TRANSITIONING TO DIGITAL HISTOLOGY - 3DHISTECH Ltd....• Colour profile / calibration • Multilayer mode (layers, distance, ext. focus) P1000 –SCAN Profile Who wins? 2013 2017

TRANSITIONING TO

DIGITAL HISTOLOGY

Dr Tamas Regenyi, 3DHISTECH Ltd.

How does digital pathology

enhance the pathological workflow?- Huge quality advantages - Remote Pathology

- Tele-consultation - Digital Case

- Faster case cycle - Monitoring and tracking

- Pulling together all type of data and information

- Computer assisted automated image analysis

- Digital Case and Image Databases

Transitioning into Digital Histology

MARKET CHALLANGES

COMPETITIVE ADVANTAGES

SALES LESSONS LEARNED

PRODUCT REGISTRATION

Agenda

Market News

• 3DHISTECH launched the P1000

• Philips announced the FDA approval

• Hamamatsu announced its S360

• Leica announced the Aperio VERSA

• LIS Integration

• DICOM

• AUTOMATED DIAGNOSIS

• ARTIFICIAL INTELLIGENCE

Market Challenges

Philips2013: First scanner

2014: Lightning off, Consumer offFocusing to Healthcare

2016: acquisition

2017: and HURON collaboration

Pixel pipeline: scanner, IMS, viewer, monitor

Any new SCANNER?

Market Challenges

Philips

- No smaller scanner

- No Z-dimension scanning

- No FL scanner

- No multiple objective, 0.75 NA

- Max resolution is 0.24µm/p

Market Challenges

Leica

- Digital microscope

- BF / FL

- Resolution is up to 0.1µm/p

- Scan time 3-4 minutes

- No live view

- External loader up to 200

- Only standard glass slide

Market Challenges

DICOM:

• All Pannoramic scanner can produce DICOM file format

• DICOM licence required

• 3-4 years

LIS INTEGRATION - CURRENT PROGRAMS:

• LIS System Integration Support

• Basic XML/HL7 System Integration

• Custom XML/HL7 System Integration

Market Challenges

The regulatory environment is changing

CE (EU)

FDA (US)

FDSAP (Canada 1st Jan 2019)https://www.sqt-training.com/2018/01/everyone-talking-mdsap-health-

canada/

Market Challenges

https://www.sqt-training.com/2018/01/everyone-talking-mdsap-health-canada/

WHY WE ARE HERE TOGETHER?Discussion about our business

Discuss how to win large deals

Fine-tuning our focus

Gathering new information

Reviewing our strategy

Capturing product and solution competence

Competitive Advantages

Time to market, 2002 - 2017

Digital PathologyWorkflow

3DHISTECH’s FULL DIGITAL PATHOLOGY

Digital MicroscopyImage Analysis Teleconsultation

Patient Handling

Case Handling

Are we a scanner manufacturer?

Integrated digital pathology workflow supplier


Mission:

Develop innovative digital pathology solutions to improve diagnosis workflow

Become an integrated digital pathology workflow supplier

Vision:

Automated and integrated fully digital pathology workflow


CANCER

WORKFLOW

IN A HOSPITALIDENTIFY – ANALYSE – DIAGNOSE – PROPSE

THERAPY – MONITORING - FEEDBACK


Fully fledged

digital pathology workflowLIS (Track & Sign)

Case Management and Reporting (CM)

Image Management (CC)

Remote Pathology – Tele-consultation

Image Viewer

Image Analysis


PATHONET

Publishing and Consulting

Portal for Pathologist

Public and Private

Database


New Business Model:

Solution as a service

versus

Hardware and Software


Time is an essence

Time to market is key


Technical support

and reliability

is an essence

The business model

Is an essence


The business model

is an essence

Vendor – User

Vendor – distributor – User

Vendor – distributor – sub-reseller - User

Market Challanges

Digital Pathology• Not a commodity product

• Not a mature market

• Highly innovative product

• Extremely complex solution

• Requires sophisticated integration

• Very high upfront investment / requires financing

Market Challanges

“Who is going to support us?”

“Who is going to support

the sub-reseller?”

“Where is the value add?”

Market Challanges

The RIGHT business model

is an essence:

Value Added Distributors

Market Challanges

Service Infrastructure:

Technical Support Node

Competence Centre

Centre of Excellence

Market Challanges

The right commitment to customer:

Support 24 / 7

Market Challanges

Competitive Landscape

RESEARCH

RO

UTI

NE

DIA

GN

OSI

S

3DHISTECH® offers

the most comprehensive

whole slide scanner solution available for diagnosis today


3DHISTECH® have

the technology

for all use cases


• Routine volume diagnosis / high throughput

• Smaller satellite labs

• Frozen section

• Larger biopsy

• Immuno

• Fluorescent / Molecular


DESK II (1) MIDI II (12) MIDI CONF SCAN II (150) FLASH III (250) P FLASH IV (1000)

Bri

ght

Fiel

d

4 configDW slides

4 config 2 config 4 config 4 configDW slides

Flu

ore

scen

t

8 config 2 config 8 config 8 config

Pannoramic Scanners

Tissue Microarray Systems

Digital Case

TumorBoard IHC stain

Automated IHC Workflow

Why Pannoramic 1000?

