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From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
General Chemistry I (First part of the course “General Chemistry”)
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
The course is an introduction to general chemistry and chemical reactions with
special emphasis on areas in chemistry of particular importance for the
understanding of biochemical and biomedical topics.
After following the course the student should
- be able to balance chemical equations and perform stochiometric
calculations.
- have knowledge of central topics of relevance for the understanding of
chemical phenomena relevant for chemical and biochemical laboratory
techniques.
- have knowledge about fundamental chemical structures and chemical
reaction, with special emphasis on the properties and reactions of
organic compounds in biochemical systems.
- should have the necessary basic chemical background for the
understanding of the central biochemical and biomedical topics.
Obligatory Textbooks:
William Brown & Thomas Poon : “Introduction to Organic Chemistry", 4. ed.,
2010. Saunders Golden Sunburst Series. (ISBN: 9780470384671)
From the office of the Director of Studies in Molecular Biomedicine
W.L. Masterton and C. N. Hurley : "Chemistry, Principles and Reactions", 6. ed.
2008, Thomson. (ISBN: 9780495387732)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
General Chemistry II (Second part of the course “General Chemistry”)
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
The course is a practical laboratory course. The course aims at introducing
basic chemical laboratory techniques and teaching the student good laboratory
skills and practice. The student will learn to use simple laboratory equipment
and work with practical chemical problems in the laboratory. Special emphasis
is placed on methods of relevance for later practical biochemical laboratory
work.
After following the course the student should
- have knowledge about how to work safely and responsibly in a chemical
laboratory.
- have acquired basic skills in chemical laboratory practice and the
practical use of experimental chemical methods.
- be able to interpret and work according to a chemical receipt or
description of an experiment.
- be able to separate mixtures of compounds by means of chromatography
and extraction and should be able to explain the underlying principles.
- be able to keep a well-structured laboratory journal that satisfies basic
requirements of readability and precision.
From the office of the Director of Studies in Molecular Biomedicine
- be able to carry out simple physico-chemical measurement and perform
simple calculations and data manipulations afterwards by means of
standard software.
Obligatory Textbooks:
William Brown & Thomas Poon : “Introduction to Organic Chemistry", 4. ed.,
2010. Saunders Golden Sunburst Series. (ISBN: 9780470384671)
W.L. Masterton and C. N. Hurley : "Chemistry, Principles and Reactions", 6.
ed., 2008. Thomson. (ISBN: 9780495387732)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
Biochemistry
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
The purpose of the course is to provide a detailed insight into how organisms
receive the necessary energy from their environment and synthesize their
macromolecular building blocks based on an understanding of chemical
reactions. At the conclusion of the course the students should be able to: (1)
Describe the reactions (strategies, substrates, products, reaction types, energy
investment or yield, and balanced reactions) involved in the following
metabolic processes: glycolysis, the citric acid cycle, electron transport,
oxidative phosphorylation, gluconeogenesis, the pentose phosphate pathway,
glycogen metabolism, lipid metabolism, amino acid metabolism and nucleotide
metabolism. (2) Explain how the processes are localized in the cell/organism
and how they are regulated. (3) Describe how metabolic diseases can arise
from blocks in metabolic pathways. (4) Explain how the processes are
integrated and coordinated in the organism.
Obligatory Textbooks:
David L. Nelson and Michael M. Cox: “Lehninger Principles of Biochemistry”, 5.
ed., 2008. W. H. Freeman and Company. (ISBN: 9781429208925)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
Comparative Anatomy
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
The student will get an understanding of how basic biological needs have found
different anatomical and physiological solutions across the biological diversity
found within vertebrates. Th4 course is based on lectures and a number of lab
sessions where a number of representative vertebrates are dissected by the
students followed by a number of lab sessions each focusing at specific organ
systems (e. g. respiratoty, excretory- and sensoryorgans).
Description of obtained skills: After the course the students are expected to be
able to:
- Describe the basic structure of the metazoan tree of life.
