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Topics for Today
• What are ions?
• How is radiation detected?
• How do you stop alpha radiation? Beta? Gamma?
• Nuclear Medicine
Topics for Friday
• Nuclear Fission– The BIG difference between U-235 and U-238– Nuclear Fission– Fission Products (Nuclear Waste and Fallout)– Quiz #2
PRELAB QUIZ for Week #3
Due BEFORE your lab
this week
You will have three attempts
this week (and for all the rest).
Topics for Today
• What are ions?
• How is radiation detected?
• How do you stop alpha particles? Beta? Gamma rays?
• Nuclear Medicine
What is an ion?
A charged atom or molecule.
The charge can be positive or negative.
I- H2O+How are ions
formed?
What is an ion?
A charged atom or molecule.
The charge can be positive or negative.
I- H2O+How are ions
formed?
Ions are formed when there are unequal numbers of protons and electrons.
Sodium in a Lake
• http://www.spikedhumor.com/player/FullScreen.aspx?file=http://www.spikedhumor.com/prerolls/78660/2/0/1/data.xml&item=1×tamp=19&id=78660
Ions commonly found in nature.
Table Salt (sodium chloride)
Limestone
(calcium carbonate and magnesium carbonate)
Baking Soda
(sodium bicarbonate)
How is iodine utilized in your body?
Chapter 11: Nutrition
• Minerals: Macro and Micro
(page 511)How long until a
sample of I-131 is “gone” from a
patient’s body?
How is iodine used in your body?
I2 molecule?
Two iodine atoms
A gas
Elemental iodine? Iodide Ion?
ORI-
Geiger Counter
• Filled with an inert gas (often argon).
Ar Ar+ + e- Detected by electronics
How is this different from a beta particle?
Alpha radiation
np n
p
Alpha radiation can generally be blocked by a piece of paper.
When is alpha
radiation dangerous
?
Ionizing Radiation
Symbol Mass Energy
Alpha Particle α 4 Low
Beta Particle β ~0 Medium
Gamma Ray γ
0 High
0
-1
0
0
4
2
Review - Isotopes
Which isotope of iodine will
concentrate in the thyroid?
131I- vs. 127I-
I-131? I-127? Both?
Review - Isotopes
Which isotope of iodine will
concentrate in the thyroid?
131I- vs. 127I-
I-131? I-127? Both!
Chemically speaking,
isotopes behave almost identically
Thyroid
The iodide ion (I-) concentrates in your thyroid
Which isotope of iodine will the patient be given
to ingest?I-127 or I-131?
A gamma scintillation camera measures the gamma rays emitted from the thyroid at three directions, producing a picture of the thyroid.
• This nuclear medicine technique measure the degree of function of the thyroid. – That is, how well does
the thyroid take up iodine?
• Positron Emission Tomography (PET)
Any other nuclear imaging
techniques?
Also requires the use of a radioisotope.
Positron Emission Tomography (PET)
A positron is an “anti-electron,” a type of anti-matter.
SAME mass as an electron
OPPOSITE charge
Known as β0
1
• Some positron emitters…
• 13N 10 min
• 15O 2 min
• 18F 110 min
t1/2ALL of these isotopes are man-made
Annihilation Reaction
• An electron is never far away…
eβ +0
1
0
-12 γ0
0
Anti-Matter
Matter ENERGY!!
Positron Electron
Annihilation Reaction
• An electron is never far away…
eβ +0
1
0
-12 γ0
0
Anti-Matter
Matter ENERGY!!
What about the gamma rays?
Annihilation Reaction
• An electron is never far away…
eβ +0
1
0
-12 γ0
0
Anti-Matter
Matter
Equal energy gamma rays
are emitted in opposite
directions.
• A common type of scan uses 18F “labeled” glucose.
• This glucose is metabolized in your body exactly as “normal” glucose.
• A common type of scan uses 18F “labeled” glucose.
• This glucose is metabolized in your body exactly as “normal” glucose.
• With PET, we can “see” exactly where the glucose is going!
So what?
• A common type of scan uses 18F “labeled” glucose.
• This glucose is metabolized in your body exactly as “normal” glucose.
• With PET, we can “see” exactly where the glucose is going!
• Like with I-131 imaging of the thyroid, PET measures REAL-TIME function of an organ (brain, for example), and NOT the anatomy.
• Like with I-131 imaging of the thyroid, PET measures REAL-TIME function of an organ (brain, for example), and NOT the anatomy.
Functional changes are noticed earlier than
structural changes in your body.