Course D e s c r i p t i o n

BTDD Semester D3 This is a summer semester for BTDD in which they will do part of project work and are required to deliver one semi-nar on a topic of modern scientific and technological importance

M.Tech. Project Part-I: Course Code 07D31BT901 (0-0-18) Seminar: Course Code 07D31BT911 (2-0-0)

BTDD Semester D4 In addition to three core courses the students are required to do a project work of eight credits and study two elec-tives of their choice

M.Tech. Project Part-II: Course Code 07D41BT902 (0-0-16)

The aim of this course is to impart a sound knowledge about diseases of both infectious and non-infectious origin, afflicting world in general and Indian population in particular. The course considers the etiological agent, patho-physiology, life cycle of the pathogen as well as symptoms, diagnostic tools and prevention strategies for each of the diseases. Topic include: bacterial diseases, viral diseases, protozoal diseases, fungal diseases, diseases caused by worms, neurodegenerative diseases, auto-immune diseases, metabolic diseases (diabetes, hypertension, cardiac disorders) genetic diseases (phenylketonuria, Tay-Sachs disease, cystic fibrosis and others) and cancers

Diseases and Healthcare: Course Code 07D41BT119 (3-0-0)

Intellectual Property, Patent law fundamentals, International IP treaties relevant to biotechnology, International agreements relevant to biotechnology-associated IP, Drafting Patent Application, Documentation, Patent Search databases, Revocation of Patent, Litigation and Infringement, Licensing and IP Management, International harmoni-zation of patent law, WIPO, EPC, WTO, India and TRIPS, Commercialization of biotechnology Patents, Plant Breed-ers rights, UPOV and protection of New plant varieties. Traditional knowledge vis-à-vis industry.

IPR and Patent Law: Course Code 07M21BT103 (3-0-0)

BTDD Semester D4 Electives DE-I, DE-II (Choose any two electives)

Dual degree M.Tech Biotechnology

The objective of this course is to enable students to correlate diseased states with malfunctioning of cell signaling pathways. Topics include: The machinery of signal transduction, Signal transduction pathways and their elucida-tion, Receptors and their targets, Control of cell signaling, Insulin function and diabetes, Regulation by Growth fac-tors, cytokines and hormones; Cell regulatory programs, Transformation of normal cells to tumor cells, targets for new cancer therapeutics Analysis and manipulation of intracellular signaling via case studies

Cell Signaling and Signal Transduction: Course Code 07M11BT101 (3-0-0)

BTDD Semester-D1 Electives DE-I, DE-II, DE-III (Choose any three electives)

Project Part-I: Course Code 07B71BT901 (0-0-20)

BTDD Semester-D2 Electives DE-IV, DE-V, DE-VI (Choose any three electives)

Metabolic Engineering: Course Code 07M21BT105 (3-0-0)

To impart understanding of designing metabolic pathways to increase the formation of desired metabolites and de-crease formation of unwanted metabolites in bioprocesses. Topics include: Overview of biochemical pathways, Importance of secondary metabolites in medicine and agriculture, Identification of gross measurement errors. Meta-bolic flux analysis: Theory and applications, Application of 13C-isotopes for quantification of metabolic fluxes, Molecu-lar biological tools in metabolic engineering, Whole genome transcription analysis using DNA arrays, Implications of adding a new pathway

Project Part-II: Course Code 07B81BT902 (0-0-20)

Semester B1 to B6 same as far as B.Tech Biotechnolology

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Course D e s c r i p t i o n

Semester D5 In addition to three core courses the students are required to do a project work of eight credits and study two elec-tives of their choice

M.Tech. Project Part-III: Course Code 07D51BT903 (0-0-16)

Diagnostics: Course Code 07M21BT108 (3-0-0) This course aims to familiarize the students with principles and applications of both the conventional and the latest state-of-art in the field of Diagnostics. Topics include: Diagnostic methods: microscopic, spectroscopic, imaging and scanning, Physiological diagnostic methods: histological, hematological, biopsies, Biochemical diagnostic meth-ods: enzymatic, toxins, hormonal; Immunological diagnostic methods: ELISA, Western blot, agglutination, Radiologi-cal, DNA-based diagnostics; DNA fingerprinting, metabolic labeling assays, quarantine issues related to biological materials, microbiological testing.

