediatric Outpatient Wound Care. J Burn Care Rehabil 23:27-31, 2002.

12. Vavilala, M.S., Nathens, A.B., Mackenzie, E., Jurkovich, G.J., Rivara, F.P.: Risk Factors for Venous Thromboembolism in Pediatric Trauma. J Trauma 52:922-7, 2002.

13. Boddu, K., Vavilala, M.S., Stevenson, G.J., Lam, A.M.: Pediatric Thoracic Nailgun Injury: A Case Report and Review of the Literature. Anesthesia & Analgesia 95:624-6, 2002.

14. Ransom, G., Mann, F., Vavilala, M.S., Rivara, F.P.: Cerebral Infarct in Head Injury: Relation to Child Abuse. Child Abuse Negl 27:381-92, 2003.

15. Vavilala, M.S., Lee, M., Lee L.A., Graham A., Visco E., Lam A.M.: Cerebral Autoregulation in Children During Sevoflurane Anesthesia. Br J Anaesth 90:636-41, 2002.

16. Vavilala, M.S., Bowen, A., Lam, A.M., Uffman, J.C., Powell, J.C., Winn, H.R., Rivara, F.P.: Blood Pressure and Outcome Following Severe Pediatric Traumatic Brain Injury. J Trauma. 55:1039-44, 2003.

17. Vavilala, M.S., Lee, L.A., Lam, A.M.: The Lower Limit of Cerebral Autoregulation in Children during <1 MAC Sevoflurane Anesthesia. J Neurosurg Anesthesiol. 15:307-12, 2003.

18. Lee, L.A., Vavilala, M.S., Douville, A.M., Newell, D.W., Lam, A.M.: Ophthalmic Artery Flow Velocity in Health Adult Volunteers. Can J Anaesth. Can J Anaesth 5:388-92, 2004.

19. Rozet, I., Vavilala, M.S., Souter M.J., Lam A.M.: Global Cerebral Edema and Subarachnoid Hemorrhage in Systemic Lupus Erythematosus. J Neurosurg Anesthesiol 16:182-3, 2004.


20. Vavilala, M.S., Cummings, P., Sharar, S., Quan, L.: Association of Hospital Trauma Designation with Admission Patterns of Injured Children. J Trauma. 57:119-24; discussion 124, 2004.

21. Vavilala, M.S., Lee, L.A., Newell D.W., Lam, A.M.: Cerebral Autoregulation in Children with Traumatic Brain Injury. Pediatric Critical Care Medicine. Pediatr Crit Care Med. 5:257-63, 2004.

22. Kincaid M.S., Vavilala, M.S., Faucher L., Zimmerman J., Heimbach D.: Feeding Intolerance Due to Small Intestine Intussusception in a Child with Major Burns. AJBCR J Burn Care Rehabil.25:212-4, 2004.

23. Bhananker S.M., Paek R., Vavilala M.S.: Water Intoxication and Symptomatic Hyponatremia after Outpatient Surgery. Anesth Analg. 98:1294-6, 2004.

24. Todd, M.M., Hindman, M.D., Clarke, W.R., Torner, J.C.: For the Intraoperative Hypothermia for Aneurysm Surgery Trail. Mild Hypothermia During Surgery for Intracranial Aneurysm. NEJM. 352:135-45, 2005.

25. Vavilala, M.S., Souter M.J., Lam, A.M.: Hyperemia and Impaired Cerebral Autoregulation in a Surgical Patient with Diabetic Ketoacidosis. Can J Anesth. 52:323-26, 2005.

26. Shah, M., Vavilala M.S, Feldman K.W., Hallam, D.K.: Motor Vehicle Crash Brain Injury in Infants and Toddlers: A Suitable Model for Inflicted Head Injury? Child Abuse Negl. 29:953-67, 2005.

27. Vavilala, M.S., Kincaid, M.S., Muangman, S.L., Suz, P., Rozet, I., Lam, A.M.: Gender Differences in Cerebral Blood Flow Velocity and Autoregulation Between Anterior and Posterior Circulations in Healthy Children. Pediatr Res. 58:574-8, 2005.

28. Rozet, I., Vavilala, M.S., Lindley A., Visco E., Treggiari, M., Lam, A.M.: Cerebral Autoregulation and CO2 in Anterior and Posterior Cerebral Circulation during Sevoflurane Anesthesia. Anesth Analg. 102(2):560-4, 2006.

29. Coates, B.M., Vavilala, M.S., Mack C., Muangman, S., Suz, P., Sharar, S.R., Bulger, E., Lam, A.M.: The Influence of Definition and Location of Hypotension on Outcome Following Severe Pediatric Traumatic Brain Injury. Crit Care Med. 33:2645-50, 2005.

30. Suz, P., Vavilala, M.S., Souter, M., Muangman, S., Lam, A.M.: Clinical Features of Fever Associated with Poor Outcome in Severe Pediatric Traumatic Brain Injury. J Neurosurg Anesthesiol. 18:5-10, 2006.

31. Vavilala, M.S., Muangman, S., Tontisirin, N., Fisk, D., Roscigno, C., Mitchell, P., Kirkness, C., Zimmerman, J.J., Chesnut, R., Lam, A.M.: Impaired Cerebral Autoregulation and 6-month Outcome in Children with Severe Traumatic Brain Injury: Preliminary Findings. Develop Neurosci. 28(4-5):348-53, 2006.

32. Roberts, J.S., Vavilala, M.S., Schenkman, K.A., Shaw, D., Martin, L.D., Lam, A.M.: Cerebral Hyperemia and Impaired Cerebral Autoregulation Associated with Diabetic Ketoacidosis in Critically Ill Children. Crit Car Med. 34(8):2217-23, 2006.

33. Miller, P., Vavilala, M.S., Lam, A.M.: The Incidence and Risk Factors for Hypotension During Emergent Decompressive Craniotomy in Children with Traumatic Brain Injury. Anesth Analg. 2006 Oct;103(4):869-75.

34. Rozet, I., Vavilala, M.S., Lam, A.M.: Clinical Experience with Dexmedetomidine for Implantation of Deep Brain Stimulators in Parkinson's Disease. Anesth Analg. 103(5):1224-8, 2006.

35. Vavilala, M.S., Muangman, S., Waitayawinyu, P., Fisk, D., Jaffe, K., Mitchell, P., Kirkness, C., Zimmerman, J., Ellenbogen, R., Lam, A.: Neurointensive Care; Impaired Cerebral Autoregulation in Infants and Young Children Early After Inflicted TBI: A Preliminary Report. Pediatric Brain Injury. J Neurotrauma. Jan;24(1):87-96, 2007.


36. Tontisirin, N., Muangman, S.L., Suz, P., Pihoker, C., Fisk, D., Moore, A., Lam, A.M., Vavilala, M.S.: Early Childhood Gender Differences in Anterior and Posterior Cerebral Blood Flow Velocity and Autoregulation. Pediatrics. Mar;119(3):e610-5, 2007.

