Tropis Tissue Helminth3 Trichinellosis

7/28/2019 Tropis Tissue Helminth3 Trichinellosis

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genus Trichinella. several other s ecies ofTrichinella are:

-T. pseudospiralis (mammals and birds worldwide)

- .

-T. nelsoni (African predators and scavengers),

- . .

6/18/2012 S. Wahyuni, Parasitology Dept, Medical Faculty, Unhas 1


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e span n e sma owe :

4 weeks

encysted larvae

female 2.2 mmmales 1.2 mm

remain viable for several years.


Encystment is completedin 4 to 5 weeks


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light infections: asymptomatic

n es na nvas on: arr ea, a omna pa n,vomiting.

after infection): periorbital and facial edema,

, , ,hemorrhages, rashes, & blood eosinophilia.

Occasional: m ocarditis central nervous s stem

involvement, and pneumonitis.

Larval enc stment in the muscles: m al ia &


weakness


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Eosinophilia always associated with T. spiralis

In severely infected cases, eosinophils may beas high as 80-95%.

, .

In patients moderately or severely infected with

and LDH are released into the circulating bloodand their presence inthe serum can be another

c ue ELISA can detect antibodies as early as 12 days



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eosinophilia

tests, including antibody detection, muscle, .

Trichinosis is definitely diagnosed by the

e ec on o arvae n e ops e musc e.



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Encysted larvae ofTrichinella in pressed muscle tissue sample.The coiled larvae can be seen inside the cysts.



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Larvae o Tric ine a, ree rom t eir cysts, typica y coi e ;length: 0.8 to 1 mm



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Be in as soon as ossible

The decision to treat is based upon symptoms,exposure to raw or undercooked meat, and.

Thiabendazole and mebendazole are useful

(Miyazaki, 1991). Albendazole may be effective, but its role is not

yet established (Markell et al., 1999).

symptoms



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Case re ort from Korea A 35- year-old men residing in Kochang-up was admitted

to Seokyong Hospital

Complained of high fever, facial and periorbital edema,and myalgia, A common ast histor of eatin raw liver, s leen, blood

and muscle of a badger, Meles meles melanogenys. Hematologic and biochemical examinations :

-- eosinophilia,- highly elevated levels of GOT, GPT, LDH and CPK.

Sohn, Korean J Parasitol. 2000;38(2):111-5.



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Muscle biopsi(By pressure method using two slide glasses)

Biopsi of Gastrocnemiusmuscle

After 24 d eating badger

Roundl coilednematode larvae

Size: 0.775-1.050 x

0.026-0.042 mm



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Fig 2. A sectioned larva in the worm cyst of muscle biopsied(H-E stained).

Fig. 3. Enlarged view of Fig. 2, showing the intense inflammatory responsearound the nurse cells (arrowheads)-larva (L) complex (H-E stained).



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- .

212 larvae/gram muscle was recovered & then given orally to a ICRmouse.

.from the mouse.

7 days flubendazole & 3d albendazole the larvae in biopsied musclewere uncoiled (Figs. 4, 5),



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,

flubendazole & albendazole given orally

and steroids were administered. sc arge a - ays pos -a mss on

What we can learn?:

Trichinellosis not only be found in pig


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Tropis Tissue Helminth3 Trichinellosis