- Capacity

- Slide processing queuing

- Speed

- 3rd objective / immersion

- Double with slide support

- Handling priority and profiles

Competitive advantages

Multiple Permanent / Temporary profiles

• Objective selection (20x - 40x - 63x)

• Output resolution (10x ... 100x)

• Image format (e.g. JPG)

• Image bit depth (8 – 16)

• Preview grabbing mode

• Tissue detection (auto – user defined)

• Focusing (focus points)

• Colour profile / calibration

• Multilayer mode (layers, distance, ext. focus)

P1000 – SCAN Profile

Who wins?

2013

2017

Philips UFS

• For high-throughput laboratories

• Automated operation

• Scan time < 60 sec @ 40x, NA 0.75

• 300 slides storage capacity (15x20 racks)

• Add or remove slide while operating

• Displays occupied and empty slide racks

• Integrated LCD touchscreen

• Change scan order for priority or STAT slides STAT = „urgent request”



Pannoramic 1000 Philips UFS

1000 slides 300 slides

Max 2000 / day Max 900 / day

Triple objective (0.8, 0.95, 1.4 immersion) Single objective (0.75)

Native resolution: 0.07 Native resolution: 0.24

Z-stack up to 30 layers No Z-stack

Standard and DW slide Only standards slide

30 sec. Less than 60 sec.

Priority handling Priority handling

External touchscreen Integrated touchscreen

Image Resolution

100x

80x

60x

40x

20x

10x

P10003

P2502Nr of obj:

Leica1

Hamamatsu1

Philips1

2012: 2016:

Scanner Contest

You can google it:

Scanner contest

How to win big deals?Close relationship / intimacy with laboratories

Early engagement / continuous presales

Budget & Financing / Partner’s financial capabilities

Partner’s competence: Pathology, Scanners, Imaging & IT

Clear vision demonstration / future proof solutions

Diversity of solution offering

Price, references, integration to laboratory technologies and laboratory information and management systems


From 1st May 2018

For all 3DHISTECH products

On-line / Off-line / Mobile Device

During the setup

1 minute process

Better technical support

Improved spare part quality

Flexible software update

Shorter repair service cycle

Product Registration

Thank you for your kind attention!

[email protected]

Transitioning into Digital Histology

MARKET CHALLANGES

COMPETITIVE ADVANTAGES

SALES LESSONS LEARNED

PRODUCT REGISTRATION

Agenda

Minta 1

Minta minta minta minta minta

Transitioning into

Completely digital pathology workflow.

Stored in the cloud or on premise

Fully flexible

Totally web enabled

Connect everthing, every database, via XML, HL7, etc


Leica / Aperio

LV1 Live View, 4 slide loader, BF only, Tile scan mode,

AT2 2x3 or 400 slide, Only BF, TDI line scan, Z-stack, No live view, 60 sec / 20x 15x15 slides, no avail in theUSA, 26x76+52x76mm slides, 50 slides / hour 20x,

AT Turbo 2x3 or 400 slide, Only BF, TDI line scan, NO Z-stack, No live view, 33 slide / h 20x, high volume, shortturn aRUOND

CS2 Loader 2x3 or 5, BF only, Z-stack, NO LIVE View, single obj 20x 0.75 NA, resolution 20x, 40x withmagnifier, TDI line scan, 0.25 um/p max , 26x76 slides, 90 sec / 15x15 slide

VersaResearch, BF+FL+FISH, motorized stage, automated oiler 40x, 63x, Z-stack, 4/8 stage, 200 with SL200, slow: 3,5min /15x15 BF slide, 26x76 mm slides, 1.25x-63x, manual changer, NO LIVE View, Tile scan

Ariol Clinical IHC / FISH, motorized stage, BF+FL+FISH, NO Z-stack, 4/8 stage, 200 with SL200, Halogen BF, 26x76 mm slides, slow: 10min /15x15 slide 20x, 15 min 40x, 1.25-40x, 63x optional, manual changer, oil imm. Tile scan mode, 0.1 um/p max

„Advanced tissue detection for faint for lightly stained brightfield and fluorescent samples”

Exact loading capacity specified:

Five easy ways to identify our competitor

Here are the top 20 cancer hospitals for this year:

University of Texas MD Anderson Cancer Center, Houston

Memorial Sloan Kettering Cancer Center, New York City

Mayo Clinic, Rochester, Minnesota

Dana-Farber/Brigham and Women's Cancer Center, Boston

UCLA Medical Center, Los Angeles

Moffitt Cancer Center and Research Institute, Tampa, Florida

Seattle Cancer Care Alliance/University of Washington Medical Center

Cleveland Clinic

Johns Hopkins Hospital, Baltimore

UCSF Medical Center, San Francisco

Massachusetts General Hospital, Boston

Hospitals of the University of Pennsylvania-Penn Presbyterian, Philadelphia

Stanford Health Care-Stanford Hospital, California


Loading capacity 300: Philips

400: LEICA

320 o 360 Hamamatsu

Tender Specification

Service oriented

architecture


Scanner ContestYou can google it:

Documents

TRANSITIONING TO DIGITAL HISTOLOGY - 3DHISTECH Ltd....• Colour profile / calibration • Multilayer mode (layers, distance, ext. focus) P1000 –SCAN Profile Who wins? 2013 2017