37. Vavilala, M.S. Cerebral Oximetry Patience is a Virtue but not a Virtue for the Patient, Yet?. Editorial. Pediatr Crit Care Med. March;8(2):192-3, 2007.

38. Hollingworth, W., Vavilala M.S., Jarvik, J.G., Chaudhry, S., Johnston, B.D., Layman, S., Tontisirin, N., Wang, M.: The use of Repeated Head Computed Tomography in Pediatric Blunt Head Trauma: Factors Predicting New and Worsening Brain Injury. Pediatr Crit Care Med. July:8(4):348-56, 2007.

39. Tontisirin, N., Armstead, W., Waitayawinyu, P., Moore, A., Udomphorn, Y., Zimmerman, J.J., Chesnut, R., Vavilala, M.S.: Change in Cerebral Autoregulation as a Function of Time In Children after Severe Traumatic Brain Injury: A Case Series. Child’s Nerv Syst. Oct;23(10):1163-9, 2007.

40. Rozet, I., Vavilala, M.S.: Risks and Benefits of Patient Positioning During Neurosurgical Care. Anesthesiol Clin. Sep;25(3):631-53, 2007.

41. Armstead, W.M., Vavilala, M.S.: Adrenomedullin Reduces Gender-dependent Loss of Hypotensive Cerebrovasodilation after Newborn Brain Injury through Activation of ATP-dependent K Channels. J Cereb. Blood Flow Metab. Oct;27(10):1702-9, 2007.

42. Olivar, H., Bramhall, J.S., Rozet, I., Vavilala, M.S., Souter, M.J., Lee, L.A., Lam, A.M.: Subarachnoid Lumbar Drains: a Case Series of Fractured Catheters and a Near Miss. Can J Anaesth. Oct;54(10):829-34, 2007.

43. Brown, J.M., Udomphorn, Y., Suz, P., Vavilala, M.S.: Antipyretic Treatment of Noninfectious Fever in Children with Severe Traumatic Brain Injury. Childs Nerv Syst. 2008 Apr;24(4):477-83. Epub 2007 Oct 5.

44. Rozet, I., Tontisirin, N., Muangman, S., Vavilala, M.S., Souter, M.J., Lee, L.A., Kincaid, M.S., Britz, G.W., Lam, A.M. Effect of Equiosmolar Solutions of Mannitol Versus Hypertonic Saline on Intraoperative Brain Relaxation and Electrolyte Balance. Anesthesiology. 2007 Nov;107(5):697-704.

45. Curry R, Hollingworth W, Ellenbogen RG, Vavilala MS. Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines. Pediatr Crit Care Med. 2008;9(2):141-6.

46. King MA, Garrison MM, Vavilala MS, Zimmerman JJ, Rivara FP. Complications associated with arterial catheterization in children. Pediatr Crit Care Med. 2008 May 19.

47. Freeman, S., Udomphorn, Y., Armstead, W.M., Vavilala, M.S. Young Age as a Risk Factor for Impaired Cerebral Autoregulation in Children after Moderate to Severe Pediatric Traumatic Brain Injury. Anesthesiology. 2008 Apr;108(4):588-95.

48. Samant, U.B., Mack, C.M., Koepsell, T., Rivara, F.P., Vavilala, M.S. Time of Hypotension and Discharge Outcome after Severe Pediatric Traumatic Brain Injury. J Neurotrauma. 2008 May;25(5):495-502.

49. King MA, Garrison MM, Vavilala M.S., Zimmerman JJ, Rivara FP. Complications associated with arterial catheterization in children. Pediatr Crit Care Med. 2008 Jul;9(4):367-71.

50. Curry R, Hollingworth W, Ellenbogen RG, Vavilala MS. Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines. Pediatr Crit Care Med. 2008 Mar;9(2):141-6.

51. Vavilala M.S., Tontisirin N, Udomphorn Y, Armstead W, Zimmerman JJ, Chesnut R, Lam AM. Hemispheric Differences in Cerebral Autoregulation in Children with Moderate and Severe Traumatic Brain Injury. Neurocrit Care. 2008 ;9(1):45-54.

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52. Sharma D, Jelacic J, Chaiwat O, Chandler W, Vavilala M.S. Neuroanesthesia Fellow. Perioperative Hyperglycemia in Pediatric Traumatic Brain Injury. Anesth & Analg 2009; 108(1):81-9.

53. Chaiwat O, Sharma D, Udomphorn Y, Armstead WM, Vavilala M.S. Cerebral Hemodynamic Predictors of Poor 6 month Glasgow Outcome Score in Severe Pediatric Traumatic Brain Injury. J Neurotrauma. 2009; 26:1–7.

54. Chaiwat O, Lang J, Wang J, Jurkovich GJ, Rivara FP, Vavilala M.S. Effect of Red Blood Cell Transfusion on ARDS in Trauma Patients. Anesthesiology. 2009; 110:351-60.

55. Relyea-Chew AM, King M, Vavilala, M.S. Hollingworth W. Radiation Risk and Cancer Estimates in Pediatric Traumatic Brain Injury. Ped Radiol. 2008 (in-press).

56. Philip S, Chaiwat O, Udomphorn Y, Zimmerman JJ, Armstead WM, Vavilala MS. Variability in Cerebral Blood Flow Velocity with Cerebral Perfusion Pressure > 40mmHg in 42 Children with Traumatic Brain Injury. Crit Care Med. Crit Care Med. 2009 Nov;37(11):2973-8.

57. Raelson C, Kanal KM, Vavilala MS, Rivara FP, Kim LJ, Stewart BK, Cohen WA. Radiation dose and excess risk of cancer in children undergoing neuroangiography. AJR Am J Roentgenol. 2009 Dec;193(6):1621-8.

58. Rozet I, Tontisirin N, Muangman S, Vavilala, M.S., Lam A.M. Lactate Levels During Prolonged Infusion of Propofol. Anesthe & Analg. Anesth Analg. 2009 Oct;109(4):1105-10.

59. King MA, Relyea-Chew AM, Kanal K, Hollingworth W, Bittles M, Vavilala, M.S. Cancer Risk from Head CT: A Biinsitutional study. Pediatr Radiol. Pediatr Radiol. 2009 Oct;39(10):1059-65.

60. Philip S, Kirkham F, Vavilala M.S. Cerebral Blood Flow and Autoregulation in Pediatric Traumatic Brain Injury. J Trauma. J Trauma. 2009 Aug;67(2 Suppl):S128-34. Invited Review.

61. Todd MM, Hindman BJ, Clarke WR, Torner JC, Weeks JB, Bayman EO, Shi Q, Spofford CM; IHAST Investigators. Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage. Neurosurgery. 2009 May;64(5):897-908; discussion 908. collaborators 508.

