Revised: June, 2015

UNIVERSITY CURRICULUM VITAE

DATE: June 13, 2015

NAME: Michael A. Lea

PRESENT TITLE: Professor

HOME ADDRESS: 52 South Orange Avenue, Newark, NJ 07103

OFFICE ADDRESS: Rutgers New Jersey Medical SchoolDepartment of Microbiology, Biochemistry and Molecular GeneticsICPH, 225 Warren StreetNewark, NJ 07103

TELEPHONE NUMBER/E-MAIL ADDRESS: 973-972-5345

CITIZENSHIP: USA

EDUCATION:A. Undergraduate

University or College: University of BirminghamBirmingham, EnglandDegree (Discipline): B.S. Biochemistry Date Awarded: 1961

B. Graduate and ProfessionalUniversity or College: University of BirminghamBirmingham, EnglandDegree (Discipline): Ph.D. Biochemistry Date Awarded: 1964

POSTGRADUATE TRAINING:A. Internship and Residencies

NA

B. Research FellowshipsNA

C. Postdoctoral AppointmentsLocation: Indiana University School of Medicine, Indianapolis, IndianaDiscipline: PharmacologyInclusive Dates: 1964-1966

MILITARY: None

ACADEMIC APPOINTMENTS:Department: PharmacologyIndiana University School of MedicineTitle: InstructorInclusive Dates (Month/Year): 1966-1967

Department: Biochemistry and Molecular BiologyRutgers, The State University of New Jersey, New Jersey Medical School

Revised: June, 2015Title: Assistant Professor (1967-1971), Associate Professor (1971-1978), Professor (1978 to the

present)

HOSPITAL APPOINTMENTS: (If applicable)NA

OTHER EMPLOYMENT OR MAJOR VISITNG APPOINTMENTS:

9/68-10/68 Visiting Scientist, Department of Pharmacology, University of Ottawa, Faculty of Medicine, Ottawa, Ontario

1973-1975 Visiting Associate Professor, Department of Cell Biology, Rockefeller University, New York, NY

4/84-7/84 Visiting Scientist, Department of Cell Biology, Roche Institute of Molecular Biology, Nutley, NJ

PRIVATE PRACTICE (If applicable): NA

LICENSURE: specialty/#/expiration: NA

DRUG LICENSURE: NA

CERTIFICATION: specialty/#/expiration: NA

MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES:1966-present Member, American Chemical Society1970-present Member, American Association for the Advancement of Science1970-present Member, American Association for Cancer Research1971-present Member, American Association of University Professors1975-present Member, American Society of Biological Chemists1981-present Member, The Advisory Board of the Ruth Estrin Goldberg

Memorial for Cancer Research1983-present Member, New Jersey Academy of Science1983-present Member, New York Academy of Science1985 Chaired the Chemistry and Biochemistry Session at the Annual

Meeting of the New Jersey Academy of Science1986 and 1987 Chaired the Biochemistry Session at the Annual Meeting of the

New Jersey Academy of Science1987-1989 Member, Executive Committee of the New Jersey Academy of

Science and Chairman of the Annual Science Program1988-1993 Member, Professional Education Committee of the New Jersey

Division of the American Cancer Society1990-1991 President, New Jersey Academy of Science1990-2000 Member, New Jersey Legislative Committee, American

Association for Cancer Research (Chairman, 1990-1997)1995-1996 Member, Program Committee, American Association for Cancer

Research2000-2010 Member, International Society for Nutrition and Cancer2008-2011 Member of the Executive Committee, Association of

Biochemistry Course Directors and Secretary from 2009 to 2011 2009-2013 Member, International Association of Medical Science Educators

HONORS AND AWARDS:1961-1964 Scholarship from the Medical Research Council of Great Britain1981 Teaching Award from the Foundation of CMDNJ1984 Biochemistry Teaching Award for New Jersey Medical School

Revised: June, 20151998, 1999, Golden Apple Award, New Jersey Medical School Student Council2004 Golden Apple Award. New Jersey Medical School Student Council2006 Excellence in Teaching Award from the Foundation of UMDNJ

BOARDS OF DIRECTORS/TRUSTEES POSITIONS:1990-1992 Member, Board of Trustees, New Jersey Inventors Congress and Hall of

Fame1997-1999 Member, Board of Governors, American Association of University

Professors, Newark Chapter

SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES:1979 Consultant, Tumor Biology Program, NIH1981 Ad Hoc Reviewer, The American Cancer Society1981-present Member, The Advisory Board of the Ruth Estrin Goldberg Memorial for

Cancer Research1986 Ad Hoc Reviewer, The Medical Research Council of Canada1993-2003 Member, Grant Review Panel, American Institute for Cancer Research2011 Reviewer of a grant application for the Dutch Cancer Society and of a grant

applicationfor the Skolkovo Foundation, Russia

SERVICE ON MAJOR COMMITTEES:A. International (Name, Inclusive Dates): NoneB, National (Name, Inclusive Dates): 1981-present Member, The Advisory Board of the Ruth Estrin Goldberg Memorial for

Cancer Research1993-2003 Member, Grant Review Panel, American Institute for Cancer Research1995-1996 Member, Program Committee, American Association for Cancer

Research2008-2011 Member of the Executive Committee, Association of Biochemistry

Course Directors and Secretary from 2009 to 2011

C. Medical School/University (Name, Inclusive Dates) 1968-1969 Laboratory Planning Committee1968-1969 Ad Hoc Committee to Integrate the Curriculum1970-1979 Cancer Committee1974-1975 Student Affairs Committee (Chairman, First Year Promotions

Committee)1975-1976 Faculty Affairs Committee1976-1977 Microbiology Chair Search Committee1976-1978 Interviewer for Medical School Admissions  Committee1976-1978 Graduate School Admissions Committee1977-1978 Research Committee1977-1978 Academic Programs and Policies Committee1977-1978,1980 Alternate Member, Faculty Committee for Appointments and

Promotions1978-present Smith Library Committee (Chairman from 1982-1991)1978-1988 Animal Care Committee1978-1982 Executive Council - Graduate School of Biomedical Sciences1980 Chairman, Research Subcommittee of the Self Study Task Force1982-1984 Faculty Committee for Appointments and Promotions1982-1986 Dean's Advisory Committee on Space, NJMS1983-1986 Director, Biomedical Science Course, GSBS1984 GSBS Self Study Committee1984-1991 University Faculty Committee on Libraries1985 Psychiatry Chair Search Committee1985-1987 ACS Institutional Research Grant Committee

Revised: June, 20151986-1989 Faculty Council1986-1988 Faculty Committee for Appointments and Promotions

(Chairman) 1987-1988 Vice President, Faculty Organization1988 University-wide Committee on Nomination of Honorary Degree

Candidates1988-2000 Oncology Committee1988-1989 President, Faculty Organization1988 Ad Hoc Committee for the Establishment of a Department of

Family Practice1989 Chairman, Institutional Self-Study Subcommittee for the Faculty1989-1991 Student Affairs Committee1990, 1991 Chairman, Faculty Organization Nominating Committee1990-1992 Faculty Committee on Appointments and Promotions1991-1995 Faculty Council1991-1993 Executive Council, Graduate School of Biomedical Sciences1993-1995 Faculty Affairs Committee (Chairman, 1993-1995)1993-1999 Cancer Education Committee1994 GSBS Ad Hoc Committee for Student Guidelines1994-2001 Preclinical Curriculum Committee1995 Faculty Promotion Appeals Committee1995-present Interviewer for Medical School Admissions Committee1996-1998 Faculty Council1996-1999 Faculty Committee on Appointments and Promotions1998-2000 Institutional Review Board2002-2004 Faculty Council2003-present Preclinical Curriculum Committee2003-2005 Curriculum, Academic Programs and Policies Committee (Vice Chair)2004 LCME Accreditation Education Committee2005 Member of the Inaugural Honorary Committee for President

John Petillo2005-2008 Curriculum, Academic Programs and Policies Committee (Chair)2005-2008 Institutional Planning and Development Committee2006-2010 Faculty Council2008-2010 Faculty Committee on Appointments and Promotions2010-2012 Faculty Affairs Committee2012- present Bylaws Committee (Chair)2013- present Faculty Council

D. Hospital (Name, Inclusive Dates): None

E. Department (Name, Inclusive Dates) 1979 Coordinator, Medical Biochemistry Course1980-1983 Seminar Coordinator1980-2012 Acting Chairman in the absence of the Chairman1980-1993 Member, Graduate Studies Committee1984 Coordinator, Dental Biochemistry Course1988-1996 Coordinator of use of departmental equipment1991-1993 Graduate Program Director1993-1994 Seminar Coordinator1994-2001 Director, Medical Biochemistry Course1999-2000 Faculty Search Committee2004 Member, MGM Course Curriculum Committees2006-2013 Director, MGM Course

