Fig

ure

II.1

.1S

D: I

ngen

uity

Pat

hway

out

put o

f th

e m

utat

iona

l-ba

sed

anal

ysis

, sho

win

g id

enti

fied

(B

old)

up

(red

) or

dow

n (g

reen

) re

gula

ted

prot

eins

and

thei

r in

volv

emen

t in

sign

ific

ant

biol

ogic

al p

roce

sses

. A s

tati

stic

sco

re is

att

ribu

ted

indi

cati

ng th

e pr

obab

ilit

y of

the

biol

ogic

al

proc

ess

assi

gned

is n

ot a

ran

dom

eve

nt b

ut it

is d

epen

dent

of

the

prot

eins

iden

tifi

ed.

Fig

ure

II.1

.2S

D: I

ngen

uity

Pat

hway

out

put o

f th

e re

spir

ator

y-ba

sed

anal

ysis

, sho

win

g id

enti

fied

(B

old)

up

(red

) or

dow

n (g

reen

) re

gula

ted

prot

eins

and

thei

r in

volv

emen

t in

sign

ific

ant b

iolo

gica

l pro

cess

es. A

sta

tist

ic s

core

is a

ttri

bute

d in

dica

ting

the

prob

abil

ity

of th

e bi

olog

ical

pro

cess

ass

igne

d is

not

a r

ando

m e

vent

but

it is

dep

ende

nt o

f th

e pr

otei

ns id

enti

fied

.