A Study On Subchronic Ganoderma Lucidum Toxicity On The Liver As A Potential Antioxidant and Anti-Inflammatory Agent Against Cardiovascular Disease Santy Cintiana Dewi 1 , Djanggan Sargowo 2 , Mohammad Aris Widodo 3 , Titin Andri Wihastuti 4 , Teuku Heriansyah 5 , Mochammad Ali Tri Hartanto 1 , Ike Dyah Ayu Pambayun 1 , Samsul Bakhri 1 , Gregorius Didik Wicaksono S 1 , Novita Qurrota A’ini 6 , Daniwing Putri Sahudi 6 , Sabrinadia Hanareta Hantoko 6 , Januardi Indra Jaya 6 , Kemala Octariny 6 , Ahmafi Izzudin Ardhi 6 . 1 Cardiology Resident, Department of Cardiology and Vascular Medicine, Medical Faculty, Brawijaya University, Dr. Saiful Anwar General Hospital- Malang, Indonesia. 2 Research Leader, Lecturer at Department of Cardiology and Vascular Medicine, Medical Faculty, Brawijaya University, Dr. Saiful Anwar General Hospital- Malang, Indonesia. 3 Lecturer at Department of Nursing, Medical Faculty, Brawijaya University- Malang, Indonesia. 4 Lecturer at Department of Parasitology, Medical Faculty, Brawijaya University, Malang, Indonesia. 5 Lecturer at Medical Faculty, Syiah Kuala University, Dr.Zainoel Abidin General Hospital - Aceh, Indonesia. 6 Medical Student, Medical Faculty, Brawijaya University- Malang, Indonesia. Abstract Background : Gonoderma lucidum is claimed to have beneficial health effects, and is developing into a comprehensive form of treatment against cardiovascular disease. Previous studies have successfully proven Ganoderma lucidum polysaccharides peptide ability as an antioxidant and anti-inflammatory agent whereby reducing levels of MDA, hs-CRP, H 2 O 2 , total cholesterol, foam cells as well as increasing the levels of HDL in experimental testing using Wistar mice (Rattus norvegicus strain wistar) fed with a high-fat diet. In order to develop Gonaderma lucidum polysaccharides peptide as an integral and comprehensive form of treatment against cardiovascular disease, further research regarding the subchronic toxicity on the liver was researche Research Article
A Study On Subchronic Ganoderma Lucidum Toxicity On The Liver As
A Potential Antioxidant and Anti-Inflammatory Agent Against
Cardiovascular DiseaseSanty Cintiana Dewi1, Djanggan Sargowo2,
Mohammad Aris Widodo3, Titin Andri Wihastuti4, Teuku Heriansyah5,
Mochammad Ali Tri Hartanto1, Ike Dyah Ayu Pambayun1, Samsul
Bakhri1, Gregorius Didik Wicaksono S1, Novita Qurrota Aini6,
Daniwing Putri Sahudi6, Sabrinadia Hanareta Hantoko6, Januardi
Indra Jaya6, Kemala Octariny6, Ahmafi Izzudin Ardhi6. 1 Cardiology
Resident, Department of Cardiology and Vascular Medicine, Medical
Faculty, Brawijaya University, Dr. Saiful Anwar General Hospital-
Malang, Indonesia.2 Research Leader, Lecturer at Department of
Cardiology and Vascular Medicine, Medical Faculty, Brawijaya
University, Dr. Saiful Anwar General Hospital- Malang, Indonesia.3
Lecturer at Department of Nursing, Medical Faculty, Brawijaya
University- Malang, Indonesia. 4 Lecturer at Department of
Parasitology, Medical Faculty, Brawijaya University, Malang,
Indonesia.5 Lecturer at Medical Faculty, Syiah Kuala University,
Dr.Zainoel Abidin General Hospital - Aceh, Indonesia. 6 Medical
Student, Medical Faculty, Brawijaya University- Malang, Indonesia.
AbstractBackground : Gonoderma lucidum is claimed to have
beneficial health effects, and is developing into a comprehensive
form of treatment against cardiovascular disease. Previous studies
have successfully proven Ganoderma lucidum polysaccharides peptide
ability as an antioxidant and anti-inflammatory agent whereby
reducing levels of MDA, hs-CRP, H2O2, total cholesterol, foam cells
as well as increasing the levels of HDL in experimental testing
using Wistar mice (Rattus norvegicus strain wistar) fed with a
high-fat diet. In order to develop Gonaderma lucidum
polysaccharides peptide as an integral and comprehensive form of
treatment against cardiovascular disease, further research
regarding the subchronic toxicity on the liver was researche