62. Pasternak JJ, McGregor DG, Lanier WL, Schroeder DR, Rusy DA, Hindman B, Clarke W, Torner J, Todd MM; IHAST Investigators. Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery. Anesthesiology. 2009 Mar;110(3):563-73.

63. Vavilala, M.S, Richards, T.R. Roberts J.S. Deeter K, Lam, A.M. Change in Blood Brain Permeability in Pediatric Diabetic Ketoacidosis. Pediatr Crit Care Med. 2010 May;11(3):332-38

64. Sharma, D.S. Bithal, P.K. Dash, H.H. Chouhan, R.S., Sookplung, P, Vavilala, M.S. Cerebral Autoregulation and CO2 Reactivity Before and After Elective Surpatentorial Tumor Resection. J Neurosurg Anesthesiol. 2010 Apr;22(2):132-7.

65. Armstead, W.M. Kiessling, J.W. Bdeir, K, Kofke, W.A., Vavilala, M.S. Adrenomedullin Prevents Sex Dependent Impairment of Autoregulation During Hypotension After Piglet Brain Injury Through Inhibition of ERK MAPK Upregulation. J Neurotrauma. 2010 Feb;27(2):391-402

66. Armstead, W.M. Kiessling, J.W. Bdeir, K, Kofke, W.A., Vavilala, M.S Impaired Cerebral Blood Flow Autoregulation During Postraumatic Arterial Hypotension After Fluid Percussion Brain Injury is Prevented by Phenylephrine in Female but Exacerbated in Male Piglets by ERK MAPK upregulation. Crit Care Med. 2010 Sep;38(9):1868-74.

67. Deeter KH, Roberts JS, Bradford H, Richards T, Shaw D, Marro K, Chiu H, Pihoker C, Lynn A, Vavilala MS. Hypertension despite dehydration during severe pediatric diabetic ketoacidosis. Pediatr Diabetes. 2011 Jun;12(4 Pt 1):295-301.

68. Malakouti, A., Sookplung, P., Sirriswakkul, A., Philip, S., Bailey, N., Farver, K., Vavilala, M.S. Nutrition Support in Severe Pediatric Traumatic Brain Injury. Ped Crit Care Med 2010.

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69. Armstead WM, Kiessling JW, Kofke WA, Vavilala MS. SNP improves cerebral hemodynamics during normotension but fails to prevent sex dependent impaired cerebral autoregulation during hypotension after brain injury. Brain Res. 2010 May 12;1330:142-50..

70. Sharma D, Vavilala MS. Should brain tissue oxygenation be the transfusion trigger in traumatic brain injury? Pediatr Crit Care Med. 2010 May;11(3):420-1.

71. Mashour GA, Lauer K, Greenfield ML, Vavilala MS, Avitsian R, Kofke A, Koht A, Brambrink A. Accreditation and standardization of neuroanesthesia fellowship programs: results of a specialty-wide survey. J Neurosurg Anesthesiol. 2010 Jul;22(3):252-5.

72. Hindman BJ, Bayman EO, Pfisterer WK, Torner JC, Todd MM; IHAST Investigators. No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010 Jan;112(1):86-101.

73. Nguyen HP, Zaroff JG, Bayman EO, Gelb AW, Todd MM, Hindman BJ; IHAST-MIDS and IHAST Investigators. Perioperative hypothermia (33 degrees) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneuriysm: findings from the Introoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010 Aug;113(2):327-42.

74. Sharma D, Ellenbogen RG, Vavilala MS. Use of transcranial Doppler ultrasonography and jugular oximetry to optimize hemodynamics during pediatric posterior fossa craniotomy. J Clin Neurosci. 2010 Dec;17(12):1583-4.

75. Di Gennaro JL, Mack CD, Malakouti A, Zimmerman JJ, Armstead W, Vavilala MS. Use and effect of vasopressors after pediatric traumatic brain injury. Dev Neurosci. 2010;32(5-6):420-30.

76. Armstead WM, Kiessling JW, Riley J, Kofke WA, Vavilala MS. Phenylephrine infusion prevents impairment of ATP- and calcium-sensitive potassium channel-mediated cerebrovasodilation after brain injury in female, but aggravates impairment in male, piglets through modulation of ERK MAPK upregulation. J Neurotrauma. 2011 Jan;28(1):105-11.

77. Curry P, Ramaiah R, Vavilala MS. Current trends and update on injury prevention. Int J Crit Illn Inj Sci. 2011 Jan;1(1):57-65.

78. Siriussawakul A, Sharma D, Sookplung P, Armstead W, Vavilala MS. Gender differences in cerebrovascular reactivity to carbon dioxide during sevoflurane anesthesia in children: preliminary findings. Paediatr Anaesth. 2011 Feb;21(2):141-7.

79. Vavilala MS. The power of speaking English. Anesthesiology. 2011 Mar;114(3):708-10. 80. Armstead WM, Kiessling JW, Kofke WA, Vavilala MS. Impaired cerebral blood flow autoregulation

during posttraumatic arterial hypotension after fluid percussion brain injury is prevented by phenylephrine in female but exacerbated in male piglets by extracellular signal-related kinase mitogen-activated protein kinase upregulation. Crit Care Med. 2010 Sep;38(9):1868-74.

81. Kanal KM, Vavilala MS, Raelson C, Mohan A, Cohen W, Jarvik J, Rivara FP, Stewart BK. Variation in pediatric head CT imaging protocols in Washington state. J Am Coll Radiol. 2011 Apr;8(4):242-50.

82. Rivara, F.P., Koepsell, T., Vavilala, M.S., Durbin D. Disability 3 and 12 months after traumatic brain injury among preschool children. Pediatrics 2011 Nov;128(5): e1129 -38.

83. Chaiwat O, Vavilala MS, Philip S, Malakouti A, Neff MJ, Deem S, Treggiari MM, Wang J, Lang JD. Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. J Crit Care. 2011 Apr;26(2):144-51.

84. Holmberg TJ, Bowman SM, Warner KJ, Vavilala MS, Bulger EM, Copass MK, Sharar SR. The association between obesity and difficult prehospital tracheal intubation. Anesth Analg. 2011 May;112(5):1132-8.

http://www.ncbi.nlm.nih.gov/pubmed/20562700







85. Deeter KH, Roberts JS, Bradford H, Richards T, Shaw D, Marro K, Chiu H, Pihoker C, Lynn A, Vavilala MS. Hypertension despite dehydration during severe pediatric diabetic ketoacidosis. Pediatr Diabetes. 2011 Jun;12(4 Pt 1):295-301.

86. Rivara, F.P., Koepsell, T., Vavilala, M.S., Durbin D. Comparison of telephone with World Wide Web-based responses by parents and teens to a survey related to traumatic brain injury. Health Serv Res. 2011 Jun;46(3):964-81.

