ToolsforADME/Tox - Főoldal · 6 ADME/Toxanalyses AsADME/Toxanalysesbecomemoreadvanced andreliableintermsofaccuracyandprediction, anincreaseintheirusageisexpectedduringthe

Tools for ADME/Toxreagents, standards and model systems

All care has been taken in the compilation of the information contained in thiscatalogue. However, any applications for products are suggestions only, and LGCStandards makes no express or implied representations or warranties regardingthe accuracy, content, completeness, or reliability of the information or anysuggestions provided, and specifically disclaims any and all implied warrantieswith respect to the same, including without limitation any warranties ofmerchantability, fitness or suitability for particular purpose.

� Metabolite standards� Labelled

� Unlabelled

� Enzyme inducers

� Enzyme and transporter,substrates and inhibitors

� Model systems

Example

Example

How to use this reference guide

The new Tools for ADME/Tox guide has been

assembled to make the often time consuming

task of finding the right standards, reagents and

model systems for your research easier than

ever before.

The general product listing on page 26 is

supported by a range of application based index

tables focusing on different pathways including:

• Cytochrome P450 isoenzymes

• Phase II metabolising enzymes

• Transporters.

Each index has been produced detailing the

metabolising enzyme with the relevant substrate,

metabolite, inhibitor or inducer. For easy

reference, substrates and metabolites for any

single metabolism enzyme have been aligned

on opposing pages of the index section.

Index listings

Each metabolism enzyme has relevant

substrates, metabolites, inducers and inhibitors

relevant to the enzyme listed with reference to

FDA Drug Development and Drug interactions:

Table of Substrates, Inhibitors and Inducers

(Appendix I).

1 Metabolising enzyme name

2 Generic substrate/metabolite/inducer/

inhibitor name

3 Reference to FDA preferred (P) and

acceptable (A) compounds as found

in the Drug Development and Drug

Interactions: Table of Substrates,

Inhibitors and Inducers. www.fda.gov

(Appendix I)

4,5,6 Tick refers to presence in the catalogue

listing as either an unlabelled, labelled or

fluorescent compound. All compounds

appear in the catalogue listing.

Compound catalogue listing

The catalogue listing includes all products

indicated by a tick in the index tables. In addition

there are specific quick reference guides for

labelled and fluorescent products (pages 41

and 43) following the general catalogue listing.

1 Generic compound name as found in

the index

2 LGC Standards catalogue number

3 Actual product description

4 Pack size available.

Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.

LGC catalogue no.

TRC-A168125TRC-A168125-100TRC-A192400TRC-A192400-2.5TRC-A192402TRC-A192402-10TRC-A247500

Product description

5-Acetylamino-6-amino-3-methyluracil, Hydrate5-Acetylamino-6-amino-3-methyluracil, HydrateAcyclovirAcyclovirAcyclovir-d4Acyclovir-d4Adefovir

Pack size

10 mg100 mg250 mg2.5 g1 mg10 mg10 mg

Index description

AAMU (5-acetylamino-6-amino-3-methyluracil)AAMU (5-acetylamino-6-amino-3-methyluracil)AcyclovirAcyclovirAcyclovirAcyclovirAdefovir

42 31

Substrates: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

CYP450metabolismenzymes

CYP1A1

CYP1A2

CYP1A2

CYP1A2

CYP1A2

Substrate

7-ethoxyresorufin

7-ethoxyresorufin

R-warfarin

Phenacetin

Tacrine

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FDA

A

P

A

Labelled

�

�

Fluorescent

1 2 4 5 63

FRANCE

Molsheim

Borås

LuckenwaldeWesel

SWEDEN

GERMANY

LomiankiPOLAND

Brno

CZECH REPUBLIC

Turku

FINLAND

Cluj-Napoca

ROMANIA

BULGARIASofia

SzentendreHUNGARY

MilanITALY

SPAINBarcelona

Beijing

CHINA

TURKEY

Istanbul

INDIAMumbai

Bangalore

Hyderabad

Magherafelt

Bury

Teddington

N. IRELAND

UKIRELAND

St Petersburg Russia

Rhode IslandUSA

dards l

About LGC Standards

LGC Standards is recognised by laboratory

scientists throughout the world as a leading

supplier of analytical standards, products and

services to support laboratory quality. The LGC

Standards product portfolio includes:

• Comprehensive source of reference materials

for a wide range of analyses including food,

environmental, pharmaceutical, clinical

and industrial;

• Production of pharmaceutical impurities

and custom synthesis;

• Proficiency testing schemes;

• Analytical quality training courses;

• Biological standards and controls.

Partnerships

Our partnerships with many of the world’s

leading standards and reference materials

producers combined with our own production

capabilities have positioned LGC Standards as

an integral supplier to both research and quality

control laboratories across a diverse range of

industries. Our partnership with ATCC® has

helped to facilitate the supply of biological

cultures and bioproducts to the European life

science research community for almost 10 years.

The new Tools for ADME/Tox guide provides

a uniquely formatted range of products that

have been developed to aid drug discovery

and development researchers find the right

standards, reagents and model systems to

support their research.

Our team of technical support and regulatory

specialists are on hand to provide expert advice

on sourcing the right materials for your research

and assistance with regulatory requirements

associated with controlled substances.

LGC Standards - global quality management solutions for the laboratory.

www.lgcstandards.com

Genuine ATCC culturesand bioproducts for theEuropean pharmaceuticalcommunity

LGC Standards is the exclusive distributor of ATCC®

cultures and bioproducts in Europe. We are committedto providing authentic, high-quality ATCC cultures tosupport quality control and research activities acrossthe pharmaceutical industry.

With a local stock of all key quality control strains anda wide selection of other cultures, LGC Standards is ableto offer:

� Faster delivery of ATCC products

� Expert technical support

� Expedited handling of special forms and paperworkto meet import regulations

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For further information or to receive any one of ourcatalogues, please contact your local office or visitour website.

www.lgcstandards-atcc.org

Primary cells

Cell lines and hybridomas

Cell culture media, seraand reagents

Animal and plant viruses

Genomic DNA

Quality control strains

cDNA clones, vectorsand libraries

Microbial media andsupplements

Cyropreservation products

Contents

Drug stability

ADME/Tox analyses

Drug-Drug interaction studies

CYP inhibition and induction

Evaluating permeability

Isotopically labelled products

Transporters

Model systems

Enzyme and transporter index

Substrates and metabolites

Phase I metabolising enzymes; CYP450

Phase II metabolising enzymes

Inhibitors

Phase I metabolising enzymes; CYP450


Inducers

Phase I metabolising enzymes


Transporters: Substrates and inhibitors

Compound catalogue list

Catalogue (labelled, unlabelled and fluorescent)

Quick reference compound lists

Fluorescent products only

Labelled products only

ATCC® microbiology cultures

ATCC® cell biology cultures

Primary cells, media and reagents

Fresh hepatocytes from LGC Standards

Ultra pure solvents

Introduction

Reagents / sorbents

Ion pair reagents

LC-MS additives

High purity solvents and acids

Appendix I

Appendix II

6

6

7

7

7

8

9

10

11

12

16

20

21

22

23

24

27

41

43

50

51

54

55

56

57

58

58

59

60

78

79

6 www.lgcstandards.com

ADME/Tox analyses

As ADME/Tox analyses become more advanced

and reliable in terms of accuracy and prediction,

an increase in their usage is expected during the

initial development and screening phase of

innovative drug development. The approval of

new drugs commonly takes between seven and

ten years and has been estimated to cost

between $700 million and $900 million. Estimates

that up to 90 per cent of the clinical candidates

are likely to fail due to pharmacokinetics,

ADME-related problems, lack of efficacy and

side effects make new compound development

a high risk business for drug companies. As a

result, researchers are realising the importance

of screening potential hit compounds for

significant ADME and toxicity profiles earlier

in their development.

Drug stability

The way in which a compound is metabolised or

accumulated in the body is a key determinant of

bioavailability. A drug that is rapidly metabolised

may require multiple daily dosing or continuous

infusion to maintain a concentration in the

bloodstream or target organ that is sufficient to

elicit a therapeutic effect. However, a slowly

metabolised drug may remain in the body for

long periods, causing toxic build-up.

For evaluating oxidative or conjugation

metabolism, a variety of model systems are

available including:

• Liver microsomes

• Liver S9

• Hepatocytes

• Intestinal microsomes

• Intestinal S9

• Individual CYP isoforms for CYP phenotyping

(phase 1 metabolism)

• Individual UGT isoforms for assessing

phase 2 metabolism.

The use of hepatocytes may provide a model

more representative of the in vivo situation

because they contain a cell membrane and

do not require additional co-factors (as with

microsomes). Hepatocytes contain enzymes

for both phase I (oxidation, reduction and/or

hydrolysis of test compound) and phase II

(conjugation of test compounds or metabolites)

metabolism.

7www.lgcstandards.com

Drug-Drug interaction studies

Metabolism-based drug-drug interactions occur

when a drug inhibits or induces the activity of a

drug metabolising enzyme, which catalyzes the

metabolism of the concomitant drug.

Metabolism-based drug-drug interaction is one

of the major factors that cause drug failures

during development. Early stage screening of

compounds for potential drug-drug interactions

using in vitro techniques becomes necessary in

order to decrease late stage compound attrition.

DMPK laboratories provide a wide variety of

valuable metabolism-based drug-drug interaction

screening assays, such as cytochrome P450

(CYP) inhibition assays and CYP induction

assays.

CYP Inhibition assays

Fluorescent dyes: The probe substrates used

in these assays are derivatives of coumarin or

resorufin, which after dealkylation by CYPs will

generate fluorescent products. Because these

substrates are generally not highly specific to

the individual CYP isozyme confirmation studies

are required to identify specific inhibition effects.

The more detailed and confirmative investigation

of CYP inhibition should use traditional probe

substrates, which are more specific to individual

CYP isoforms. For instance, midazolam

1-hydroxylation and testosterone 6β-hydroxylationare pathways catalysed predominantly by

CYP2D6. Because these substrates are more

specific to individual CYP isoforms, the inhibition

assays can be performed with not only the

individual recombinant CYP isoform but also the

liver microsomes or other tissue preparations,

such as hepatocytes, which contain all CYP

enzymes (see page 12).

CYP Induction

Some chemicals can induce the activity of CYP

enzymes. The chemical inducers will increase

the metabolism of concomitant drugs that are

the substrates of the induced CYP enzymes,

resulting in concomitant drugs losing efficacy.

CYP enzymes such as CYP1A2, CYP2B6,

and CYP3A4 are susceptible to induction (see

page 22).

The induction assays are typically performed

using plateable human or rat hepatocytes

(see page 55).

Evaluating permeability

Drug permeability through cell monolayer has

been shown to correlate well with intestinal

permeability and oral bioavailability. Drugs with

low membrane permeability, i.e. low lipophilicity,

are generally absorbed slowly from solution in

the stomach and small intestine. Knowing the

rate and extent of absorption across the intestinal

tract is critical if a drug is to be orally delivered.

One of the most important systems for in vitro

human experimentation is the Caco-2 cell

system for monitoring intestinal absorption

and secretion of drugs (see page 53).

Caco-2 / TC7 (ATCC® CRL-2102TM and HTB-37TM)

Mandin-Darby canine kidney (MDCK) cells are

used as a model for studying drug transport in

distal renal epithelia (see page 51).

MDCKII, MDCK (ATCC® CCL-34TM)

MDR1-MDCKII


Isotopically labelled products

Due to its high selectivity and sensitivity liquid

chromatography-mass spectrometry (LC-MS)

with quadrupole mass analysers are replacing

traditional UV detection in many bioanalytical

laboratories. ESI, APCI and APPI have become

the ionization techniques of choice, covering a

wide variety of analytes.

The LC-MS methods are usually validated

according to the FDA’s 2001 Guidance:

Bioanalytical Method Validation.

Isotopically labeled (2H or 13C) internal

standards have become very popular because

they are capable of compensating for losses

during sample preparation; LC separation; and

differences in ionisation efficiencies or degree

of ionisation often caused by co-elution of matrix

constituents with the analyte.

The labelled products listing begins on page 43.


Transporters

Current evidence suggests that the role of

transporters in the absorption, distribution, and

excretion of drugs as well as in pharmacology,

toxicology and drug-drug interactions (DDIs)

may be significant. Currently, regulatory

agencies are focusing on these potential

transporter-mediated DDIs.

The molecular and functional characterisation

of transport proteins is emerging rapidly and

significant numbers of drugs have been shown

to be substrates or inhibitors.

Two major groups of proteins are involved in

drug transport. The first includes multispecific

solute carrier (SLC) transporters, facilitating

the cellular entry or exit of a wide range of

compounds. In the liver, transport proteins are

present on the sinusoidal membrane that can

be the rate-limiting step in hepatic clearance for

some drugs. Mechanistic studies clearly suggest

a key role and broad substrate specificity for the

SLC family.

The second major group of transporters are the

multidrug resistance (MDR) ATP binding

cassette (ABC) proteins. They play an important

role in cancer drug resistance, protection against

xenobiotics, and in the passage of drugs through

cellular and tissue barriers. For absorption, a

clear role has emerged for P-glycoprotein (Pgp)

in limiting permeability across the gastrointestinal

tract. Pgp and MRP2 govern also active biliary

excretion. Similarly, at the blood-brain barrier

a range of drugs has limited brain penetration

due to Pgb-mediated efflux, which can limit

therapeutic effectiveness of CNS agents.

In drug discovery, key challenges are to choose

the most appropriate and convenient assay, and

to implement and validate the results. According

to the current guidelines of the FDA, such

investigations should be performed in the early

stage of drug development, using ‘suitable in vitro

probes’. For predicting in vivo drug–transporter

interactions, the FDA recommends cell-based

transport assays, such as Caco-2 and

Pgp-transfected forms of the MDCK or LLC-PK1

cells (see page 51).


Model systems

There are a variety of cell types and other model

systems used across many different applications

in pre-clinical research. These models, many

of which are described on page 6 are used to

develop an insight into the efficacy and potential

of new drug candidates including applications

in pharmacology, toxicology and other assay

or study types. ATCC® cells which may be

appropriate as model systems can be found

on pages 51 - 54.

Fresh hepatocytes

LGC Standards can supply fresh hepatocytes

from a variety of species. The use of fresh

hepatocytes offers a number of advantages

over other model systems particularly in

experiments designed to investigate enzyme

induction, membrane transport and phase II

metabolism. Each batch of cells can be provided

with a certificate of analysis and despatched

guaranteeing delivery the following day.


(page 55)

• Plateable single source hepatocyte

preparations

• Availability from a variety of species

• Full enzyme profile maintained allowing

assessment of phase II metabolism

• Transport mechanisms and functional

integrity maintained allowing increasingly

important transport mechanisms to be

investigated

• Cells available in suspension or multi-well

plated format.

Hepatocytes are available in a range of formats.

Discounts are available for large volume users.

Contact your local LGC Standards office for

further information including isolation schedules

.

ATCC® Primary Cell Solutions™ (page 54)

Primary cell cultures more closely mimic the

physiological state of cells in vivo and generate

more relevant data representing living systems.

ATCC® Primary Cell Solutions™ are designed

to provide all of the components needed to

assemble a complete culture system for specific

cell types. Backed by the same quality, service,

and support that you have come to expect from

ATCC, the product offering is comprised of:

• Cryopreserved primary cells of the highest

quality from a trusted source;

• Optimised media and growth factor kits to

support growth in serum-free or low serum

conditions; and,

• Reagents that have been fine-tuned for

reliable use with primary cells.

Enzyme and transporterindex

� Metabolite standards

� Substrates

� Inhibitors

� Inducers




CYP1A1

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1B1

CYP2A1

CYP2A6

CYP2A6

CYP2A6

CYP2B1

CYP2B6

CYP2B6

CYP2B6

CYP2B6

CYP2C8

CYP2C8

CYP2C8

CYP2C8

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C11

CYP2C11

CYP2C19

CYP2C19

CYP2C19

Substrate

7-ethoxyresorufin

7-ethoxyresorufin

R-warfarin

Phenacetin

Tacrine

Theophylline

Caffeine

R-warfarin

7-benzyloxyresorufin

Testosterone

Coumarin

Nicotine

Nicotine

Testosterone

S-mephenytoin

Bupropion

Propofol

Efavirenz

Taxol

Amodiaquine

Paclitaxel

Rosiglitazone

Naproxen

Tolbutamide

Diclofenac

R-warfarin

S-warfarin

Tolbutamide

Flurbiprofen

Phenytoin

Testosterone

Testosterone

S-mephenytoin

Omeprazole

Fluoxetine

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FDA Drug development and drug interaction guidance tables (Appendix I)P = Preferred substrate A = Acceptable substrate

Please note: Greyed substrates were not available at date of printing. Please contact your local LGC Standards for current availability.