E. Editorial Boards (Journal Name, Inclusive Dates)

Revised: June, 20151984-2000 Member: The Editorial Board of Cancer Biochemistry Biophysics2012-present Member: The Editorial Board of the Journal of Cancer Research

and Therapy

F. AdHoc Reviewer (Journal Name, Inclusive Dates) 1967-1996 Reviewer: Cancer Research1985, 1990 Reviewer: Analytical Biochemistry1985 External Examiner for D.Sc., University of Bristol, England1989 Reviewer: Biochemical Medicine and Metabolic Biology1992, 1995 Reviewer: Biotechniques1993 Reviewer: Chemico-Biological Interactions1993, 1996 Reviewer: Biochemical Pharmacology1994, 1998 Reviewer: Life Sciences1995, 1999 Reviewer: Oncology Research1999 Reviewer for a grant, Medical Research Council of Canada

2000 Reviewer: Molecular Medicine2002 Reviewer: Oncogene2003 Reviewer: Leukemia, Cancer Letters, Cancer Research, Cancer Detection and

Prevention, Clinical Cancer Research, Journal of Medicinal Chemistry, Raine Medical Research Foundation (Australia)

2004 Reviewer: Clinical Cancer Research, Carcinogenesis2005 Reviewer: Redox Reports, Cancer Letters, Expert Opinion on Investigational

Drugs, Molecular Cancer Therapeutics, Toxicology2006 Reviewer, Diabetes UK, Cellular and Molecular Biology Letters, Nutrition and

Cancer, Journal of Agricultural and Food Chemistry2007 Reviewer: Biochimica et Biophysica Acta2008 Reviewer: Cancer Detection and Prevention, Biologics: Targets and Therapy,

Cancer Biology and Therapy, PPAR Research, Molecular Nutrition and Food Research

2009 Reviewer: Journal of Biological Chemistry, Carcinogenesis, Cell Biology International, Pharmaceutical Research, Digestive Diseases and Sciences

2010 Reviewer: Molecular and Cellular Biochemistry, Nutrition Research, Cell Biochemistry and Function, DNA and Cell Biology, Critical Reviews in Biochemistry and Molecular Biology

2011 Reviewer: Anti-Cancer Drugs; Current Cancer Drug Targets; Cell Biology and Toxicology

2012 Reviewer: International Journal of Food Science and Nutrition; Pharmaceutical Biology; Journal of Cancer Research and Therapy

2013 Reviewer: Journal of Natural Products; Nutrition and Cancer; Journal of Medicinal Food; Tropical Medicine and Surgery; Cell Biochemistry and Function; Oncology Discovery; Medical Science Monitor; PLOS ONEReviewed a grant application for the National Science Center, Krakow, Poland

2014 Reviewer: Nutrition and Cancer; PLOS ONE; Seminars in Cancer Biology; Current Drug Targets

2015 Reviewer: Journal of Cellular Biochemistry, Current Drug Targets, Journal of Cellular Physiology, Anti-Cancer Drugs, Biochimica et Biophysica Acta

SERVICE ON GRADUATE SCHOOL COMMITTEES: Thesis Advisory Committees for the following students:

Ming Wu Chou Wasyl SydorVeena Dayal (Chairman) Thomas PolefkaTheresa Hoffman James KaysenWarren Miller Samuel VargheseMaria Rey (Chairman) Philip KeetingJohn Pezzuto (Co-Chair) Jane Cyran (Chairman)Frank Perrella (Chairman) Mohan Chellani (Chairman)

Revised: June, 2015Lauro Janocko David WadeMichael Koch (Chairman) Norbert SeidlerChristian Reboulleau Junyan HongNancy Fox George KatzenbergerDwight Lee Jennifer Hu (Chairman)Anthony Iacopino Charles KuckelMeera Ramananda Venkata NanduriDavid Parish Qin Xiao (Chairman)Mark Russo Xu FengBo Hang Clifford TepperChristopher Patten Amartya Basu (Chairman)Daphne Reddy William W. WangDeba Saha Youzhen WangRoman Wernyj Lynn AnglinCindy Arrigo Yan JiEdward Kwon Thelma ThompsonImran Hamid (Chairman) Daniel HooverEric Oh Adam KorayemCaroline Palavicino-Maggio Mehreen Qureshi (Chairman)Anastasios Fotinos Eman AbouhabibJasmine Huerta Julianne F. Avrutik

SERVICE ON HOSPITAL COMMITTEES: None

SERVICE TO THE COMMUNITY: 1972-1973 Assistant Treasurer, Edison Jaycees1973-1974 Treasurer, Edison Jaycees1988-1989 President, Faculty Organization of the New Jersey Medical School1989-1990 President Elect, New Jersey Academy of Science1990-1991 President, New Jersey Academy of Science1990-1992 Member, Board of Trustees, New Jersey Inventors Congress and

Hall of Fame1992-1997 Chairman, New Jersey Legislative Committee, American Association

for Cancer Research

SPONSORSHIP OF CANDIDATES FOR POSTGRADUATE DEGREE: NA

SPONSORSHIP OF POSTDOCTORAL FELLOWS: NA

TEACHING RESPONSIBILITIES: (Teaching effectiveness should be addressed in nominating letter)A. Lectures or Course Directorships

School, course name, lecture title, hours

New Jersey Medical SchoolBiochemistry Cordinator for Molecular and Genetic Medicine

New Jersey Dental SchoolInstructor in the Dental Biochemistry course

Graduate School of Biomedical ScienceCourse Director and instructor for the following courses:Molecular OncologyFundamentals of Biomedical Science A. Biochemistry and Molecular Biology

Instructor in the course

Revised: June, 2015Fundamentals of Biomedical Science B. Cell Biology

B. Research TrainingPost Doctoral Fellows: Fikry Khalil, Rosemary Barra, Theresa Campana, John Kallos and Qin XiaoPre Doctoral Students: Maria Rey, 1973, John Pezutto, 1977, Veena K. Dayal, 1978, Frank W. Perrella, 1979, Michael R. Koch, 1981, Jane Cyran, 1988, Mohan Chellani, 1989, Qin Xiao, 1990, Amartya Basu, 1994, Imran Hamid, 2009, Mehreen Qureshi, 2013

CLINICAL RESPONSIBILITIES: (Clinical effectiveness should be addressed in nominating letter): NA

GRANT SUPPORT: (Please list newest or most current first)A. Principal Investigator

Title: Cancer ResearchAgency: Alma Toorock Memorial for Cancer ResearchDate: 1990-2015Award: $76,000

Title: Influence of Chain Length and Unsaturation on the Induction of Histone Acetylation and Inhibition of Cell Growth by Phenyl Alkanoic and Alkenoic Acids

Agency: Circagen PharmaceuticalDate: 2001-2003Award: $25,000

Title: The Effect of CG1521 on the Induction of Hyperacetylation and Histone/Gene Expression Related Activities in Cancer Cell Lines.

Agency: Circagen PharmaceuticalDate: 2001Award: $16,500

Title: The Effect of Compounds upon the Induction of Hyperacetylation in Cancer Cells.

Agency: Beacon LaboratoriesDate: 2000Award: $25,000

Title: The Effect of Bl-1255 and 1552 upon the Induction of Hyperacetylation and Histone/Gene Expression Related Activities in Cancer Cell Lines.

Agency: Beacon LaboratoriesDate: 2000Award: $26,000

Title: Induction of Histone Acetylation by Diallyl SulfidesAgency: NJMS Dean’s Biomedical Research Support GrantDate: 1998-1999Award: $15,000

Title: Mechanism of Action of Butyrate and Analogs on CancerAgency: NIH (Biomedical Research Support Grant)Date: 1993-1994Award: $8,000

Title: Nucleotide Metabolism and Promotion of CarcinogenesisAgency: NIHDate: 1988-1992

Revised: June, 2015Award: $196,637

Title: Dietary Induction of Nucleotide Imbalance and Promotion of Carcinogenesis

Agency: American Institute for Cancer ResearchDate 1986-1987Award: $76,522

Title: Neoplasia and Metabolite Transport in LiverAgency: New Jersey Commission on Cancer ResearchDate: 1984-1986Award: $76,809

Title: Inhibition of Tumor Circulation and Metabolite UptakeAgency: NIHDate: 1984-1988Award: $107,518

Title: Nonhistone Chromosomal Proteins and Hepatoma GrowthAgency: NIHDate: 1974-1981Award: $182,513

Title: Histone Metabolism in Neoplastic TissuesAgency: NIHDate: 1972-1978Award: $170,057

Title: The Metabolic Basis of Hepatoma GrowthAgency: NIHDate: 1971-1972Award: $12,626

B. Co-Investigator

Title: Designing Foods for HealthAgency: U.S. Department of AgricultureDate: 2006-2007Sub-award $11,000

Title: Hepatic Proliferation Inhibitor(s): Isolation and CharacterizationAgency: Veterans AdministrationDate: 1986-1989Award: $157,900

C. Pending1. Funding Organziation, title, proposed funding date, proposed awardNone

Revised: June, 2015PUBLICATIONS: (Please list newest or most current first; published or accepted for publication only; should be segregated into the following categories)

A. Refereed Original Article in Journal

1. M. A. Lea and D. G. Walker. The metabolism of glucose 6-phosphate in developing mammalian tissues. Biochem. J. 91, 417-424 (1964).