87. Pecha T, Sharma D, Hoffman NG, Sookplung P, Curry P, Vavilala MS. Hyperglycemia during craniotomy for adult traumatic brain injury. Anesth Analg. 2011 Aug;113(2):336-42.

88. Sookplung P, Siriussawakul A, Malakouti A, Sharma D, Wang J, Souter MJ, Chesnut RM, Vavilala MS. Vasopressor use and effect on blood pressure after severe adult traumatic brain injury. Neurocrit Care. 2011 Aug;15(1):46-54.

89. Koepsell, T., Rivara, F.P., Vavilala, M.S., Durbin D. Epidemiology of Traumatic Brain Injury In Washington State. Pediatrics. (in-press).

90. Sharma D, Vavilala M.S., Lund concept for the management of traumatic brain injury: a physiological principle awaiting stronger evidence.. J Neurosurg Anesthesiol. 2011 Oct;23(4):363-7.

91. Roscigno CI, Swanson KM, Vavilala MS, Solchany J. Children's longing for everydayness: life following traumatic brain injury in the USA. Brain Inj. 2011;25(9):882-94.

92. Koepsell TD, Rivara FP, Vavilala MS, Wang J, Temkin N, Jaffe KM, Durbin DR. Incidence and descriptive epidemiologic features of traumatic brain injury in King County, Washington. Pediatrics. 2011 Nov;128(5):946-54.

93. Vavilala MS, Richards TL, Roberts JS, Chiu H, Pihoker C, Bradford H, Deeter K, Marro KI, Shaw D. Change in blood-brain barrier permeability during pediatric diabetic ketoacidosis treatment. Pediatr Crit Care Med. 2010 May;11(3):332-8.

94. Vavilala MS, Marro KI, Richards TL, Roberts JS, Curry P, Pihoker C, Bradford H, Shaw D. Change in mean transit time, apparent diffusion coefficient, and cerebral blood volume during pediatric diabetic ketoacidosis treatment. Pediatr Crit Care Med. 2011 Nov;12(6):e344-9.

95. Rivara FP, Koepsell TD, Wang J, Temkin N, Dorsch A, Vavilala MS, Durbin D, Jaffe KM. Disability 3, 12, and 24 months after traumatic brain injury among children and adolescents. Pediatrics. 2011 Nov;128(5):e1129-38.

96. Vavilala MS. Intracranial pressure monitoring in meningitis: thinking beyond traumatic brain injury. Pediatr Crit Care Med. 2011 Nov;12(6):689-90.

97. Sharma D, Vavilala MS. Sedating the injured brain: searching for the "ideal" pharmacological recipe. Crit Care Med. 2011 Dec;39(12):2780-2.

98. Blume HK, Vavilala MS, Jaffe KM, Koepsell TD, Wang J, Temkin N, Durbin D, Dorsch A, Rivara FP. Headache after pediatric traumatic brain injury: a cohort study. Pediatrics. 2012 Jan;129(1):e31-9.

99. Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, Tong KA, Vavilala MS, Wainwright MS, Warden CR; American Academy of Pediatrics-Section on Neurological Surgery; American Association of Neurological Surgeons/Congress of Neurological Surgeons; Child Neurology Society; European Society of Pediatric and Neonatal Intensive Care; Neurocritical Care Society; Pediatric Neurocritical Care Research Group; Society of Critical Care Medicine; Paediatric Intensive Care Society UK; Society for Neuroscience in Anesthesiology and Critical Care; World Federation of Pediatric Intensive and Critical Care Societies. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med. 2012 Jan;13 Suppl 1:S1-82.











100. Malakouti A, Sookplung P, Siriussawakul A, Philip S, Bailey N, Brown M, Farver K, Zimmerman JJ, Bell MJ, Vavilala MS. Nutrition support and deficiencies in children with severe traumatic brain injury. Pediatr Crit Care Med. 2012 Jan;13(1):e18-24.

101. Tham SW, Palermo TM, Vavilala MS, Wang J, Jaffe KM, Koepsell TD, Dorsch A, Temkin N, Durbin D, Rivara FP. The longitudinal course, risk factors, and impact of sleep disturbances in children with traumatic brain injury. J Neurotrauma. 2012 Jan 1;29(1):154-61.

102. Sharma, D.S., Sirriswakkul, A., Sookplung, P., Armstead, W.M., Vavilala, M.S. Gender Differences in CO2 Reactivity in Children during Sevoflurane Anesthesia. Paediatr Anaesth. 2011 Feb;21(2):141-7.

103. Sharma D, Vavilala MS. Intracerebral cytokines in traumatic brain injury: clinical and radiological correlates. Crit Care Med. 2011 Mar;39(3):599-601.

104. Swanson JO, Vavilala MS, Wang J, Pruthi S, Fink J, Jaffe KM, Durbin D, Koepsell T, Temkin N, Rivara FP. Association of initial CT findings with quality-of-life outcomes for traumatic brain injury in children. Pediatr Radiol. 2012 Aug;42(8):974-81.

105. Armstead WM, Riley J, Vavilala MS. TBI sex dependently upregulates ET-1 to impair autoregulation, which is aggravated by phenylephrine in males but is abrogated in females. J Neurotrauma. 2012 May 1;29(7):1483-90.

106. O'Connor SS, Zatzick DF, Wang J, Temkin N, Koepsell TD, Jaffe KM, Durbin D, Vavilala MS, Dorsch A, Rivara FP. Association between posttraumatic stress, depression, and functional impairments in adolescents 24 months after traumatic brain injury. J Trauma Stress. 2012 Jun;25(3):264-71.

107. Sharma D, Vavilala MS. Perioperative management of adult traumatic brain injury. Anesthesiol Clin. 2012 Jun;30(2):333-46.

108. Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, Tong KA, Vavilala MS, Wainwright MS, Warden CR. Comments about the revised Guidelines for the Acute Medical Management of Severe Traumatic Brain Injury in Infants, Children, and Adolescents. Pediatr Crit Care Med. 2012 Jul;13(4):496-497.

109. Rivara FP, Vavilala MS, Durbin D, Temkin N, Wang J, O'Connor SS, Koepsell TD, Dorsch A, Jaffe KM. Persistence of disability 24 to 36 months after pediatric traumatic brain injury: a cohort study. J Neurotrauma. 2012 Oct 10;29(15):2499-504.

110. Sharma D, Brown MJ, Curry P, Noda S, Chesnut RM, Vavilala MS. Prevalence and risk factors for intraoperative hypotension during craniotomy for traumatic brain injury. J Neurosurg Anesthesiol. 2012 Jul;24(3):178-84.

111. Vavilala MS. Adapting the electronic clinical and quality improvement toolkit for research: the case of the thrombus risk assessment tool. Pediatr Crit Care Med. 2012 Jul;13(4):481-2.

112. Bell MJ, Pineda JA, Vavilala MS, Wainwright MS, Doctor A, Stanley R, Thompson AE. Neurocritical Care Research Networks-Pediatric Considerations. Neurocrit Care. 2012 Dec;17(3):468-9.

