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SURF-IT Symposium Presentation: August 26,2011. CALIT-2 University of California, Irvine. Simulations of an Extrinsic Stochastic Model of the Development, as a function of age, of the average neuron/synapse population densities in the various cortical regions of the human brain. - PowerPoint PPT Presentation
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Simulations of an Extrinsic Stochastic Model of the Development, as a function of age, of the average neuron/synapse population densities in the various cortical regions of the human brain
Undergrad Student: Johnathan DoMentor: Prof. Rui de Figueiredo
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
What?
• Create a Computer Simulated Test-bed to model a biological system developed by Rui de Figueiredo. • An extrinsic stochastic model for the development, as a
functions of age, of the average neuron/synapse population densities in cortical regions of the human brain. • The model describes the behavior of neurons and
synapses during neuron-genesis based on input of glial cells and neuron-necrosis based on the input of microglial cells to the system.
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
Need to start somewhere.• Glial Cells Radial Glia (Generate astrocytes as well as
neurons)
Astrocytes (Creates barrier between neurons and external blood)
Oligodendrocytes (Myelin sheaths in central nervous system)
Microglia (The first line of defense)
Scwann Cells (Form myelin sheaths in Peripheral Nervous System)
What happens if mutation occurs? (Alexander Disease,hindering the development of glial cells)
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
What to do?
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
End Goal?
• Reverse Engineering the Brain• For example:• Studying an Eagle, reverse engineer an Eagle in order to build a
plain.
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine
Special Thanks• Rui de Figeuiredo• CALIT2 Administrators• SURF-IT Program Directors• Stuar Ross• Said Shockir• Anna Lynn Spitzer• Shellie Nazarenus
SURF-IT Symposium Presentation: August 26,2011
CALIT-2University of California, Irvine