This course provides the basic knowledge of chemo informatics and its application in drug discovery process. Top-ics include: Overview of Pharmacology and pharmacokinetics, Basics of chemoinformatics, Biomolecules structures and formats, SMILE and SMART code, Chemical libraries, Combi Chem, QSAR, Pharmacophore, Virtual screening, Bioinformatics tools for 3-D visualization and computation, molecular modeling, computational identification of drug targets and possible lead molecules, computer-aided drug designing,

Chemoinformatics: Course Code 07M21BT107 (3-0-0)

Bioremediation: Course Code 07M21BT106 (3-0-0) The course aims to provide the major present day technologies available for reclaiming contaminated sites. It covers the application of various physical and chemical technologies, but emphasis is on the biological systems for the cleanup of hazardous chemicals to reduce pollution levels. Topics include: Environment pollution vis-a-vis bioreme-diation, Methods of bio-remediation (ex situ and in situ), Biodegradation, Remediation of Industrial effluents – Solid, Liquid and Gaseous effluents, Biofilters, Industrial waste management with Bioreactors, Biomethanation, manage-ment of Hazardous and radioactive wastes, Bioleaching, Biomining, Revegetation of Wastelands, Biofertilizers and composting, Bio-restoration of aquatic ecosystems, Reforestation: carbon budgeting and microbial conversion, Phy-toremediation, GMO’s for bio-remediation.

BTDD Semester D5 Electives DE-III, DE-IV (Choose any two electives)

Research Methodology and Data validation: Course Code 07M21BT104 (3-0-0)

This course attempts at imparting research skills to the students and involves conceptualization of an innovative pro-ject, literature search and analysis, research and experiment design, developing a research plan – case studies, Biological data types (Quantitative and Qualitative), Sampling methods, Data collection, Processing and statistical analysis, Critical assessment and evaluation of research and project proposals, report writing and interpretation, preparation, presentation and submission of manuscript, translation of a research project into a commercial venture-case studies.

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Electives DE-I, DE-II, DE-III for B.Tech BI, B.Tech BT and BTDD in Semester-B7 and D1

System Biology :Course Code 07B72BI401 (3-0-0) The subject introduces the student to apply the bioinformatics approaches to understand the functionalities of com-plex biological systems in holistic approaches. Topics include: system biology approaches, genetic network analy-sis, system discovery, modeling complex biological system, metabolic pathway analysis, Mass/Flux balance analysis, simulation of regulatory pathways, system approaches to metabolic networks, protein-protein interaction networks, Biocircuits: blocks and designing, case studies, E-cell project and applications in drug testing a case study.

This course will make student to understand organization of human genome, causes, pathophysiology, therapies, management of human genetic diseases and principles, technology and applications of gene therapy. Topics in-clude: General organization of the human nuclear and mitochondrial genome, Nucleosome, genome complexity, Chromosomes as functioning organelles: the Centromere and Telomere, Telomere replication Organization and dis-tribution of human genes, Human multigene families and repetitive coding DNA and non coding DNA. elements, Human chromosomal abnormalities- cause clinical symptoms, management and therapies, Human allelic diseases- cause, clinical symptoms, diagnosis, pathophysiology, therapies, management and potential treatments, Gene ther-apy and other molecular genetic-based therapeutic approaches.

Human genome and therapeutics :Course Code 07B72BI407 (3-0-0)

This course is designed for individuals interested in the scientific, policy, and management aspects of clinical trials. Topics include: Types of clinical research, study design, treatment allocation, randomization and stratification, qual-ity control, sample size requirements, patient consent, and interpretation of results. Students design a clinical investi-gation data base in their own field of interest.