113. Vavilala MS, Sharma D. Neuroprotection with phenylephrine in traumatic brain injury: cerebral perfusion or beyond? Crit Care Med. 2012 Aug;40(8):2515-7.

114. Sharma D, Siriussawakul A, Dooney N, Hecker JG, Vavilala MS. Clinical experience with intraoperative jugular venous oximetry during pediatric intracranial neurosurgery. Paediatr Anaesth. 2013 Jan;23(1):84-90.

115. Roudsari B, Psoter KJ, Mack C, Vavilala MS, Jarvik JG. Burden of alcohol-related injuries on radiology services at a level I trauma center. AJR Am J Roentgenol. 2012 Oct;199(4):W444-8.











116. Rivara FP, Koepsell TD, Wang J, Temkin N, Dorsch A, Vavilala MS, Durbin D, Jaffe KM. Incidence of disability among children 12 months after traumatic brain injury. Am J Public Health. 2012 Nov;102(11):2074-2079.

117. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2163-96.

118. Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010: Lancet. 2012 Dec 15;380(9859):2197-223.

119. Krishnamoorthy V, Sharma D, Prathep S, Vavilala MS. Myocardial dysfunction in acute traumatic brain injury relieved by surgical decompression. Case Rep Anesthesiol. 2013;2013:482596.

120. Armstead WM, Riley J, Vavilala MS. Dopamine prevents impairment of autoregulation after traumatic brain injury in the newborn pig through inhibition of Up-regulation of endothelin-1 and extracellular signal-regulated kinase mitogen-activated protein kinase. Pediatr Crit Care Med. 2013 Feb;14(2):e103-11.

121. Krishnamoorthy V, Beckmann K, Mueller M, Sharma D, Vavilala MS. Perioperative estimation of the intracranial pressure using the optic nerve sheath diameter during liver transplantation. Liver Transpl. 2013 Mar;19(3):246-9.

122. Asher SR, Curry P, Sharma D, Wang J, O’Keefe GE, Daniel-Johnson J, Vavilala MS. Survival advantage and PaO2 threshold n severe traumatic brain injury. J Neurosurg Anesthesiol. 2013 Apr;25(2):168-73.

123. Ramaiah VK, Sharma D, Ma L, Prathep S, Hoffman NG, Vavilala MS. Admission oxygenation and ventilation parameters associated with discharge survival in severe pediatric traumatic brain injury. Childs Nerv Syst. 2013 Apr;29(4):629-34.

124. Roudsari BS, Psoter KJ, Vavilala MS, Mack D, Jarvik JG. CT use in hospitalized pediatric trauma patients: 15-year trends in a level I pediatric and adult trauma center. Radiology. 2013 May;267(2):479-86.

125. Graves JM, Sears JM, Vavilala MS, Rivara FP. The burden of traumatic brain injury among adolescent and young adult workers in Washington State. J Safety Res. 2013 Jun;45:133-139.

126. Jimenez N, Ebei BE, Wang J, Koepsell TD, Jaffe KM, Dorsch A, Durbin D, Vavilala MS, Temkin N, Rivara FP. Disparities in disability after traumatic brain injury among Hispanic children and adolescents. Pediatrics. 2013 Jun;131(6):e1850-6.

127. Kernic MA, Rivara FP, Zatzick DF, Bell MJ, Wainwright MS, Groner JI, Giza CC, Mink RB, Ellenbogen RG, Boyle L, Mitchell PH, Kannan N, Vavilala MS; PEGASUS Pediatric Guideline Adherence and Outcomes Project. Triage of children with moderate and severe traumatic brain injury to trauma centers. J Neurotrauma. 2013 Jul 1;30(13):1129-36.

128. US Burden of Disease Collaborators. The state of US health, 1990-2010:burden of diseases, injuries, and risk factors. JAMA. 2013 Aug 14;310(6):591-608.

129. Prathep S, Sharma D, Hallman M, Joffe A, Krishnamoorthy V, Mackensen GB, Vavilala MS. Preliminary Report on Cardiac Dysfunction After Isolated Traumatic Brain Injury. Crit Care Med. 2013 Aug 19. doi: 10.1097/CCM.0b013e318298a890 [Epub ahead of print]

130. Vavilala MS. Treating cerebral edema in diabetic ketoacidosis: caveats in extrapolating from traumatic brain injury*. Pediatr Crit Care Med. 2013 Sep;14(7):723-4.


131. Graves JM, Iyer KR, Willis MM, Ebel BE, Rivara FP, Vavilala MS. Emergency department-reported injuries associated with mechanical home exercise equipment in the USA. Inj Prev. 2013 Sep 23. doi: 10.1136/injuryprev-2013-040833. [Epub ahead of print]

132. Krishnamoorthy V, Vavilala MS, Fettiplace MR, Weinberg G. Epinephrine for Cardiac Arrest: Are We Doing More Harm Than Good? Anesthesiology. 2013 Oct 16. [Epub ahead of print]

133. Bell MJ, Adelson PD, Hutchinson JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR, Multiple Medical Therapies for Pediatric Traumatic Brain Injury Workgroup. Differences in medical therapy goals for children with severe traumatic brain injury—an international study. Pediatr Crit Care Med. 2013 Oct; 14(8):811-8.

134. Dervan L, Poliakov A, Friedman SD, Shaw D, Pihoker C, Roberts JS, Richards T, Marro K, Vavilala MS. Change in fractional anisotropy during treatment of diabetic ketoacidosis in children. Pediatr Res. 2013 Oct 8. doi: 10.1038/pr.2013.168. [Epub ahead of print]

135. Van Cleve W, Kernic MA, Ellenbogen RG, Wang J, Zatzick DF, Bell MJ, Wainwright MS, Groner JI, Mink RB, Giza CC, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS; PEGASUS (Pediatric Guideline Adherence and Outcomes) Project. National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery. 2013 Nov;73(5):746-52.

136. Graves JM, Whitehill JM, Stream JO, Vavilala MS, Rivara FP. Emergency department reported head injuries from skiing and snowboarding among children and adolescents. Inj Prev. 2013 Dec;19(6):399-404.

137. Fujita Y, Algarra NN, Vavilala MS, Prathep S, Prapruettham S, Sharma D. Intraoperative secondary insults during extracranial surgery in children with traumatic brain injury. Childs Nerv Syst. 2014 Jan 16. [Epub ahead of print]

138. Mtaweh H, Smith R, Kochanek PM, Wisniewski SR, Fabio A, Vavilala MS, Adelson PD, Toney NA, Bell MJ. Energy Expenditure in Children After Severe Traumatic Brain Injury. Pediatr Crit Care Med. 2014 Jan 3. [Epub ahead of print]

139. Graves JM, Kanal KM, Rivara FP, Jarvik JG, Vavilala MS. Dose Reduction Efforts for Pediatric Head CT Imaging in Washington State Trauma Centers: Follow-Up Survey Results. J Am Coll Radiol. 2014 Feb;11(2):161-168.e3. doi: 10.1016/j.jacr.2013.07.004. Epub 2013 Dec 20.

