6
Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis by Helen D. Donoghue, Oona Y.-C. Lee, David E. Minnikin, Gurdyal S. Besra, John H. Taylor, and Mark Spigelman Proceedings B Volume 277(1678):51-56 January 7, 2010 ©2010 by The Royal Society

Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Embed Size (px)

Citation preview

Page 1: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be

scientifically examined and given a medical diagnosis

by Helen D. Donoghue, Oona Y.-C. Lee, David E. Minnikin, Gurdyal S. Besra, John H. Taylor, and Mark Spigelman

Proceedings BVolume 277(1678):51-56

January 7, 2010

©2010 by The Royal Society

Page 2: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

The original appearance of the Granville mummy.

Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56

©2010 by The Royal Society

Page 3: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Demonstration of M. tuberculosis complex DNA in mummy lung sample.

Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56

©2010 by The Royal Society

Page 4: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Detection of M. tuberculosis complex mycolic acid PBA–PFB derivatives by reverse-phase fluorescence HPLC, from the Granville mummy femur and lung samples, in comparison with a

known standard strain of M. tuberculosis.

Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56

©2010 by The Royal Society

Page 5: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Normal-phase HPLC analyses of the collected total mycolates from the reverse-phase separation, from the Granville mummy femur and lung samples, in comparison with a known

standard strain of M. tuberculosis.

Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56

©2010 by The Royal Society

Page 6: Tuberculosis in Dr Granville's mummy: a molecular re- examination of the earliest known Egyptian mummy to be scientifically examined and given a medical

Reverse-phase HPLC analyses of the collected fractions from the normal-phase HPLC separation, from the Granville mummy femur and lung samples, in comparison with a known

standard strain of M. tuberculosis.

Helen D. Donoghue et al. Proc. R. Soc. B 2010;277:51-56

©2010 by The Royal Society