2. M. A. Lea and D. G. Walker. Factors affecting hepatic glycolysis and some changes that occur during development. Biochem. J. 94, 655-665 (1965).

3. M. A. Lea, H. P. Morris and G. Weber. Comparative biochemistry of hepatomas. VI. Thymidine incorporation into DNA as a measure of hepatoma growth rate. Cancer Res. 26, 465-460 (1966).

4. G. Weber, R. L. Singhal, N. B. Stamm, M. A. Lea and E. A. Fisher. Synchronous behavior pattern of glycolytic enzymes: Glucokinase, phosphofructokinase and pyruvate kinase. Advan. Enzyme Regulation 4, 59-81 (1966).

5. G. Weber and M. A. Lea. The molecular correlation concept of neoplasia. Advan. Enzyme Regulation 4, 115-145 (1966).

6. G. Weber, M. A. Lea, E. A. Fisher and N. B. Stamm. Regulatory pattern of liver carbohydrate metabolizing enzymes: Insulin as inducer of key glycolytic enzymes. Enzymol. Biol. Clin. 7, 11-24 (1966).

7. G. Weber, H. J. H. Convery, M. A. Lea, and N. B. Stamm. Feedback inhibition of key glycolytic enzymes in liver: Action of free fatty acids. Science 154, 1357-1360 (1966).

8. M. A. Lea and D. G. Walker. Glycogenesis in the guinea pig liver during development. Development. Biol. 15, 51-61 (1967).

9. D. G. Walker, M. A. Lea, G. Rossiter and M. E. B. Addison. Glucose metabolism in the placenta. Archives. Biochem. Bio phys. 120, 646-653 (1967).

10. G. Weber, M. A. Lea, H. J. Convery and N. B. Stamm. Regulation of gluconeogenesis and glycolysis: Studies of mechanisms controlling enzyme activity. Advan. Enzyme Regulation 5, 257-298 (1967).

11. G. Weber, M. A. Lea, and N. B. Stamm. Inhibition of pyruvate kinase and glucokinase by acetyl CoA and inhibition of glucokinase by phosphoenolpyruvate. Life Science 6, 2441-2452 (1967).

12. M. A. Lea, H. P. Morris and G. Weber. DNA metabolism in liver and kidney tumors of different growth rates. Cancer Res. 28, 71-74 (1968).

13. M. A. Lea, and G. Weber. Role of enzymes in homeostasis. VIII. Inhibition of the activity of glycolytic enzymes by free fatty acids. J. Biol. Chem. 243, 1096-1192 (1968).

14. W. J. Malaisse, M. A. Lea, and F. Malaisse-Lagae. The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by Islets of Langerhans. Meta bolism 17, 126-132 (1968).

Revised: June, 201515. G. Weber, M. A. Lea and N. B. Stamm. Sequential feedback inhibition and regulation

of liver carbohydrate metabolism through control of enzyme activity. Advan. Enzyme Regulation 5, 101-123 (1968).

16. M. A. Lea, D. Sasovetz and H. P. Morris. Some factors affecting carbohydrate metabolism in hepatic tissues of different growth rates. Int. J. Cancer 4, 487-494 (1970).

17. M. A. Lea, R. L. Singhal and J. R. E. Valadares. Metabolic control mechanisms in mammalian systems. VI. Estrogen control in uterine lactate and -glycerophosphate production in ovariectomized rats. Biochem. Pharmacol. 19, 113-124 (1970).

18. M. A. Lea, D. Sasovetz, A. Musella and H. P. Morris. Effects of hydroxyurea and 6-mercaptopurine on growth and some aspects of carbohydrate metabolism in regenerating and neoplastic liver. Cancer Res. 30, 1994-1999 (1970).

19. M. A. Lea, P. Murphy and H. P. Morris. Glycogen metabolism in regenerating liver and liver neoplasms. Cancer Res. 32, 61-65 (1972).

20. M. A. Lea, S. Miller, I. Mackauf, E. Hirschberg and H. P. Morris. Action of Miracil D and related compounds on DNA and RNA synthesis in regenerating liver and hepatomas. Int. J. Cancer 9, 484-489 (1972).

21. M. A. Lea, F. L. Khalil, M. I. Rey and H. P. Morris. Effects of formamidoxime on macromolecular synthesis in regenerating liver and hepatomas. Chem. Biol. Interactions 6, 339-349 (1973).

22. M. A. Lea, F. L. Khalil and M. I. Rey. Action of Miracil D and related compounds on histone synthesis and phosphorylation in regenerating liver. Chem. Biol. Interactions 7, 367-374 (1973).

23. M. A. Lea, L. A. Youngworth and H. P. Morris. Acid soluble nuclear proteins of rat liver: Differential absorbance of bound dyes and changes in neoplasia. Biochem. Biophys. Res. Commun. 58, 862-867 (1974).

24. M. A. Lea, J. Bullock, F. L. Khalil and H. P. Morris. Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatoma and liver of the rat. Cancer Res. 34, 3414-3420 (1974).

25. M. A. Lea, M. R. Koch and H. P. Morris. Nuclear protein changes in rat hepatomas correlating with growth rate. Cancer Res. 35, 1693-1697 (1975).

26. M. A. Lea, M. R. Koch and H. P. Morris. Tumor selective inhibition of the incorporation of 3H-labeled amino acids into proteins by cyanate. Cancer Res. 35, 2321-2326 (1975).

27. B. Wilson, M. A. Lea, G. Vidali and V. G. Allfrey. Fractionation of nuclei and analysis of nuclear proteins of rat liver and Morris hepatoma 7777. Cancer Res. 35, 2954-2958 (1975).

28. M. A. Lea, M. R. Koch, V. G. Allfrey and H. P. Morris. Inhibition by cyanate of DNA synthesis in hepatomas. Cancer Biochem. Biophys 1, 129-133 (1975).

29. J. M. Pezzuto, M. A. Lea and C. S. Yang. Binding of metabolically activated benzo[a]pyrene to nuclear macromolecules. Cancer Res. 36, 3647-3653 (1976).

Revised: June, 201530. M. A. Lea, M. R. Koch and H. P. Morris. Decreased uptake of orotate in kidney

tumors. Cancer Biochem. Biophys. 1, 265-268 (1976).

31. M. A. Lea, G. Weber and H. P. Morris. Inhibition of glycolytic enzymes of rat liver and hepatomas by free fatty acids. Oncology 33, 205-208 (1976).

32. R. Barra, B. Beres, M. R. Koch and M. A. Lea. Action of exogenous histones and other proteins on 3H-thymidine incorporation into DNA of Novikoff hepatoma cells. Cytobios. 17, 123-136 (1976).

33. M. A. Lea, M. R. Koch, B. Beres and V. Dayal. Divergent effects of cyanate on amino acid and phosphate uptake by liver and hepatoma. Biochim. Biophys. Acta 474, 321-328 (1977).

34. M. A. Lea, R. Barra, M. R. Koch, H. Hicks and C. Daly. Inhibition of macromolecular synthesis in tumors by L-1-tosylamido-2-phenylethyl chloromethyl ketone. Biochem. Biophys. Res. Commun. 75, 519-524 (1977).

35. M. A. Lea, and M. R. Koch. Decreased incorporation of phosphate and amino acids into low-solubility, nuclear proteins in rapidly growing hepatomas. Int. J. Biochem. 8, 565-572 (1977).

36. J. M. Pezzuto, M. A. Lea and C. S. Yang. The role of microsomes and nuclear envelope in the metabolic activation of benzo[a]pyrene leading to binding with nuclear macromolecules. Cancer Res. 37, 3427-3444 (1977).

37. J. M. Pezzuto, M. A. Lea and C. S. Yang. Binding of metabolically activated benzo[a]pyrene to DNA and histones of rat liver, lung and regenerating liver. Life Sciences 22, 105-110 (1978).

38. F. W. Perrella and M. A. Lea. Polyamine induced changes in the ADP-ribosylation of nuclear proteins from rat liver. Biochem. Biophys. Res. Commun. 82, 575-581 (1978).

39. R. Barra, H. Hicks, M. R. Koch and M. A. Lea. Stimulatory effect of dimethylsulfoxide on 3H-thymidine incorporation into DNA in Novikoff hepatoma cells. Int. J. Biochem. 9, 389-394 (1978).