140. Zonfrillo MR, Durbin DR, Koepsell TD, Wang J, Temkin NR, Dorsch AM, Vavilala MS, Jaffe KM, Rivara FP. Prevalence of and Risk Factors for Poor Functioning after Isolated Mild Traumatic Brain Injury in Children. J Neurotrauma. 2014 Jan 9. 31(8), 722-727

141. Krishnamoorthy V, Prathep S, Sharma D, Gibbons E, Vavilala MS. Association between electrocardiographic findings and cardiac dysfunction in adult isolated traumatic brain injury. Indian J Crit Care Med. 2014 Sep;18(9):570-4. doi: 10.4103/0972-5229.140144.

142. Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP; Pediatric Guideline Adherence and Outcomes Study. Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury. Crit Care Med. 2014 Oct;42(10):2258-66. doi: 10.1097/CCM.0000000000000507.

143. Ma L, Roberts JS, Pihoker C, Richards TL, Shaw DW, Marro KI, Vavilala MS. Transcranial Doppler-based assessment of cerebral autoregulation in critically ill children during diabetic ketoacidosis treatment. Pediatr Crit Care Med. 2014 Oct;15(8):742-9. doi: 10.1097/PCC.0000000000000197.


144. Van Cleve WC, Vavilala MS. Response to journal club: national variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery. 2014 Aug;75(2):194. doi: 10.1227/NEU.0000000000000417. No abstract available.

145. Kannan N, Ramaiah R, Vavilala MS. Pediatric neurotrauma. Int J Crit Illn Inj Sci. 2014 Apr;4(2):131-7. doi: 10.4103/2229-5151.134152.

146. Graves JM, Kanal KM, Vavilala MS, Applegate KE, Jarvik JG, Rivara FP. Hospital-level factors associated with use of pediatric radiation dose-reduction protocols for head CT: results from a national survey. J Am Coll Radiol. 2014 Jul;11(7):717-724.e1. doi: 10.1016/j.jacr.2013.12.002.

147. Hardcastle N, Benzon HA, Vavilala MS. Update on the 2012 guidelines for the management of pediatric traumatic brain injury - information for the anesthesiologist. Paediatr Anaesth. 2014 Jul;24(7):703-10. doi: 10.1111/pan.12415. Epub 2014 May 12.

148. Kassebaum NJ, and Colleagues. Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014 Sep 13;384(9947):980-1004. doi: 10.1016/S0140-6736(14)60696-6. Epub 2014 May 2. Erratum in: Lancet. 2014 Sep 13;384(9947):956.

149. Psoter KJ, Roudsari BS, Mack C, Vavilala MS, Jarvik JG. Outcomes and resource utilization associated with underage drinking at a level I trauma center. J Adolesc Health. 2014 Aug;55(2):195-200. doi: 10.1016/j.jadohealth.2014.01.018. Epub 2014 Mar 21.

150. Greene NH, Kernic MA, Vavilala MS, Rivara FP. Variation in pediatric traumatic brain injury outcomes in the United States. Arch Phys Med Rehabil. 2014 Jun;95(6):1148-55. doi: 10.1016/j.apmr.2014.02.020. Epub 2014 Mar 11.

151. Moore M, Robinson G, Mink R, Hudson K, Dotolo D, Gooding T, Ramirez A, Zatzick D, Giordano J, Crawley D, Vavilala MS. Developing a Family-Centered Care Model for Critical Care After Pediatric Traumatic Brain Injury. Pediatr Crit Care Med. 2015 Jul 1.

152. Flynn-O'Brien, K. T., Fawcett, V. J., Nixon, Z. A., Rivara, F. P., Davidson, G. H., Chesnut, R. M., Ellenbogen R.G., Vavilala, M.S., Bulger, E.M., Maier, Ronald V., & Arbabi, S. (2015). Temporal Trends in Surgical Intervention for Severe Traumatic Brain Injury Caused by Extra-axial Hemorrhage, 1995 to 2012. Neurosurgery, 76(4), 451-460.

153. Armstead, W. M., Riley, J., & Vavilala, M. S. (2013). Dopamine prevents impairment of autoregulation after TBI in the newborn pig through inhibition of upregulation of ET-1 and ERK MAPK. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 14(2), e103.

154. Krishnamoorthy, V., Sharma, D., Prathep, S., & Vavilala, M. S. (2013). Myocardial dysfunction in acute traumatic brain injury relieved by surgical decompression. Case reports in anesthesiology, 2013.

155. Prathep, S., Sharma, D., Hallman, M., Joffe, A., Krishnamoorthy, V., Mackensen, G. B., & Vavilala, M. S. (2014). Preliminary report on cardiac dysfunction after isolated traumatic brain injury. Critical care medicine, 42(1).

156. Krishnamoorthy, V., Prathep, S., Sharma, D., Gibbons, E., & Vavilala, M. S. (2014). Association between electrocardiographic findings and cardiac dysfunction in adult isolated traumatic brain injury. Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine, 18(9), 570.

157. Krishnamoorthy, V., Borbely, X., Rowhani-Rahbar, A., Souter, M. J., Gibbons, E., & Vavilala, M. S. (2015). Cardiac Dysfunction Following Brain Death in Children: Prevalence, Normalization, and Transplantation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.




158. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. GBD 2013 Risk Factors Collaborators. Lancet. 2015 Sep 10. pii: S0140-6736(15)00128-2. doi: 10.1016/S0140-6736(15)00128-2. [Epub ahead of print].

159. Graves JM, Rivara FP, Vavilala MS. Health Care Costs 1 Year After Pediatric Traumatic Brain Injury.Am J Public Health. 2015 Oct;105(10):e35-41. doi: 10.2105/AJPH.2015.302744. Epub 2015 Aug 13.

160. Krishnamoorthy V, Distelhorst JT, Vavilala MS, Thompson H. Traumatic Brain Injury in the Elderly: Burden, Risk Factors, and Prevention. J Trauma Nurs. 2015 Jul-Aug;22(4):204-8.

161. Krishnamoorthy V, Prathep S, Sharma D, Fujita Y, Armstead W, Vavilala MS. Cardiac dysfunction following brain death after severe pediatric traumatic brain injury: A preliminary study of 32 children. Int J Crit Illn Inj Sci. 2015 Apr-Jun;5(2):103-7. doi: 10.4103/2229-5151.158409.

162. Moore M, Robinson G, Mink R, Hudson K, Dotolo D, Gooding T, Ramirez A, Zatzick D, Giordano J, Crawley D, Vavilala MS. Developing a Family-Centered Care Model for Critical Care After Pediatric Traumatic Brain Injury. Pediatr Crit Care Med. 2015 Jul 1. [Epub ahead of print].