Metabolites: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’


CYP1A1

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP1B1

CYP2A1

CYP2A6

CYP2A6

CYP2A6

CYP2B1

CYP2B6

CYP2B6

CYP2B6

CYP2B6

CYP2C8

CYP2C8

CYP2C8

CYP2C8

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C11

CYP2C11

CYP2C19

CYP2C19

CYP2C19

Metabolite

Resorufin

Resorufin

6-hydroxywarfarin

Paracetamol (Acetaminophen)

1-methylxanthine

Paraxanthine

8-hydroxywarfarin

Resorufin

6α-hydroxytestosterone (rat metabolite)7-hydroxycoumarin

Cotinine

3-hydroxycotinine (secondary)

S-(+)-N-desmethylmephenytoin (S-Nirvanol)

Hydroxybupropion

4-hydroxypropofol

8-hydroxyefavirenz

Desethylamodiaquine

6α-hydroxypaclitaxel5-hydroxyrosiglitazone

O-desmethylnaproxen

Carboxytolbutamide

4'-hydroxydiclofenac

6-hydroxywarfarin

7-hydroxywarfarin

4-hydroxytolbutamide

4'-hydroxyflurbiprofen

4-hydroxymephenytoin

5-hydroxyomeprazole

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CYP2D6

CYP2D6

CYP2D6

CYP2D6

CYP2D6

CYP2E1

CYP2E1

CYP2E1

CYP3A2

CYP3A2

CYP3A1&2

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4/5

CYP3A4/5

CYP2J2

CYP4F12

Substrate

Metoprolol

Tramadol

Bufuralol

Debrisoquin

Dextromethorphan

Lauric acid

Chlorzoxazone

7-ethoxycoumarin

Testosterone

Testosterone

Felodipine

Terfenadine

Quinidine

Dapsone

Oxybutynin

Cortisol

Terfenadine

Paclitaxel

Testosterone

7-benzyloxyresorufin

R-warfarin

S-warfarin

Midazolam

Dextromethorphan

Midazolam

Terfenadine alcohol metabolite

Nifedipine

Erythromycin

Triazolam



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FDA Drug development and drug interaction guidance tables (Appendix I)P = Preferred substrate A = Acceptable substrate

Please note: Greyed substrates were not available at date of printing. Please contact your local LGC Standards for current availability.


Metabolites: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’


CYP2D6

CYP2D6

CYP2D6

CYP2D6

CYP2D6

CYP2E1

CYP2E1

CYP2E1

CYP3A2

CYP3A2

CYP3A1&2

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4/5

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4/5

CYP3A4/5

CYP2J2

CYP4F12

Metabolite

α-hydroxymetoprololO-desmethyltramadol

1-hydroxybufuralol

(Â±)-4-hydroxydebrisoquin sulfate

Dextrorphan

6-hydroxychlorzoxazone

7-hydroxycoumarin

Dehydrofelodipine

(3S)-3-hydroxyquinidine

Dapsonehydroxylamine

Desethyloxybutynin

6β-hydroxycortisol

p-3-hydroxypaclitaxel

6β-hydroxytestosteroneResorufin

10-hydroxywarfarin

4-hydroxywarfarin

1'-hydroxymidazolam

4-hydroxymidazolam

Fexofenadine

N-demethylerythromycin

4-hydroxytriazolam

Fexofenadine

Fexofenadine

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Substrates: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase IIMetabolismEnzymes

UGTs

UGTs

UGTs

UGTs

UGTs

GSTs

SULTs

SULTs

NATs

UGT Isoform

1A1

1A1

1A1

1A4

1A4

1A4

1A4

1A4

1A6

1A6

1A6

1A8

1A9

1A9

1A10

2B7

2B7

2B7

2B7

Substrate

Morphine

4-hydroxymidazolam

Naproxen

Hydromorphone

7-hydroxycoumarin



7-hydroxycoumarin

Dapsone

SN-38 (Irinotecan metabolite)

Estradiol

Etoposide

Imipramine

Olanzapine

Trifluoperazine

Midazolam

Posaconazole

Serotonin

Deferiprone

Diclofenac

Hydroxydesloratadine

Propofol

Sulfinpyrazone

Dopamine

Carbamazepine

21-hydroxyprogesterone

Zidovudine (azidothymidine, AZT)

Morphine

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Metabolites: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase IIMetabolismEnzymes

UGTs

UGTs

UGTs

UGTs

UGTs

GSTs

SULTs

SULTs

NATs

UGT Isoform

1A1

1A1

1A1

1A4

1A4

1A4

1A4

1A4

1A6

1A6

1A6

1A8

1A9

1A9

1A10

2B7

2B7

2B7

2B7

Metabolite

Morphine-3-β-D-glucuronide4-hydroxymidazolam-β-D-glucuronideNaproxen acyl-β-D-glucuronideHydromorphone-3-glucuronide

7-hydroxycoumarin-glucuronide

Paracetamol-glutathione

Paracetamol sulfate

7-hydroxycoumarin sulfate

Monoacetyldapsone

Olanzapine-glucuronide

1'-hydroxymidazolam-β-D-glucuronide

Deferiprone-3-O-β-D-glucuronideDiclofenac acyl-β-D-glucuronide3-hydroxydesloratadine-β-D-glucuronide

Dopamine-3-β-D-glucuronide

Morphine-6-β-D-glucuronide

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Substrates: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

SULT Isoform

2A1

1E1

1E1

1A3

NAT Isoform

Mouse Nat-1

Mouse Nat-2

NAT-1

NAT-1

NAT-2

NAT-2

NAT-2

NAT-2

NAT-2

Substrate

Raloxifene

4-hydroxytamoxifen

Ethynylestradiol

Troglitazone

Isoniazid

p-aminobenzoic acid

p-aminosalicylic acid

p-aminobenzoic acid

Sulfamethazine

Procainamide

Isoniazid

7-aminoclonazepam

AFMU (5-acetylamino-6-formylamino-3-methyluracil)

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Metabolites: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

SULT Isoform

2A1

1E1

1E1

1A3

NAT Isoform

Mouse Nat-1

Mouse Nat-2

NAT-1

NAT-1

NAT-2

NAT-2

NAT-2

NAT-2

NAT-2

Metabolite

Ethynylestradiol-3-sulfate

N-acetyl-4-aminosalicylic acid

N-acetylsulfamethazine

AAMU (5-acetylamino-6-amino-3-methyluracil)

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Fluorescent


Inhibitors: Phase l metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase Imetabolismenzymes

CYP1A2

CYP1A2

CYP2A6

CYP2A6

CYP2A6

CYP2A6

CYP2B6

CYP2B6

CYP2B6

CYP2B6

CYP2B6

CYP2B6

CYP2C8

CYP2C8

CYP2C8

CYP2C8

CYP2C8

CYP2C9

CYP2C9

CYP2C9

CYP2C9

CYP2C19

CYP2C19

CYP2C19

CYP2C19

CYP2C19

CYP2C19

CYP2C19

CYP2D6

CYP3A4

CYP3A4

CYP3A4

CYP3A4/5

CYP3A4/5

CYP3A4/5

CYP3A4/5

Inhibitor

Fluvoxamine

α-naphthoflavoneMethoxsalen

Pilocarpine

Tranylcypromine

Tryptamine

Ketoconazole

Clopidogrel

Phencyclidine

Sertraline

Ticlopidine

Thiotepa

Gemfibrozil

Quercetin

Montelukast

Pioglitazone

Trimethoprim

Fluvastatin

Fluconazole

Fluoxetine

Fluvoxamine

(+/-)-N-3-benzylnirvanol

(S)-(+)-N-3-benzylnirvanol

(R)-(-)-N-3-benzylnirvanol

Ticlopidine

Tranylcypromine

Nootkatone

Oxybutynin

Quinidine

6',7-dihydroxybergamottin

Erythromycin

Troleandomycin

Ketoconazole

Azamulin

Itraconazole

Verapamil

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Inhibitors: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase IImetabolismenzymes

UGTs

UGTs

UGTs

UGT 1A1

UGT 1A4

UGT 2B7

SULT 1E1

NAT2

NAT2

Inhibitor

Quercetin

Valproic acid

Probenecid

Atazanavir

Hecogenin

Fluconazole

Tricin

Paracetamol(Acetaminophen)

Retinoic acid

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Labelled

FDA Drug development and drug interaction guidance tables (Appendix I)

P = Preferred inhibitor

A = Acceptable inhibitor


Inducers: Phase I metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase Imetabolismenzymes

CYP1A

CYP1A1

CYP1A2

CYP1A2

CYP1A2

CYP1A2

CYP2A6

CYP2B6

CYP2B6

CYP2B6

CYP2C8

CYP2C9

CYP2C9

CYP2C19

CYP3A

CYP3A1

CYP3A2

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

CYP3A4

Inducer

β-naphthoflavone (RatCYP1A)Omeprazole3-methylcholanthreneLansoprazoleβ-naphthoflavoneOmeprazoleDexamethasonePhenobarbitalPhenytoinRifampicinPhenobarbitalPhenobarbitalRifampicinRifampicinDexamethasone (RatCYP3A)RifampicinRifampicinRifampicinDexamethasonePhenobarbitalPhenytoinRifapentineTroglitazone

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Inducers: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’

Phase IImetabolismenzymes

UGTs

UGTs

UGTs

UGTs

GST

Inducer

Phenobarbital

Phenytoin

Carbamazepine

Efavirenz

Sulforaphane

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Labelled

FDA Drug development and drug interaction guidance tables (Appendix I)

P = Preferred inducer

A = Acceptable inducer


Substrates and inhibitors: TransportersThe catalogue tab contains all compounds listed in substrate and inhibitor columns available as labelled and non-labelled products.

Gene

ABCB1

ABCB4

ABCB11

ABCC1

abcc2

ABCC2

ABCC3

ABCC4

ABCC5

ABCC6

ABCG2

slco1a1

SLCO1A2

SLCO1B1

Aliases

P-gp, MDR1,GP170, PGY1,CLCS

MDR2, MDR3, PGY3,GBD1, PFIC-3BSEP, PFIC-2,PGY4, SPGPMRP1, GS-X

ratMrp2MRP2, CMOAT,DJS

MRP3, cMOAT2,MLP2, MOAT-D

MRP4, MOAT-BMRP5, MOAT-C,SMRPMRP6, MLP1, PXE,ARABCRP, MXR, ABCP

ratOatp1a1OATP1A2, OATP-A,OAT-P, SLC21A3OATP1B1, OATP-C,LST-1, SLC21A6

Inhibitor

Cyclosporine A, Elacridar,Ketoconazole, Nelfinavir,Quinidine, Reserpine, Ritonavir,Saquinavir, Tacrolimus,Verapamil

Cyclosporine A

Elacridar (GF120918), Gefitinib,Lapatinib, Erlotinib, Novobiocin,Ritonavir, Chlorothiazide

Ketoconazole

Cyclosporine A, Rifamycin

Substrate

Digoxin, Loperamide,Quinidine, Vinblastine

Digoxin, Paclitaxel, Vinblastine

Vinblastine

Adefovir, Indinavir, Paclitaxel,Flutamide, EtoposideProbenecidIndinavir, Cisplatin,Probenecid, Estradiol,Bilirubin glucuronide,Etoposide, DoxorubicinEtoposide (VP-16),Methotrexate,Benzbromarone, CisplatinMethotrexate, Adefovir6-mercaptopurine,ThioguanineCisplatin, Daunorubicin

Daunorubicin, Doxorubicin,Topotecan, Rosuvastatin,Sulfasalazine, Mitoxantrone,Prazosin, Methotrexate

Rifampicin, Rosuvastatin,Methotrexate, Pravastatin,Thyroxine, Atorvastatin,Pitavastatin, Valsartan,Olmesartan, Enalapril,Temocaprilat, Benzylpenicillin,Cerivastatin


Substrates and inhibitors: TransportersThe catalogue tab contains all compounds listed in substrate and inhibitor columns available as labelled and non-labelled products.

Gene

SLCO1B3

SLCO2B1

SLCO4C1

SLC10A1

SLC15A1

SLC15A2

SLC22A1

SLC22A2

SLC22A3

SLC22A4

SLC22A5

SLC22A6

SLC22A7

SLC22A8

Aliases

OATP1B3, OATP8,SLC21A8

SLC21A9, OATP-B,OATP2B1OATP4C1, OATP-H,OATPX, SLC21A20NTCPPEPT1, HPECT1,HPEPT1PEPT2

OCT-1

OCT-2

OCT-3, EMT

OCTN1,MGC34546OCTN2, SCD,CDSPOAT1, ROAT1,PAHTOAT2, NLTOAT3

Inhibitor

Fluvastatin

Fluvastatin

Cefadroxil

Disopyramide, Midazolam,Phenformin, Phenoxy-benzamine,Quinidine, Quinine, Ritonavir,VerapamilDesipramine, Phenoxy-benzamine,Quinine, VerapamilDesipramine, Prazosin,Phenoxy-benzamine

Probenecid, Cefamandole,Cefazolin, Benzbromarone

Probenecid, Cefadroxil,Cefamandole, Cefazolin

Substrate

Digoxin, Methotrexate,Rifampicin, Rosuvastatin,Pravastatin, Pitavastatin,Fexofenadine, Digoxin,Paclitaxel, Repaglinide,Telmisartan, Valsartan,OuabainPravastatin, Benzylpenicillin

Digoxin, Ouabain

RosuvastatinAmpicillin, Amoxicillin,Captopril, ValacyclovirAmpicillin, Amoxicillin,Captopril, ValacyclovirAcyclovir, Amantadine,Desipramine, Ganciclovir,Metformin

Amantadine, Cimetidine,MemantineCimetidine

Quinidine, Verapamil

Quinidine, Verapamil

Acyclovir, Adefovir,Methotrexate, ZidovudineZidovudineCimetidine, Methotrexate,Zidovudine

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Picograde® solvents forresidue analysis

Optigrade® solvents for HPLC

New LC-MS solvents

Customised solvent mixes

Special grades for highlyvolatile halogenated andaromatic hydrocarbonsand EOX

Solvents for high accuracymeasurements


Compound catalogue list

Labelled and unlabelled

� Metabolite standards

� Enzyme substrates

� Enzyme inducers

� Enzyme inhibitors

� Transporter inhibitors

� Transporter substrates



LGC catalogue no.

