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Dry and swollen hydrogel
Free Swelling
One example: starting concept
I generation
DVS
Patents
WO 98 58686 (1998)
WO 98 58688 (1998)
First Failure
Egypt Desert
Komatsuna plants grown in a SAP-powered soil
–Source: Green Earth Project
Third Concept: Dialysis
Third Failure
Fourth Concept: Diets
Gastric Bendages
The concept
The Team
Co-founder PureTechVentures & multiplestart-ups
Former President ofPfizer Global R&D
John LaMattina, PhD Yishai Zohar
Christian Demitri, PhD
Chairman CEOWorld leading scientist onpolymer science
World leading scientist onBiomaterials
Inventor
Inventor
Luigi Nicolais
Luigi Ambrosio
Experienced bio-materialsengineer at Univ. ofSalento
Project scientist
20+ years exp. devel-oping devices/drugs
Eyal Ron, PhD
CTO
32 years exp. in clin.studies (metabolic focus)
Hassan Heshmati, MD
CMO
Academic polymerscientist
Alesandro Sannino
Inventor
Industrial Advisory Board
Scientific Advisory Board
Re-designing IP
BROAD IP(7 Families of Pending and Issued Patent Applications)
Materials
Composition of matter and formulations
Manufacturing / Synthesis
Uses
Weight management
Glycemiccontrol
Foods
SAEF® (Super
Absorbent Edible Fiber)
Scale up
GMP
Future Perspectives: IPO
Finance the scale up
to Commercialization(expected in 2020)
http://www.nasdaq.com/article/the-latest-weight-loss-capsule-gelesis-
files-for-a-60-million-ipo-cm461413
Bottom line…
There is much more money than good ideas
Fundraising, Investments,
Divestments: European picture 2016
FUNDRAISING
In 2016, total fundraising reached €74.5bn, the highest level for Europe since 2008 and
a 37% increase on 2015. Almost 400 funds raised new capital, a 9% decrease compared
to 2015, indicating a trend to larger funds
INVESTMENTS
The total equity amount invested in European companies remained stable at €53.7bn,
marking the second highest level since 2008. About a third of this amount was invested
cross-border. The 83% of companies receiving these investments were SMSs
DIVESTMENTS
Over 3,500 European companies were exited in 2016, representing former equity
investments (divestments at cost) of €38.9bn. About 14% lower than 2015, but in line with
the annual average since 2012.
Source: Invest Europe / EDC
Investments by stage: 2016
Investments by sector: 2012-2016
Source: Invest Europe / EDC
US vs EU imbalance
Europe
0.028
US
0.150
VC Investment in proportion
to GDP
Source: Invest Europe / EDC and EVCA Eurostat
The Massachusetts Area
✓ 25,000 enterprises in 2006;
✓ 900 new start ups per year since 2006;
✓ Total of more than 3,000,000 employees;
✓ 2 trillion dollars revenues/year
Together, they would represent the 11th Economic Power of the World
VC Geographical investment flows
Source: Invest Europe / EDC
Drivers in Translational Path:
3 Balances
Falling in Love Love Actually
Drivers in Translational Path:
3 Balances
Falling in Love Love Actually
Risk Specialization
Drivers in Translational Path:
3 Balances
Falling in Love Love Actually
Risk Specialization
Failure Success
Thank You!
