Transitioning to Symyx NotebookTransitioning to Symyx Notebook by AccelrysFrom other Electronic Lab Notebooks (ELNs)

Transition to a Higher‐value ELN

Enterprise ELN• Single ELN configurable for multiple scientificSingle ELN  configurable for multiple scientific  domains for collaborative productivity

Domain specific ELNDomain‐specific ELN• Focused on productivity for specific scientists

Paper‐on‐glass ELN• Simple electronic replacement for  paper notebooks

“Four Top‐10 Pharma have expressed interest in switching their existinginterest in switching their existing 

chemistry ELNs.”

Why Transition to Accelrys? – Strategic

Single ELN for the Enterprise

Providing global organizations with an enterprise ELN that: y 

Design

with an enterprise ELN that:

•Enhances scientific workflow

Collaborate & Make InferencesDistribute

& Share Results

Search & Find Data

Identify New

Opportunity

uality by

•Enhances scientific workflow, experiment, and process optimization

Collaborate & Make InferencesDistribute

& Share Results

Search & Find Data

Identify New

Opportunity

Qu

• Enables improved insight and management of complex scientific data 

•Enables compliance with standards and regulatory processes and controls

Accelrys ELN: Built on Solid VisionThe Four Pillars of Scientific Enterprise R&D

Collaborate & Make 

Inferences

Identify New Opportunity Search & 

Find DataDistribute &Share Results Find Data

Analyze DataGenerate Reports

Share Results

Plan/Design 

Reformat & Store Results in Database 

Make Decision

Modeling and Workflow 

ExperimentSetup Lab 

& EquipmentRun 

Experiment

Capture & Process Results

Modeling and Simulation

Data Management & Informatics

Enterprise Lab Management

Definition and Capture

& Informatics

Accelrys ELN: Enabled By Unique Platform Enterprise R&D Architecture

Workflow Definitiond li d Si l i Data Management 3rd Party Partner

Scientists R&D ManagerLab Manager

VP, R&D Head of IT &Informatics

ManufacturingPlant Workers

Enterprise Lab Management Workflow Definitionand Capture

Modeling and Simulation Data Managementand Informatics

3rd Party, Partner & ISV Apps

Discovery Studio

Materials Studio

Isentris Registration Pipeline PilotLEA ELN Web

Pipeline Pilot™

Ch i tCh i tORACLEORACLE Bi lBi lMaterial AnalyticalBiologyChemistry DDDD ChemistryChemistryORACLEORACLE

OtherOther33rdrd Party Party VendorsVendorsLIMSLIMS

BiologyBiologyMaterial Science

Analytical Instruments

BiologyChemistry DocsDocsDocsDocs

VendorsVendors

Text & Image Analytics

Statistics &Analytics

Reporting 3rd Party and ISV

Laboratory Ops

Symyx Notebook by Accelrys: Enterprise ELN

Synthetic

Expand access to institutional knowledge and data assets enabling b d i i Synthetic

& ParallelChemistry

Formulation

better decisions

Scientists save time Process Chemistry

Sc e t sts sa e t ecreating and reusingscientific knowledge

Target Id &Validationdi i l

IP protection and document workflow

ValidationMedicinal Chemistry Analytical 

Chemistry Lowers costs by integrating lab operations and application 

PharmacologyBiologicsconsolidation

Partnerships to build best of breed Partnerships to build best of breed solutions for your lab

Why Transition to Accelrys? – Tactical

• Highly‐rated customer support and consulting servicesservices

• Proven partnerships – with customers and third‐party vendors

• Industry leading chemistry and data access• Industry‐leading chemistry and data access solutions

• Information accessibility, world class chemical search and re‐use promoting internal and external collaborationexternal collaboration

• Configurability and extensibility enable rapidConfigurability and extensibility enable rapid startup

Reactions from Multiple Chemical Domains

View both conceptual and proven pathways from the 

ELN datasource

Find the best and most scalable pathway with 

di i l &medicinal  & process chemistry and literature in a 

single view

Generate synthetic pathways for compounds and view relevant data for 

creating a planAccess to reactions inAccess to reactions in a non‐Accelrys ELN

Now: Accelrys Pipeline Pilot and ELN provide rapid, scalable workflows

Rapid application extensions

Library of  re‐usable scientific productivity components Symyx Notebook by Accelrys

Pipeline Pilot client Custom Pipeline Pilot Protocols

Pipeline Pilot Collections

D iDesign DistributePublish

Accelrys Framework for Transitioning ELNs

E il h b d

Access multiple ELN repositories via ONE user interface

Easily search, browse and view  experiments from multiple ELN repositories

Import legacy data to create NEW experiments in 

the Accelrys ELN

Symyx Notebook

Process Notebook

V i 5 4

Formulations Notebook

Discovery Notebook

3rd Party ELN

Version 6.5 Version 5.4Version 5.6

Version  5.4Version 5.6

Version 4.1

The Enabling Technology: Symyx Notebook Browser web services

Transition Strategy

Protect IP – Keep signed experiments unaltered in existing third party ELN database repositorythird‐party ELN database repository.