TRC-A168125TRC-A168125-100TRC-A192400TRC-A192400-2.5TRC-A192402TRC-A192402-10TRC-A247500TRC-A247500-100TRC-A247502TRC-A247502-25TRC-A168210

TRC-A168210-50

TRC-A168212

TRC-A168212-10

TRC-A168213

TRC-A168213-10

TRC-A575820TRC-A575820-50TRC-A575822TRC-A575822-10CERA-915CERA-916CERA-917

TRC-A603610TRC-A603610-10TRC-A634200TRC-A634200-100TRC-A634202TRC-A634202-10EPA0800000MM0232.00TRC-A634237TRC-A634238TRC-A634238-10EPA1100000MM0253.15TRC-A634302TRC-A790051TRC-A790051-50TRC-A790052TRC-A790052-10TRC-A791750TRC-A791750-500TRC-A791752TRC-A791752-10TRC-A801530TRC-A801530-50EPY0000775MM0456.00TRC-B285770TRC-B285770-100TRC-B285775TRC-B285775-50TRC-B285776TRC-B285776-50EPB0700000MM0160.00TRC-B288600TRC-B288600-100TRC-B385310

Product description

5-Acetylamino-6-amino-3-methyluracil, Hydrate5-Acetylamino-6-amino-3-methyluracil, HydrateAcyclovirAcyclovirAcyclovir-d4Acyclovir-d4AdefovirAdefovirAdefovir-d4Adefovir-d45-Acetylamino-6-formylamino-3-methyluracil

5-Acetylamino-6-formylamino-3-methyluracil

5-Acetyl-d3-amino-6-formylamino-3-methyluracil

5-Acetyl-d3-amino-6-formylamino-3-methyluracil

5-Acetylamino-6-formylamino-3-methyluracil-d3


Amantadine HydrochlorideAmantadine HydrochlorideAmantadine-d15 HydrochlorideAmantadine-d15 Hydrochloride7-Aminoclonazepam, 100 µg/mL, in Acetonitrile7-Aminoclonazepam, 1.0 mg/mL, in Acetonitrile7-Aminoclonazepam-D4, 100 µg/mL, inAcetonitrile7-Amino Clonazepam7-Amino ClonazepamAmodiaquinAmodiaquinAmodiaquin-d10Amodiaquin-d10Amoxicillin trihydrateAmoxicillin TrihydrateAmoxicillin-13C6Amoxicillin-d4Amoxicillin-d4Ampicillin TrihydrateAmpicillin TrihydrateAmpicillin-d5 (Mixture of Diastereomers)AtazanavirAtazanavirAtazanavir-d5Atazanavir-d5Atorvastatin, Calcium SaltAtorvastatin, Calcium SaltAtorvastatin-d5, Sodium SaltAtorvastatin-d5, Sodium SaltAzamulinAzamulinBenzbromaroneBenzbromarone(+/-)-N-3-Benzylnirvanol(+/-)-N-3-Benzylnirvanol(S)-(+)-N-3-Benzylnirvanol(S)-(+)-N-3-Benzylnirvanol(R)-(-)-N-3-Benzylnirvanol(R)-(-)-N-3-BenzylnirvanolBenzylpenicillin potassiumBenzylpenicillin PotassiumBenzylpenicillinate-d7, Potassium SaltBenzylpenicillinate-d7, Potassium SaltBilirubin Acyl-β-D-glucuronide (Mixture ofMonoglucuronides)

Pack size

10 mg100 mg250 mg2.5 g1 mg10 mg10 mg100 mg2.5 mg25 mg5 mg

50 mg

1 mg

10 mg

1 mg

10 mg

5 g50 g1 mg10 mg1 mL/ampule1 mL/ampule1 mL/ampule

1 mg10 mg10 mg100 mg1 mg10 mg100 mg500 mg10 mg1 mg10 mg150 mg500 mg10 mg5 mg50 mg1 mg10 mg50 mg500 mg1 mg10 mg5 mg50 mg10 mg500 mg10 mg100 mg5 mg50 mg5 mg50 mg50 mg250 mg10 mg100 mg1 mg

Index description

AAMU (5-acetylamino-6-amino-3-methyluracil)AAMU (5-acetylamino-6-amino-3-methyluracil)AcyclovirAcyclovirAcyclovirAcyclovirAdefovirAdefovirAdefovirAdefovirAFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AmantadineAmantadineAmantadineAmantadine7-aminoclonazepam7-aminoclonazepam7-aminoclonazepam

7-aminoclonazepam7-aminoclonazepamAmodiaquineAmodiaquineAmodiaquineAmodiaquineAmoxicillinAmoxicillinAmoxicillinAmoxicillinAmoxicillinAmpicillinAmpicillinAmpicillinAtazanavirAtazanavirAtazanavirAtazanavirAtorvastatinAtorvastatinAtorvastatinAtorvastatinAzamulinAzamulinBenzbromaroneBenzbromarone(+/-)-N-3-benzylnirvanol(+/-)-N-3-benzylnirvanol(S)-(+)-N-3-benzylnirvanol(S)-(+)-N-3-benzylnirvanol(R)-(-)-N-3-benzylnirvanol(R)-(-)-N-3-benzylnirvanolBenzylpenicillinBenzylpenicillinBenzylpenicillinBenzylpenicillinBilirubin glucuronide



LGC catalogue no.

TRC-B385310-10

TRC-B689540TRC-B689540-100TRC-B689542TRC-B689542-10CERB-034

TRC-B689625TRC-B689625-10TRC-B689627TRC-B689627-10CERC-051TRC-C080100TRC-C080100-50TRC-C080102TRC-C080102-25CDX-00003145-001TRC-C175750TRC-C175752TRC-C175752-10CERC-053TRC-C175840TRC-C175840-10TRC-C175842TRC-C175842-10TRC-C175843TRC-C175843-10TRC-C183200TRC-C183200-50TRC-C183202TRC-C183202-10TRC-C235750TRC-C235750-100TRC-C235752TRC-C235752-10TRC-C237500TRC-C237500-1TRC-C242500TRC-C242500-10TRC-C277000TRC-C277000-25TRC-C380000TRC-C380000-2.5TRC-C380002TRC-C380002-10TRC-C428700TRC-C428700-100TRC-C428702TRC-C428702-10CERC-055TRC-C441650TRC-C441650-1TRC-C441652TRC-C441652-10TRC-C499500TRC-C499500-1TRC-C587250TRC-C587250-1TRC-C587252TRC-C587252-10TRC-C696302TRC-C696302-5CERC-017CERC-035TRC-C725004TRC-C725004-50TRC-C725005

Product description

Bilirubin Acyl-β-D-glucuronide (Mixture ofMonoglucuronides)Bufuralol, HydrochlorideBufuralol, HydrochlorideBufuralol-d9 HydrochlorideBufuralol-d9 HydrochlorideBupropion HCl, 1.0 mg/mL (as free base), inMethanolBupropion HydrochlorideBupropion HydrochlorideBupropion-d9 HydrochlorideBupropion-d9 HydrochlorideCaffeine, 1.0 mg/mL, in MethanolCaffeineCaffeineCaffeine-d9Caffeine-d9CaptoprilCaptoprilCaptopril-d7Captopril-d7Carbamazepine, 1.0 mg/mL, in MethanolCarbamazepineCarbamazepineCarbamazepine-13C,d2Carbamazepine-13C,d2Carbamazepine-d2Carbamazepine-d24-Carboxy Tolbutamide4-Carboxy Tolbutamide4-Carboxy Tolbutamide-d94-Carboxy Tolbutamide-d9CefadroxilCefadroxilCefadroxil-d4 (major)Cefadroxil-d4 (major)Cefamandole Sodium SaltCefamandole Sodium SaltCefazolin Sodium SaltCefazolin Sodium SaltCerivastatin, Sodium SaltCerivastatin, Sodium SaltChlorothiazideChlorothiazideChlorothiazide-13C,15N2Chlorothiazide-13C,15N2ChlorzoxazoneChlorzoxazoneChlorzoxazone-4,6,7-d3Chlorzoxazone-4,6,7-d3CimetidineCimetidineCimetidineCimetidine-d3Cimetidine-d3CisplatinCisplatin(+)-Clopidogrel Hydrogen Sulfate(+)-Clopidogrel Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen SulfateCortisol-9,11,12,12-d4Cortisol-9,11,12,12-d4S-(±)-Cotinine-D3, 100 µg/mL, in MethanolS-(±)-Cotinine-D3, 1.0 mg/mL, in Methanolrac Cotininerac Cotininerac Cotinine-d3

Pack size

10 mg

10 mg100 mg1 mg10 mg1 mL/ampule

1 g10 g1 mg10 mg1 mL/ampule5 g50 g2.5 mg25 mg1 g10 g1 mg10 mg1 mL/ampule1 g10 g1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg10 mg100 mg1 mg10 mg100 mg1 g1 g10 g2.5 mg25 mg250 mg2.5 g1 mg10 mg10 mg100 mg1 mg10 mg250 mg100 mg1 g1 mg10 mg100 mg1 g100 mg1 g1 mg10 mg0.5 mg5 mg1 mL/ampule1 mL/ampule5 mg50 mg10 mg

Index description

Bilirubin glucuronide

BufuralolBufuralolBufuralolBufuralolBupropion

BupropionBupropionBupropionBupropionCaffeineCaffeineCaffeineCaffeineCaffeineCaptoprilCaptoprilCaptoprilCaptoprilCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarboxytolbutamideCarboxytolbutamideCarboxytolbutamideCarboxytolbutamideCefadroxilCefadroxilCefadroxilCefadroxilCefamandoleCefamandoleCefazolinCefazolinCerivastatinCerivastatinChlorothiazideChlorothiazideChlorothiazideChlorothiazideChlorzoxazoneChlorzoxazoneChlorzoxazoneChlorzoxazoneCimetidineCimetidineCimetidineCimetidineCimetidineCisplatinCisplatinClopidogrelClopidogrelClopidogrelClopidogrelCortisolCortisolCotinineCotinineCotinineCotinineCotinine



LGC catalogue no.

TRC-C725005-100CERC-073EPY0000438USP1158504TRC-D193250TRC-D193250-10TRC-D193255TRC-D193255-10TRC-D193260TRC-D193260-100TRC-D193262TRC-D193262-10TRC-D194500TRC-D194500-50TRC-D194502TRC-D194502-5TRC-D208700TRC-D208700-1TRC-D208702TRC-D208702-10TRC-D474000TRC-D474000-10TRC-D474010TRC-D474010-10TRC-D229650TRC-D229650-10TRC-D229652TRC-D229652-10CERD-039

CERD-040

TRC-D288825TRC-D288825-50TRC-D288827TRC-D288827-10TRC-D289475TRC-D289475-50TRC-D289477TRC-D289477-10CERD-903

CERD-906

TRC-D290050TRC-D290050-100TRC-D290052TRC-D290052-10TRC-D298800TRC-D298800-10TRC-D298802TRC-D298802-25CERD-013TRC-D299455TRC-D299455-1TRC-D299457TRC-D299457-50CERD-034

CERD-041TRC-D299485TRC-D299485-250TRC-D299487TRC-D299487-25CERD-028TRC-D436450TRC-D436450-100TRC-D436452

Product description

rac Cotinine-d3Coumarin, 1.0 mg/mL, in AcetonitrileCoumarinCyclosporineDapsoneDapsoneDapsone-D8 (Major)Dapsone-D8 (Major)Dapsone HydroxylamineDapsone HydroxylamineDapsone Hydroxylamine-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Daunorubicin, HydrochlorideDaunorubicin, HydrochlorideDaunorubicin-13C,d3Daunorubicin-13C,d3Debrisoquin HemisulfateDebrisoquin HemisulfateDebrisoquin-13C,15N2 HemisulfateDebrisoquin-13C,15N2 HemisulfateDeferiproneDeferiproneDeferiprone 3-O-ß-D-GlucuronideDeferiprone 3-O-ß-D-GlucuronideDehydro FelodipineDehydro FelodipineDehydro Felodipine-d3Dehydro Felodipine-d3N-Desethylamodiaquine dihydrochloride, 1.0mg/mL (as free base), in MethanolN-Desethylamodiaquine-D5 dihydrochloride,100 µg/mL (as free base), in MethanolN-Desethyl AmodiaquineN-Desethyl AmodiaquineN-Desethyl Amodiaquine-d5N-Desethyl Amodiaquine-d5rac Desethyl Oxybutynin Hydrochloriderac Desethyl Oxybutynin HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesipramine-D3 HCl, 100 µg/mL (as free base),in MethanolDesipramine HCl, 1.0 mg/mL (as free base), inMethanolDesipramine HydrochlorideDesipramine HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDexamethasoneDexamethasoneDexamethasone-d3Dexamethasone-d3Dextromethorphan, 1.0 mg/mL, in MethanolDextromethorphan Hydrobromide MonohydrateDextromethorphan Hydrobromide MonohydrateDextromethorphan-d3Dextromethorphan-d3Dextrorphan tartrate, 1.0 mg/mL (as free base),1 mL/ampule in MethanolDextrorphan-D3, 100 µg/mL, in MethanolDextrorphan, Tartrate SaltDextrorphan, Tartrate SaltDextrorphan-d3, Tartrate SaltDextrorphan-d3, Tartrate SaltDiclofenac sodiumDiclofenac Sodium SaltDiclofenac Sodium SaltDiclofenac-D4 (Major)

Pack size

100 mg1 mL/ampule80 mg50 mg1 g10 g1 mg10 mg10 mg100 mg1 mg10 mg5 mg50 mg0.5 mg5 mg100 mg1 g1 mg10 mg1 mg10 mg1 g10 g1 mg10 mg1 mg10 mg1 mL/ampule

1 mL/ampule

5 mg50 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mL/ampule

1 mL/ampule

10 mg100 mg1 mg10 mg1 g10 g10 mg25 mg1 mL/ampule100 mg1 g5 mg50 mg1 mL/ampule

1 mL/ampule25 mg250 mg2.5 mg25 mg250 mg10 g100 g1 mg

Index description

CotinineCoumarinCoumarinCyclosporine ADapsoneDapsoneDapsoneDapsoneDapsonehydroxylamineDapsonehydroxylamineDapsonehydroxylamineDapsonehydroxylamineDaunorubicinDaunorubicinDaunorubicinDaunorubicinDebrisoquinDebrisoquinDebrisoquinDebrisoquinDeferiproneDeferiproneDeferiprone-3-O-ß-D-glucuronideDeferiprone-3-O-ß-D-glucuronideDehydrofelodipineDehydrofelodipineDehydrofelodipineDehydrofelodipineDesethylamodiaquine

Desethylamodiaquine

DesethylamodiaquineDesethylamodiaquineDesethylamodiaquineDesethylamodiaquineDesethyloxybutyninDesethyloxybutyninDesethyloxybutyninDesethyloxybutyninDesipramine

Desipramine

DesipramineDesipramineDesipramineDesipramineDexamethasoneDexamethasoneDexamethasoneDexamethasoneDextromethorphanDextromethorphanDextromethorphanDextromethorphanDextromethorphanDextrorphan

DextrorphanDextrorphanDextrorphanDextrorphanDextrorphanDiclofenacDiclofenacDiclofenacDiclofenac



LGC catalogue no.

TRC-D436452-10TRC-D436475TRC-D436475-10CERD-029TRC-D446575TRC-D446575-10TRC-D446577TRC-D446577-25TRC-D493450TRC-D493450-1TRC-D493452TRC-D493452-10EPD2960000MM0384.00TRC-D533782TRC-D533782-10TRC-D533790TRC-D533790-10TRC-D558000TRC-D558000-250TRC-D558002TRC-D558002-2.5TRC-E425000TRC-E425000-100TRC-E425002TRC-E425002-10TRC-E489000TRC-E489000-100TRC-E489002TRC-E489002-10TRC-E555250TRC-E555250-50TRC-E555252TRC-E555252-10TRC-E555253TRC-E555253-10TRC-E625000TRC-E625000-50TRC-E625002TRC-E625002-10TRC-E649950TRC-E649950-10TRC-E649952TRC-E649952-10TRC-E888000TRC-E888000-50TRC-E888002TRC-E888002-10TRC-E891725TRC-E891725-10TRC-E891727TRC-E891727-100TRC-E892875TRC-E892875-100TRC-E685100TRC-E685100-25TRC-E685102TRC-E685102-10TRC-E685115TRC-E685115-10CDX-00005365-025TRC-E933750TRC-E933750-1TRC-F232375TRC-F232375-1TRC-F232377TRC-F232377-10TRC-F322470

Product description

Diclofenac-D4 (Major)Diclofenac Acyl-β-D-glucuronideDiclofenac Acyl-β-D-glucuronideDigoxin, 1.0 mg/mL, in MethanolDigoxinDigoxinDigoxin-d3Digoxin-d3DisopyramideDisopyramideDisopyramide-d14 Tosylate SaltDisopyramide-d14 Tosylate SaltDopamine hydrochlorideDopamine HydrochlorideDopamine-d4 HydrochlorideDopamine-d4 HydrochlorideDopamine 3-β-D-GlucuronideDopamine 3-β-D-GlucuronideDoxorubicin, HydrochlorideDoxorubicin, HydrochlorideDoxorubicin-13C,d3Doxorubicin-13C,d3EfavirenzEfavirenzrac Efavirenz-d4rac Efavirenz-d4ElacridarElacridarElacridar-d4Elacridar-d4Enalapril MaleateEnalapril MaleateEnalapril-d5 Maleate SaltEnalapril-d5 Maleate SaltEnalapril-d3Enalapril-d3Erlotinib, Hydrochloride SaltErlotinib, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErythromycinErythromycinErythromycin-13C,D3Erythromycin-13C,D317β-Estradiol17β-Estradiol17β-Estradiol-16,16,17-d317β-Estradiol-16,16,17-d37-Ethoxycoumarin7-Ethoxycoumarin7-Ethoxycoumarin-d57-Ethoxycoumarin-d57-Ethoxyresorufin7-EthoxyresorufinEthynyl EstradiolEthynyl EstradiolEthynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol 3-SulfateEthynyl Estradiol 3-SulfateEtoposideEtoposideEtoposideFelodipineFelodipinerac Felodipine-d3rac Felodipine-d3Fexofenadine

Pack size

10 mg1 mg10 mg1 mL/ampule1 g10 g2.5 mg25 mg100 mg1 g1 mg10 mg50 mg500 mg1 mg10 mg1 mg10 mg25 mg250 mg0.25 mg2.5 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg5 g50 g1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg1 g10 g1 mg10 mg5 g50 g1 mg10 mg1 g10 g10 mg100 mg10 mg100 mg2.5 g25 g1 mg10 mg1 mg10 mg25 mg100 mg1 g100 mg1 g1 mg10 mg100 mg

Index description

DiclofenacDiclofenac acyl-β-D-glucuronideDiclofenac acyl-β-D-glucuronideDigoxinDigoxinDigoxinDigoxinDigoxinDisopyramideDisopyramideDisopyramideDisopyramideDopamineDopamineDopamineDopamineDopamine-3-β-D-glucuronideDopamine-3-β-D-glucuronideDoxorubicinDoxorubicinDoxorubicinDoxorubicinEfavirenzEfavirenzEfavirenzEfavirenzElacridarElacridarElacridarElacridarEnalaprilEnalaprilEnalaprilEnalaprilEnalaprilEnalaprilErlotinibErlotinibErlotinibErlotinibErythromycinErythromycinErythromycinErythromycinEstradiolEstradiolEstradiolEstradiol7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxyresorufin7-ethoxyresorufinEthynylestradiolEthynylestradiolEthynylestradiolEthynylestradiolEthynylestradiol 3-sulfateEthynylestradiol 3-sulfateEtoposideEtoposideEtoposideFelodipineFelodipineFelodipineFelodipineFexofenadine



LGC catalogue no.