- Describe the systematics of vertebrates (to the level of class)
- Fluent in relevant zoological and morphological terminology
- Describe the morphology of selected vertebrates including position,
morphology and function of their organs and organ systems
- Make comparative descriptions across the vertebrates of the position,
morphology and function of selected organs
- Dissiminate their knowledge regarding the above in written form
From the office of the Director of Studies in Molecular Biomedicine
Obligatory Textbooks:
Hickman, Eisenhour, Keen & Larson: “Integrated principles of zoology”. 14th
ed., 2008 . McGraw Hill (ISBN: 9780071287975)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
Protein Chemistry and Enzymology I
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
Competencies: Students will obtain insight into the correlation between the
physicochemical properties of proteins and their function
Content: A basic theoretical course n protein chemistry and enzymology. A
thorough back ground in the chemistry of the amino acids, levels of protein
structure, protein structure determination, protein stability and folding, protein
dynamics enzyme kinetics and enzyme mechanisms, protein-ligand
interactions as well as protein modifications will be obtained. Special emphasis
will be on the link between protein structure and function and the
understanding of protein-relevant diseases and the treatment of such.
Obligatory Textbooks:
David L. Nelson and Michael M. Cox: “Lehninger Principles of Biochemistry”, 5.
ed., 2008. W. H. Freeman and Company. (ISBN: 9781429208925)
“Problems and Notes for Protein Chemistry and Enzymology I for Molecular
Biomedicine”, Department of Molecular Biology, University of Copenhagen,
2009.
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
Protein Chemistry and Enzymology II
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
Competencies: Students will obtain insight into the correlation between the
physicochemical properties of proteins and their function as well as work in
laboratories concerned with protein chemistry and enzymology, including data
analysis and use of laboratory equipment.
Content: A basic theoretical and practical course in protein chemistry and
enzymology. The theoretical part focuses on the following themes: “proteoms:
from sequence to function” and “folding related diseases”. In the practical part
of the course basic skills in protein purification, protein characterization and
steady-state kinetics will be acquired. Among other techniques, the following
will be used: Chromatography, electrophoresis, mass spectrometry,
spectroscopy, fluorescence, protein bioinformatics and molecular graphics.
Obligatory Textbooks:
David L. Nelson and Michael M. Cox: “Lehninger Principles of Biochemistry”, 5.
ed., 2008. W. H. Freeman and Company. (ISBN: 9781429208925)
“Lab-manual and methods for Protein Chemistry and Enzymology II for
Molecular Biomedicine”, Department of Molecular Biology, University of
Copenhagen, 2009.
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 1st year
Title:
Basic Human Biology
ECTS points (out of a total of 60 ECTS points per year):
15 ECTS
Course description:
The purpose of the course is to give insight in the structures of elements in the
human organism: the cell, selected tissues and organs. The goal is for the
students to be able to:
- describe the structure of the cell and organelles with a specification of
functions
- describe each step in the mitosis
- describe passive and active transport over the cell membrane
- describe subdivisions of selected tissues and structures
- use the Latin terminology to describe body parts, organs, muscles,
nerves, bones, vessels and joints
- describe the skin and associated structures: hair, nails and specialized
sweat and fat producing glands, specialized senses which are associated
with the body’s reaction on pain, pressure, touch and change in
temperature
- describe the motoric apparatus and the structure of muscles, bones,
joints with associated cartilage and ligaments with specification of name
and function of each part; and the importance of providing the body firm
structure and mobility through the joints.
