Of the top 10 gastrointestinal drugs with the highest reportedadherence on Medisafe, GSK and Shire hold two spots each.

Gastroesophageal Reflux Disease

Heartburn

Gastroesophageal Reflux Disease

Diuretic

Ulcerative Colitis

Nausea, Vomiting

Irritable Bowel Syndrome

Nausea, Vomiting

Irritable Bowel Syndrome

Ulcerative Colitis

Dexilant

Prevacid

Protonix

Lasix

Lialda

Zofran ODT

Linzess

Zofran

Bentyl

Pentasa

Takeda

GlaxoSmithKline

Pfizer

Validus

Shire

Novartis

Allergen

GlaxoSmithKline

Forest Labs

Shire

BrandCondition Company

79%

79%

79%

81%

79%

75%

75%

76%

78%

74%

Adherence

?40+1+27+7+21+4+C4%

Worried about side

effects

1%Worried about cost

7%Ran out of meds 27%

Forgot/med not nearby

40%Didn’t need dose

21%Other

The highest GI adherence rates on Medisafe are in the morning hours, then decrease throughout the day until the night hours.

64 5 7 8 9 10 11 12 1 2 3 4 5 6 7 8 9 10

AM PM

75%

70%

65%

60%

55%

Canada

Mexico

USA77%

UK77%

78%

Brazil 77%

82%

Italy81%

75%

79%

Australia77%

Germany

Turkey

Germany and Italy lead other nations in reported gastroenterology adherence on Medisafe.

S M T TW F S77%77%

78%76% 76%

74%74%

Like many therapeutic areas, Saturday and Sunday prove the most challenging for GI medication adherence.

50% Average adherence across all therapeutic classes without Medisafe2

80%

79%

77%

76%

75%

74%

73%

71%

Esophagitis | Duodenal Ulcer

Diarrhea | Ascites

Dyspepsia

Crohn’s Disease | Gastroenteritis

Constipation | Bile Acid Seqauestrants

Irritable Bowel Syndrome

Pancreatic

Diabetic Gastroparesis

Worldwide medication adherence rates for most gastroenterology conditions are 75% or higher on Medisafe.

75+25+K 81+19+K81%80+20+K80%79+21+K79%76+24+K76%75%74+26+K74%

Top GI Companies by Highest Adherence

Top GI Meds with Highest Adherence

Adherence Rates by Type of GI Treatment

How Day of Week Affects GI Adherence

Most Adherent Countries for Gastroenterology Meds

Medisafe Reported Gastrointestinal Drug Adherence By Company

Medisafe Reported Gastrointestinal Drug Adherence by Drug Name5

Medisafe Reported Gastrointestinal Drug Adherence By Condition

Medisafe Reported Gastrointestinal Drug Adherence by Geography

Medisafe Reported Gastrointestinal Drug Adherence By Day

How Hour of Day Affects GI Adherence

Medisafe Reported Gastrointestinal Adherence by Hour

Why Gastrointestinal Patients Say They Miss Doses

Medisafe GI Patients’ Reasons for Skipping a Dose

Medisafe, the leading personalized medication management platform addressing all major causes of

non-adherence, delivers better medication adherence1, with more than 750M doses managed.

Gastroenterology Adherence Data:

Real-time stats on Medisafe that pharma should know

Medisafe is the leading personalized medication management platform addressing all major causes of non-adherence.

Far more than a pill reminder app, Medisafe is a cloud-based platform that personalizes content, resources and interventions

— such as educational videos, coupons and motivational messages — based on each user’s regimen, condition and specific

circumstance. Visit medisafe.com/pharma for more information.

1) Medisafe demonstrates up to 20% increase in med adherence in IMS study, presented at ISPOR.2) Medication Adherence in developed countries averages 50%, and is lower in developing regions (WHO). Source: http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf3) Medisafe reported adherence of active users that approved notification with more than 3 doses taken from the first take to the last take in relation to scheduled doses.4) Patients are generally considered adherent to their medication if their medication adherence percentage, dened as the number of pills absent in a given time period (“X”) dividedby the number of pills prescribed by the physician in that same time period, is greater than 80%. (NIH). Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068890/#R65) Some gastroenterology medications are only infused at a medical center or physician’s office over weekly or monthly intervals, and thereby not represented in this adherence data.

Find out how you can get behavioral insights and answers from the 4 million patients who are using Medisafe’s medication management platform.

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