TRC-F322470-1TRC-F322490TRC-F322490-1TRC-F322500TRC-F322500-10TRC-F421000TRC-F421000-1TRC-F421002TRC-F421002-10CERF-918

CERF-919

TRC-F597100TRC-F597100-1TRC-F597102TRC-F597102-10TRC-F598700TRC-F598700-50TRC-F598702TRC-F598702-50TRC-F598850TRC-F598850-100TRC-F598852TRC-F598852-10TRC-F601250TRC-F601250-5TRC-F601252TRC-F601252-10TRC-F603500TRC-F603500-1TRC-F603502TRC-F603502-10TRC-G235000TRC-G235000-10TRC-G235002TRC-G235002-10TRC-G304000TRC-G304000-50TRC-G305750TRC-G305750-100TRC-G305752TRC-G305752-50CDX-00008061-100CERH-004CERH-010CERH-049NMIAD 785BCERH-051

TRC-H830480TRC-H830480-10TRC-H830482

TRC-H830482-5

CERH-062

CERH-066

TRC-H830675TRC-H830675-100TRC-H830677TRC-H830677-10TRC-D452230TRC-D452230-100CERH-063

Product description

FexofenadineFexofenadine, HydrochlorideFexofenadine, HydrochlorideFexofenadine-D6Fexofenadine-D6FluconazoleFluconazoleFluconazole-d4Fluconazole-d4Fluoxetine HCl, 1.0 mg/mL (as free base),in MethanolFluoxetine-D6 Oxalate, 100 µg/mL (as freebase), in MethanolFluoxetine, HydrochlorideFluoxetine, HydrochlorideFluoxetine-d5 HydrochlorideFluoxetine-d5 HydrochlorideFlurbiprofenFlurbiprofenFlurbiprofen-d3Flurbiprofen-d3FlutamideFlutamideFlutamide-d7Flutamide-d7Fluvastatin, Sodium SaltFluvastatin, Sodium SaltFluvastatin-D8 (Major), Sodium SaltFluvastatin-D8 (Major), Sodium Salt(E)-Fluvoxamine Maleate(E)-Fluvoxamine Maleate(E)-Fluvoxamine-d3 Maleate(E)-Fluvoxamine-d3 MaleateGanciclovirGanciclovirGanciclovir-d5Ganciclovir-d5GefitinibGefitinibGemfibrozilGemfibrozilGemfibrozil-d6Gemfibrozil-d6HecogeninHydromorphone, 1.0 mg/mL, in MethanolHydromorphone-D3, 1.0 mg/mL, in MethanolHydromorphone-D6, 100 µg/mL, in MethanolHydromorphone HCl*Hydromorphone-3-β-D-glucuronide, 100 µg/mL,in Methanol:Water (1:1)1’-Hydroxy Bufuralol1’-Hydroxy Bufuralol1’-Hydroxybufuralol-d9 (Mixture ofDiastereomers)1’-Hydroxybufuralol-d9 (Mixture ofDiastereomers)(±)-Hydroxybupropion-D6, 100 µg/mL, inAcetonitrile(±)-Hydroxybupropion, 1.0 mg/mL, inAcetonitrileHydroxy BupropionHydroxy BupropionHydroxy Bupropion-d6Hydroxy Bupropion-d66',7'-Dihydroxy Bergamottin6',7'-Dihydroxy Bergamottin6-Hydroxychlorzoxazone, 100 µg/mL, inMethanol

Pack size

1 g100 mg1 g1 mg10 mg100 mg1 g1 mg10 mg1 mL/ampule

1 mL/ampule

100 mg1 g1 mg10 mg5 g50 g5 mg50 mg10 mg100 mg1 mg10 mg500 mg5 g1 mg10 mg100 mg1 g1 mg10 mg1 g10 g1 mg10 mg5 mg50 mg10 g100 g5 mg50 mg100 mg1 mL/ampule1 mL/ampule1 mL/ampule20 mg1 mL/ampule

1 mg10 mg0.5 mg

5 mg

1 mL/ampule

1 mL/ampule

10 mg100 mg1 mg10 mg10 mg100 mg1 mL/ampule

Index description

FexofenadineFexofenadineFexofenadineFexofenadineFexofenadineFluconazoleFluconazoleFluconazoleFluconazoleFluoxetine

Fluoxetine

FluoxetineFluoxetineFluoxetineFluoxetineFlurbiprofenFlurbiprofenFlurbiprofenFlurbiprofenFlutamideFlutamideFlutamideFlutamideFluvastatinFluvastatinFluvastatinFluvastatinFluvoxamineFluvoxamineFluvoxamineFluvoxamineGanciclovirGanciclovirGanciclovirGanciclovirGefitinibGefitinibGemfibrozilGemfibrozilGemfibrozilGemfibrozilHecogeninHydromorphoneHydromorphoneHydromorphoneHydromorphoneHydromorphone-3-glucuronide

1-hydroxybufuralol1-hydroxybufuralol1-hydroxybufuralol

1-hydroxybufuralol

Hydroxybupropion

Hydroxybupropion

HydroxybupropionHydroxybupropionHydroxybupropionHydroxybupropion6´,7´-dihydroxybergamottin6´,7´-dihydroxybergamottin6-hydroxychlorzoxazone



LGC catalogue no.

CERH-064

TRC-H825120TRC-H825120-50TRC-H825122TRC-H825122-2.5TRC-H922300TRC-H922300-25TRC-H922302TRC-H922302-10TRC-H924500TRC-H924500-100TRC-H924505TRC-H924505-50TRC-H924510TRC-H924510-10CERH-060CERH-061

TRC-H924875TRC-H924875-25TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924890TRC-H924890-50TRC-H924892

TRC-H924892-2.5

TRC-H924880

TRC-H924880-10

TRC-H924882

TRC-H924882-10

TRC-H924883TRC-H924883-10TRC-H933875TRC-H933875-100TRC-H933877TRC-H933877-10TRC-H936750TRC-H936750-50TRC-H936752TRC-H936752-10TRC-H936760TRC-H936760-10CERH-052CERH-053

TRC-H825225TRC-H825225-10TRC-H825227TRC-H825227-10TRC-H825228TRC-H825228-10TRC-H941825TRC-H941825-10TRC-H941827TRC-H941827-10TRC-H942440TRC-H942440-50TRC-H942442TRC-H942442-10

Product description

6-Hydroxychlorzoxazone-D2,15N, 100 µg/mL,in Methanol6-Hydroxy Chlorzoxazone6-Hydroxy Chlorzoxazone6-Hydroxy Chlorzoxazone-13C66-Hydroxy Chlorzoxazone-13C66β-Hydroxy Cortisol6β-Hydroxy Cortisol6β-Hydroxy Cortisol-d46β-Hydroxy Cortisol-d4(3'R,5'S)-3'-Hydroxycotinine(3'R,5'S)-3'-Hydroxycotinine(3S,5S)-3'-Hydroxycotinine(3S,5S)-3'-Hydroxycotininetrans-3'-Hydroxycotinine, Methyl-d3trans-3'-Hydroxycotinine, Methyl-d37-Hydroxycoumarin, 1.0 mg/mL, in Acetonitrile7-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin7-Hydroxy Coumarin7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-Glucuroniderac 4-Hydroxydebrisoquine Hemisulfaterac 4-Hydroxydebrisoquine Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfate3-Hydroxy Desloratadine3-Hydroxy Desloratadine3-Hydroxy Desloratadine-d43-Hydroxy Desloratadine-d43-Hydroxy Desloratadine β-D-Glucuronide3-Hydroxy Desloratadine β-D-Glucuronide4'-Hydroxydiclofenac, 100 µg/mL, in Acetonitrile4'-Hydroxydiclofenac-13C6, 100 µg/mL, inMethanol4’-Hydroxy Diclofenac4’-Hydroxy Diclofenac4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-13C64’-Hydroxy Diclofenac-13C6rac 8-Hydroxy Efavirenzrac 8-Hydroxy Efavirenzrac 8-Hydroxy Efavirenz-d4rac 8-Hydroxy Efavirenz-d44’-Hydroxy Flurbiprofen4’-Hydroxy Flurbiprofen4’-Hydroxy Flurbiprofen-d34’-Hydroxy Flurbiprofen-d3

Pack size

1 mL/ampule

5 mg50 mg0.25 mg2.5 mg5 mg25 mg1 mg10 mg10 mg100 mg5 mg50 mg1 mg10 mg1 mL/ampule1 mL/ampule

2.5 g25 g0.25 mg2.5 mg0.25 mg2.5 mg5 mg50 mg0.25 mg

2.5 mg

1 mg

10 mg

1 mg

10 mg

1 mg10 mg10 mg100 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mL/ampule1 mL/ampule

1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg

Index description

6-hydroxychlorzoxazone

6-hydroxychlorzoxazone6-hydroxychlorzoxazone6-hydroxychlorzoxazone6-hydroxychlorzoxazone6β-hydroxycortisol6β-hydroxycortisol6β-hydroxycortisol6β-hydroxycortisol3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine7-hydroxycoumarin7-hydroxycoumarin

7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate






7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronide(Â±)-4-hydroxydebrisoquin sulfate(Â±)-4-hydroxydebrisoquin sulfate(Â±)-4-hydroxydebrisoquin sulfate(Â±)-4-hydroxydebrisoquin sulfateHydroxydesloratadineHydroxydesloratadineHydroxydesloratadineHydroxydesloratadine3-hydroxydesloratadine-β-D-glucuronide3-hydroxydesloratadine-β-D-glucuronide4’-hydroxydiclofenac4’-hydroxydiclofenac

4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac8-hydroxyefavirenz8-hydroxyefavirenz8-hydroxyefavirenz8-hydroxyefavirenz4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen



LGC catalogue no.

TRC-H944875TRC-H944875-250TRC-H944877TRC-H944877-25TRC-H948390TRC-H948390-50TRC-H948392

TRC-H948392-10

CERH-902CERH-921

TRC-H948420TRC-H948420-50TRC-H948422TRC-H948422-10TRC-H948430TRC-H948430-10TRC-H948425TRC-H948425-50TRC-H948427TRC-H948427-5TRC-H948435TRC-H948435-10CDX-00008685-010TRC-H948863TRC-H948863-10TRC-H948864TRC-H948864-10TRC-H950770TRC-H950770-10TRC-H953230TRC-H953230-10TRC-H953232TRC-H953232-10TRC-H953440TRC-H953440-10TRC-H953450TRC-H953450-10TRC-H954730TRC-H954730-10TRC-H954757TRC-H954757-100TRC-H956755TRC-H956755-10CERH-059CERT-034

TRC-H956750TRC-H956750-50TRC-H956752TRC-H956752-10CERH-054CERH-055

TRC-H969850TRC-H969850-50TRC-H969852TRC-H969852-10TRC-H971330TRC-H971330-10TRC-H996100TRC-H996100-50TRC-H996120TRC-H996120-50TRC-H996130TRC-H996130-50

Product description

(+/-) - 4’-HydroxyMephenytoin(+/-) - 4’-HydroxyMephenytoin(+/-)-4’-Hydroxy Mephenytoin-d3(+/-)-4’-Hydroxy Mephenytoin-d3α-Hydroxy Metoprolol (Mixture of Diastereomers)α-Hydroxy Metoprolol (Mixture of Diastereomers)α-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)α-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)α-Hydroxymidazolam, 100 µg/mL, in Methanolα-Hydroxymidazolam-D4, 100 µg/mL, inMethanol1’-Hydroxy Midazolam1’-Hydroxy Midazolam1’-Hydroxymidazolam-13C31’-Hydroxymidazolam-13C31’-Hydroxymidazolam-β-D-glucuronide1’-Hydroxymidazolam-β-D-glucuronide4-Hydroxy Midazolam4-Hydroxy Midazolam4-Hydroxy Midazolam-d54-Hydroxy Midazolam-d54-Hydroxymidazolam β-D-Glucuronide4-Hydroxymidazolam β-D-Glucuronide21-Hydroxyprogesterone5-Hydroxy Omeprazole Sodium Salt5-Hydroxy Omeprazole Sodium Salt5-Hydroxy Omeprazole-d3 Sodium Salt5-Hydroxy Omeprazole-d3 Sodium Salt4-Hydroxy Propofol4-Hydroxy Propofol(3S)-3-Hydroxy Quinidine(3S)-3-Hydroxy Quinidine(3S)-3-Hydroxy Quinidine-vinyl-d3(3S)-3-Hydroxy Quinidine-vinyl-d35-Hydroxy Rosiglitazone5-Hydroxy Rosiglitazone5-Hydroxy Rosiglitazone Sulfate5-Hydroxy Rosiglitazone Sulfate4'-Hydroxy Tamoxifen4'-Hydroxy Tamoxifen4-Hydroxy Tamoxifen Ethyl-d54-Hydroxy Tamoxifen Ethyl-d56α-Hydroxy Testosterone6α-Hydroxy Testosterone6β-Hydroxytestosterone, 100 µg/mL, in Methanol6β-Hydroxytestosterone-D3, 100 µg/mL, inMethanol6β-Hydroxy Testosterone6β-Hydroxy Testosterone6β-Hydroxy Testosterone-d36β-Hydroxy Testosterone-d34-Hydroxytolbutamide, 1.0 mg/mL, in Acetonitrile4-Hydroxytolbutamide-D9, 100 µg/mL, inAcetonitrileHydroxy TolbutamideHydroxy TolbutamideHydroxy Tolbutamide-d9Hydroxy Tolbutamide-d94-Hydroxy Triazolam4-Hydroxy Triazolam4’-Hydroxy Warfarin4’-Hydroxy Warfarin6-Hydroxy Warfarin6-Hydroxy Warfarin7-Hydroxy Warfarin7-Hydroxy Warfarin

Pack size

25 mg250 mg2.5 mg25 mg5 mg50 mg1 mg

10 mg

1 mL/ampule1 mL/ampule

5 mg50 mg1 mg10 mg1 mg10 mg5 mg50 mg0.5 mg5 mg1 mg10 mg10 mg1 mg10 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mL/ampule1 mL/ampule

5 mg50 mg1 mg10 mg1 mL/ampule1 mL/ampule

5 mg50 mg1 mg10 mg1 mg10 mg5 mg50 mg5 mg50 mg5 mg50 mg

Index description

4-hydroxymephenytoin4-hydroxymephenytoin4-hydroxymephenytoin4-hydroxymephenytoinα-hydroxymetoprololα-hydroxymetoprololα-hydroxymetoprolol

α-hydroxymetoprolol

1'-hydroxymidazolam1'-hydroxymidazolam

1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam-β-D-glucuronide1'-hydroxymidazolam-β-D-glucuronide4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam-β-D-glucuronide4-hydroxymidazolam-β-D-glucuronide21-hydroxyprogesterone5-hydroxyomeprazole5-hydroxyomeprazole5-hydroxyomeprazole5-hydroxyomeprazole4-hydroxypropofol4-hydroxypropofol(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine5-hydroxyrosiglitazone5-hydroxyrosiglitazone5-hydroxyrosiglitazone5-hydroxyrosiglitazone4-hydroxytamoxifen4-hydroxytamoxifen4-hydroxytamoxifen4-hydroxytamoxifen6α-hydroxytestosterone6α-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone

6β-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone4-hydroxytolbutamide4-hydroxytolbutamide

4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytriazolam4-hydroxytriazolam4-hydroxywarfarin4-hydroxywarfarin6-hydroxywarfarin6-hydroxywarfarin7-hydroxywarfarin7-hydroxywarfarin



LGC catalogue no.