40. J. Kallos and M. A. Lea. Nuclear binding of cyclic AMP receptor. Int. J. Biochem. 9, 767-773 (1978).

41. M. A. Lea and M. R. Koch. Selective effects of two chloromethyl ketones on amino acid and phosphate uptake in rat live and tumors. J. Natl. Cancer Inst. 62, 181-185 (1979).

42. F. W. Perella and M. A. Lea. Spermine induced variation in the ADP-ribosylation patterns of nuclear proteins from rat liver and hepatoma. Cancer Res. 39, 1382-1389 (1979).

43. R. Barra, J. Parsons, M. R. Koch and M. A. Lea. Soluble factors from liver and hepatomas which inhibit [3H]thymidine incorporation into DNA of Novikoff hepatoma cells. Cancer Res. 39, 1655-1660 (1979).

44. V. K. Dayal, A. Saha and M. A. Lea. Partial characterization of non-histone nuclear proteins which are decreased in hepatomas of the rat. Int. J. Biochem. 10, 759-767 (1979).

Revised: June, 201545. M. A. Lea and M. R. Koch. Effects of cyanate, thiocyanate and amygdalin on

metabolite uptake in normal and neoplastic tissues. J. Natl. Cancer Inst. 63, 1279-1283 (1979).

46. M. R. Koch, F. L. Khalil and M. A. Lea. Decreased uptake of 14C-labeled dicarboxylic amino acids in rapidly growing hepatomas. Cancer Res. 40, 4053-4058 (1980).

47. F. L. Khalil and M. A. Lea. X-Irradiation and the incorporation of precursors for salvage and de novo synthesis of DNA in hepatomas and liver. Neoplasma 28, 171-177 (1981).

48. M. R. Koch and M. A. Lea. Uptake of 14C-labeled dicarboxylic amino acids in hepatocytes and hepatoma cells. Cancer Res. 41, 3065-3070 (1981).

49. M. A. Lea and J. Parsons. Effects of cyanate on the distribution of isotope labeled H20 and extracellular markers in rat liver and tumors. Cancer Res. 41, 4988-4992 (1981).

50. R. Barra, G. R. Collin, J. Parsons and M. A. Lea. Differences in cytosol factors in liver and hepatomas revealed by real or apparent effects on the incorporation of [3H]thymidine. Int. J. Biochem. 13, 1233-1240 (1981).

51. M. A. Lea. Colchicine affects the distribution of isotope-labeled H20 and extracellular markers in rat liver and hepatomas. Cancer Letters 14, 317-321 (1981).

52. R. Barra, V. Randolph, M. Sumas, K. W. Lanighan and M. A. Lea. Effects of nicotinamide, isonicotinamide and bleomycin on DNA synthesis and repair in hepatocytes and hepatoma cells. J. Natl. Cancer Inst. 69, 1352-1357 (1982).

53. M. A. Lea. Increased fraction of acid-soluble proteins in 0.35 M NaCl extracts of nuclei from rat liver tumors. Int. J. Biochem. 15, 513-522, (1983).

54. M. A. Lea. Nuclear proteins of tumors. Int. J. Biochem. 15, 767-770 (1983).

55. M. A. Lea. Decreased sensitivity to colchicine-mediated inhibition of metabolite uptake in isolated hepatoma cells. J. Natl. Cancer Inst. 71, 1073-1076 (1983).

56. M. A. Lea, M. E. Sumas and V. Randolph. DNA in cytosol fractions obtained by differential centrifugation of homogenates of rapidly growing liver tumors. Exp. Mol. Pathol. 40, 195-205 (1984).

57. M. A. Lea, R. Barra, V. Randolph and W. G. Kuhr. Effects of nicotinamide and structural analogs on DNA synthesis and cellular replication of rat hepatoma cells. Cancer Biochem. Biophys. 7, 195-202 (1984).

58. M. A. Lea, S. V. Grasso, J. Hu and N. Seidler. Factors affecting the assay of histone H1 and polylysine by binding of Coomassie blue G. Anal. Biochem. 141, 390-396 (1984).

59. V. K. Dayal, Y. S. Arkel and M. A. Lea. Study of a basic protein in AIDS plasma and normal human semen. Annal. N. Y. Acad. Sci. 435, 405-407 (1984).

60. M. A. Lea and S. V. Grasso. Anomalous behavior of H1 histone and polylysine in the Bradford assay for protein. Annal. N. Y. Acad. Sci. 435, 170-172 (1984).

61. M. A. Lea, J. J. Hu and S. V. Grasso. Disparity in the effects of two N-methyl nicotinamides on poly (ADP-ribose) synthetase and macromolecular synthesis in hepatomas. Cancer Biochem. Biophys. 8, 1-7 (1985).

Revised: June, 2015

62. M. A. Lea, A. Luke, C. Martinson and O. Velazquez. Influence of carbamoylation on some analytical properties of basic polypeptides. Int. J. Peptide Protein Res. 27, 251-260 (1986).

63. M. A. Lea, A. Luke, O. Velazquez, L. Carpenter, C. F. Martinson, H. Z. Hill and G. J. Hill Effects of sodium cyanate in mice bearing B16 melanoma. Cancer Chemother. Pharmacol. 17, 231-235 (1986).

64. V. K. Dayal, M. A. Lea and Y. S. Arkel. Plasma protein alterations in AIDS and hemophilia. AIDS Res. 2, 309-319 (1986).

65. M. A. Lea, A. Luke, C. Martinson and O. Velazquez. Effect of cyanate on assay of proteins by the Bradford procedure. Annal. N. Y. Acad. Sci. 463, 109-111 (1986).

66. M. A. Lea, V. Oliphant and A. Luke. Orotate uptake and metabolism in normal and neoplastic tissues. Comp. Biochem. Physiol. 86B, 581-586 (1987).

67. M. A. Lea and A. Luke. Effects of carbamoylation with alkyl isocyanates on the assay of proteins by dye binding. Int. J. Peptide Protein Res. 29, 561-567 (1987).

68. M. A. Lea, A. Luke and V. Oliphant. Orotate uptake in normal and neoplastic tissues. Annal. N. Y. Acad. Sci. 494, 342-344 (1987).

69. M. A. Lea. Effects of carbamoylating agents on tumor metabolism. CRC Crit. Rev. Oncol. Hematol. 7, 329-371 (1987).

70. M. A. Lea. Relationship of H1o histone to differentiation and cancer. Cancer Biochem. Biophys. 9, 199-209 (1987).

71. M. A. Lea, A. Luke, J. J. Hu and O. Velazquez. Action of carbamoylating agents on the uptake of metabolites in hepatomas and liver. Biochem. Pharmacol. 36, 2775-2781 (1987).

72. R. I. Shah and M. A. Lea. Chromatin solubilization in rapidly growing hepatomas. Exp. Mol. Pathol. 47, 403-410 (1987).

73. M. A. Lea, A. Luke and V. Oliphant. Selective modulation of nucleotide levels in rat liver and hepatomas by high-orotate or arginine-deficient diets and by carbamoylating agents. Biochim. Biophys. Acta 964, 121-128 (1988).

74. J. J. Hu, A. Luke, M. Chellani, K. A. Zirvi and M. A. Lea. pH-related effects of sodium cyanate on macromolecular synthesis and tumor cell division. Biochem. Pharmacol. 37, 2259-2266 (1988).

75. M. A. Lea, V. Oliphant, A. Luke, J. V. Tesoriero and K. M. Klein. Orotate metabolism and nucleotide levels in normal and neoplastic liver. Annal. N. Y. Acad. Sci. 529, 75-77 (1988).

76. J. Cyran, M. A. Lea and T. W. Lysz. Prostaglandin biosynthetic capacity of hepatomas with different growth rates. Int. J. Biochem. 21, 445-451 (1989).

77. J. Hu, M. J. Dimaira, K. A. Zirvi, G. Dikdan and M. A. Lea. Influence of pH on the modification of thiols by carbamoylating agents and effects on glutathione levels in normal and neoplastic cells. Cancer Chemother. Pharmacol. 24, 95-101 (1989).

Revised: June, 201578. J. J. Hu, K. A. Zirvi and M. A. Lea. Interrelationship between sodium cyanate and pH

in the regulation of tumor cell division. Cancer Biochem. Biophys. 10, 269-274 (1989).

79. M. A. Lea. Review of the debate on whether "New Jersey causes cancer". Bull. N. J. Acad. Sci. 34, 37-44 (1989).

80. T. S. Chen, J. Ottenweller, A. Luke, S. Santos, P. Keeting, R. Cuy and M. A. Lea. Fraction from human and rat liver which is inhibitory for proliferation of liver cells. Cytobios 59, 79-86 (1989).

81. M. Chellani and M. A. Lea. Levels of oncogene transcripts in hepatomas of different growth rates and in liver in response to diets which cause a nucleotide imbalance. Cancer Biochem. Biophys. 11, 127-133 (1990).