163. Rozet I, Metzner J, Brown M, Treggiari MM, Slimp JC, Kinney G, Sharma D, Lee LA, Vavilala MS. Dexmedetomidine Does Not Affect Evoked Potentials During Spine Surgery. Anesth Analg. 2015 Aug;121(2):492-501. doi: 10.1213/ANE.0000000000000840.

164. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Aug 22;386(9995):743-800. doi: 10.1016/S0140-6736(15)60692-4. Epub 2015 Jun 7.

165. Greene NH, Kernic MA, Vavilala MS, Rivara Validation of ICDPIC software injury severity scores using a large regional trauma registry. Inj Prev. 2015 Oct;21(5):325-30. doi: 10.1136/injuryprev-2014-041524. Epub 2015 May 18.

166. Thompson HJ, Vavilala MS, Rivara FP. Chapter 1 Common Data Elements and Federal Interagency Traumatic Brain Injury Research Informatics System for TBI Research. Annu Rev Nurs Res. 2015;33(1):1-11. doi: 10.1891/0739-6686.33.1.

167. Undraneta A, Krishnamoorthy, Fink KA, Gibbons T, Vavilala M.S. Radiographic Predictors of Cardiac Dysfunction after Traumatic Brain Injury. J Crit Care. (in-press).

168. Kannan N, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS.; Pediatric Guideline Adherence and Outcomes Study. Timely Resuscitation and Outcomes in Severe Pediatric Traumatic Brain Injury. Pediatric Emergency Care. (in-press).

169. Krishnamoorthy V, Mills B, Rowhani AA, Vavilala, M.S. Hypotension and Outcomes in Isolated Traumatic Brain Injury. Chest (in-press).

170. Jimenez N, Jaffe K, Temkin N, Vavilala M.S., Rivara FP. Health Disparities in Traumatic Brain Injury Rehabilitation. Pediatrics (in-press).

Book Chapters:

1. Vavilala, M.S.: Klein, E.J.: Emergency Airway Management in Pediatric Trauma. Progress in Anesthesiology. Vol XII, chapter 21:383-396, 1998.






















2. Vavilala, M.S., Rivara, F.P.: Pediatric Trauma, in Bergman, A. (ed): Twenty Common Problems in Pediatrics. N.Y, McGraw-Hill, 2001,pp 117-134.

3. Vavilala, M.S., Lam, A.M.: Perioperative Management of Pediatric Traumatic Brain Injury, in International Anesthesiology Clinics 2002;40:69-87.

4. Vavilala, M.S., Lee L.A., Lam A.M.: Cerebral Blood Flow and Vascular Physiology, in Anesthesiology Clinics of North America 2002:20:247-64.

5. Vavilala, M.S.: Anesthesia for pediatric head trauma, Strategies in Pediatric Anesthesia. Edited by Litman RS. Philadelphia, Pocketmedicine.com, 2002.

6. Vavilala, M.S.: Perioperative Considerations in Pediatric Brain Injury. Progress in Anesthesiology. Vol XVI, Chapter 23:403-416, 2002.

7. Bhananker, S.M., Vavilala, M.S.: Perioperative Anesthetic Management for Neonatal Emergencies. Progress in Anesthesiology. Vol XVII, Chapter 7:107-120, 2003.

8. Vavilala, M.S.: Pediatric Trauma and Burns. Pediatric Anesthesia. Edited by Litman RS. Requisites in Anesthesiology. Mosby. 2004.

9. Uffman J, MD., Vavilala, M.S.: Pediatric Trauma. Case Studies in Pediatric Critical Care. Cambridge University Press. Eds Peter Murphy, Stephen Marriage, Peter Davis. Cambridge University Press. 2009, pps 268-286.

10. Waitayawinyu P, Vavilala, M.S.: Pediatric Traumatic Brain Injury: Emergency Evaluation and Management. Up To Date.

11. Rozet, I., Vavilala, M.S.: Risks and Benefits of Patient Positioning During Neurosurgical Care. Anesthesiol Clin. Sep;25(3):631-53, 2007.

12. Udomphorn Y, Armstead WM, Vavilala M.S.: Cerebral Autoregulation in Pediatric Traumatic Brain Injury. Ped Neurology. 2008 Apr;38(4):225-34.

13. Hardcastle N, Benzon HA, Vavilala MS. Update on the 2012 guidelines for the management of pediatric traumatic brain injury - information for the anesthesiologist. Paediatr Anaesth. 2014 Jul;24(7):703-10. doi: 10.1111/pan.12415. Epub 2014 May 12. Review.

14. Kannan N, Ramaiah R, Vavilala MS. Pediatric neurotrauma. Int J Crit Illn Inj Sci. 2014 Apr;4(2):131-7. doi: 10.4103/2229-5151.134152.

15. Waitayawinyu P, Sookplung S, Vavilala, M.S.: What’s New in Pediatric Traumatic Brain Injury: Pediatric Emergency Manual. Ed. Ewen Wang 2015.

16. Vavilala, M.S. Soriano SG. Pediatric Neruoanesthesia. Smith’s textbook on Pediatric Anesthesia. 2015. Letters To The Editor:

1. Vavilala, M.S., Bramhall, J.S.: Suction Laryngoscope. Anesth Analg 83:664-665, 1996. 2. Vavilala, M.S., Lam, A.M.: Neostigmine for the Treatment of Colonic Pseudo-Obstruction. NEJM 18:

341(21):1622, 1999. 3. Vavilala, M.S., Lam A.M.: Propofol Decreases Cerebral Blood Flow Velocity in Children. Can J

Anaesth. 50:527-8, 2003. 4. Vavilala M.S., Lam A.M.: CBF Reactivity to Changes in MAP (Cerebral Autoregulation) or CO2

(CO2 Reactivity) is Lost in Hypotensive, Ventilated, Preterm Infants (author reply). Pediatr Res. 55(5):898, 2004.

5. Vavilala, M.S., Lam, A.M.: Identification of Pressure Passive Cerebral Perfusion and Its Mediators after Infant Cardiac Surgery. Pediatr Res. 57(1):35, 2005.





6. Vavilala, M.S., Lam, A.M.: Cerebral Pressure Autoregulation and Vasoreactivity in the Newborn Rat. Pediatr Res. 57:294-8, 2005.

Manuscripts Submitted:

1. Kannan N, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS.; Pediatric Guideline Adherence and Outcomes Study. Early Intracranial Pressure Monitoring and Outcomes in Pediatric Brain Injury.

2. Ajdari A, Boyle, LN, Kannan N, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Mitchell PH, Rivara FP, Vavilala MS.; Pediatric Guideline Adherence and Outcomes Study. Value Stream Mapping in Traumatic Brain Injury.