TRC-H996140TRC-H996140-50TRC-H996160TRC-H996160-50TRC-I465983TRC-I465983-25TRC-I525000TRC-I525000-50TRC-I525002TRC-I525002-10EPI0500000TRC-I821452TRC-I821452-10USP1349706TRC-I937500TRC-I937500-500TRC-I937502TRC-I937502-10TRC-K186000TRC-K186000-5TRC-K186002TRC-K186002-25CERL-012TRC-L175000TRC-L175000-10TRC-L175002TRC-L175002-25TRC-L175800TRC-L175800-50TRC-L175802TRC-L175802-5CDX-00012080-010CDX-00012080-100TRC-L469450TRC-L469450-250TRC-L469452TRC-L469452-10TRC-M218000TRC-M218000-1TRC-M218002TRC-M218002-10TRC-M225450TRC-M225450-25TRC-M258812TRC-M258812-10TRC-M258815TRC-M260675TRC-M260675-10TRC-M260677TRC-M260677-50TRC-M260795TRC-M260795-100TRC-M294460TRC-M294460-2TRC-M338575TRC-M338575-100TRC-M338577TRC-M338577-10CERM-123

TRC-M338790TRC-M338790-1TRC-M338792TRC-M338792-10CERM-908CERM-918

TRC-M343000

Product description

8-Hydroxy Warfarin8-Hydroxy Warfarin10-Hydroxy Warfarin10-Hydroxy WarfarinImipramine-d6Imipramine-d6Indinavir SulfateIndinavir SulfateIndinavir-d6Indinavir-d6IsoniazidIsoniazid-d4Isoniazid-d4IsoniazidItraconazoleItraconazoleItraconazole-d5Itraconazole-d5KetoconazoleKetoconazoleKetoconazole-d8Ketoconazole-d8LansoprazoleLansoprazoleLansoprazoleLansoprazole-d4Lansoprazole-d4Lapatinib DitosylateLapatinib DitosylateLapatinib-13C2,15N DitosylateLapatinib-13C2,15N DitosylateLauric AcidLauric AcidLoperamide, HydrochlorideLoperamide, HydrochlorideLoperamide-d6 HydrochlorideLoperamide-d6 HydrochlorideMemantine, HydrochlorideMemantine, HydrochlorideMemantine-d6, HydrochlorideMemantine-d6, Hydrochloride6-Mercaptopurine Monohydrate6-Mercaptopurine MonohydrateMetformin-d6, HydrochlorideMetformin-d6, HydrochlorideMetformin, HydrochlorideMethotrexateMethotrexateMethotrexate-methyl-d3Methotrexate-methyl-d3MethoxsalenMethoxsalen3-Methylcholanthrene3-Methylcholanthrene1-Methylxanthine1-Methylxanthine1-Methylxanthine-d31-Methylxanthine-d3Metoprolol Tartrate, 1.0 mg/mL (as free base),in Methanolrac Metoprolol Hemi (+)-Tartraterac Metoprolol Hemi (+)-Tartraterac Metoprolol-d7rac Metoprolol-d7Midazolam, 1.0 mg/mL, in MethanolMidazolam-D4 maleate, 100 µg/mL (as freebase), in MethanolMidazolam

Pack size

5 mg50 mg5 mg50 mg2.5 mg25 mg5 mg50 mg1 mg10 mg100 mg1 mg10 mg200 mg50 mg500 mg1 mg10 mg500 mg5 g2.5 mg25 mg250 mg1 g10 g2.5 mg25 mg5 mg50 mg0.5 mg5 mg10 mg100 mg25 mg250 mg1 mg10 mg100 mg1 g1 mg10 mg2.5 g25 g1 mg10 mg100 g1 g10 g5 mg50 mg10 mg100 mg200 mg2 g10 mg100 mg1 mg10 mg1 mL/ampule

100 mg1 g1 mg10 mg1 mL/ampule1 mL/ampule

100 mg

Index description

8-hydroxywarfarin8-hydroxywarfarin10-hydroxywarfarin10-hydroxywarfarinImipramineImipramineIndinavirIndinavirIndinavirIndinavirIsoniazidIsoniazidIsoniazidIsoniazidItraconazoleItraconazoleItraconazoleItraconazoleKetoconazoleKetoconazoleKetoconazoleKetoconazoleLansoprazoleLansoprazoleLansoprazoleLansoprazoleLansoprazoleLapatinibLapatinibLapatinibLapatinibLauric acidLauric acidLoperamideLoperamideLoperamideLoperamideMemantineMemantineMemantineMemantine6-mercaptopurine6-mercaptopurineMetforminMetforminMetforminMethotrexateMethotrexateMethotrexateMethotrexateMethoxsalenMethoxsalen3-methylcholanthrene3-methylcholanthrene1-methylxanthine1-methylxanthine1-methylxanthine1-methylxanthineMetoprolol

MetoprololMetoprololMetoprololMetoprololMidazolamMidazolam

Midazolam



LGC catalogue no.

TRC-M343000-1TRC-M343002TRC-M343002-10TRC-M373425TRC-M373425-1TRC-M373427TRC-M373427-10TRC-A168435TRC-A168435-100TRC-A168437TRC-A168437-10TRC-M568000TRC-M568000-100TRC-M568002TRC-M568002-10MM0037.00

CERM-017CERM-018CERM-031

TRC-M652310TRC-M652310-10TRC-M652312TRC-M652312-10TRC-A168325TRC-A168325-10TRC-A187850TRC-A187850-100TRC-A187852TRC-A187852-10CERN-042TRC-N377520TRC-N377527TRC-N377527-10TRC-N377530TRC-N377530-10CDX-00014014-001CDX-00014014-010CDX-00014015-001CDX-00014015-010TRC-D230930TRC-D230930-50TRC-N389750TRC-N389750-100TRC-N389752TRC-N389752-10CERN-048TRC-N412420TRC-N412420-2.5TRC-N412423TRC-N412423-100TRC-N412427TRC-N412427-25TRC-N457000TRC-N457000-100TRC-N457002TRC-N457002-10CDX-00014497-001USP1475008TRC-D292127TRC-D292127-10TRC-D294740TRC-D294740-25TRC-D294742TRC-D294742-10TRC-O253750TRC-O253750-1

Product description

MidazolamMidazolam-d5 (Major)Midazolam-d5 (Major)MitoxantroneMitoxantroneMitoxantrone-d8Mitoxantrone-d8N-Acetyl DapsoneN-Acetyl DapsoneN-Acetyl Dapsone-D8 (Major)N-Acetyl Dapsone-D8 (Major)Montelukast Sodium SaltMontelukast Sodium SaltMontelukast-d6, Sodium SaltMontelukast-d6, Sodium SaltMorphine Hydrochloride Trihydrate [ControlledSubstance]Morphine-3-β-D-glucuronide-D3Morphine-3-β-D-glucuronide (0.1 mg/ml)Morphine-3-β-D-glucuronide (1.0 mg/ml) inMethanolMorphine 6-β-D-GlucuronideMorphine 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideN-Acetyl-4-aminosalicylic AcidN-Acetyl-4-aminosalicylic AcidN-Acetyl SulfamethazineN-Acetyl SulfamethazineN-Acetyl Sulfamethazine-d4N-Acetyl Sulfamethazine-d4Naproxen, 1.0 mg/mL, in Methanol(S)-Naproxenrac Naproxen-d3rac Naproxen-d3Naproxen Acyl-β-D-glucuronideNaproxen Acyl-β-D-glucuronideα-Naphthoflavoneα-Naphthoflavoneβ-Naphthoflavoneβ-NaphthoflavoneN-Demethyl ErythromycinN-Demethyl ErythromycinNelfinavir, MesylateNelfinavir, MesylateNelfinavir-d3Nelfinavir-d3(±)-Nicotine-D4, 100 µg/mL, in Acetonitrile(+/-)-Nicotine(+/-)-Nicotine(+/-)-Nicotine-3’-d3(+/-)-Nicotine-3’-d3Nicotine-d4Nicotine-d4NifedipineNifedipineNifedipine-d6Nifedipine-d6NootkatoneNovobiocinrac O-Desmethyl Naproxen-d3rac O-Desmethyl Naproxen-d3O-Desmethyl Tramadol HydrochlorideO-Desmethyl Tramadol Hydrochloriderac O-Desmethyl Tramadol-d6rac O-Desmethyl Tramadol-d6OlanzapineOlanzapine

Pack size

1 g1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg250 mg

1 mL/ampule1 mL/ampule1 mL/ampule

1 mg10 mg1 mg10 mg1 g10 g10 mg100 mg1 mg10 mg1 mL/ampule25 g1 mg10 mg1 mg10 mg1 g10 mg1 g10 mg5 mg50 mg10 mg100 mg1 mg10 mg1 mL/ampule250 mg2.5 g10 mg100 mg2.5 mg25 mg10 mg100 mg1 mg10 mg1 g200 mg1 mg10 mg2.5 mg25 mg1 mg10 mg100 mg1 g

Index description

MidazolamMidazolamMidazolamMitoxantroneMitoxantroneMitoxantroneMitoxantroneMonoacetyldapsoneMonoacetyldapsoneMonoacetyldapsoneMonoacetyldapsoneMontelukastMontelukastMontelukastMontelukastMorphine

Morphine-3-β-D-glucuronideMorphine-3-β-D-glucuronideMorphine-3-β-D-glucuronide

Morphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideN-acetyl-4-aminosalicylic acidN-acetyl-4-aminosalicylic acidN-acetylsulfamethazineN-acetylsulfamethazineN-acetylsulfamethazineN-acetylsulfamethazineNaproxenNaproxenNaproxenNaproxenNaproxen acyl-b-D-glucuronideNaproxen acyl-b-D-glucuronideα-naphthoflavoneα-naphthoflavoneβ-naphthoflavoneβ-naphthoflavoneN-demethylerythromycinN-demethylerythromycinNelfinavirNelfinavirNelfinavirNelfinavirNicotineNicotineNicotineNicotineNicotineNicotineNicotineNifedipineNifedipineNifedipineNifedipineNootkatoneNovobiocinO-desmethylnaproxenO-desmethylnaproxenO-desmethyltramadolO-desmethyltramadolO-desmethyltramadolO-desmethyltramadolOlanzapineOlanzapine



LGC catalogue no.

TRC-O253752TRC-O253752-10TRC-O253755TRC-O253755-10TRC-O253757TRC-O253757-2.5TRC-O550001TRC-O550001-100TRC-O550002TRC-O550002-10CERO-021TRC-O635000TRC-O635000-5TRC-O635002TRC-O635002-10EPO0200000TRC-O868525TRC-O868525-25TRC-O868527TRC-O868527-10TRC-H948890TRC-H948890-10TRC-H948892TRC-H948892-5TRC-H948895TRC-H948895-2.5TRC-H948897TRC-H948897-2.5CDX-00016011-001CDX-00016011-005TRC-P132500TRC-P132500-250TRC-P132502TRC-P132502-5MM 0094.03USP1026401CERA-064CERP-909CERP-917TRC-A161220TRC-A161220-50TRC-A161222TRC-A161222-100TRC-A161230TRC-A161230-100TRC-A161232TRC-A161232-10TRC-A161223

TRC-A161223-10

TRC-P192500TRC-P192500-2TRC-P192502TRC-P192502-10CERP-061U-RCC-216CERNMID748CERP-003

CERP-006

CERP-007TRC-P295500TRC-P296900TRC-P296900-100CERP-008

Product description

Olanzapine-methyl-d3Olanzapine-methyl-d3Olanzapine GlucuronideOlanzapine GlucuronideOlanzapine-methyl-d3 GlucuronideOlanzapine-methyl-d3 GlucuronideOlmesartan AcidOlmesartan AcidOlmesartan-d6Olmesartan-d6Omeprazole, 1.0 mg/mL, in MethanolOmeprazoleOmeprazoleOmeprazole-d3Omeprazole-d3OuabainOxybutynin ChlorideOxybutynin ChlorideOxybutynin-d11 ChlorideOxybutynin-d11 Chloride6α-Hydroxy Paclitaxel6α-Hydroxy Paclitaxel6α-Hydroxy Paclitaxel-d56α-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel3’-p-Hydroxy Paclitaxel3’-p-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel-d5Paclitaxel C13 Labeled (for Non-Human use only)Paclitaxel C13 Labeled (for non-human use only)PaclitaxelPaclitaxelPaclitaxel-d5Paclitaxel-d54-Aminobenzoic AcidAminosalicylic AcidAcetaminophen, 1.0 mg/mL, in MethanolAcetaminophen-D4, 100 µg/mL, in MethanolAcetaminophen-D4, 1.0 mg/mL, in MethanolAcetaminophenAcetaminophenAcetaminophen-D4 (Major)Acetaminophen-D4 (Major)4-Acetaminophen Sulfate Potassium Salt4-Acetaminophen Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium SaltAcetaminophen Glutathione

Acetaminophen Glutathione

ParaxanthineParaxanthineParaxanthine-1-methyl-d3Paraxanthine-1-methyl-d3Phenacetin, 1.0 mg/mL, in AcetonitrilePhenacetinPhencyclidine hydrochloridePCP-D5 (Phencyclidine-D5), 100 µg/mL, inMethanolPCP-D5 (Phencyclidine-D5), 1.0 mg/mL, inMethanolPCP (Phencyclidine), 1.0 mg/mL, in MethanolPhencyclidine HydrochloridePhenformin HydrochloridePhenformin HydrochloridePhenobarbital, 1.0 mg/mL, in Methanol

Pack size

1 mg10 mg1 mg10 mg0.25 mg2.5 mg10 mg100 mg1 mg10 mg1 mL/ampule i500 mg5 g1 mg10 mg150 mg2.5 g25 g1 mg10 mg1 mg10 mg0.5 mg5 mg1 mg2.5 mg1 mg2.5 mg1 mg5 mg25 mg250 mg1 mg5 mg100 mg125 mg1 mL/ampule1 mL/ampule1 mL/ampule5 g50 g10 mg100 mg10 mg100 mg1 mg10 mg1 mg

10 mg

200 mg2 g1 mg10 mg1 mL/ampule100 mg50 mg1 mL/ampule

1 mL/ampule

1 mL/ampule10 mg10 g100 g1 mL/ampule

Index description

OlanzapineOlanzapineOlanzapine GlucuronideOlanzapine GlucuronideOlanzapine GlucuronideOlanzapine GlucuronideOlmesartanOlmesartanOlmesartanOlmesartanOmeprazoleOmeprazoleOmeprazoleOmeprazoleOmeprazoleOuabainOxybutyninOxybutyninOxybutyninOxybutynin6α-hydroxypaclitaxel6α-hydroxypaclitaxel6α-hydroxypaclitaxel6α-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelp-aminobenzoic acidp-aminosalicylic acidParacetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol-glutathione (Acetaminophen-glutathione)Paracetamol-glutathione (Acetaminophen-glutathione)ParaxanthineParaxanthineParaxanthineParaxanthinePhenacetinPhenacetinPhencyclidinePhencyclidine

Phencyclidine

PhencyclidinePhencyclidinePhenforminPhenforminPhenobarbital



LGC catalogue no.