Clinical Trials and Database Management: Course Code 07B71BT404 (3-0-0)

Emphasis of the course will be on application of bioinformatics approaches for screening of desire genes, proteins and lead compounds from a repository sources. Topics include: defining high throughput screening techniques and their applications, Microarray and high throughput screening of genes: general protocols, types, fabrication and print-ing of microarray, hybridization, image segmentation, data acquisition, data normalizations, analysis and clustering; Protein array and high throughput screening of proteins, Screening and annotation of genes and proteins based on in Silico approaches, Structure and ligand based approaches of screening of lead molecules.

High Throughput Screening Techniques: Course Code 07B72BI406 (3-0-0)

Introduction to Microbial world; Microbes of Importance to Environment, Health, Energy, Agriculture, and Industry; Microbial Genetics: Bacteria, Fungi, Viruses, etc.; Organization of Microbial Genomes; Microbial Genome Sequenc-ing and Analysis; Case Studies of Selected Bacteria and Fungi; Microbial Genome Databases; Bioinformatics Tools for Comparative Genome Analysis; Genome Evolution; Genome Engineering (reduced genome; pathway engineer-ing; Genome transplantation in bacteria); Microbial Genome Arrays; Microbial bio-prospecting: Industrial Sectors, Markets, and Strategies; Extremophiles: Genomics for Discovery of Novel Genes and Metabolites; Metagenomics: Technologies and Applications; Microbial e-Cell: Concept and Applications; Functional Genomics of Microbes: Tech-nologies and Applications

Microbial Genomics: Course Code 07B72BI402 (3-0-0)

Immunotechnology: Course Code 07B71BT407 (3-0-0)

An advanced course related to the subject of Immunology. This course dwells on practical and applied aspects of Immunology. Upon completion, the students will have an outlook on the applied aspects of Immunology. This elec-tive is offered in tandem with the elective Vaccine Manufacturing. Thus, indirectly, this course becomes an advanced level preparatory course

Stem Cells and HealthCare: Course Code 07B71BT414 (3-0-0)

This is an optional subject in which students will be acquainted with the general characteristics of various kinds of stem cells and the mechanisms by which they carry out their functions and the ethical consideration facing this re-search field would be discussed. Topics include: Stem cell categories, sources, isolation ,signaling, role in regen-erative medicine stem cell banking and guidelines pertaining to stem cell research in India and abroad

Molecular Diagnostics: Course Code 07B71BT409 (3-0-0)

This course aims to familiarize the students with the principles and applications of the latest state-of-the-art bio-molecular technology (with specific reference to Nucleic Acids and Proteins) used in Medical, Veterinary, and Foren-sic and Agricultural laboratories the world over.

Course D e s c r i p t i o n

The course presents the concepts and biotechnology applications that address global environmental concerns. Top-ics include: Successful evaluation, application and use of biotechnology in developing working models to mitigate environmental ills arising due to industrialization, urbanization, deforestation and global warming. Knowledge of envi-ronmental regulations followed in industries and ecosystem management will be discussed.

Environmental Biotechnology: Course Code 07B51BT304 (3-0-0)

Electives DE-IV, DE-V, DE-VI for B.Tech BI, B.Tech BT and BTDD in Semester-B8 and D2

Because the immune system shows a perfect ability to protect the organism, with an in-built memory, the same pre-sents itself as a good model for designing a computer immune system. Stand alone computers or several computers connected by a network can reproduce a number of properties of the biological immune system that include dis-tributability, fault tolerance, memory, autonomy, multi-layering, dynamic coverage, novelty detection, etc. In this course a background of artificial/natural immune systems/networks, architecture, algorithms and applications will be researched and presented

Immunocomputing: Introduction, Principles and Applications: Course Code 07B72BI416 (3-0-0)

Molecular Aspects of Life style Diseases :Course Code 07B71BT432 (3-0-0)

