Supplementary Materials for ‘Alpha hyperconnectivity and atypical memory processing in soldiers with PTSD’

Figure S1. 90 cortical and subcortical seed regions derived from the AAL atlas (Tzourio-Mazoyer et al., 2002) that were used in the beamformer reconstruction.

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Table S1. AAL seed regions (Tzourio-Mazoyer et al., 2002).

Region x y zPrecentral.L -40 -6 51Precentral.R 40 -8 52Frontal.Sup.L -19 35 42Frontal.Sup.R 20 31 44Frontal.Sup.Orb.L -18 47 -13Frontal.Sup.Orb.R 17 48 -14Frontal.Mid.L -34 33 35Frontal.Mid.R 37 33 34Frontal.Mid.Orb.L -32 50 -10Frontal.Mid.Orb.R 32 53 -11Frontal.Inf.Oper.L -49 13 19Frontal.Inf.Oper.R 49 15 21Frontal.Inf.Tri.L -47 30 14Frontal.Inf.Tri.R 49 30 14Frontal.Inf.Orb.L -37 31 -12Frontal.Inf.Orb.R 40 32 -12Rolandic.Oper.L -48 -8 14Rolandic.Oper.R 52 -6 15Supp.Motor.Area.L -6 5 61Supp.Motor.Area.R 8 0 62Olfactory.L -9 15 -12Olfactory.R 8 16 -11Frontal.Sup.Medial.L -6 49 31Frontal.Sup.Medial.R 8 51 30Frontal.Med.Orb.L -6 54 -7Frontal.Med.Orb.R 7 52 -7Rectus.L -6 37 -18Rectus.R 7 36 -18Insula.L -36 7 3Insula.R 38 6 2Cingulum.Ant.L -5 35 14Cingulum.Ant.R 7 37 16Cingulum.Mid.L -6 -15 42Cingulum.Mid.R 7 -9 40Cingulum.Post.L -6 -43 25Cingulum.Post.R 6 -42 22Hippocampus.L -26 -21 -10Hippocampus.R 28 -20 -10

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ParaHippocampal.L -22 -16 -21ParaHippocampal.R 24 -15 -20Amygdala.L -24 -1 -17Amygdala.R 26 1 -18Calcarine.L -8 -79 6Calcarine.R 15 -73 9Cuneus.L -7 -80 27Cuneus.R 13 -79 28Lingual.L -16 -68 -5Lingual.R 15 -67 -4Occipital.Sup.L -18 -84 28Occipital.Sup.R 23 -81 31Occipital.Mid.L -33 -81 16Occipital.Mid.R 36 -80 19Occipital.Inf.L -37 -78 -8Occipital.Inf.R 37 -82 -8Fusiform.L -32 -40 -20Fusiform.R 33 -39 -20Postcentral.L -43 -23 49Postcentral.R 40 -25 53Parietal.Sup.L -24 -60 59Parietal.Sup.R 25 -59 62Parietal.Inf.L -44 -46 47Parietal.Inf.R 45 -46 50SupraMarginal.L -57 -34 30SupraMarginal.R 57 -32 34Angular.L -45 -61 36Angular.R 45 -60 39Precuneus.L -8 -56 48Precuneus.R 9 -56 44Paracentral.Lobule.L -9 -25 70Paracentral.Lobule.R 6 -32 68Caudate.L -12 11 9Caudate.R 14 12 9Putamen.L -25 4 2Putamen.R 27 5 2Pallidum.L -19 0 0Pallidum.R 20 0 0Thalamus.L -12 -18 8Thalamus.R 12 -18 8Heschl.L -43 -19 10

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Heschl.R 45 -17 10Temporal.Sup.L -54 -21 7Temporal.Sup.R 57 -22 7Temporal.Pole.Sup.L -41 15 -20Temporal.Pole.Sup.R 47 15 -17Temporal.Mid.L -57 -34 -2Temporal.Mid.R 56 -37 -1Temporal.Pole.Mid.L -37 15 -34Temporal.Pole.Mid.R 43 15 -32Temporal.Inf.L -51 -28 -23Temporal.Inf.R 53 -31 -22

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Figure S2. Group-mean, whole-brain connectivity strength times series for the theta, beta, gamma and high gamma band in encoding and recognition trials during the working memory task (-0.2 to 0.8 seconds, stimulus appears at 0 time point; PTSD in blue, control in green, ±1 standard error bars, difference in red).

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Table S2 & S3. Table of significant connectivity differences for encoding trials in the working memory task, 50-150 ms and 150-250 ms, for nodes greater than degree of 2.