CERP-017

CERP-019

TRC-P316760TRC-P316760-1TRC-P316762TRC-P316762-50USP1526007CERP-063TRC-D491652TRC-D491652-25TRC-P441500TRC-P441500-100TRC-P441502TRC-P441502-10TRC-P471000TRC-P471000-1TRC-P471002TRC-P471002-10TRC-P531000TRC-P531000-100TRC-P689600TRC-P689600-10TRC-P689602TRC-P689602-10TRC-P702000TRC-P702000-1TRC-P702002TRC-P702002-10TRC-P702325TRC-P702325-100TRC-P755000TRC-P755002TRC-P755002-10EPP3050000USP1563502MM0461.00CDX-00017030-025CDX-00017030-100TRC-Q685000TRC-Q685000-100TRC-Q685002TRC-Q685002-10TRC-Q694000TRC-Q694000-10TRC-Q694002TRC-Q694002-10TRC-R100000TRC-R100000-10TRC-R100001TRC-R100001-10TRC-R144500TRC-R144500-1TRC-R144502TRC-R144502-10CDX-00018040-025CDX-00018040-100TRC-R146500TRC-R250200TRC-R250200-10TRC-R250202TRC-R250202-10TRC-R508000TRC-R508000-25TRC-R508002TRC-R508002-10TRC-R508500

Product description

Phenobarbital-D5 (deuterium label on sidechain), 1.0 mg/mL, in MethanolPhenobarbital-D5 (deuterium label on ring), 1.0mg/mL, in MethanolPhenobarbitalPhenobarbitalPhenobarbital-ethyl-d5Phenobarbital-ethyl-d5Phenoxybenzamine HClPhenytoin, 1.0 mg/mL5,5-Diphenyl-d10-hydantoin5,5-Diphenyl-d10-hydantoinPilocarpine HydrochloridePilocarpine HydrochloridePilocarpine-d3 HydrochloridePilocarpine-d3 HydrochloridePioglitazone HydrochloridePioglitazone HydrochloridePioglitazone-d4Pioglitazone-d4Pitavastatin CalciumPitavastatin CalciumPosaconazolePosaconazolePosaconazole-d4Posaconazole-d4Pravastatin SodiumPravastatin SodiumPravastatin-D3 Sodium SaltPravastatin-D3 Sodium SaltPrazosin HydrochloridePrazosin HydrochlorideProbenecidProbenecid-d14Probenecid-d14Procainamide hydrochlorideProcainamide HClPropofolQuercetinQuercetinQuinidineQuinidineQuinidine-d3Quinidine-d3QuinineQuinineQuinine-d3Quinine-d3Raloxifene, HydrochlorideRaloxifene, HydrochlorideRaloxifene-d4Raloxifene-d4RepaglinideRepaglinideRepaglinide-ethyl-d5Repaglinide-ethyl-d5ReserpineReserpineResorufin sodium salt, 90%all-trans Retinoic Acidall-trans Retinoic Acidall-trans Retinoic Acid-d5all-trans Retinoic Acid-d5RifampicinRifampicinRifampicin-d3Rifampicin-d3Rifapentine

Pack size

1 mL/ampule

1 mL/ampule

100 mg1 g5 mg50 mg250 mg1 mL/ampule2.5 mg25 mg10 mg100 mg1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg100 g1 mg10 mg100 mg200 mg250 mg25 mg100 mg10 g100 g1 mg10 mg1 g10 g1 mg10 mg1 g10 g1 mg10 mg100 mg1 g1 mg10 mg25 mg100 mg1 g1 g10 g1 mg10 mg2.5 g25 g1 mg10 mg10 mg

Index description

Phenobarbital

Phenobarbital

PhenobarbitalPhenobarbitalPhenobarbitalPhenobarbitalPhenoxy-benzaminePhenytoinPhenytoinPhenytoinPilocarpinePilocarpinePilocarpinePilocarpinePioglitazonePioglitazonePioglitazonePioglitazonePitavastatinPitavastatinPosaconazolePosaconazolePosaconazolePosaconazolePravastatinPravastatinPravastatinPravastatinPrazosinPrazosinProbenecidProbenecidProbenecidProcainamideProcainamidePropofolQuercetinQuercetinQuinidineQuinidineQuinidineQuinidineQuinineQuinineQuinineQuinineRaloxifeneRaloxifeneRaloxifeneRaloxifeneRepaglinideRepaglinideRepaglinideRepaglinideReserpineReserpineResorufinRetinoic acidRetinoic acidRetinoic acidRetinoic acidRifampicinRifampicinRifampicinRifampicinRifapentine



LGC catalogue no.

TRC-R508200TRC-R508200-1TRC-R508500-100TRC-R535000TRC-R535000-100TRC-R535002TRC-R535002-5TRC-R535003TRC-R535003-5TRC-R693500TRC-R693500-250TRC-R693502TRC-R693502-10TRC-R700500TRC-R700500-100TRC-R700502TRC-R700502-10TRC-D292070TRC-D292070-250TRC-S135000TRC-S135000-100TRC-S135002TRC-S135002-10CDX-00019180-100CERS-006TRC-S280000TRC-S280000-1TRC-S280002TRC-S280002-10TRC-M225000TRC-M225000-100TRC-S589950TRC-S589950-50TRC-S589952TRC-S589952-10TRC-S699072TRC-S699072-10TRC-S699074TRC-S699074-100TRC-S699084TRC-S699084-100EPS2159000USP1637008TRC-S699115TRC-S699115-10USP1642700USP1642802CDX-00020070-010CDX-00020070-025EPY0000648TRC-T017000TRC-T017000-500TRC-T017002TRC-T017002-10TRC-T017305TRC-T017305-10TRC-T114500TRC-T114500-100CERNMID508CERNMID644TRC-T155000TRC-T155000-100TRC-T155002TRC-T155002-50CERIMPC-051-01USP1660000USP1664000TRC-T425600

Product description

Rifamycin SV SodiumRifamycin SV SodiumRifapentineRitonavirRitonavirRitonavir-d6Ritonavir-d6Ritonavir-13C3Ritonavir-13C3Rosiglitazone MaleateRosiglitazone MaleateRosiglitazone-d3Rosiglitazone-d3Rosuvastatin, Calcium SaltRosuvastatin, Calcium SaltRosuvastatin-d6, Sodium SaltRosuvastatin-d6, Sodium SaltS-(+)-N-Desmethyl MephenytoinS-(+)-N-Desmethyl MephenytoinSaquinavir, MesylateSaquinavir, MesylateSaquinavir-d9Saquinavir-d9Serotonin hydrochlorideSertraline, 1.0 mg/mL, in MethanolSertraline, HydrochlorideSertraline, Hydrochloriderac Sertraline-d3 Hydrochloriderac Sertraline-d3 Hydrochloride(S)-Mephenytoin(S)-MephenytoinSN-38SN-38SN-38-d3SN-38-d3Sulfamethazine-d4Sulfamethazine-d4SulfamethazineSulfamethazineSulfasalazineSulfasalazineSulfinpyrazoneSulfinpyrazoneD,L-SulforaphaneD,L-SulforaphaneTacrine HClTacrolimusTaxol CTaxol CTelmisartanTelmisartanTelmisartanTelmisartan-d3Telmisartan-d3TemocaprilatTemocaprilatTerfenadineTerfenadineTestosterone sulfate19-d3-TestosteroneTestosteroneTestosteroneTestosterone-d3Testosterone-d3Theophylline, 1.0 mg/mL, in MethanolThioguanineThiotepaThyroxine

Pack size

100 mg1 g100 mg10 mg100 mg0.5 mg5 mg0.5 mg5 mg25 mg250 mg1 mg10 mg10 mg100 mg1 mg10 mg25 mg250 mg10 mg100 mg1 mg10 mg100 mg1 mL/ampule100 mg1 g1 mg10 mg10 mg100 mg5 mg50 mg1 mg10 mg1 mg10 mg10 mg100 mg10 g100 g30 mg200 mg1 g10 g500 mg150 mg10 mg25 mg30 mg50 mg500 mg1 mg10 mg1 mg10 mg10 g100 g1 mg1 mg10 g100 g5 mg50 mg1 mL/ampule200 mg500 mg1 g

Index description

RifamycinRifamycinRifapentineRitonavirRitonavirRitonavirRitonavirRitonavirRitonavirRosiglitazoneRosiglitazoneRosiglitazoneRosiglitazoneRosuvastatinRosuvastatinRosuvastatinRosuvastatinS-(+)-N-desmethyl mephenytoinS-(+)-N-desmethyl mephenytoinSaquinavirSaquinavirSaquinavirSaquinavirSerotoninSertralineSertralineSertralineSertralineSertralineS-mephenytoinS-mephenytoinSN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SulfamethazineSulfamethazineSulfamethazineSulfamethazineSulfasalazineSulfasalazineSulfinpyrazoneSulfinpyrazoneSulforaphaneSulforaphaneTacrineTacrolimusTaxolTaxolTelmisartanTelmisartanTelmisartanTelmisartanTelmisartanTemocaprilatTemocaprilatTerfenadineTerfenadineTestosteroneTestosteroneTestosteroneTestosteroneTestosteroneTestosteroneTheophyllineThioguanineThiotepaThyroxine



LGC catalogue no.

TRC-T425600-10TRC-T425602TRC-T425602-5TRC-T438325TRC-T438325-50CERT-036TRC-T542500TRC-T542500-10TRC-T542502TRC-T542502-10CERT-029

TRC-T712480TRC-T712480-10TRC-T712500TRC-T712500-10TRC-P319680TRC-P319680-1TRC-P319682

TRC-P319682-10

CERT-908CERT-910TRC-T767380TRC-T767380-100CDX-00020640-001TRC-T779200TRC-T779200-100TRC-T779202TRC-T779202-10TRC-T795615TRC-T795615-100TRC-T795616TRC-T795616-10TRC-T795617TRC-T795617-10TRC-T795618TRC-T795618-10TRC-T892500TRC-T892500-100USP1697000TRC-T894600TRC-V085000TRC-V085000-1TRC-V085002TRC-V085002-10TRC-V094750TRC-V094750-100TRC-V094752TRC-V094752-50TRC-V095750TRC-V095750-100TRC-V095752TRC-V095752-10CERV-002

TRC-V125000TRC-V125000-50TRC-V125002TRC-V125002-50CDX-00022518-005CDX-00022518-010TRC-V314000TRC-V314000-200EPZ1900000USP1724500

Product description

ThyroxineThyroxine-13C6Thyroxine-13C6Ticlopidine, HydrochlorideTiclopidine, HydrochlorideTolbutamide, 1.0 mg/mL, in AcetonitrileTopotecan HydrochlorideTopotecan HydrochlorideTopotecan-d6Topotecan-d6Tramadol-13C, D3 HCl, 100 µg/mL (as freebase), in MethanolTramadol-d6 HydrochlorideTramadol-d6 HydrochlorideTramadol HydrochlorideTramadol Hydrochloridetrans 2-Phenylcyclopropylamine Hydrochloridetrans 2-Phenylcyclopropylamine Hydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochlorideTriazolam-D4, 100 µg/mL, in MethanolTriazolam, 1.0 mg/mL, in MethanolTriazolamTriazolamTricinTrifluoperazine DihydrochlorideTrifluoperazine DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrimethoprimTrimethoprimTrimethoprim-13C3Trimethoprim-13C3Trimethoprim-d9 (Major)Trimethoprim-d9 (Major)Trimethoprim-d3Trimethoprim-d3TroglitazoneTroglitazoneTroleandomycinTryptamineValacyclovir, HydrochlorideValacyclovir, HydrochlorideValacyclovir-d4, HydrochlorideValacyclovir-d4, HydrochlorideValproic AcidValproic AcidValproic Acid-d6Valproic Acid-d6ValsartanValsartanValsartan-d3Valsartan-d3Verapamil HCl, 1.0 mg/mL (as free base), inMethanolVerapamil HydrochlorideVerapamil HydrochlorideVerapamil-d6 HydrochlorideVerapamil-d6 HydrochlorideVinblastine SulfateVinblastine SulfateVinblastine SulfateVinblastine SulfateZidovudineZidovudine

Pack size

10 g1 mg5 mg5 g50 g1 mL/ampule1 mg10 mg1 mg10 mg1 mL/ampule

1 mg10 mg1 g10 g100 mg1 g1 mg

10 mg

1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg250 mg50 g100 mg1 g1 mg10 mg10 g100 g5 mg50 mg10 mg100 mg1 mg10 mg1 mL/ampule

5 g50 g5 mg50 mg5 mg10 mg20 mg200 mg60 mg400 mg

Index description

ThyroxineThyroxineThyroxineTiclopidineTiclopidineTolbutamideTopotecanTopotecanTopotecanTopotecanTramadol

TramadolTramadolTramadolTramadolTranylcypromineTranylcypromineTranylcypromine

Tranylcypromine

TriazolamTriazolamTriazolamTriazolamTricinTrifluoperazineTrifluoperazineTrifluoperazineTrifluoperazineTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTroglitazoneTroglitazoneTroleandomycinTryptamineValacyclovirValacyclovirValacyclovirValacyclovirValproic acidValproic acidValproic acidValproic acidValsartanValsartanValsartanValsartanVerapamil

VerapamilVerapamilVerapamilVerapamilVinblastineVinblastineVinblastineVinblastineZidovudine (azidothymidine, AZT)Zidovudine (azidothymidine, AZT)

Fluorescent products

Fluorescent products onlyQuick reference catalogue listing of fluorescent reagents only.

LGC catalogue no.

CERC-073EPY0000438TRC-E891725TRC-E891725-10TRC-E891727TRC-E891727-100TRC-E892875TRC-E892875-100CERH-060CERH-061

TRC-H924875TRC-H924875-25TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924890TRC-H924890-50TRC-H924892

TRC-H924892-2.5

TRC-H924880

TRC-H924880-10

TRC-H924882

TRC-H924882-10

TRC-H924883TRC-H924883-10TRC-R146500

Product description

Coumarin, 1.0 mg/mL, in AcetonitrileCoumarin7-Ethoxycoumarin7-Ethoxycoumarin7-Ethoxycoumarin-d57-Ethoxycoumarin-d57-Ethoxyresorufin7-Ethoxyresorufin7-Hydroxycoumarin, 1.0 mg/mL, in Acetonitrile7-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin7-Hydroxy Coumarin7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-GlucuronideResorufin sodium salt, 90%

Pack size

1 mL/ampule80 mg1 g10 g10 mg100 mg10 mg100 mg1 mL/ampule1 mL/ampule

2.5 g25 g0.25 mg2.5 mg0.25 mg2.5 mg5 mg50 mg0.25 mg

2.5 mg

1 mg

10 mg

1 mg

10 mg

1 mg10 mg1 g

Index description

CoumarinCoumarin7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxyresorufin7-ethoxyresorufin7-hydroxycoumarin7-hydroxycoumarin

7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate






7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronideResorufin


Labelled products


Labelled products onlyQuick reference catalogue listing for labelled compounds only.

LGC catalogue no.

TRC-A192402TRC-A192402-10TRC-A247502TRC-A247502-2.5TRC-A168213

TRC-A168213-10

TRC-A575822TRC-A575822-10CERA-917

TRC-A634202TRC-A634202-10TRC-A634237-10TRC-A634238TRC-A634238-10TRC-A634302TRC-A790052TRC-A790052-10TRC-A791752TRC-A791752-10TRC-B288600TRC-B288600-100TRC-B689542TRC-B689542-10TRC-B689627TRC-B689627-10TRC-C080102TRC-C080102-25TRC-C175752TRC-C175752-10TRC-C175842TRC-C175842-10TRC-C175843TRC-C175843-10TRC-C183202TRC-C183202-10TRC-C235752TRC-C235752-10TRC-C380002TRC-C380002-10TRC-C428702TRC-C428702-10TRC-C441652TRC-C441652-10TRC-C587252TRC-C587252-10TRC-C696302TRC-C696302-5CERC-017CERC-035TRC-C725005TRC-C725005-100TRC-D193255TRC-D193255-10TRC-D193262TRC-D193262-10TRC-D194502TRC-D194502-5TRC-D208702TRC-D208702-10TRC-D474010TRC-D474010-10TRC-D229652TRC-D229652-10CERD-040

Product description

Acyclovir-d4Acyclovir-d4Adefovir-d4Adefovir-d45-Acetylamino-6-formylamino-3-methyluracil-d3


Amantadine-d15 HydrochlorideAmantadine-d15 Hydrochloride7-Aminoclonazepam-D4, 100 µg/mL, inAcetonitrileAmodiaquin-d10Amodiaquin-d10Amoxicillin-13C6Amoxicillin-d4Amoxicillin-d4Ampicillin-d5 (Mixture of Diastereomers)Atazanavir-d5Atazanavir-d5Atorvastatin-d5, Sodium SaltAtorvastatin-d5, Sodium SaltBenzylpenicillinate-d7, Potassium SaltBenzylpenicillinate-d7, Potassium SaltBufuralol-d9 HydrochlorideBufuralol-d9 HydrochlorideBupropion-d9 HydrochlorideBupropion-d9 HydrochlorideCaffeine-d9Caffeine-d9Captopril-d7Captopril-d7Carbamazepine-13C,d2Carbamazepine-13C,d2Carbamazepine-d2Carbamazepine-d24-Carboxy Tolbutamide-d94-Carboxy Tolbutamide-d9Cefadroxil-d4 (major)Cefadroxil-d4 (major)Chlorothiazide-13C,15N2Chlorothiazide-13C,15N2Chlorzoxazone-4,6,7-d3Chlorzoxazone-4,6,7-d3Cimetidine-d3Cimetidine-d3rac Clopidogrel-d4 Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen SulfateCortisol-9,11,12,12-d4Cortisol-9,11,12,12-d4(±)-Cotinine-D3, 100 µg/mL, in Methanol(±)-Cotinine-D3, 1.0 mg/mL, in MethanolCotinine-methyl-d3Cotinine-methyl-d3Dapsone-D8 (Major)Dapsone-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Daunorubicin-13C,d3Daunorubicin-13C,d3Debrisoquin-13C,15N2 HemisulfateDebrisoquin-13C,15N2 HemisulfateDeferiprone 3-O-ß-D-GlucuronideDeferiprone 3-O-ß-D-GlucuronideDehydro Felodipine-d3Dehydro Felodipine-d3N-Desethylamodiaquine-D5 dihydrochloride,100 µg/mL (as free base), in Methanol

Pack size

1 mg10 mg2.5 mg25 mg1 mg

10 mg

1 mg10 mg1 mL/ampule

1 mg10 mg10 mg1 mg10 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.5 mg5 mg1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg1 mg10 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule

Index description

AcyclovirAcyclovirAdefovirAdefovirAFMU (5-acetylamino-6-formylamino-3-methyluracil)AFMU (5-acetylamino-6-formylamino-3-methyluracil)AmantadineAmantadine7-aminoclonazepam

AmodiaquineAmodiaquineAmoxicillinAmoxicillinAmoxicillinAmpicillinAtazanavirAtazanavirAtorvastatinAtorvastatinBenzylpenicillinBenzylpenicillinBufuralolBufuralolBupropionBupropionCaffeineCaffeineCaptoprilCaptoprilCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarboxytolbutamideCarboxytolbutamideCefadroxilCefadroxilChlorothiazideChlorothiazideChlorzoxazoneChlorzoxazoneCimetidineCimetidineClopidogrelClopidogrelCortisolCortisolCotinineCotinineCotinineCotinineDapsoneDapsoneDapsonehydroxylamineDapsonehydroxylamineDaunorubicinDaunorubicinDebrisoquinDebrisoquinDeferiprone-3-O-ß-D-glucuronideDeferiprone-3-O-ß-D-glucuronideDehydrofelodipineDehydrofelodipineDesethylamodiaquine



LGC catalogue no.