From the office of the Director of Studies in Molecular Biomedicine
- describe the bones role as storage of minerals and structure and function
of the red bone marrow
- describe structure of striped skeleton muscle both macroscopic and
microscopic. Specify the importance of the attachment of the muscle
related to effect on joints
- describe the subdivision of the nervous system, give examples of
malfunctions after lesions of peripheral nerves and hypo and hyper
function of the autonomic nervous system
- describe the subdivision of the sense apparatus and the different
specialized functions
- describe the hormonal regulation of the cellular functions
- describe the structure of the endocrine system and the physiological role
of the major endocrine systems
- describe the cardiovascular system, the heart’s impulse generation, the
conduction system, the connection between physical activity and minute
volume of the heart, plus to recognize the depolarisation of different
parts of the heart in a electrocardiogram
- describe the importance of the blood transporting nutrients, gasses,
waste products, proteins, hormones and immune competent cells plus
the regulation of the body temperature
- describe the respiratory system and regulation during relaxation and
during activity, the relation between respiration and acid-base balance
plus explain the connection between respiration and circulation
- describe and (under supervision) perform peak flow measurement and
spirometry
- describe the importance of the gastro intestinal system in relation to
digest food plus state basic nourishment and calculate BMI (body mass
index)
- describe urogenital system including the kidneys role in preservation and
regulation of electrolyte, water and acid-base balance
- describe the reproduction system and function in males and females
- describe the individual’s growth and development
From the office of the Director of Studies in Molecular Biomedicine
- describe the lymphatic system, it’s subdivision and the importance of
transporting lymph, lymphocytes, proteins and fat
- describe the light microscopic principles of developing contrasts in
preparations plus describe techniques of preparation and handling a light
microscope
Obligatory Textbooks:
Shier, Butler & Lewis: Hole’s Essentials of Human Anatomy and Physiology,
10th edition. (ISBN: 9780071283526)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 2nd year
Title:
Cell Biology
ECTS points (out of a total of 60 ECTS points per year):
22.5 ECTS
Course description:
This is a relatively extensive introductory course to cell and molecular biology.
The students are introduced to:
- The cell – structure and function of the dynamic cell, including cellular
structure and function including organelles involved in secretion
(ribosomes, rough ER, Golgi and secretory vesicles) endocytosis
(endosomes and lysosomes) metabolism (smooth ER, mitochondrion,
peroxisome) plus the cytoskeleton. The structure of the nucleus,
including the inner and outer membrane, pores, lamina, chromatin and
nucleoli.
- Organization and maintenance of genetic information, including the
synthesis of DNA and DNA repair. The synthesis and processing of RNA,
including examples of mechanisms for regulation of gene expression and
synthesis and turnover of proteins.
- Control of cell division and apoptosis, and the loss of this control in
malignant cells
- The structure and function of cellular membranes and various classes of
membrane proteins, and their involvement in transport of a diversity
compounds and intracellular signalling. The molecular basis of membrane
From the office of the Director of Studies in Molecular Biomedicine
conductance and membrane potentials, exability, synaptic transmission
and muscular contraction.
- Tissues, the microenvironment of the cells and their organization,
including the extracellular matrix and its interaction with the cells.
- Examples of the structure of epithelia, connective tissues, muscles,
nerves, vasculature.
Obligatory Textbooks:
Alberts, Johnson, Walter, Lewis, Raff & Roberts: “Molecular Biology of the Cell”
5th ed., 2008. Garland. (ISBN: 9780815341062).
Blaustein, Kao & Matteson: “Cellular Physiology” 1st ed., 2004. Mosby. (ISBN:
9780323013413).
Pawlina & Ross: “Histology”, 5th ed., 2006. Lippincott, Williams and Wilkins.
(ISBN: 9780781772211)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum,2nd year
Title:
Medical Genetics
ECTS points (out of a total of 60 ECTS points per year):
(Part of 22.5 ECTS Cell Biology course)
Course description:
This course is a theoretical and practical introduction to medical genetics, and
structured to be an integrated part of the cell biology course.
After completing the course the student should:
- be able to understand basic genetics and genetic problems.
- understand the context between genotypes and phenotypes.
- be able to discriminate between different types of mutations, how they
arise and how they affect the person and descendant.
- have knowledge about inheritance and be able to calculate the risks of
inheritance for the next generation.
- understand the interaction between the genetic, epigenetic and
environmental factors that affect the phenotype and thereby modify the
inheritance.
- be able to understand genetic variation.
- have knowledge about methods of genetic diagnosis and gene mapping
of genetic diseases.
Obligatory Textbooks:
Jorde, Carey & Bamshad: “Medical Genetics”, 4th ed., 2009. Elsevier. (ISBN:
9780323053730)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 2nd year
Title:
Ethics and Philosophy of Science
ECTS points (out of a total of 60 ECTS points per year):
7.5 ECTS
Course description:
Philosophical and ethical issues of relevance to students in Molecular
Biomedicine, both general aspects and aspects specific to the scientific
discipline, will be covered. Relevant themes are scientific method, theory
development, causation, reduction, and the interplay of data, models, theories,
experiments and the real world. History of genetics and molecular biology will
be taught in addition to ethical topics including ethical theories, research ethics
and ethical problems related to biotechnology, stem cells, gene therapy, and
biomedical research in developing countries. In addition to the lecture series
the will be several discussion sessions in smaller groups. One obligatory group
work paper is required in addition to the individual written exam.
