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Total endovascular arch repair: what we learned so far? Ciro Ferrer, MD Fisiopatologia Chirurgica ad Interesse Vascolare Sapienza Università di Roma

Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

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Page 1: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Total endovascular archrepair: what welearned so far?

Ciro Ferrer, MDFisiopatologia Chirurgica ad Interesse Vascolare

Sapienza Università di Roma

Page 2: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Disclosure

Speaker name:

Ciro Ferrer

I do not have any potential conflict of interest

Page 3: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

OPEN REPAIR

- Mediansternotomy

- Hypothermia

- Cardiopulmonarybypass

- Antegrade cerebralpurfusion

- Massive heparinization

Page 4: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

ENDOVASCULAR REPAIR

Car-Subclbypass/transposition

DOUBLE INNER BRANCHENDOGRAFT

Page 5: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Arch branched stentgraftOPERATIVE DETAILS

VASCULAR ACCESSES:

- R femoral a (aortic main body)- L femoral a (angiography)- L femoral v (pacing)- R axillary (innominate stent)- L brachial (L carotid stent)

X X

X

X

X

Page 6: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

J Vasc Surg 2011

30 patients screened: 75% conical shapewithout a proximal landing zone

Page 7: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

BUILDING A DURABLE ARCH REPAIR

- Avoid landing in diseased ascending aorta Ectatic ascending aorta (>38mm)

Page 8: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Male, 78 yo

Page 9: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

CT scan @ 24h

Page 10: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Chronic type B dissection

40 mm

Page 11: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Ascending aorta replacement + total debranching + TEVAR

Dacron graft of at least

5 cm in length

Page 12: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

09/2009 – 09/2015

TEVAR n = 483Arch TEVAR n = 181

Page 13: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

16 mm

Middle-distal arch disease

Page 14: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

5 mm shrinkage @ 24 monthsafter Branched Arch TEVAR

More stable sealingfor a potentiallyfeasible zone 1 repair

Double branch stentgraft

Page 15: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

2012 – 2016

Arch branchedprocedures: 14

Bolton (n=9) Cook (n=5)

Single branch: 2/14Double branch: 12/14Technical success: 14/1430-day mortality: 3/1430-day stroke: 2/14

Page 16: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

#Implant

DateDevice Age Sex Pathology

Intraoperative

Complication

Perioperative

ComplicationAlive

1 25/06/13 Bolton 70 M TAA N Stroke - death N

2 19/09/13 Bolton 83 M TAA N N Y

3 17/03/14 Bolton 84 M TAA N N Y

4 29/04/14 Bolton 79 M Dissection N N Y

5 22/07/14 Bolton 72 M TAA N N Y

6 06/11/14 Cook 76 M TAA N N Y

7 12/01/15 Cook 64 M DissectionCoverage of L vertebral

artery by vascular plug Stroke Y

8 16/02/15 Bolton 84 M TAA NRetrograde

dissection - deathN

9 05/06/15 Cook 77 M TAA N N Y

10 24/09/15 Cook 75 M TAA N N Y

11 06/02/16 Cook 83 M TAA N N Y

12 21/11/16 Bolton 78 M TAA N N Y

Double inner branch N=12

Page 17: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Arch aneurysmpost type A repair

Dissection ofInnominate artery

Dissection ofR common carotid

Dissection ofLSA

Page 18: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Double branch stentgraft

R car to RSAtransposition

L car - LSAbypass

Page 19: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Car-subcl bypass + LSA emboliz (Plug) + Branched Arch TEVAR

Elongation of Plug due to LSA dissection

Partial coverage of L Vertebral artery

Posterior Stroke

Page 20: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

LSA re-entry tear

RCCA re-entry tear

Arch aneurysmpost type A repair

Page 21: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Deployment of a 10-mm V-12 stentgraft in the LSA and a 6-mm Vascular Plug in the false lumen

Deployment of a 9-mm Viabahnstentgraft in the RCCA

Page 22: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Post-op CTA afterSPOT STENTINGtechinique

Page 23: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Male, 86 yo70 mm arch aneurysmThoracic painHorsenessRespiratory distress

Page 24: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

LIMA to LADpatent bypass

Page 25: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Persistent aneurysmperfusion

Page 26: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Journal of Endovascular Therapy 2016

2 patients with acute type A aortic dissection treated with

combination of tubular and branched stentgrafts

Page 27: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

RelayBranch off-the-shelf device

PROX DIAMETER32 · 34 ∙ 36 ∙ 38 ∙ 40 ∙

42 ∙ 44 ∙ 46 ∙ 48

DISTAL DIAMETER22 · 24 ∙ 26 ∙ 28 ∙ 30 ∙32 ∙ 34 ∙ 36 ∙ 38∙ 40 ∙

42 ∙ 44 ∙ 46 ∙ 48

MAIN BODY LENGTH45 · 60

TOTAL MAIN BODY LENGTH250 · 270

WINDOWLENGTH

50

WINDOWWIDTH

26 ∙ 32 ∙ 38TUNNEL DIAMETER12

PROX DIAMETER13

PROX DIAMETER13

DISTAL DIAMETER8 · 9 ∙ 10 ∙ 11 ∙ 12 ∙ 13

DISTAL DIAMETER14 · 16 ∙ 18 ∙20 ∙ 22 ∙ 24

TOTAL BRANCH LENGTH70 · 80 · 90 · 100

110 · 120 · 130 · 140

Page 28: Total endovascular arch repair: what wecacvsarchives.org/.../01-thursday19/1432_Auditorium_FERRER_Ciro.pdf · Ciro Ferrer I do not have any potential conflict of interest . OPEN REPAIR

Conclusion

Endovascular approach is a valid alternative to open surgery for all patients when morphologically feasible

Identification of a suitable proximal landing zone remains a major concern in TEVAR for arch disease

Dacron ascending aorta is the safest landing zone

An arch branched endograft should be at most 42 mmin proximal diameter (ascending aorta no larger than 38 mm)

Off-the-shelf solutions will be the future for extending the treatment also to emergency