Transferrin-a modulates hepcidin expression in zebrafish embryos

by Paula G. Fraenkel, Yann Gibert, Jason L. Holzheimer, Victoria J. Lattanzi, Sarah F. Burnett, Kimberly A. Dooley, Rebecca A. Wingert, and Leonard I. Zon

BloodVolume 113(12):2843-2850

March 19, 2009

©2009 by American Society of Hematology

The zebrafish mutant gavi.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Phenotypic characterization of gavi.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Effect of morpholino knockdown of transferrin-a or TfRs on o-dianisidine staining for hemoglobin at 48 hpf.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Coinjection of transferrin-a or TfR1a cRNA rescues anemia in transferrin-a morphants.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Coinjection of transferrin-a cRNA improves somite iron stores in transferrin-a morphants.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Changes in gene expression in gavi and other hypochromic mutants.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology

Effect of morpholino knockdown of transferrin-a or TfRs on gene expression.

Paula G. Fraenkel et al. Blood 2009;113:2843-2850

©2009 by American Society of Hematology