Obligatory Textbooks:
Andersen, Emmeche, Norup & Sandøe: Videnskabsteori for de biologiske fag.
1st ed., 2006. Biofolia. (ISBN: 8791319323)
”Videnskabsteori og Etik, Molekylær Biomedicin”. Jan Kyrre Berg Friis,
Department of Public Health, University of Copenhagen.
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 2nd year
Title:
Molecular Biology
ECTS points (out of a total of 60 ECTS points per year):
15 ECTS
Course description:
Aim: The course will provide the necessary background to solve basic
molecular biological issues by applying a relevant experimental strategy, thus
giving the student an ability to interpret and communicate original molecular
biological research.
Content: Genomics. DNA-mediated processes such as replication,
recombination, transposition and transcription. Post-transcriptional events such
as RNA splicing, RNA export, RNA localization and translation. Regulatory
mechanisms as observed in studies of experimental organisms.
Obligatory Textbooks:
Weaver: “Molecular Biology”, 4. ed., McGraw Hill. (ISBN: 9780071275484)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 2nd year
Title:
Signal Transduction
ECTS points (out of a total of 60 ECTS points per year):
15 ECTS
Course description:
Advanced course in molecular biology with specific emphasis on cellular
signalling pathways and networks, their integration with the extra cellular
environment, and the resulting control of the cell cycle and apoptosis. It is one
of the major goals of this course to familiarize the students with the study of
primary literature to be able to follow this rapidly evolving field.
Format: 4 hours of lectures/week, 2 hours of problem solving/week and 3
hours of Journal Club/week.
Aims: After completing this course, the student is expected to be able to:
- Describe several inter- and intracellular molecular signal networks in
detail, and use this knowledge to analyze novel experimental results.
- Describe cell cycle control in molecular detail.
- Describe regulation of apoptosis in molecular detail.
- Demonstrate knowledge of many common methods in molecular biology.
- Read primary literature in the field, and critically relate the reported
experiments to already established theories within the field.
Obligatory Textbooks:
“Signal Transduction” by Bastien D. Gomperts (ISBN: 0-12-289632-7)
From the office of the Director of Studies in Molecular Biomedicine
“Principles and Techniques of Biochemistry and Molecular Biology” 6.ed. by
Keith Wilson & John Walker, (ISBN: 0-521-53581-6)
From the office of the Director of Studies in Molecular Biomedicine
University of Copenhagen Molecular Biomedicine
Course information on obligatory courses from the Molecular
Biomedicine curriculum, 3rd year
Title:
Molecular Pathophysiology
ECTS points (out of a total of 60 ECTS points per year):
15 ECTS
Course description:
This course gives the students present knowledge about fundamental
molecular mechanisms underlying different pathologic conditions. Emphasis is
placed on the different experimental disease models that are used in present
biomedical research. Fundamental biological definitions of disease are
introduced as systematic descriptions of structural and functional changes in
cells and tissues in diseased states and the like (adaptation, degeneration,
inflammation, neoplasia and others).
First, the students are introduced to the terminology of pathobiology, followed
by teachings in fundamental molecular mechanisms, central experimental
methods and present pathophysiological theories within the following main
topics
- Cancer
- Metabolism
- The nervous system
- The musculoskeletal system
- The circulatory system
- Environmental pathology
From the office of the Director of Studies in Molecular Biomedicine
Still with emphasis on molecular mechanisms, inclusive identification and
validation of molecular targets for diagnosis, prevention and treatment. No
time is spent on directly clinical aspects.
Format: 20 lectures and 18 hours demonstrations of micro- and macroscopic
specimens, 36 hours group discussions and other student-centered activity
based on problem-centered learning
Obligatory Textbooks:
Kierszenbaum: “Histology and Cell Biology”, 2nd ed. Mosby. (ISBN:
9780323045278)
Kumar, Abbas, Fausto & Aster: “Robbins and Cotran: Pathologic Basis of
Disease”, 8th ed. Saunders (W.B.) Co Ltd. (ISBN: 9781416031215)