Symposium 2014United Kingdom & Ireland Controlled Release Society

www.ukicrs.org

Thursday 10 April 2014Workshop & Dinner

Friday 11 April 2014Symposium

University College CorkIreland

UKICRS Symposium

Followed by:

SYMPOSIUM DINNER:Amicus Restaurant Paul St, Cork 7.30 pm

The UKCIRS is hosting a free workshop for all attendees at this year’s sympUniversity College Cork. The workshop will feature short presentations anddemonstrations of equipment and technology from a number of industrial exhibitors. The UKICRS is grateful to the sponsors of the workshopSystems (BPS), Broadband Acoustics Resonance Dissolution Spectroscopy (Interface and Surface Analysis CentreMeasurement Systems (SMS).

WORKSHOP 10th April 2014, 2pm-5pm

UKICRS Symposium- University College Cork, Ireland 2014

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SYMPOSIUM DINNER: Amicus Restaurant Paul St, Cork 7.30 pm

The UKCIRS is hosting a free workshop for all attendees at this year’s symp. The workshop will feature short presentations and

demonstrations of equipment and technology from a number of industrial exhibitors.

The UKICRS is grateful to the sponsors of the workshop Anton Paar, Biopharma Process Broadband Acoustics Resonance Dissolution Spectroscopy (

and Surface Analysis Centre (ISAC), Stable Micro Systems and .

WORKSHOP 5pm

The UKCIRS is hosting a free workshop for all attendees at this year’s symposium in . The workshop will feature short presentations and hands-on

demonstrations of equipment and technology from a number of industrial exhibitors.

Biopharma Process Broadband Acoustics Resonance Dissolution Spectroscopy (BARDS),

and Surface

UKICRS Symposium- University College Cork, Ireland 2014

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SYMPOSIUM AGENDA 11th April 20148.30 am Registration / Poster Setup 9.30 am Dr Katie Ryan, UKICRS Symposium Organiser (University College Cork)

Welcome & Opening Remarks 9.40 am Dr. Marcus Brewster (Janssen Pharmaceuticals R&D, Belgium)

Designing Amorphous Solid Dispersions: In Silico Tools and Down-Scaled Automation 10.20 am Miss Hiteshri Makwana (University of Nottingham)

Location! Location! Location! Site-specific conjugation of recombinant transferrin to polymers for applications in targeted drug delivery

10.35am Dr. Waleed Faisal (Minia University, Egypt) A novel lipid-based solid dispersion for enhancing oral bioavailability of fenofibrate -in vivo evaluation using a pig model

10.50 am Tea / Coffee 11.10 am Mr. Éanna Forde (Royal College of Surgeons in Ireland)

Evaluating host defence peptide prodrugs targeted for use in the cystic fibrosis lung 11.25 am Miss Elisabeth Kastner (Aston University)

Manufacturing of liposomes with desired particle characteristics by factorial design 11.40 am Dr. Yiwei Tian (Queen’s University Belfast)

The understanding of phase separation of amorphous drug polymer solid dispersions based on Flory-Huggins theory

11.55 am Poster Session 1 12.40 pm Lunch 1.25 pm UKICRS Annual General Meeting 1.40 pm Dr. Andy Lewis (Ipsen, France)

Patient focused peptide delivery 2.20 pm Miss Rachel Evans-Hurson (University College Cork)

Application of Broadband Acoustic Resonance Dissolution Spectroscopy in pharmaceutical formulations

2.35 pm Miss Vanessa Loczenski Rose (University of Nottingham) Novel CRP routes to phosphonium polymethacrylates for siRNA delivery

2.50 pm Dr. Joanne Ramsey (Royal College of Surgeons in Ireland) Nebulised siRNA nanoparticles can induce knockdown in healthy and inflamed pulmonary epithelial models

3.05 pm Tea / Coffee 3.20 pm Poster Session 2 3.50 pm Mr. Edward Mansfield (University of Reading)

Probing diffusion of functionalised nanoparticles in gastric mucin using nanoparticle tracking analysis.

4.05 pm Miss Rosanne Raftery (Royal College of Surgeons in Ireland) Gene-activated scaffolds facilitate controlled release of growth factor for bone regeneration

4.20 pm Dr. Meenakshi Malhotra (University College Cork) RVG tagged modified cyclodextrins for receptor-mediated delivery of siRNA in glioblastoma cells

4.35 pm Dr Gavin Andrews, UKICRS Chairperson (Queens University, Belfast): Poster Prizes and Closing Remarks