The course is designed for the students to develop a sound concept about the life style diseases – their molecular basis and associated risk factors. The course broadly covers the major life style diseases recognized currently by WHO as well as the issues related to STD, drugs, substance abuses and stress. Topics include: Concept of health and wellness; major life style diseases (cardiovascular diseases, diabetes, hypertension, obesity, renal disorder) – patho-physiology, related risk factors and preventive strategies; sexually transmitted diseases; diseases associated with smoking, alcohol, drug and substance abuse; stress related disorder; nutritional habits and their impact on health; complete health concerns: consumer education/ awareness and life style impact

Bioenergy Technology: Course Code 07B71BT435 (3-0-0)

The aim of the course is to presents the fundamental aspects of the technology for using biofuels in the energy system. Topic include: Global considerations, biological constraints, fuel supply systems, fuel quality and combustion technology aspects will be discussed. Emphasis will be on understanding the need and know how of the bioenergy technology and biofuels.

The students will get acquainted with various aspects of commercial plant tissue culture and new innovations in this area, new innovation in up scaling micro propagation and phytochemical production through plant cell cultures. Top-ics include: Plant tissue culture/ Micropropagation at a glance, Designing commercial tissue culture Units, various routs and stages of micropropagation, Cost reduction and scale up of commercial micropropagation, New innova-tions to make commercial micro propagation efficient, Industrial Production Phytochemiclas, Secondary metabolites through plant cell cultures.

Industrial Plant tissue culture: Course Code 07B71BT433 (3-0-0)

Industrial enzymes: Course code 07B81BT421 (3-0-0)

Students will be acquainted with various applications of enzymes in biotechnology and pharmaceutical industry. Top-ics include: Fundamentals of catalytic mechanisms, Enzyme kinetics, Enzyme preparation and use, large-scale use of enzymes in solution proteases, in leather, production of glucose syrup, in sucrose industry, lactase in dairy and catalase in food industry, Immobilised enzymes and their uses, Future prospects for enzyme technology , Enzyme stabilization by selection and genetic engineering, Specific enzymes and their applications (Thermozymes, cold-adapted enzymes, ribozymes, hybrid enzymes, diagnostic enzymes, therapeutic enzymes).

Antibody engineering and manufacturing: Course code Techniques 07M31BT410 (3-0-0)

This is an advanced course related to the subject of Immunology. The goal of this course is to offer students an in-sight into the understanding of monoclonal antibodies engineering for practical use in medicine and biotechnology. Topics include: Generation of monoclonal antibody fragment, screening and selection strategies, clinical applica-tions in oncology, immuno-conjugates, manufacturing challenges, and the latest update on intellectual property is-sues and regulations related to antibody therapeutics.

Course D e s c r i p t i o n

This subject familiarizes the student with the basic principles of dealing with a bioterrorist event and demonstrate an understanding of the rules governing the dissemination, propagation and management of relevant diseases. Topics include: Historical perspectives, Danger of biowarfare/ terrorist acts, Estimates of socioeconomic impact, Biological agents employed against plants and animals, Anti-human Biological Agents - Types and Characteristics Anthrax, Plague, Tularemia, Q fever, Smallpox, Viral hemorrhagic fevers, Viral equine encephalitis, Botulism, Ricin, Staphylo-coccus entertoxin B (SEB) (Diagnosis, treatment prevention, control and potential use as bioweapon), Bioethics and prevention of the misuse of biological sciences, Other possibilities (Future concer)

Bioterrorism: Course Code 07B71BT418 (3-0-0)

Introduction to Product development in pharmaceutical company, process development, Operation and System, For-mulation development and Regulatory affairs involved in pharmaceutical industry; Manufacturing steps in pharma-ceutical industry: discovery of biopharmaceuticals, Initial Product characterization, Unit operations in the production of biopharmaceutical, Final product formulation, Product analysis; Manufacturing processes in food industry-Beverage Industry; Manufacturing processes in food industry- Dairy:

Manufacturing Processes and QC: Course Code 07B81BT424 (3-0-0)

To impart understanding of the basis of protein folding and stability in order to design mutations to modify protein structure, stability and function. Topics include: Introduction to protein engineering , Molecular Evolution Combina-torial Methods, Phage display and related methods, Methods of random mutagenesis, Expression of proteins in dif-ferent systems, Engineering to improve purification processes, Applications of protein engineering.

