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fibrinolisis
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Presenter : dr. SteviyaniModerator : Blood coagulation and fibrinolysis: mechanisms of thrombosis*
INTRODUCTIONblood coagulation plays a role in atherothrombosis
blood coagulation in the mechanisms of thrombosis cells, proteins, lipids, and calcium All these elements interplay to stop bleeding the primary task of hemostasis
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Thrombolysis remove intravascular fibrin deposits & restore blood flow
coagulation in a way as it also comprises cells, factors, activators, and inhibitors*
Primary hemostasisoccurs in response to damage of the vascular wall by the exposure of blood to endothelial tissue.leading to a platelet plug, is a complex process involving cells, plasma proteins, receptors, and phospholipids.*
Primary hemostasis*
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Blood coagulation*
Initiation of coagulation
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Amplification of coagulation
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Propagation of coagulation or full thrombin activity
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THROMBINOGRAPH Y*
Regulation of coagulation or the roleof inhibitors
Three main inhibitors are involved: the tissue factor pathway inhibitor (TFPI), the protein Cprotein S system antithrombin*
Tissue factor pathway inhibitor*
ProteinCprotein S system*
AntithrombinInhibit thrombin, factor Xa, as well as other factors.Physiologically heparin-like substances (heparan sulfate) & antithrombin-binding pentasaccharide sequence to render intact endothelium non-thrombogenic, as well as an ecto-ADPase that suppresses amplification of platelet activation by ADP release*
Fibrinolysis*
Mechanisms of thrombosisMost strokes are secondary to arterial thrombosis. however, venous thrombosis can also occur in the brain
Venous thrombosis decrease in inhibitors, or dysregulation of fibrinolysis*
Arterial thrombosis rupture of atherosclerotic plaque exposes thrombogenic material to circulating platelets & blood coagulation factors
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THANKYOU
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