50-150 ms

Region x y Z DegreeRolandic.Oper.L -47.16 -8.48 13.95 16Frontal.Sup.Orb.L -16.56 47.32 -13.31 7Rectus.L -5.08 37.07 -18.14 7Postcentral.L -42.46 -22.63 48.92 6SupraMarginal.L -55.79 -33.64 30.45 5Supp.Motor.Area.L -5.32 4.85 61.38 4Supp.Motor.Area.R 8.62 0.17 61.85 4Cingulum.Mid.R 8.02 -8.83 39.79 4Hippocampus.L -25.03 -20.74 -10.13 4Lingual.L -14.62 -67.56 -4.63 4Fusiform.L -31.16 -40.3 -20.23 4Thalamus.L -10.85 -17.56 7.98 4Precentral.R 41.37 -8.21 52.09 3Frontal.Sup.Orb.R 18.49 48.1 -14.02 3ParaHippocampal.R 25.38 -15.15 -20.47 3Occipital.Inf.R 38.16 -81.99 -7.61 3Postcentral.R 41.43 -25.49 52.55 3

150-250 ms

Region x y z DegreeThalamus.L -10.85 -17.56 7.98 7Rolandic.Oper.L -47.16 -8.48 13.95 6ParaHippocampal.L -21.17 -15.95 -20.7 5Hippocampus.L -25.03 -20.74 -10.13 4Hippocampus.R 29.23 -19.78 -10.33 4Precuneus.L -7.24 -56.07 48.01 4Temporal.Mid.L -55.52 -33.8 -2.2 4Frontal.Sup.Orb.L -16.56 47.32 -13.31 3Frontal.Inf.Oper.L -48.43 12.73 19.02 3Frontal.Inf.Tri.L -45.58 29.91 13.99 3Fusiform.R 33.97 -39.1 -20.18 3Postcentral.L -42.46 -22.63 48.92 3Heschl.R 45.86 -17.15 10.41 3

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Table S4. Table for significant regions in the recognition trials for the working memory task, 150-250 ms, for nodes greater than degree of 2.

Region x y z DegreeOlfactory.R 10.43 15.91 -11.26 7ParaHippocampal.L -21.17 -15.95 -20.7 7Precuneus.R 9.98 -56.05 43.77 6ParaHippocampal.R 25.38 -15.15 -20.47 5Amygdala.R 27.32 0.64 -17.5 5Temporal.Inf.R 53.69 -31.07 -22.32 5Frontal.Sup.Medial.R 9.1 50.84 30.22 4Pallidum.R 21.2 0.18 0.23 4Frontal.Inf.Orb.L -35.98 30.71 -12.11 3Occipital.Inf.L -36.36 -78.29 -7.84 3

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Figure S3. Group-mean, whole-brain connectivity strength times series for the theta, beta, gamma and high gamma band during war-related and neutral trials in the long-term recognition task (-0.2 to 0.8 seconds, stimulus appears at 0 time point; PTSD in blue, control in green, ±1 standard error bars, difference in red).

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Table S5. For war-related trials in the long-term recognition task, 50-150 ms, for nodes greater than degree of 2.

Region x y z DegreeOccipital.Sup.L -16.54 -84.26 28.17 12Rectus.R 8.35 35.64 -18.04 8Cuneus.L -5.93 -80.13 27.22 7Rolandic.Oper.R 52.65 -6.25 14.63 5Olfactory.R 10.43 15.91 -11.26 5Amygdala.R 27.32 0.64 -17.5 5Heschl.R 45.86 -17.15 10.41 5Temporal.Pole.Mid.R 44.22 14.55 -32.23 5Postcentral.L -42.46 -22.63 48.92 4Temporal.Sup.L -53.16 -20.68 7.13 4Temporal.Mid.R 57.47 -37.23 -1.47 4Precuneus.R 9.98 -56.05 43.77 3Pallidum.L -17.75 -0.03 0.21 3

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Table S6. For neutral trials in the long-term recognition task, 50-150 ms, for nodes greater than degree of 2.

50-150 ms

Region x y z DegreeFrontal.Inf.Oper.L -48.43 12.73 19.02 7Supp.Motor.Area.R 8.62 0.17 61.85 7Parietal.Inf.R 46.46 -46.29 49.54 6Heschl.L -41.99 -18.88 9.98 4Temporal.Pole.Mid.R 44.22 14.55 -32.23 4Thalamus.L -10.85 -17.56 7.98 4Frontal.Inf.Tri.L -45.58 29.91 13.99 3Calcarine.L -7.14 -78.67 6.44 3Occipital.Sup.R 24.29 -80.85 30.59 3Postcentral.L -42.46 -22.63 48.92 3SupraMarginal.R 57.61 -31.5 34.48 3

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