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Total Synthesis of Pleuromutilin
2017/06/17 Hiroaki Matoba
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Pleuromutilin
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Retrosynthesis
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Gibbons’ synthesis (1)
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Gibbons’ synthesis (2)
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Gibbons’ synthesis (3)
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Problem for construction of C12 quaternary center
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Gibbons’ synthesis (4)
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Gibbons’ synthesis (5)
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Short summary
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Derivatization of preulomutilin
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Epimerization at C12 position
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12-epi-preulomutilin derivative
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Herzon’s synthesis (1)
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Zincate mediated 3 component coupling reaction
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Herzon’s synthesis (2)
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Herzon’s synthesis (3)
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Herzon’s synthesis (4)
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Herzon’s synthesis (5)
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Herzon’s synthesis (6)
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Regioselective reductive cyclization (1)
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Regioselective reductive cyclization (2)
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Stereoselectivity
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Herzon’s synthesis (7)
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Herzon’s synthesis (8)
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Summary
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