Trypanosomidae Family

4 Genera (Forms)

Leishmani

(Amastigote)Leptomonade

(Promastigote)

Trypanosoma

Trypomastigote

Critidia

(Epimastigote)

Dr.Fata/Cl12Dr.Fata/Cl12

Genus: Trypanosoma • African Trypanosomiasis

• T.gambiens

• T.rhodesiense

• American Trypanosomiasis

• T.cruzi

African Trypanosomiasis

Transmission: Bite of Tsetse Fly

Vector:Glossina palpalis

Glossina muristans

Reservoir:Deer,Bovine

African Trypanosomiasis Clinical signs

Febrile stage Shiver & Fever

Malaise & Headache

Anorexia &weakness

Nocturnal sweating

Adenopathy

(winter bottom sign)

CNS stage Tiredness

Confusion & Sleepy

Sever cachexia

Puffy face & Lips

Ataxia

Kerandel’s Sign

Dr.Fata/Tr05

African Trypanosomiasis

Dr.Fata/Tr05

M

African Trypanosomiasis

African Trypanosomiasis

Dr.Fata/Tr05

African Trypanosomiasis

African Trypanosomiasis

Dr.Fata/Tr05

M

African Trypanosomiasis

African Trypanosomiasis

• Blood Examination

• Direct smear

• Culture

• Lymph node Puncture

• Immunoserologic Tests

African Trypanosomiasis

Diagnosis

African Trypanosomiasis

• Diagnosis

• Blood smear

• Lymph node puncture

• Immunoserology

African Trypanosomiasis

Trypanosoma gambiense

Trypanosoma rhodesiense

American Trypanosomiasis

American Trypanosomiasis

Vector

Dr.Fata/Tr05

Triatoma

Agent: Trypanosoma cruzi

Transmission:Wound contamination

by faeces of Reduviid bugs (Triatoma)

Vector: Triatoma infestans

Triatoma megistans

Reservoir:Armadillo

American Trypanosomiasis Chagass Disease

American Trypanosomiasis • Acute Stage • Weakness,Shiver,Fever

• Muscular pain , Epistaxy

• Progressive tiredness

• Lymphadenopathy

• Hepatosplenomegaly

• Chagoma(Rommana sign)

• Oculoglandular syndrom

• Chronic Stage

• CNS involvement

• Myocarditis

• Megaoesophagus

• Megacolon

• Death

American Trypanosomiasis

• Diagnosis

• Blood smear

• Lymph node puncture

• Immunoserology

• Xenodiagnosis

American Trypanosomiasis

•Chagoma(Rommana sign)

American Trypanosomiasis

Chest X.Ray

American Trypanosomiasis •Chagoma(Rommana sign)

Diagnosis

• Blood smear

• Blood culture in NNN

• Immunologic tests:

Elisa

IF

PCR

TREATMENT

• GLUCANTIME