TRC-D288827TRC-D288827-10TRC-D289477TRC-D289477-10CERD-903

TRC-D290052TRC-D290052-10TRC-D298802TRC-D298802-25TRC-D299457TRC-D299457-50CERD-041TRC-D299487TRC-D299487-25TRC-D436452TRC-D436452-10TRC-D446577TRC-D446577-25TRC-D493452TRC-D493452-10TRC-D533782TRC-D533782-10TRC-D533790TRC-D533790-10TRC-D558002TRC-D558002-2.5TRC-E425002TRC-E425002-10TRC-E489002TRC-E489002-10TRC-E555252TRC-E555252-10TRC-E555253TRC-E555253-10TRC-E625002TRC-E625002-10TRC-E649952TRC-E649952-10TRC-E888002TRC-E888002-10TRC-E891727TRC-E891727-100TRC-E685102TRC-E685102-10TRC-F232377TRC-F232377-10TRC-F322500TRC-F322500-10TRC-F421002TRC-F421002-10CERF-919

TRC-F597102TRC-F597102-10TRC-F598702TRC-F598702-50TRC-F598852TRC-F598852-10TRC-F601252TRC-F601252-10TRC-F603502TRC-F603502-10TRC-G235002TRC-G235002-10TRC-G305752TRC-G305752-50CERH-006

Product description

N-Desethyl Amodiaquine-d5N-Desethyl Amodiaquine-d5Desethyl Oxybutynin-d11 HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesipramine-D3 HCl, 100 µg/mL (as freebase), in MethanolDesipramine-2,4,6,8-d4 HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDexamethasone-d3Dexamethasone-d3Dextromethorphan-d3Dextromethorphan-d3Dextrorphan-D3, 100 µg/mL, in MethanolDextrorphan-d3, Tartrate SaltDextrorphan-d3, Tartrate SaltDiclofenac-D4 (Major)Diclofenac-D4 (Major)Digoxin-d3Digoxin-d3Disopyramide-d14 Tosylate SaltDisopyramide-d14 Tosylate SaltDopamine-d4 HydrochlorideDopamine-d4 HydrochlorideDopamine 3-β-D-GlucuronideDopamine 3-β-D-GlucuronideDoxorubicin-13C,d3Doxorubicin-13C,d3rac Efavirenz-d4rac Efavirenz-d4Elacridar-d4Elacridar-d4Enalapril-d5 Maleate SaltEnalapril-d5 Maleate SaltEnalapril-d3Enalapril-d3Erlotinib-d6, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErythromycin-13C,D3Erythromycin-13C,D317β-Estradiol-16,16,17-d317β-Estradiol-16,16,17-d37-Ethoxycoumarin-d57-Ethoxycoumarin-d5Ethynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol-2,4,16,16-d4rac Felodipine-d3rac Felodipine-d3Fexofenadine-D6Fexofenadine-D6Fluconazole-d4Fluconazole-d4Fluoxetine-D6 Oxalate, 100 µg/mL (as freebase), in MethanolFluoxetine-d5 HydrochlorideFluoxetine-d5 HydrochlorideFlurbiprofen-d3Flurbiprofen-d3Flutamide-d7Flutamide-d7Fluvastatin-D8 (Major), Sodium SaltFluvastatin-D8 (Major), Sodium Salt(E)-Fluvoxamine-d3 Maleate(E)-Fluvoxamine-d3 MaleateGanciclovir-d5Ganciclovir-d5Gemfibrozil-d6Gemfibrozil-d6Hydromorphone-D3, 100 µg/mL, in Methanol

Pack size

1 mg10 mg1 mg10 mg1 mL/ampule

1 mg10 mg10 mg25 mg5 mg50 mg1 mL/ampule2.5 mg25 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg0.25 mg2.5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule

1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mL/ampule

Index description

DesethylamodiaquineDesethylamodiaquineDesethyloxybutyninDesethyloxybutyninDesipramine

DesipramineDesipramineDexamethasoneDexamethasoneDextromethorphanDextromethorphanDextrorphanDextrorphanDextrorphanDiclofenacDiclofenacDigoxinDigoxinDisopyramideDisopyramideDopamineDopamineDopamine-3-β-D-glucuronideDopamine-3-β-D-glucuronideDoxorubicinDoxorubicinEfavirenzEfavirenzElacridarElacridarEnalaprilEnalaprilEnalaprilEnalaprilErlotinibErlotinibErythromycinErythromycinEstradiolEstradiol7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)EthynylestradiolEthynylestradiolFelodipineFelodipineFexofenadineFexofenadineFluconazoleFluconazoleFluoxetine

FluoxetineFluoxetineFlurbiprofenFlurbiprofenFlutamideFlutamideFluvastatinFluvastatinFluvoxamineFluvoxamineGanciclovirGanciclovirGemfibrozilGemfibrozilHydromorphone



LGC catalogue no.

CERH-010CERH-049CERH-062

CERH-066TRC-H830482TRC-H830482-5TRC-H830677TRC-H830677-10TRC-H922302TRC-H922302-10TRC-H924510TRC-H924510-10CERH-061

TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924892

TRC-H924892-2.5

TRC-H924882

TRC-H924882-10

TRC-H924883TRC-H924883-10TRC-H933877TRC-H933877-10TRC-H936752TRC-H936752-10CERH-064

TRC-H825122TRC-H825122-2.5CERH-053

TRC-H825227TRC-H825227-10TRC-H825228TRC-H825228-10TRC-H941827TRC-H941827-10TRC-H942442TRC-H942442-10TRC-H944877TRC-H944877-25CERH-921

TRC-H948422TRC-H948422-10TRC-H948427TRC-H948427-5TRC-H948864TRC-H948864-10TRC-H948892TRC-H948892-5TRC-H954757TRC-H954757-100CERT-034

TRC-H956752TRC-H956752-10CERH-055

TRC-H969852

Product description

Hydromorphone-D3, 1.0 mg/mL, in MethanolHydromorphone-D6, 100 µg/mL, in Methanol(±)-Hydroxybupropion-D6, 100 µg/mL, inAcetonitrile(±)-Hydroxybupropion, 1.0 mg/mL, in Acetonitrile1’-Hydroxybufuralol-d9 (Mixture of Diastereomers)1’-Hydroxybufuralol-d9 (Mixture of Diastereomers)Hydroxy Bupropion-d6Hydroxy Bupropion-d66β-Hydroxy Cortisol-d46β-Hydroxy Cortisol-d4trans-3'-Hydroxycotinine, Methyl-d3trans-3'-Hydroxycotinine, Methyl-d37-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-Glucuroniderac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfate3-Hydroxy Desloratadine-d43-Hydroxy Desloratadine-d46-Hydroxychlorzoxazone-D2,15N, 100 µg/mL,in Methanol6-Hydroxy Chlorzoxazone-13C66-Hydroxy Chlorzoxazone-13C64'-Hydroxydiclofenac-13C6, 100 µg/mL, inMethanol4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-13C64’-Hydroxy Diclofenac-13C6rac 8-Hydroxy Efavirenz-d4rac 8-Hydroxy Efavirenz-d44’-Hydroxy Flurbiprofen-d34’-Hydroxy Flurbiprofen-d3(+/-)-4’-Hydroxy Mephenytoin-d3(+/-)-4’-Hydroxy Mephenytoin-d3α-Hydroxymidazolam-D4, 100 µg/mL, inMethanol1’-Hydroxymidazolam-13C31’-Hydroxymidazolam-13C34-Hydroxy Midazolam-d54-Hydroxy Midazolam-d55-Hydroxy Omeprazole-d35-Hydroxy Omeprazole-d36α-Hydroxy Paclitaxel-d56α-Hydroxy Paclitaxel-d54-Hydroxy Tamoxifen Ethyl-d54-Hydroxy Tamoxifen Ethyl-d56β-Hydroxytestosterone-D3, 100 µg/mL, inMethanol6β-Hydroxy Testosterone-d36β-Hydroxy Testosterone-d34-Hydroxytolbutamide-D9, 100 µg/mL, inAcetonitrileHydroxy Tolbutamide-d9

Pack size

1 mL/ampule1 mL/ampule1 mL/ampule

1 mL/ampule0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule

0.25 mg2.5 mg0.25 mg2.5 mg0.25 mg

2.5 mg

1 mg

10 mg

1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule

0.25 mg2.5 mg1 mL/ampule

1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg2.5 mg25 mg1 mL/ampule

1 mg10 mg0.5 mg5 mg0.5 mg5 mg0.5 mg5 mg10 mg100 mg1 mL/ampule

1 mg10 mg1 mL/ampule

1 mg

Index description

HydromorphoneHydromorphoneHydroxybupropion

Hydroxybupropion1-hydroxybufuralol1-hydroxybufuralolHydroxybupropionHydroxybupropion6β-hydroxycortisol6β-hydroxycortisol3-hydroxycotinine3-hydroxycotinine7-hydroxycoumarin

7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate




7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronide(Â±)-4-hydroxydebrisoquin sulfate(Â±)-4-hydroxydebrisoquin sulfateHydroxydesloratadineHydroxydesloratadine6-hydroxychlorzoxazone

6-hydroxychlorzoxazone6-hydroxychlorzoxazone4’-hydroxydiclofenac

4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac8-hydroxyefavirenz8-hydroxyefavirenz4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4-hydroxymephenytoin4-hydroxymephenytoin1'-hydroxymidazolam

1'-hydroxymidazolam1'-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam5-hydroxyomeprazole5-hydroxyomeprazole6α-hydroxypaclitaxel6α-hydroxypaclitaxel4-hydroxytamoxifen4-hydroxytamoxifen6β-hydroxytestosterone

6β-hydroxytestosterone6β-hydroxytestosterone4-hydroxytolbutamide

4-hydroxytolbutamide



LGC catalogue no.

TRC-H969852-10TRC-H953232TRC-H953232-10TRC-I465983TRC-I465983-25TRC-I525002TRC-I525002-10TRC-I821452TRC-I821452-10TRC-I937502TRC-I937502-10TRC-K186002TRC-K186002-25TRC-L175002TRC-L175002-25TRC-L175802TRC-L175802-5TRC-L469452TRC-L469452-10TRC-M218002TRC-M218002-10TRC-M258812TRC-M258812-10TRC-M260677TRC-M260677-50TRC-M338577TRC-M338577-10TRC-M338792TRC-M338792-10CERM-918

TRC-M343002TRC-M343002-10TRC-M373427TRC-M373427-10TRC-A168437TRC-A168437-10TRC-M568002TRC-M568002-10CERM-017TRC-M652312TRC-M652312-10TRC-A187852TRC-A187852-10TRC-N377527TRC-N377527-10TRC-N389752TRC-N389752-10CERN-048TRC-N412423TRC-N412423-100TRC-N412427TRC-N412427-25TRC-N457002TRC-N457002-10TRC-D292127TRC-D292127-10TRC-D294742TRC-D294742-10TRC-O253752TRC-O253752-10TRC-O253757TRC-O253757-2.5TRC-O550002TRC-O550002-10TRC-O635002TRC-O635002-10TRC-O868527

Product description

Hydroxy Tolbutamide-d9(3S)-3-Hydroxy Quinidine-vinyl-d3(3S)-3-Hydroxy Quinidine-vinyl-d3Imipramine-d6Imipramine-d6Indinavir-d6Indinavir-d6Isoniazid-d4Isoniazid-d4Itraconazole-d5Itraconazole-d5Ketoconazole-d8Ketoconazole-d8Lansoprazole-d4Lansoprazole-d4Lapatinib-13C2,15N DitosylateLapatinib-13C2,15N DitosylateLoperamide-d6 HydrochlorideLoperamide-d6 HydrochlorideMemantine-d6, HydrochlorideMemantine-d6, HydrochlorideMetformin-d6, HydrochlorideMetformin-d6, HydrochlorideMethotrexate-methyl-d3Methotrexate-methyl-d31-Methylxanthine-d31-Methylxanthine-d3rac Metoprolol-d7rac Metoprolol-d7Midazolam-D4 maleate, 100 µg/mL (as freebase), in MethanolMidazolam-d5 (Major)Midazolam-d5 (Major)Mitoxantrone-d8Mitoxantrone-d8N-Acetyl Dapsone-D8 (Major)N-Acetyl Dapsone-D8 (Major)Montelukast-d6, Sodium SaltMontelukast-d6, Sodium SaltMorphine-3-β-D-glucuronide-D3Morphine-d3 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideN-Acetyl Sulfamethazine-d4N-Acetyl Sulfamethazine-d4rac Naproxen-d3rac Naproxen-d3Nelfinavir-d3Nelfinavir-d3(±)-Nicotine-D4, 100 µg/mL, in Acetonitrile(+/-)-Nicotine-3’-d3(+/-)-Nicotine-3’-d3Nicotine-d4Nicotine-d4Nifedipine-d6Nifedipine-d6rac O-Desmethyl Naproxen-d3rac O-Desmethyl Naproxen-d3rac O-Desmethyl Tramadol-d6rac O-Desmethyl Tramadol-d6Olanzapine-methyl-d3Olanzapine-methyl-d3Olanzapine-methyl-d3 GlucuronideOlanzapine-methyl-d3 GlucuronideOlmesartan-d6Olmesartan-d6Omeprazole-d3Omeprazole-d3Oxybutynin-d11 Chloride

Pack size

10 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg2.5 mg25 mg2.5 mg25 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mL/ampule

1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule10 mg100 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.25 mg2.5 mg1 mg10 mg1 mg10 mg1 mg

Index description

4-hydroxytolbutamide(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidineImipramineImipramineIndinavirIndinavirIsoniazidIsoniazidItraconazoleItraconazoleKetoconazoleKetoconazoleLansoprazoleLansoprazoleLapatinibLapatinibLoperamideLoperamideMemantineMemantineMetforminMetforminMethotrexateMethotrexate1-methylxanthine1-methylxanthineMetoprololMetoprololMidazolam

MidazolamMidazolamMitoxantroneMitoxantroneMonoacetyldapsoneMonoacetyldapsoneMontelukastMontelukastMorphine-3-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideN-acetylsulfamethazineN-acetylsulfamethazineNaproxenNaproxenNelfinavirNelfinavirNicotineNicotineNicotineNicotineNicotineNifedipineNifedipineO-desmethylnaproxenO-desmethylnaproxenO-desmethyltramadolO-desmethyltramadolOlanzapineOlanzapineOlanzapineOlanzapineOlmesartanOlmesartanOmeprazoleOmeprazoleOxybutynin



LGC catalogue no.

