Unité de Glycobiologie Structurale et

FonctionnelleUMR 8576 CNRS/USTL – IFR 147

EARLY PROGRAMMING OF MODERN DISEASES

Stefania MACCARI, FRProfessor in NeurosciencesHead of Neuroplasticity Team

Structural and Fonctional Glycobiology Unit UMR CNRS 8576

GDRE CNRS: French National Scientific Council of Research

Unité de Glycobiologie Structurale et

FonctionnelleUMR 8576 CNRS/USTL – IFR 147

http://ugsf-umr-glycobiologie.univ-lille1.fr/

Director:

Jean-Claude MICHALSKI

Unité de Glycobiologie Structurale et

FonctionnelleUMR 8576 CNRS/USTL – IFR 147

GDRE

EARLY PROGRAMMING OF MODERN DISEASES

ROME BORDEAUX

LILLE

FRANCE-ITALY Network

EARLY PROGRAMMING OF MODERN DISEASES

THE PRENATAL RESTRAINT STRESS MODEL AND AN IMPAIRED RESPONSE TO STRESS and ALTERED NEUROPLASTICITY

GDRE

Restraint stress procedure : 100% french..

EARLY PROGRAMMING OF MODERN DISEASES

LILLE:UMR-8576 and USR3078 CNRS ; U837,INSERM

BORDEAUX : UMR-5227 CNRS -

STRASBOURG : UPR 3212 CNRS

ROME :IN-CNR; Sapienza University; Univ.Cattolica Sacro Cuore

MARSEILLE :UMR6216 CNRS-

LILLE:UMR-8576 and USR3078 CNRS ; U837,INSERM

BORDEAUX : UMR-5227 CNRS -

STRASBOURG : UPR 3212 CNRS

ROME :IN-CNR; Sapienza University; Univ.Cattolica Sacro Cuore

MARSEILLE :UMR6216 CNRS-

GDRE The network is headed by 2 co-coordinators:

Stefania Maccari

Anna Moles

ITALY CNR IN-CNR Anna Moles, CR

Francesca Romana D’Amato, CR

Martine Ammassari-Teule, DR

Sara Bellantuono, PhD Student

Luciana Garbugino, PhD Student

Roberto Coccurello, Post-Doc

Sapienza Physiology andPharmacologyDpt V.Erspamer

Nicoletti Ferdinando, Full Prof.

Assia Catalani, Associate Prof.

Silvana Gaetani, Researcher

Annarita Zuena, Post-Doc

Vivianna Silletti, PhD Student

Cattolica SacroCuore Neuroscience

Dp

Institute ofPharmacology

Gioacchino Mennuni, CR

Olivier Van Reeth, DR FNRS

Giacomo Della Marca, Researcher

Pier Luigi Navarra, Prof.

European Research Network, GDRE

EARLY PROGRAMMING OF MODERN DISEASES, EPMD

THE ITALIAN NETWORK:

Anna Moles, CR Francesca Romana D’Amato, CRMartine Ammassari-Teule, DRSara Bellantuono, PhD StudentLuciana Garbugino, PhD StudentRoberto Coccurello, Post-Doc

EARLY PROGRAMMING OF MODERN DISEASES

GDRE

MONDAY, OCTOBER 19TH 2009

AT NAVY PIER, CHICAGO

EARLY PROGRAMMING OF MODERN DISEASES

Scientific Associate Director CNRS :

Bernard BIOULAC, FR (CNRS, Univ. Bordeaux 2)

EPMD Co-coordinators:

Stefania MACCARI, FR (CNRS, Univ. Lille1): Animal model PRS, Neuroproteomics, Depression

Anna MOLES, IT (CNR, Rome): Genomics and energy homeostasis

Members of EPMD:

Ferdinando NICOLETTI, IT (Univ. Rome): Metabotropic Glutamate Receptors and Depression

Arndt BENECKE, FR (CNRS Univ. Lille1, Lille2): Epigenomics

Annie DASZUTA, FR (CNRS, Univ. Marseille): Serotonin and adult neurogenesis

Sebastien BOURET, FR (Inserm Univ. Lille2), USA (Univ. Southern California): Neurodevelopment & obesity

Silvana GAETANI, IT (Univ. Roma): Endocannabinoids and feeding behaviour

Vincent PRÉVOT, FR (Inserm, Univ. Lille2): Reproduction

Valérie SIMONNEAUX, FR (CNRS, Univ. Strasbourg): Biological Rhythms

Paolo GIACOBINI, FR (Inserm, Univ. Lille2): GnRH neuronal migration

Thomas BORAUD, FR (CNRS, Univ. Bordeaux2): Neural substrate of motivated behaviours

Associated Partners:

Elisabeth MOCAER, FR (Servier): Agomelatine, antidepressant, intracellular mechanism

Fred TUREK, USA (Northwestern University): Sleep and Obesity

GDRE

Neuronal Plasticity

EARLY PROGRAMMING OF MODERN DISEASES

GDRE

Roma circadian studies & sleep lab. :

EARLY PROGRAMMING OF MODERN DISEASES, EPMDEuropean Research Network, GDRE

30 seconds

EEG 1

EEG 2

EMG

WAKE

Non-REM

REM

Jerome Mairesse

depressive-like behavior: sleep alterations

EARLY PROGRAMMING OF MODERN DISEASES, EPMDEuropean Research Network, GDRE

wake CONT

wake PRS

SWS CONTSWS PRS

REM CONT

REM PRS

wake CONT

wake PRS

SWS CONTSWS PRS

REM CONT

REM PRS

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,,,

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* REM Episode Number (24h)

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(Mairesse et al.)Reduced Slow Wave Sleep and increased REM

Hippocampus Proteome of PRS rats :Down-regulation of proteins involved in

neuroplasticity regulation

Morley-Fletcher et al 2008 SFN

Sara Morley-Fletcher

Epigenomic approach 1. Proteomics and post translational modifications?

The “epigenetic role” of the mother

1. Energy homestasis1. Energy homestasis

2. Emotional behaviourEmotional behaviour

3. Learning, memory and neuroplasticity

Anna Moles