Protein Engineering and Applications: Course Code 07B81BT426 (3-0-0)

This course is designed to give a comprehensive understanding of what constitutes functional foods and nutraceuti-cals, specific research areas within functional foods and nutraceuticals. And the global regulatory issues pertaining to functional foods and nutraceuticals. Topics include: Introduction and definition of functional food, Nutraceuticals, Physiological targets of functional food- Anti obesity functional food, Influence of diet on aging and longevity, food and food components in prevention of cancer, Biotechnology strategies for producing specific food ingredients: pre-biotics from lactose, dextran and glucooligosaccharides, proteins and peptides, Probiotics: genomics of Lactic acid bacteria an its impact on functional food, Current research trends in functional food technology: bakery products, grains, beta-glucan, herbal tea, seaweeds, pectin, rutin, synbiotics from carrot juice, Technologies use in functional food: Encapsulation method, Nutrigenomics, Consumer issues of functional food.

Functional Food Technology: Course Code 07B71BT434 (3-0-0)

Plant genetic Engineering: Course Code 08B81BT433 (3-0-0)

The subject introduces the student to understand the nature of the non-directive counseling process and the need to educate the patient and family to make informed decisions relating to complex genetic situations. Topics include: Genetic Counseling an overview: Counseling, diagnostic testing and management of genetic disorders Human allelic diseases (monogenic and oligogenic), some important autosomal recessive and dominant disorders, Muscle disor-ders, Human chromosomal disorders, Genetic basis of neoplastic disorders, Perinatal Genetic counseling, Gene therapy, Genetic Counseling Risk Assessment and Genetic counseling and ethical issues

Genetic Counseling :Course Code 08B81BT429 (3-0-0)

The aim of this course is to make students familiar with the principles of plant genetic engineering and then to ex-pose them to the current status, trends. They will also get acquainted with latest innovative techniques, approaches and different potential plant metabolic pathaways which can be targets of plant genetic engineering for beneficial use. Topics include: Plant transformation technology, Transgene stability and gene silencing, Application of Plant genetic engineering for agronomic and quality traits, Chloroplast Transformation: advantages, vectors. Marker free transformation, Use of RNAi in plant metabolic engineering, Recent advances in metabolic engineering of plants for biotic and biotic stress, yield enhancement, production of secondary metabolites and other useful products.

The elective course is designed for students interested in learning about the molecular and cell biology of cancer and how this knowledge is being applied to the prevention, diagnosis and therapy of cancer. Topics include: Tumor pathology and epidemiology; tumor viruses and oncogenes; intracellular signaling; tumor suppressors; multi-step carcinogenesis and tumor progression; genetic instability in cancer; tumor-host interactions; invasion and metasta-sis; tumor immunology; cancer therapy.

Cancer Biology: Course Code 07B81BT419 (3-0-0)

Course D e s c r i p t i o n

To impart understanding of designing metabolic pathways to increase the formation of desired metabolites and de-crease formation of unwanted metabolites in bioprocesses. Topics include: Overview of biochemical pathways, Importance of secondary metabolites in medicine and agriculture, Identification of gross measurement errors. Meta-bolic flux analysis: Theory and applications, Application of 13C-isotopes for quantification of metabolic fluxes, Molecu-lar biological tools in metabolic engineering, Whole genome transcription analysis using DNA arrays, Implications of adding a new pathway.

Metabolomics Biosensors advanced biomaterials: Course Code 07D21BT116 (3-0-0)

This course is designed to give the biotechnology students a thorough understanding of the manufacturing proc-esses and quality control tests involved in different biotech industries including pharmaceutical, beverage and dairy. Topics include: Introduction to Product development in pharmaceutical company, process development, Operation and System, Formulation development and Regulatory affairs involved in pharmaceutical industry, Manufacturing steps in pharmaceutical industry: discovery of biopharmaceuticals, Initial Product characterization, Unit operations in the production of biopharmaceutical, Final product formulation, Product analysis, Manufacturing processes in food industry-Beverage Industry, Manufacturing processes in food industry- Dairy.