3. Ostaowski P, Kannan N, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS.; Pediatric Guideline Adherence and Outcomes Study. Variation in Anti Epileptic Agent Use in Brain Injury.

4. Narayan A, Kannan N, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP, Vavilala MS.; Pediatric Guideline Adherence and Outcomes Study. Trauma Team Design and Outcomes in Pediatric Traumatic Brain injury.

Abstracts (selected from 150):

1. Vavilala, M.S.: The Role of IL2 on Autologous and Allogeneic Bone Marrow Transplantation. MD Anderson Cancer Center. Summer Research, 1986.

2. Vavilala, M.S.: Topical Diphenhydramine Hydrochloride Hypersensitivity in Ten Patients. Clin Res 40:850A, 1993.

3. Vavilala, M.S., Dunbar, P.J., Lam, A.M., Rivara, F.P.: Coagulopathy Predicts Outcome Following Head Injury in Children. J Neurosurg Anesthesiol 11(4): 315, 1999.

4. Vavilala, M.S., Dunbar, P.J., Lam, A.M., Rivara, F.P.: Coagulopathy Predicts Outcome Following Head Injury in Children. Anesthesiol 91,3A: A 1397, 1999.

5. Ransom, G., Mann, F., Vavilala, M.S., Rivara, F.P.: Cerebral Infarct in Head Injury: Relation to Child Abuse. APS/SPR, 2000.

6. Vavilala, M.S., Junger, E., Douville, C.A., Rivara, F.P., Newell, D., Lam, A.M.: Cerebral Autoregulation in Healthy Children. Pediatr Anesthesiol 87, 2000.

7. Vavilala, M.S., Junger, E., Douville, C.A., Rivara, F.P., Newell, D., Lam, A.M.: Cerebral Autoregulation in Healthy Children. Anesthesiol 93, 3A: A378, 2000.

8. Vavilala, M.S., Junger, E., Douville, C.A., Rivara, F.P., Newell, D., Lam, A.M.: Cerebral Autoregulation in Healthy Children. J Neurosurg Anesthesiol 12 (4) 405, 2000.

9. Lee, LA, Douville, C.A., Moore, A, Vavilala, M.S., Newell, D.W., Visco, E., Lam, A.M.: Hypocapnia Causes Increased Cerebral Blood Flow Velocity in the Ophthalmic Artery. J Neurosurg Anesthesiol 408, 2000.

10. Vavilala, M.S., Lee, M., Graham, A., Lee, L.A., Visco, E., Lam, A.M.: Static autoregulation in Children of various ages. J Neurosurg Anesthesiol 405, 2000.

11. Visco, E. Lee, M, Lee, L.A., Vavilala, M.S., Lam, A.M.: Influence of Phenylephrine Induced Bradycardia on Cerebral Autoregulation Testing. J Neurosurg Anesthesiol 406, 2000.


12. Sharar, S.R, Carrougher, G.J., Selzer, K., O’Donnell, F., Vavilala, M.S., Lee, L.A. : Oral Transmucosal Fentanyl Citrate (OFTC) vs. Oral Oxycodone (OC) for Pediatric Outpatient Wound Care. J Burn Care Rehabil. 2000: S81, 2001.

13. Vavilala, M,S., Lee, M., Graham, A., Lee, L.A., Visco, E., Lam, A.M.: Static Autoregulation in Children of Various Ages. Pediatr Anesth 89, 2001.

14. Vavilala, M.S., Lee, L.A., Visco, E., Newell, D.W., Lam, A.M.: Static Autoregulation in Children Following Traumatic Brain Injury. Pediatr Anesthesiol 90, 2001.

15. Roberts, J.S., Vavilala, M.S., Schenkman, K.A., Shaw, D., Martin, L.D., Lam, A.M.: Hyperemia in Pediatric Diabetic Ketoacidosis. Pediatr Res Vol 55(4); 64A, 2004.

16. Vavilala, M.S., Muangman, S., Zimmerman, J.J., Newell, D.W., Lam, A.M.: Cerebral Autoregulation in Pediatric Traumatic Brain Injury. Pediatr Res Vol 55(4); 64A, 2004.

17. Miller, P., Vavilala, M.S., Rozet, I., Lee, L., Muangman, S., Mack, C., Wang, M., Hollingworth, C.: Risk Factors for Intraoperative Hypotension During Emergency Decompressive Pediatric Craniotomy. J Neurosurg Anesthesiol 22, 2005.

18. Vavilala, M.S., Muangman, P., Suz, P., Kincaid, M.S., Lam, A.M.: Relationship Between Cerebral Autoregulation and Outcome in Children with Severe Traumatic Brain Injury. J Neurosurg Anesthesiol 220, 2005.

19. Muangman, S., Vavilala, M.S., Suz, P., Kincaid, M.S., Lam, A.M.: Return of Cerebral Autoregulation During the First Week Following Severe Pediatric Traumatic Brain Injury. J Neurosurg Anesthesiol 220, 2005.

20. Muangman, S., Rozet, I., Vavilala, M.S., Lee, L.A., Kincaid, M.S., Souter, M.J., Lam, A.M.: Iso-osmolar Solutions of Mannitol vs. Hypertonic Saline for Intraoperative Brain Relaxation. J Neurosurg Anesthesiol 243, 2005.

Invited Articles:

1. Vavilala, M.S. Autoregulation and 6 month Outcome in Severe Pediatric Traumatic Brain Injury. Develop Neurosci. 2006.

2. Vavilala, M.S. Impaired Cerebral Autoregulation in Inflicted Pediatric Brain Injury. J Neurotrauma. 2006.

3. Vavilala, M.S. Editorial. Cerebral Oximetry. Pediatr Crit Care Med. 2006. 4. Vavilala, M.S. Editorial. Transfusion Triggers. Ped Crit Care Med. 2010. 5. Vavilala, M.S. Editorial. A Call to Education: Pediatric Emergency Care. Ped Crit Care Med. (in-press) 6. DiGenarro JL, Armstead WM, Zimmerman JJ, Vavilala, M.S. Vasporessor Choice and Effectiveness

after Severe Pediatric Traumatic Brain Injury. Dev Neurosci. 2010;32(5-6):420-30. 7. Vavilala MS. Quality of pediatric prehospital trauma care: a call to education. Pediatr Crit Care Med.

2011 Jul;12(4):477-8. 8. Vavilala MS. Moving forward: advancing venous thromboembolism knowledge in pediatric trauma.

Pediatr Crit Care Med. 2011 May;12(3):348-9. 9. Sharma D, Vavilala MS. Intracerebral cytokines in traumatic brain injury: clinical and radiological

correlates. Crit Care Med. 2011 Mar;39(3):599-601. Rev: 09/30/15





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University of Washington February 4, 2016 School of ...€¦ · Curriculum Vitae – Monica S. Vavilala, M.D. Page 2 2013-2014 Interim Director, UW Harborview Injury Prevention and