82. J. Cyran, T. W. Lysz and M. A. Lea. Influence of inhibitors of eicosanoid metabolism on proliferation of rat hepatoma cells and on tumor-host interaction. Prostaglandins Leuko trienes Essen. Fatty Acids 39, 311-317 (1990).

83. M. A. Lea, A. Luke, A. Assad and S. Ayyala. Inhibitory effects of orotate on precursor incorporation into nucleic acids. Chem. Biol. Interactions 75, 49-59 (1990).

84. J. J. Hu, K. A. Zirvi and M. A. Lea. Combined effect of pH and sodium cyanate on the inhibition of tumor cell proliferation and metabolism by CBNU and hyperthermia. Cancer Chemother. Pharmacol. 26, 269-272 (1990).

85. Q. Xiao, A. Luke and M. A. Lea. dUTP pyrophosphatase and uracil-DNA glycosylase in rat liver and hepatomas. Int. J. Biochem., 24, 437-445 (1992).

86. M. A. Lea, A. Luke, A. Assad, M. Patel and P. A. Reddy. Inhibitory action of orotate, 2-thioorotate and isoorotate on nucleotide metabolism and nucleic acid synthesis in hepatoma cells. Int. J. Biochem. 24, 1453-1459 (1992).

87. M. A. Lea Action of exogenous differentiating agents on gene expression in cancer cells. Crit. Rev. Oncol/Hematol. 13, 189-214 (1992).

88. M. A. Lea, Q. Xiao, A. Sadhukhan, S. Cottle, Z. Y. Wang and C. W. Yang. Inhibitory effects of tea extracts and (-)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells. Cancer Lett. 68, 231-236 (1993).

89. M. A. Lea. Regulation of gene expression in hepatomas. Int. J. Biochem. 25, 457-469 (1993).

90. M. A. Lea, Q. Xiao, A. Sadhukhan, S. Sharma and H. L. Newmark. Butyramide and monobutyrin: Growth inhibitory and differentiating agents. Anticancer Res. 13, 145-150 (1993).

91. M. A. Lea, Q. Xiao, K. M. Klein and E. Grote-Holman. Inhibitory effect of arginine restriction on hepatoma growth. Cancer Biochem. Biophys. 13, 171-179 (1993).

92. Q. Xiao, I. Jaspers, E. Matthew and M. A. Lea. Changes in the glucose-6-phosphatase complex in hepatomas. Mol. Cell Biochem. 122, 17-24 (1993).

93. M. A. Lea and N. Tulsyan. Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase. Anticancer Res. 15, 879-884 (1995)..

Revised: June, 2015

94. C. desBordes and M. A. Lea. Effects of C18 fatty acid isomers on DNA synthesis in hepatoma and breast cancer cells. Anticancer Res. 15, 2017-2911 (1995).

95. G. Xu, G. Salen, M. Lea, G. S. Tint, L. B. Nguyen, A. Batta, T. S. Chen and S. Shefer. Blocking late cholesterol biosynthesis inhibits the growth of transplanted Morris hepatomas (7288CTC) in rats. Hepatology, 24, 440-445 (1996).

96. M. A. Lea and U. S. Ayyala. Differentiating and growth inhibitory effects of diallyl disulfide on cancer cells. Int. J. Oncol. 11, 181-186 (1997).

97. J. J. Hu, J.-Y. Hong, M. A. Lea and C. S. Yang. Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats. Int. J. Oncol. 12, 1049-1053 (1998).

98. M. A. Lea and V. M. Randolph. Induction of reporter gene expression by inhibitors of histone deacetylase. Anticancer Res. 18,2717-2722 (1998).

99. M.A. Lea, V.M. Randolph and S.K. Hodge. Induction of histone acetylation and growth regulation in erythroleukemia cells by 4-phenylbytyrate and structural analogs. Anticancer Res., 19: 1971-1976 (1999).

100. M.A. Lea, V.M. Randolph and M. Patel. Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. Int. J. Oncol., 15: 347-352 (1999).

101. M.A. Lea, V.M. Randolph, J.E. Lee and C. desBordes. Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. Int. J. Cancer 92, 784-789 (2001).

102. M.A.Lea and V.M. Randolph. Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide. Anticancer Res., 21, 2841-2846 (2001).

103. K.O. Clarke, S. Ludeman, J.B. Springer, O.M. Colvin, M.A. Lea and L.E. Harrison. Exposure to a deuterated analogue of phenylbutyrate retards S phase progression in HT-29 colon cancer cells. J. Pharm. Sci., 91, 1054-1064 (2002).

104. M.A. Lea, M. Rasheed, V.M. Randolph, F. Khan, A. Shareef and C. desBordes. Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine. Nutrition and Cancer, 43, 90-102, 2002.

105. M.A. Lea, A. Shareef, M. Sura and C.desBordes. Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules. Cancer Chemother. Pharmacol., 54, 57-63, 2004.

106. M.A. Lea, M. Sura and C.desBordes. Inhibition of cell proliferation by potential peroxisome proliferator-activated receptor (PPAR) gamma agonists and antagonists. Anticancer Res., 24: 2765-2771 (2004).

107. M.A. Lea, C. Ibeh, N. Shah and M.P. Moyer. Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. Anticancer Res., 27, 741-748, 2007.

108. M.A.Lea, C. Ibeh, C. desBordes, M. Vizzotto, L. Cisneros-Zevallos, D.H. Byrne, W.R. Okie and M.P. Moyer. Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. Anticancer Res., 28, 2067-2076, 2008.

Revised: June, 2015109. M.A. Lea, C. Ibeh, L.Han and C. desBordes. Inhibition of growth and induction of

differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res., 30, 311-318, 2010.

110. M.A. Lea. Recent and potential targets for treating colon cancer. Future Oncol., 6, 993-1002, 2010.

111. M.A. Lea, C. Ibeh, J.K. Deutsch, I. Hamid and C. desBordes. Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides. Anticancer Res., 30: 3629-3636, 2010.

112. M.A. Lea, J. Chacko, S. Bolikal, J.Y. Hong, R. Chung, A. Ortega and C. desBordes. Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin, Anticancer Res., 31: 421-426, 2011.

113. M.A. Lea, M.S. Qureshi, M. Buxhoeveden, N. Gengel, J. Kleinschmit and C. desBordes. Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides. Anticancer Res., 33, 401-407, 2013.

114. M.A, Lea, J. Pourat, R. Patel and C. desBordes. Inhibition of growth of colon cancer cells by compounds affecting AMPK activity. World J. Gastrointest. Oncol., 6, 244-252, 2014.

115 M.A. Lea. Flavonol Regulation of tumor cells, J. Cellular Biochem., 116, 1190-1194, 2015.

B. Books, Monographs and Chapters

1. G. Weber and M. A. Lea. The molecular correlation concept: An experimental and conceptual method in cancer research. In: Methods in Cancer Research (ed. by H. Busch) pp. 523-578, Academic Press, New York (1967).

2. G. Weber, C. R. Morgan, P. H. Wright, J. Ashmore, M. A. Lea and H. J. H. Convery. Insulin and glucocorticoids: Hepatic mechanism of action at the enzyme level. In: Progress in Endocrinology (C. Gual and F. J. G. Ebling, eds.), pp. 52-60, Excerpta Medica Foundation, Amsterdam (1969).

3. M. A. Lea. Regulation of macromolecular synthesis in Morris hepatomas. In: Morris Hepatomas: Mechanisms of Regula tion (H. P. Morris and W. E. Criss, eds.), pp. 289-305, Plenum, New York (1978).

4. F. W. Perrella and M. A. Lea. Adenosine 5'-diphosphate ribosylation of nuclear proteins from rat liver and hepatomas: Effects of polyamines and implication in DNA repair. In: Novel ADP - Ribosylations of Regulatory Enzymes and Proteins (M. E. Smulson and T. Sugimura, eds.), pp. 99-108, Elsevier North Holland, New York (1980).

5. M. A. Lea. Organosulfur compounds and cancer. In: Dietary Phytochemicals in Cancer Prevention and Treatment, American Institute for Cancer Research (ed.) New York, Plenum Press, pp. 147-154 (1996).

6. M.A. Lea. Fruit phenolics in colon cancer prevention and treatment. In: Bioactive Foods and Extracts: Cancer Treatment and Prevention. R.R. Watson and V.R. Preedy (eds.) Boca Raton, FL, CRC Press, p. 415-426 (2011).

Revised: June, 20157. B. Dayal, V.R. Yannamreddy, A.P. Singh, M. Lea and N.H. Ertel. Bioactive compounds from okra seeds:

potential inhibitors of advanced glycation end products. In: Emerging Trends in Dietary Components for Preventing and Combating Disease. ACS Symposium Series Vol. 1093, Chapter 16, pp. 287-302, 2012.