E ti d C fi S N t b kEnsure continued access – Configure Symyx Notebook Browser web services to translate third‐party ELN data into Accelrys ELN format so it can be easily searched and viewed.

Re‐use legacy IP – The web services convert legacy data at runtime so scientists can clone experiments from the third‐runtime so scientists can clone experiments from the thirdparty ELN into Symyx Notebook by Accelrys.

Keep your scientists in touch with their experiments.

11

Recommended Transition Phases

Phase 1 – Deploy Symyx Notebook by Accelrys to new groups

Symyx Notebook by AccelrysThird‐party ELN 

d/Read/WriteExperimentsRead/Write

Experiments

Thi d tSymyx 

Third‐party ELN

Notebook

Recommended Transition Phases

Phase 2 – Implement hybrid access with staged transitions to Symyx Notebook by Accelrys.

Symyx Notebook by AccelrysNotebook Explorer

Symyx Notebook by AccelrysExperiment Editor Third‐party ELN 

Open

Clone

Search andRead/WriteExperiments

Search and Browse

ExperimentsRead/WriteExperiments

Third‐party ELN

Symyx Notebook

Recommended Transition Phases

Phase 3‐ Access data from multiple ELNs through one UI—Symyx Notebook by Accelrysy y y y

O

Symyx Notebook by Accelrys Notebook Explorer

Symyx Notebook by AccelrysExperiment Editor

OpenClone

Search and B Read/Write

Experiments

BrowseExperiments

Thi d t SymyxPreserveThird‐party 

ELN

Symyx Notebook

Legacy IP 

How IT WorksMapping the Legacy Data Model to Accelrys formatExample Conversion – Accelrys Services maps data from a third‐party ELN into Accelrys format using Accelrys web services

3rd Party ELN Symyx Notebook by Accelrys

Background Form (Form Section)Background

Background Form (Form Section)

Background Description (Text Section)

MaterialsMaterialsSynthetic Chemistry Section (Materials Section)Material Amounts

ProductsProducts

Reaction Scheme Reaction Scheme Section

Procedure Procedure (Text Section)

Results and Conclusions (Sketch only) Results and Conclusions (Text Section)

Embedded Reports (Sketch only) Embedded Reports (File Section)

How IT WorksRead and Re‐use Legacy Data in Symyx Notebook by Accelrys

1 2 3

Clone legacy experiments into Accelrys format

1 2 3

Select Target Experiment from external repository

Accelrys Web Service Extracts and Converts

Accelrys ELN Reads and Inserts Data into p y

Data to XML Format Appropriate Sections

Data Sources

Select ‘Create New From…’ Accelrys Services configures  Structures/Reactionsthe web service to translate data from 3rd party ELN to Accelrys format

StoichiometryMethods/SOPsEmbedded files(pdf/xls/doc/images)

How IT WorksSymyx Notebook Browser web application

• Aids while transitioning users to the Accelrys ELNView legacy and new ELN experiments in a web browser

Aids while transitioning users to the Accelrys ELN• Enables third‐party ELN users to easily view data in all mapped repositories• Scientists can view metadata, materials, and the reaction in the experiment 

record without opening it• PDF report of the experiment is available on‐line• Read only access• Read‐only access

How IT WorksSymyx Notebook Browser web application

• Search criteria include dmetadata, structure, 

and reaction.

• Scientists can restrict searches to specificsearches to specific, mapped ELN repositories.p

• Chemistry integrated y gfor structure/reaction drawing.

How IT WorksTransition completed

Scientists access mapped legacy ELN repositories via SymyxNotebook by Accelrysy y

Experiment Metadata

Experiment pMaterials

View Reactions

View PDF of ExperimentExperiment

Making the Transition: RecommendationsRead the white paper for technical details

Contact your Account Manager or Accelrys Services to scope the project:

• Assess your current ELN deployment and business issues/needsand business issues/needs

• Present recommendations on transition strategy, cost, and risk assessment

• Mutually agree with you on a transition• Mutually agree with you on a transition and roll‐out strategy

• Support your transition!20