Stress proteins in medicine: Course Code 08B81BT431 (3-0-0)

Vaccine Manufacture: Course Code 08B81BT430 (3-0-0)

This course will provide an insight into the various roles of stress proteins in medicine. Topics include: Overview of the structure and function of stress proteins, Stress Proteins as Molecular Chaperones, Clinical Implications of the Stress Response, Stress proteins in aging and disease, Stress Proteins and Expression in Diseased Tissue, Stress Proteins and Specific Immune Responses, Heat shock proteins as emerging therapeutic targets.

Course D e s c r i p t i o n

Industrial Interaction and Summer Internship:

The B. Tech. students are required to undergo industrial training of 6-8 weeks after 6th semester in reputed industries or institutes pursuing advanced re-search of industrial relevance. The purpose of industrial training is to acquaint students with the RandD set up of industries working in India or abroad. The students also develop a team spirit while doing their project work.

Electives in Modules Addition to teaching core courses the Department has introduced a system of elective modules to the final year students of Biotechnology and Bioinformatics wherein students choose electives to strengthen skills in a particular technology. The Bioinformatics disci-pline has several sub-disciplines such as computational drug designing, bioinformatics tool development, biological databases, computational genome analysis, systems biology, etc. Similarly Biotechnology has several sub-disciplines such as industrial biotechnology, medi-cal biotechnology, agricultural biotechnology, food process engineering, environmental biotechnology, and pharmaceutical biotechnology, etc. The students are given an option of choosing elective modules from any branch of bioinformatics or biotechnology in order to broaden their knowledge and skill profile. We carry two electives in a module so that each student will have an option of specializing in 3 modules in 7th and 8th Semesters. We have also formulated interdisciplinary modules such as a module in biomathematics will have electives from the Department of Mathematics; a module in bioprogramming will have sub-jects from computer science and IT; a module in biomedical engineering will have electives from electronics and communication engineering; a module in nanobiotechnology will have subjects from physics. The module system is very dynamic w.r.t addition of new module and changing combination of electives in a module in order to keep pace with the advance-ments in science and technology. This system of modules complements effective imple-mentation of project work because the students can choose 3 modules relevant to their project work.

Final year project A distinctive feature of B. Tech. curriculum is the project work of total 20 credits in 7th and 8th semesters wherein the students are asked to come up with a research problem aimed at addressing unanswered questions in any area of bioinformatics or biotechnology or any other branch of science and technology. Each project student is affiliated to a faculty mem-ber to supervise the project work and also to provide guidance for effective and productive implementation of the project work. The monitoring of project work is quite stringent wherein the students are supposed to make a presentation before the entire faculty of the department. We in the department encourage students to come up with a publication, be in a national or international conference or journals. At the end of semester the students are required to write a project report which is graded as per the performance. The project work helps students in not only pursuing career in industry but also in getting admissions in top class Universities of the world. Since our students have very good hands on training which helps them to take up challenging projects in their future career pursuits.

Course D e s c r i p t i o n

Instructional Methodology We at the JUIT follow modern methods of teaching to B. Tech and M. Tech students in contrast to traditional methods of teaching. The teaching approach has been diversified with the overall objective of creating an environment of independent thinking and problem solving skills among students. Following is the distribution of teaching methodology followed for the B. Tech programmes.

Teacher centric: Theoretical concepts are provided by the teacher through lectures and discussions in the class room. Learner centric: The student is an active participant in the process of learning; the pace of learning is controlled by the class. Tutorial teaching: Aimed at developing instant problem solving skills Practical training: Aimed at developing technological skills

Classroom learning:

Class room

BI Lab BT Lab

Classroom learning Tutorial

learning

Practical

Presentations &

seminars Workshops and

Visits to Plant sites

Industrial training Guest lectures

& conferences

Assignments

Test-III (30%) Test-II (25%)

Test-I (20%)