8. M.A, Lea. Compounds in vegetables including okra and fenugreek of potential value in the treatment of diabetes. In: Bioactive Food as Dietary Interventions for Diabetes, R.R. Watson and V.R. Preedy (eds.) San Diego: Academic Press, pp. 291-306 (2013).

9. B. Dayal, V.R. Yannamreddy, R. Amin, M.A. Lea and A.B. Attygalle. Bioactive compounds in Moringa oleifera: isolation, structure elucidation, and their antiproliferative properties. In:Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits, ACS Symposium Series Vol. 1129, Chapter 13, pp 203–219 (2013).

10. B. Dayal, V.R. Yannamreddy, C. Ragunath, N. Ramasubbu, T. Roy, R. Amin, S.W. Nirujogi and M.A. Lea. Breaking up of biofilms with Moringa oleifera: insight into mechanisms. In: Advances in Applied Nanotechnology for Agriculture. B. Park and M. Appell (eds.), ACS Symposium Series Vol. 1143. Chapter 10, pp. 177-191 (2013).

C. Patents Held: NA

D. Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other Professional CommunicationsNA

E. Abstracts

1. M. A. Lea and D. G. Walker. Changes in glucose 6-phosphate metabolism during development. Biochem. J. 85, 30P (1962).

2. D. G. Walker and M. A. Lea. Carbohydrate metabolism in foetal and neonatal liver. Abstr. Proc. 6th Int. Congr. Biochem., New York, 475 (1964).

3. M. A. Lea and D. G. Walker. Hepatic glycolysis during development. Biochem. J. 91, 25P (1964).

4. G. Weber, M. A. Lea, R. L. Singhal, N. B. Stamm and E. A. Fisher. Coordinated biosynthetic pattern in liver: Synchronous pattern of key glycolytic enzymes. Fed. Proc. 25, 378 (1966).

5. M. A. Lea and G. Weber. Inhibition of glycolytic enzymes of normal and neoplastic liver by free fatty acids. Biochem. J. 104, 37P (1967).

6. M. A. Lea, H. J. H. Convery, N. B. Stamm, H. P. Morris and G. Weber. Carbohydrate metabolism and DNA synthesis in kidney tumors. Proc. Am. Assoc. Cancer Res. 8, 39 (1967).

7. M. A. Lea, H. J. H. Convery, N. B. Stamm and G. Weber. Inhibition of lactate production and glycolytic enzymes by the free fatty acids, laurate, myristate and octanoate. Fed. Proc. 26, 564 (1967).

8. M. A. Lea and H. P. Morris. Rate-limiting factors in glycolysis of regenerating and neoplastic liver. Proc. Am. Assoc. Cancer Res. 10, 48 (1969).

9. M. A. Lea, R. L. Singhal and J. R. E. Valadares. Regulation of lactate and -glycerophosphate production in rat uterus. Fed. Proc. 28, 707 (1969).

Revised: June, 201510. M. A. Lea, I. Mackauf, E. Hirschberg and H. P. Morris. Action of Miracil D on nucleic

acid synthesis in regenerating and neoplastic liver. Proc. Am. Assoc. Cancer Res. 12, 10 (1971).

11. M. A. Lea, F. L. Khalil, M. I. Rey, S. Miller and H. P. Morris. Effects of formamidoxime on nucleic acid and protein synthesis in regenerating liver and hepatomas. Proc. Am. Assoc. Cancer Res. 13, 15 (1972).

12. M. A. Lea, F. L. Khalil and M. I. Rey. Inhibition of histone synthesis and phosphorylation of lysine-rich histones in regenerating liver by Miracil D and hycanthone. Fed. Proc. 32, 588 (1973).

13. M. A. Lea, F. L. Khalil and H. P. Morris. Incorporation of macromolecular precursors into hepatomas. Proc. Am. Assoc. Cancer Res. 14, 11 (1973).

14. M. A. Lea, L. A. Youngworth and H. P. Morris. Isoelectric focusing of nonhistone nuclear proteins of Morris hepatomas and normal rat liver. Proc. Am. Assoc. Cancer Res. 15, 24 (1974).

15. M. A. Lea, B. Wilson and V. G. Allfrey. Influence of neoplasia on nuclear populations and their protein composition. Proc. Am. Assoc. Cancer Res. 16, 53 (1975).

16. M. A. Lea and H. P. Morris. Changes in nuclear proteins correlating with the growth rate of hepatomas. Fed. Proc. 34, 702 (1975).

17. R. Barra, B. Beres, M. R. Koch and M. A. Lea. Action of exogenous proteins on DNA synthesis in Novikoff hepatoma cells. Fed. Proc. 35, 1488 (1976).

18. J. M. Pezzuto, M. A. Lea and C. S. Yang. Binding of 3H-benzo[a]pyrene metabolites to nuclear constituents of rat lung and liver. Proc. Am. Assoc. Cancer Res. 17, 97 (1976).

19. M. A. Lea and M. R. Koch. Decreased incorporation of amino acids and phosphate into low-insolubility nuclear proteins of rapidly growing Morris hepatomas. Fed. Proc. 36, 648 (1977).

20. J. M. Pezzuto, M. A. Lea and C. S. Yang. Role of microsomes and nuclear envelope in benzo[a]pyrene activation and binding. Proc. Am. Assoc. Cancer Res. 18, 214 (1977).

21. V. Dayal, A. Saha and M. A. Lea. Differences in nonhistone nuclear proteins of Morris hepatomas and rat liver. Fed. Proc. 37, 1787 (1978).

22. R. Barra, H. Hicks, M. R. Koch and M. A. Lea. Biphasic effect of dimethylsulfoxide on [3H]thymidine incorporation into Novikoff hepatoma cells. Proc. Am. Assoc. Cancer Res. 19, 27 (1978).

23. J. Bullock, M. A. Lea, J. A. Ianzano and O. Mandrusiak. Effect of host age on DNA and cholesterol synthesis in rat liver and Morris hepatoma 9618A2. Age 1, 34 (1978).

24. M. A. Lea and J. Parsons. Alterations in acid soluble nuclear proteins in hepatomas. Fed. Proc. 38, 491 (1979).

25. F. L. Khalil, J. Parsons and M. A. Lea. Anomalous results with [14C]aspartate as a precursor for DNA synthesis in rat liver hepatomas. Proc. Am. Assoc. Cancer Res. 20, 135 (1979).

Revised: June, 201526. M. R. Koch and M. A. Lea. Decreased uptake of dicarboxylic amino acids in rapidly

growing hepatomas. Fed. Proc. 39, 1903 (1980).

27. M. A. Lea and J. Parsons. Cyanate affects the distribution of [3H]H2O in normal and neoplastic tissues. Proc. Am. Assoc. Cancer Res. 21, 260 (1980).

28. R. Barra, J. Parsons and M. A. Lea. A rat liver cytosol fraction which inhibits DNA synthesis and stimulates protein synthesis in hepatocytes and hepatoma cells. J. Cell Biol. 87, 2a (1980).

29. M. A. Lea. Evidence that sodium cyanate inhibits circulation in rat hepatomas. Proc. Am. Assoc. Cancer Res. 22, 253 (1981).

30. M. R. Koch and M. A. Lea. Dicarboxylic amino acid uptake in hepatocytes and hepatoma cells. Fed. Proc. 40, 1894 (1981).

31. R. Barra, V. Randolph, M. Sumas, K. W. Lanighan and M. A. Lea. Effects of bleomycin, nicotinamide and isonicotinamide on DNA replication and repair in hepatoma cells and hepatocytes. J. Cell Biol. 91, 131a (1981).

32. M. A. Lea. Increase in hepatomas of nuclear proteins extracted with 0.35 M NaCl and soluble in 2% trichloroacetic acid. Fed. Proc. 41, 1464 (1982).

33. R. Barra, V. Randolph, W. G. Kuhr and M. A. Lea. Effects of nicotinamide and 3-aminobenzamide on rat hepatoma cells previously exposed to methylmethanesulfonate. J. Cell Biol. 95, 67a (1982).

34. V. Dayal, M. A. Lea, G. Obiedzinski and Y. Arkel. Similar change in a plasma protein of AIDS and Hemo A patients. Biochemistry 22, 31A-32A (1983).

35. M. E. Sumas and M. A. Lea. DNA in cytosol fractions of rapidly growing hepatomas. Bull. N. J. Acad. Sci. 28, 15 (1983).

36. M. A. Lea and J. Hu. Factors affecting the assay of histone H1 and polylysine by the Bradford procedure. Bull. N. J. Acad. Sci. 29, 30 (1984).

37. M. A. Lea and S. V. Grasso. Nicotinamide analogs and DNA synthesis in hepatomas. Proc. Am. Assoc. Cancer Res. 25, 19 (1984).

