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Training Report (JUST)

Name: Ghada Khalifah BY Student No.: 20080031011

Section: 2\ Dr.Khawla Nuseir-----------------------------------------------------------------------------------------System: CNS

Class/ Group: SNRI

Active ingredient: Duloxetine Original Brand: Cymbatala

1- Indications:

Duloxetine is used to treat major depressive disorder and general anxiety disorder.

Duloxetine is also used to treat fibromyalgia (a chronic pain disorder), or chronicmuscle or joint pain (such as low back pain and osteoarthritis pain).

Duloxetine is also used to treat pain caused by nerve damage in people withdiabetes (diabetic neuropathy).

2- Dosage forms and Strength:

Caplets; 60mg

3- Dose:

For use in the management of neuropathic pain associated with diabetic

 peripheral neuropathy and for the management of chronic

musculoskeletal pain in patients with chronic low back pain and chronic

 pain due to osteoarthritis:

Usual Dose: 60 mg once a day without regard to meals.

Usual Adult Dose for Depression:

Initial Dose: 40 mg per day (administered as 20 mg twice daily) to 60 mg

 per day (given either once a day or as 30 mg twice daily) without regard

to meals.

Usual Adult Dose for Anxiety:

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Initial dose: 60 mg orally once a day If necessary, dosage may be

increased in increments of no more than 30 mg per day Maximum dose:

120 mg per day For patients in whom tolerability is a concern, a lower an

initial dose of 30 mg orally once a day may be considered. Following one

week of therapy, the dose may be increased to 60 mg orally once a day inthis patient population. Although a 120 mg per day dose was shown to be

safe and effective, there is no evidence that doses higher than 60 mg have

any additional benefit.

Usual Adult Dose for Fibromyalgia:

Initial Dose: 30 mg once a day without regard to meals for one week.

Usual Dose: 60 mg once a day without regard to meals.

4- Drug Interactions:

aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac(Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac(Lodine), and others. Taking any of these drugs with duloxetine may cause you tobruise or bleed easily.

Do not use Cymbalta together with thioridazine (Mellaril), or an MAOinhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine(Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), ortranylcypromine (Parnate). A dangerous drug interaction could occur, leading toserious side effects. You must wait at least 14 days after stopping an MAO

inhibitor before you can take Cymbalta. After you stop taking Cymbalta, youmust wait at least 5 days before you start taking an MAOI.

5- Drug store and company:

Drug store; 

Company; Lilly S.A

6- Generic name or Alternatives

There is no alternative to Cymbtala in Jordan

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