38. M. A. Lea and J. Hu. Disparity in the effects of N-methyl nicotinamides on ADP-ribosyl transferase and macromolecular synthesis in hepatomas. Seventh Int. Symp. on ADP-ribosylation Reactions. Program, p. 70 (1984).

39. M. A. Lea and A. Luke. Chemical and pharmacological properties of ethyl isocyanate. Fed. Proc. 44, 1140 (1985).

40. M. A. Lea, A. Luke, O. Velazquez, L. Carpenter, C. F. Martinson, H. Z. Hill and G. J. Hill. Action of cyanate on B16 melanoma. Proc. Am. Assoc. Cancer Res. 26, 321 (1985).

41. M. A. Lea, A. Luke, M. Chellani, R. Shah and V. Oliphant. Expression of myc gene in hepatomas and liver. Proc. 13th Int. Congress Biochem., p. 366 (1985).

42. J. Hu, A. Luke, O. Velazquez, C. F. Martinson, J. S. H. Yoo, C. S. Yang and M. A. Lea. Action of carbamoylating agents on tumors. Fed. Proc. 45, 447 (1986).

Revised: June, 201543. M. A. Lea, V. Oliphant, A. Luke and J. V. Tesoriero. Uptake and metabolism of

orotate in normal and neoplastic tissues. Proc. Am. Assoc. Cancer Res. 27, 18 (1986).

44. R. Shah and M. A. Lea. Decreased potential for endonuclease activity in hepatoma nuclei. Fed. Proc. 45, 1591 (1986).

45. J. Cyran, M. A. Lea and T. W. Lysz. Production of additional metabolites of arachidonic acid by rapidly growing hepatomas. Fed. Proc. 45, 1813 (1986).

46. J. J. Hu, A. Luke and M. A. Lea. Effect of pH on the inhibition of macromolecular synthesis in hepatomas by cyanate. J. Cell Biol. 103, 29a (1986).

47. J. J. Hu, A. Luke, V. Oliphant, M. Chellani, K. Zirvi and M. A. Lea. pH-related effects of carbamoylating agents on tumor metabolism. Proc. Am. Assoc. Cancer Res. 28, 416 (1987).

48. G. J. Katzenberger, M. A. Lea and S. Kumar. Plasminogen activator activity of rat hepatomas. Fed. Proc. 46, 1963 (1987).

49. J. Cyran, T. W. Lysz and M. A. Lea. Prostaglandin synthesis by hepatoma cells. Fed. Proc. 46, 1944 (1987).

50. M. A. Lea, A. Luke and V. Oliphant. Nucleotide levels in rats on diets containing 1% orotate or deficient in arginine. Fed. Proc. 46, 585 (1987).

51. J. J. Hu, M. J. Dimaira, K. A. Zirvi and M. A. Lea. Inhibitory effects of sodium cyanate on tumors may be related to modification of sulfhydryl groups. Proc. Am. Assoc. Cancer Res. 29, 472 (1988).

52. G. J. Katzenberger, M. A. Lea and S. Kumar. mRNA levels of plasminogen activators of rat hepatomas. FASEB J. 2, A388 (1988).

53. M. A. Lea, A. Luke and K. Klein. Carcinogenesis and nucleotide metabolism in mice treated with N-nitrosodimethylamine and fed a high-orotate or arginine-deficient diet. FASEB J. 2, A1413 (1988).

54. A. Assad, A. Luke and M. A. Lea. Pharmacological activity of 2-thioorotic acid. Bull. N. J. Acad. Sci. 33, 31 (1988).

55. M. A. Lea. Review of the debate on whether "New Jersey Causes Cancer". Bull. N. J. Acad. Sci. 33, 37 (1988).

56. M. A. Lea, J. Ottenweller, A. Luke, S. Santos, P. Keeting, R. Cuy and T. Chen. Growth inhibitory fractions from human and rat liver. J. Cell Biol. 107, 502a (1988).

57. T. S. Chen, J. E. Ottenweller, M. A. Lea and S. Santos. Effects of bombesin, gastrin, and hydrocortisone on DNA synthesis in fetal chick hepatocytes. Hepatology 8, 1305 (1988).

58. Q. Xiao and M. A. Lea. Uracil DNA glycosylase activity in normal and neoplastic tissues. Bull. N. J. Acad. Sci. 34, 47 (1989).

59. J. J. Hu, M. A. Lea and C. S. Yang. Effect of phenethyl isothiocyanate on normal and neoplastic tissue metabolism. Proc. Am. Assoc. Cancer Res. 30, 175 (1989).

Revised: June, 201560. M. Chellani and M. A. Lea. Oncogene expression in hepatomas and in livers of rats

on diets which cause an imbalance in pyrimidine and purine nucleotides. Proc. Am. Assoc. Cancer Res. 30, 20 (1989).

61. M. A. Lea and A. Luke. Action of orotate on DNA synthesis and nucleotide levels in normal and transformed cells. Proc. Am. Assoc. Cancer Res. 31, 11 (1990).

62. J. J. Hu, J.-Y. Hong, M. A. Lea and C. S. Yang. Cytochrome P450IIE1 in rat Morris hepatomas. Proc. Am. Assoc. Cancer Res. 31, 129 (1990).

63. Q. Xiao, A. Luke and M. A. Lea. Enzymes related to uracil incorporation into DNA in hepatocarcinogenesis. FASEB J. 4, A1171 (1990).

64. M. A. Lea, A. Luke and A. Assad. Effects of 2-thioorotate on nucleotide metabolism in rat liver and hepatoma cells. FASEB J. 4, A1987 (1990).

65. M. A. Lea and A. Luke. Orotate alters nucleotide ratios in several types of cultured cells. Bull. N. J. Acad. Sci. 35, 32 (1990).

66. M. A. Lea, P. A. Reddy, Q. Xiao and K. M. Klein. Arginine-deficient diet and liver cancer. Proc. Am. Assoc. Cancer Res. 32, 144 (1991).

67. Q. Xiao, I. Jaspers, E. Matthew and M. A. Lea. Glucose-6-phosphatase and mannose-6-phosphatase activities of rat liver and hepatomas. J. Cell Biol. 115, 59a (1991).

68. M. A. Lea, Q. Xiao, A. K. Sadhukhan and H. L. Newmark. Inhibitory action of butyramide on DNA synthesis in hepatoma cells. Proc. Am. Assoc. Cancer Res. 33, 41 (1992).

69. M. A. Lea, Q. Xiao, A. K. Sadhukhan, S. Cottle, Z. Y. Wang and C. S. Yang. Inhibitory action of the tea extracts and (-)-epigallocatechin gallate on cell proliferation. Proc. Am. Assoc. Cancer Res. 34, 130 (1993).

70. C. desBordes, Q. Xiao, M. A. Lea, R. T. Dauchy and L. A. Sauer. Linoleic and Linolelaidic acids: Effects on DNA synthesis in hepatoma cells. Mol. Biol. Cell 4, 441a (1993).

71. M. A. Lea, N. Tulsyan and H. L. Newmark. Discordant effects of butyrate analogs on erythroleukemia cell proliferation and differentiation and on histone deacetylase. Proc. Am. Assoc. Cancer Res. 35, 383 (1994).

72. C. desBordes and M. A. Lea. Effects of linoleic acid isomers on DNA synthesis in hepatoma and breast cancer cells. Proc. Am. Assoc. Cancer Res. 36, 505 (1995).

73. M. A. Lea and U. S. Ayyala. Growth inhibitory and differentiating actions of diallyl disulfide. Proc. Am. Assoc. Cancer Res. 37, 386 (1996).

74. M. A. Lea and V. Randolph. Enzyme induction by butyrate, tributyrin, and trichostatin A. Proc. Am. Assoc. Cancer Res. 38, 187 (1997).

75. M. A. Lea and V. Randolph. Induction of gene expression by inhibitors of histone deacetylase including phenyl butyrate. Mol. Biol. Cell 8, 215a (1997).

76. M. A. Lea and V. Randolph. Histone hyperacetylation as a mechanism of action for phenylbutyrate on cancer cells. Proc. Am. Assoc. Cancer Res. 39, 451 (1998).

Revised: June, 201577. C. desBordes, N. Vangeepuram and M. A. Lea. Combined effects of polyunsaturated

fatty acids on formation of peroxidation products by liver and breast cancer cells. FASEB J. 12, A1376 (1998).

78. M.A. Lea, V.M. Randolph and M. Patel. Induction of histone hyperacetylation by diallyl disulfide and allyl mercaptan. Mol. Biol. Cell 9:450a (1998).

79. M.A. Lea, S.K. Hodge and V.M. Randolph. Growth regulation and induction of histone acetylation by 4-phenylbutyrate and structural analogs. Proc. Am. Assoc. Cancer Res. 40:368 (1999).

80. M.A. Lea, V.M. Randolph, J.E. Lee and C. desBordes. Induction of histone acetylation by some allyl sulfur compounds. Proc. Am. Assoc. Cancer Res. 41: 10 (2000).

81. M.A. Lea, V.M. Randolph, J.E. Lee and C. desBordes. Induction of histone acetylation by some organosulfur compounds including allyl isothiocyanate, allicin and butanethiol. Proc 18th Int. Congr. Biochem. Mol. Biol., Birmingham, U.K., p. 238 (2000).

82. M.A. Lea, V.M. Randolph, J.E. Lee, A. Kuehn, C. desBordes and L. Harrison. Induction of histone acetylation and inhibition of cell proliferation by phenylbutyrate and allyl sulfur compounds. Int. J. Mol. Med. 6: S23 (2000).

83. M.A. Lea, M. Rasheed and V.M. Randolph. Regulation of histone acetylation and erythroleukemia cell growth by some allyl compounds. Proc. Am. Assoc. Cancer Res. 42: 251-252 (2001).

84. N.Wiech, H. Lan-Hargest, M. Lea, M. Jung, J.E. Welsh, K. Helquist, M. Tenniswood, K. Packwood and R. Jeffrey. Characterization of the activity of the histone deacetylase inhibitor CG-1521 in solid tumor models. Proc. Am. Assoc. Cancer Res. 43: 69 (2002).

85. M.A. Lea, V.M. Randolph, B. Heltweg, M. Jung, H. Lin-Hargest and N.L. Wiech. Action of 7-phenyl-2,4,6-heptatrienoylhydroxamic acid (CG-1521) on histone acetylation and growth of cancer cells. Proc. Am. Assoc. Cancer Res. 43: 334 (2002).

86. M.A. Lea, V.M. Randolph, F. Khan, A. Shareef and C. desBordes. Induction of histone acetylation by garlic extracts and individual garlic compounds. J. Nutr. 132: 3549S (2002).

87. C. desBordes, M.A. Lea, L. Cisneros-Zevallos and D.H. Byrne. Inhibitory effects on cancer cell growth of methanolic extracts of anthocyanin-containing fruits and vegetables. Proc. Am. Assoc. Cancer Res. 44 (2nd Edition), 949, 2003.

88. M.A. Lea, A. Shareef and C. desBordes. Actions other than inhibition of histone deacetylase may be more important for growth inhibition by some phenyl alkanoic and phenyl alkenoic acids. Proc. Am. Assoc.Cancer Res. 44 (2nd Edition), 1315, 2003.

89. M.A. Lea, M. Sura and C. desBordes. Inhibition of cell proliferation by PPAR gamma agonists and componds reported to act as PPAR gamma antagonists. Proc. Am. Assoc. Cancer Res., 45, 705, 2004.

90. M.A. Lea, M. Sura, A. Abichandani, D. Stein, C. desBordes, M. Vizzotto and D.H. Byrne. Inhibitory effects on histone methylation and block of cytokinesis by extracts of anthocyanin-enriched fruits and vegetables. J. Nutr. 134, 3538S-3539S, 2004.

91. A. Honda, T. Hirayama, Y. Matsuzaki, T. Miyazaki, M. Doy, G.R. Xu, M.A, Lea and G. Salen. Overexpression of sterol regulatory element binding protein 2 (SREBP2) causes loss of feedback inhibition of cholesterol biosynthesis in McA-RH7777 rat hepatoma. Gastroenterology 128, A370, Suppl. 2, 2005.

92. M.A. Lea, C. Ibeh, C. desBordes, D.H. Byrne, M. Vizzoto, L. Cisneros-Zevallos and M.P. Moyer. Growth inhibiory and differentiating effects of anthocyanin-enriched fruit extracts on colon cancer cells. Proc. Am. Assoc. Cancer Res. 47, 536, 2006.

Revised: June, 2015

93. M.A. Lea, C. Ibeh, N. Shah and M.P. Moyer. Enhanced differentiation of colon cancer cells induced by combinations of inhibitors of kinases and of histone deacetylases. Proc. Am. Assoc. Cancer Res. 47, 1184, 2006.

94. M.A. Lea, C. Ibeh, Z. Muhammad, C. desBordes, L. Cisneros-Zevallos and D.H. Byrne. Induction of growth inhibition, altered ploidy, apoptosis and differentiation by anthocyanin-enriched fruit extracts and plant phenolics in leukemic and colon cancer cells. Proc. Am. Assoc. Cancer Res. 48, 1308, 2007.

95. M.A. Lea, C. Ibeh and C. desBordes. Inhibition of growth and induction of differentiation by plant polyphenols in colon cancer cells. Proc. Am. Assoc. Cancer Res. 49, 108-109, 2008.

96. M.A. Lea, C. Ibeh and C.desBordes. Inhibition of colon cancer cell proliferation is greater with quercetin 3-beta-glucoside than with quercetin or its rutinoside. Abstract BIOL95, 237th American Chemical Society National Meeting, Salt Lake City, Utah, 2009.

97. L. Han and M.A. Lea. Histone side-chain modifications and the induction of differentiation in colon cancer cells. Proc. Am. Assoc. Cancer Res., 50, 1101, 2009.

98. J.K. Deutsch and M.A. Lea. Inhibition of growth and induction of differentiation by apigenin, baicalein and quercetin in colon cancer cells. Proc. Am. Assoc Cancer Res., 51, 135, 2010.

99. M.A. Lea. Facilitating communication among biochemistry course directors. Program of the 14th annual meeting of the International Association of Medical Science Educators, page 103, New Orleans, 2010.

100. S. Bolikal, B. Dayal, T. Anderson, C. desBordes and M.A. Lea. Composition and bioactivity of okra seed extracts: Effect on colon cancer cells, Abstract AGFD 40, 241st American Chemical Society National Meeting, Anaheim, CA, 2011.

101. M.A. Lea, J. Chako, S. Bolikal, J.Y. Hong, R. Chung, A. Ortega and C. desBordes. 2-Deoxyglucose and compound C reversed acidification but enhanced growth inhibition in colon cancer cells treated with metformin and phenformin. Proc. Am. Assoc. Cancer Res. 52, 973, 2011.

102. M.A. Lea, I. Hamid, P. Jeong, E.S. Lee and M. Ndukwe. Colon cancer cells differ in their requirement for glucose and glutamine as an energy source. Proc. AACR Conference on Metabolism and Cancer, Pages 58-59, Baltimore, 2011.

103. B. Dayal, V.R. Yannamreddy, Ritesh R. Amin, M.A. Lea and A.B. Attygale. Bioactive Compounds Present in Moringa oleifera: Isolation and Structure Elucidation by Thin Layer Chromatography and Electro-Spray Ionization Mass Spectrometry. Abstract AGFD 153, American Chemical Society National Meeting, San Diego, CA, 2012.

104. M.A. Lea, T. Akinpelu, R. Amin, K. Yarlagadda, R. Enugala, B. Dayal and C. desBordes. Inhibition of growth and induction of differentiation of colon cancer cells by extracts from okra (Abelmoschus esculentus) and drumstick (Moringa oleifera). Proc. Am. Assoc. Cancer Res. 53, 1314-1315, 2012.

105. M.A. Lea, M.S. Qureshi, M. Buxhoeveden, N. Gengel, J. Kleinschmit and C. desBordes. Regulation of the proliferation of colon cancer cells by compounds affecting glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides. Proc. Am. Assoc. Cancer Res. 54, 450, 2013.

106. B. Dayal, V.R. Yannamreddy and M. Lea.. Chemistry and structure of aliphatic glucosinolates and isothiocyanates of Moringa oleifera: Potential chemopreventive agents. Abstract AGFD 15, 246th American Chemical Society National Meeting, Indianapolis, IN, 2013.

108. M.A. Lea, R. Geherty, R. David and C. desBordes. Inhibition of glycolysis and proliferation of colon

Revised: June, 2015cancer cells by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) an inhibitor of 6-phosphofructo-2-kinase (PFKFB3). Proc. Am. Assoc. Cancer Res. 55, 812, 2014.

106. R.Gohil, M. Lea, C. desBordes and B. Dayal, Inhibitory effects of turmeric extracts and curcumin on proliferation and differentiation of human colon cancer cells, Abstract AGFD 164, 248th American Chemical Society National Meeting, San Francisco, CA, 2014.

107. M.A, Lea and C. desBordes. Growth regulation of bladder cancer cells by compounds that affect glucose metabolism. Proc. Am. Assoc. Cancer Res. 56, 291, 2015.

108. M.A. Lea, M. Altayyar and C. desBordes. Inhibition of growth of bladder cancer cells by compounds that affect glucose metabolism. Proc. AACR Conference on Metabolism and Cancer, Abstract A60, Belleview, WA, 2015.

F. Reports: NA

PRESENTIONS:

A. Scientific (Basic Science): NA

B. Professional (Clinical): NA

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