TRC-O868527-10TRC-H948897TRC-H948897-2.5CDX-00016011-001CDX-00016011-005TRC-P132502TRC-P132502-5CERP-909CERP-917TRC-A161222TRC-A161222-100TRC-A161232TRC-A161232-10TRC-P192502TRC-P192502-10CERP-003

CERP-006

CERP-017

CERP-019

TRC-P316762TRC-P316762-50TRC-D491652TRC-D491652-25TRC-P441502TRC-P441502-10TRC-P471002TRC-P471002-10TRC-P689602TRC-P689602-10TRC-P702002TRC-P702002-10TRC-P755002TRC-P755002-10TRC-Q685002TRC-Q685002-10TRC-694002TRC-694002-10TRC-Q694002TRC-Q694002-10TRC-R100001TRC-R100001-10TRC-R144502TRC-R144502-10TRC-R250202TRC-R250202-10TRC-R508002TRC-R508002-10TRC-R535002TRC-R535002-5TRC-R535003TRC-R535003-5TRC-R693502TRC-R693502-10TRC-R700502TRC-R700502-10TRC-S135002TRC-S135002-10TRC-S280002TRC-S280002-10TRC-S589952TRC-S589952-10TRC-S699072TRC-S699072-10TRC-T017002

Product description

Oxybutynin-d11 Chloride3’-p-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel-d5Paclitaxel C13 Labeled for Non-Human use onlyPaclitaxel C13 Labeled (for non-human use only)Paclitaxel-d5Paclitaxel-d5Acetaminophen-D4, 100 µg/mL, in MethanolAcetaminophen-D4, 1.0 mg/mL, in MethanolAcetaminophen-D4 (Major)Acetaminophen-D4 (Major)4-Acetaminophen-d3 Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium SaltParaxanthine-1-methyl-d3Paraxanthine-1-methyl-d3PCP-D5 (Phencyclidine-D5), 100 µg/mL, inMethanolPCP-D5 (Phencyclidine-D5), 1.0 mg/mL, inMethanolPhenobarbital-D5 (deuterium label on side chain),1.0 mg/mL, in MethanolPhenobarbital-D5 (deuterium label on ring), 1.0mg/mL, in MethanolPhenobarbital-ethyl-d5Phenobarbital-ethyl-d55,5-Diphenyl-d10-hydantoin5,5-Diphenyl-d10-hydantoinPilocarpine-d3 HydrochloridePilocarpine-d3 HydrochloridePioglitazone-d4Pioglitazone-d4Posaconazole-d4Posaconazole-d4Pravastatin-D3 Sodium SaltPravastatin-D3 Sodium SaltProbenecid-d14Probenecid-d14Quinidine-d3Quinidine-d3Quinine methoxy-D3Quinine methoxy-D3Quinine-d3Quinine-d3Raloxifene-d4Raloxifene-d4Repaglinide-ethyl-d5Repaglinide-ethyl-d5all-trans Retinoic Acid-d5all-trans Retinoic Acid-d5Rifampicin-d3Rifampicin-d3Ritonavir-d6Ritonavir-d6Ritonavir-13C3Ritonavir-13C3Rosiglitazone-d3Rosiglitazone-d3Rosuvastatin-d6, Sodium SaltRosuvastatin-d6, Sodium SaltSaquinavir-d9Saquinavir-d9rac Sertraline-d3 Hydrochloriderac Sertraline-d3 HydrochlorideSN-38-d3SN-38-d3Sulfamethazine-d4Sulfamethazine-d4Telmisartan-d3

Pack size

10 mg1 mg2.5 mg1 mg5 mg1 mg5 mg1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg1 mg10 mg1 mL/ampule

1 mL/ampule

1 mL/ampule

1 mL/ampule

5 mg50 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.5 mg5 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg

Index description

Oxybutyninp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelParacetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)ParaxanthineParaxanthinePhencyclidine

Phencyclidine

Phenobarbital

Phenobarbital

PhenobarbitalPhenobarbitalPhenytoinPhenytoinPilocarpinePilocarpinePioglitazonePioglitazonePosaconazolePosaconazolePravastatinPravastatinProbenecidProbenecidQuinidineQuinidineQuinineQuinineQuinineQuinineRaloxifeneRaloxifeneRepaglinideRepaglinideRetinoic acidRetinoic acidRifampicinRifampicinRitonavirRitonavirRitonavirRitonavirRosiglitazoneRosiglitazoneRosuvastatinRosuvastatinSaquinavirSaquinavirSertralineSertralineSN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SulfamethazineSulfamethazineTelmisartan



LGC catalogue no.

TRC-T017002-10CERNMID644TRC-T155002TRC-T155002-50TRC-T425602TRC-T425602-5TRC-T542502TRC-T542502-10CERT-029

TRC-T712480TRC-T712480-10TRC-P319682

TRC-P319682-10

CERT-908TRC-T779202TRC-T779202-10TRC-T795616TRC-T795616-10TRC-T795617TRC-T795617-10TRC-T795618TRC-T795618-10TRC-V085002TRC-V085002-10TRC-V094752TRC-V094752-50TRC-V095752TRC-V095752-10TRC-V125002TRC-V125002-50TRC-H948392

TRC-H948392-10

Product description

Telmisartan-d319-d3-TestosteroneTestosterone-d3Testosterone-d3Thyroxine-13C6Thyroxine-13C6Topotecan-d6Topotecan-d6Tramadol-13C, D3 HCl, 100 µg/mL (as freebase), in MethanolTramadol-d6 HydrochlorideTramadol-d6 Hydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochlorideTriazolam-D4, 100 µg/mL, in MethanolTrifluoperazine-d3 DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrimethoprim-13C3Trimethoprim-13C3Trimethoprim-d9 (Major)Trimethoprim-d9 (Major)Trimethoprim-d3Trimethoprim-d3Valacyclovir-d4, HydrochlorideValacyclovir-d4, HydrochlorideValproic Acid-d6Valproic Acid-d6Valsartan-d3Valsartan-d3Verapamil-d6 HydrochlorideVerapamil-d6 Hydrochloridea-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)a-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)

Pack size

10 mg1 mg5 mg50 mg1 mg5 mg1 mg10 mg1 mL/ampule

1 mg10 mg1 mg

10 mg

1 mL/ampule1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg5 mg50 mg1 mg

10 mg

Index description

TelmisartanTestosteroneTestosteroneTestosteroneThyroxineThyroxineTopotecanTopotecanTramadol

TramadolTramadolTranylcypromine

Tranylcypromine

TriazolamTrifluoperazineTrifluoperazineTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimValacyclovirValacyclovirValproic acidValproic acidValsartanValsartanVerapamilVerapamilα-hydroxymetoprolol

α-hydroxymetoprolol


Description

Salmonella enterica subsp. enterica



Escherichia coli

ATCC® no.

29629TM

29630TM

29631TM

49979TM

Designation

TA 1535

TA 1537

TA 1538

NCIMB 11188[WP2 uvrA]

Common applications include

Mutation tests (Ames assay), Genotoxicity /Bacterial mutation assays

Mutation tests (Ames assay), Genotoxicity /Bacterial mutation assays

Mutation tests (Ames assay)

Genotoxicity / Bacterial mutation assays

ATCC® microbiology cultures

Bacteria

ATCCGenuine Cultures®: Direct from the Source

The ATCC Genuine Cultures emblem was

designed to help scientists identify authentic ATCC

microbial strains that come directly from ATCC.

ATCC Genuine Cultures are backed by meticulous

laboratory procedures and 80 years of experience

and represent ATCC’s high standards of quality for

microbial strains:

• Full characterisation of each strain to

establish identity;

• Utilisation of a seed stock system to minimise

subculturing;

• Careful preservation and storage protocols

to maintain the culture safely and effectively.

As always, a customer who purchases a genuine

ATCC culture from LGC Standards is receiving a

culture that is a direct, minimal-passage

descendant of the original material deposited with

ATCC and has been handled only by ATCC. These

products are backed by our warranty and covered

by our expert technical support.

Don’t take chances on the quality of your cultures.

Insist on products that meet ATCC’s high standards

of full characterisation and low passage number.

ATCC Genuine Cultures are only available in

Europe through LGC Standards.

®

All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC microbiology collection can be viewed at www.lgcstandards-atcc.org.


Description

Mus musculus (mouse); areolar fibroblast

Homo sapiens (human); cervicaladenocarcinoma

Canis familiaris; kidney

Cricetulus griseus (hamster, Chinese); ovary

Cercopithecus aethiops (african greenmonkey); kidney

Cricetulus griseus (hamster, Chinese); lung

Homo sapiens (human); neuroblastoma

Homo sapiens (human); rhabdomyosarcoma

Mus musculus (mouse); embryo fibroblast

Homo sapiens (human); lung carcinoma

Homo sapiens (human); lung fibroblast

Homo sapiens (human); promyelocyticleukemia

Homo sapiens (human); leukemia (CML)

Homo sapiens (human); colorectal carcinoma

Homo sapiens (human); prostateadenocarcinoma

Homo sapiens (human); pancreatic carcinoma

Homo sapiens (human); breast carcinoma

Homo sapiens (human); epidermoid carcinoma

ATCC® no.

CCL-1™

CCL-2™

CCL-34™

CCL-61™

CCL-70™

CCL-93™

CCL-127™

CCL-136™

CCL-163™

CCL-185™

CCL-186™

CCL-240™

CCL-243™

CL-187™

CRL-1435™

CRL-1469™

CRL-1500™

CRL-1555™

Designation

NCTC clone 929

HeLa

MDCK (NBL-2)

CHO-K1

CV-1

V79-4

IMR-32

RD

BALB/3T3 clone A31

A549

IMR-90

HL-60

K-562

LS 180

PC-3

PANC-1

ZR-75-1

A-431

Common applications include

Agar overlay, MEM elution

Transactivation assays (hormone-sensitivetranscription of reporter genes)

Cytosensor microphysiometer bioassay, P-gpinhibition with calcein AM substrate

Transactivation assays (hormone-sensitivetranscription of reporter genes), Genotoxicity /Mammalial cell assays (ICH Guideline), Uptaketransporter assays, micronucleus assay, hERGin vitro assay


Cytotoxicity

Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability


Cell transformation test, Phototoxicity



Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability, Dye transportassays (Calcein and Hoechst 33342 assays)

Dye transport assays (Calcein and Hoechst33342 assays)

Pgp induction / inhibition assay

Transactivation assays (hormone-sensitivetranscription of reporter genes), Cytotoxicity:Apoptosis, Cellular anabolism, Cellularmetabolism, Cellular respiration (ATP/ADP),Proliferation, Viability




Cell lines


The ATCC Cell Biology Collection is the most comprehensive and diverse of its kind in the world, consisting of over

3,400 cell lines from over 80 different species. It holds over 950 cancer cell lines, 1,000 hybridomas and several special

collections including stem cells and primary cells. The full collection can be found at www.lgcstandards-atcc.org.

®

All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC collection can be viewed at www.lgcstandards-atcc.org.


DescriptionATCC® no. Designation Common applications include


Cell lines

CRL-1573™

CRL-1593.2™

CRL-1650™

CRL-1658™

CRL-1721™

CRL-1722™

CRL-1730™

CRL-1740™

CRL-1934™

CRL-1935™

CRL-1990™

CRL-2026™

CRL-2062™

CRL-2064™

CRL-2102™

CRL-2103™

CRL-2142™

CRL-2266™

CRL-2873™

CRL-8015™

Homo sapiens (human); embryonic kidney

Homo sapiens (human); histiocytic lymphoma

Cercopithecus aethiops (african greenmonkey); kidney

Mus musculus (mouse); embryonic fibroblast

Rattus norvegicus (rat); pheochromocytoma

Mus musculus (mouse); lymphoma

Homo sapiens (human); vascularendothelium

Homo sapiens (human); prostate carcinoma

Mus musculus (mouse); stem cell

Cricetulus griseus (hamster, Chinese); lung

Homo sapiens (human); acute T cellleukemia

Mus musculus (mouse); liver hepatoma

Homo sapiens (human); human lung, smallcell carcinoma (licence may be required)

Homo sapiens (human); lung carcinoma

Homo sapiens (human); colonadenocarcinoma

Homo sapiens (human); normal skinfibroblast


Homo sapiens (human) neuroblastoma

Homo sapiens (human); vascularendothelium

Homo sapiens (human); lymphoblast

293 [HEK-293]

U-937

COS-1

NIH/3T3

PC-12

L5178-R (LY-R)

HUV-EC-C

LNCaP clone FGC

ES-D3 [D3]

CHL/IU [CHL-11]

J45.01

Hepa-1c1c7

DMS 53

DMS 153

C2BBe1 [clone ofCaco-2 (HTB-37™)]

CCD-1086Sk

SK-N-F1

SH-SY5Y

HUVEC-CS

TK6

Transactivation assays (hormone-sensitivetranscription of reporter genes), hERG in vitroassay



Phototoxicity assay


Cell mutation tests, In vitro mammalian cellmicronucleus test, Genotoxicity / Mammaliancell assays (ICH guideline), Mammalian genemutation test (MLA)



Reproductive toxicity (ES)

Chromosome aberrations assay





In vitro absorption, Active efflux determination,P-gp substrate determination, P-gp inhibitiondetermination





Cytokinesis-blocked micronucleus assay,in vitro aneuploidy, Genotoxicity / Mammaliancell assays (ICH guideline)

®



DescriptionATCC® no. Designation Common applications include


Cell lines

CRL-11609™

HB-8065™

HTB-11™

HTB-22™

HTB-26™

HTB-30™

HTB-37™

HTB-38™

HTB-85™

HTB-112™

HTB-133™

HTB-148™

HTB-153™

PCS-100-010

TIB-202™

Homo sapiens (human); prostate epithelium

Homo sapiens (human); hepatocellularcarcinoma


Homo sapiens (human); breastadenocarcinoma





Homo sapiens (human); osteosarcoma

Homo sapiens (human); uterusadenocarcinoma

Homo sapiens (human); endometrialcarcinoma

Homo sapiens (human); neuroglioma

Homo sapiens (human); rhabdomyosarcoma

Homo sapiens (human); primary umbilicalvein endothelial cells; normal

Homo sapiens (human); acute monocyticleukemia

RWPE-1

Hep G2

SK-N-SH

MCF7

MDA-MB-231

SK-BR-3

Caco-2

HT-29

Saos-2

HEC-1-A

T-47D

H4

Hs 729 [Hs 729T]

HUVEC

THP-1


Cytotoxicity, Transactivation assays(hormone-sensitive transcription of reportergenes), Phospholipidosisa


Induction of hormone-responsive mammaliancell proliferation, Transactivation assays(hormone-sensitive transcription of reportergenes), Cytotoxicity: Apoptosis, Cellularanabolism, Cellular metabolism, Cellularrespiration (ATP/ADP), Proliferation, Viability



In vitro absorption, Active efflux determination,P-gp substrate determination, P-gp inhibitiondetermination




Transactivation assays (hormone-sensitivetranscription of reporter genes), Cytotoxicity:Apoptosis, Cellular anabolism, Cellularmetabolism, Cellular respiration (ATP/ADP),Proliferation, Viability





®


Culture reagent descriptionCulture reagentcatalogue no.

Vascular Cell Basal Medium; 500mlEndothelial Cell Growth Kit-BBEEndothelial Cell Growth Kit-VEGF

Vascular Cell Basal Medium; 500mlEndothelial Cell Growth Kit-BBEEndothelial Cell Growth Kit-VEGF

Vascular Cell Basal Medium; 500mlVascular Smooth Muscle Cell Growth Kit

Dermal Cell Basal Medium; 485 mlKeratinocyte Growth Kit

Dermal Cell Basal Medium; 485 mlKeratinocyte Growth Kit

Dermal Cell Basal Medium; 485 mlMelanocyte Growth Kit

Fibroblast Basal MediumFibroblast Growth Kit-Serum-freeFibroblast Growth Kit-Low serum



Airway Epithelial Cell Basal MediumBronchial Epithelial Cell Growth Kit

Airway Epithelial Cell Basal MediumSmall Airway Epithelial Cell Growth Kit

Renal Epithelial Cell Basal MediumRenal Epithelial Cell Growth Kit



Phenol Red

Penicillin-Streptomycin-Amphotericin B Solution

Trypsin/EDTA Solution for Primary Cells

Trypsin Neutralizing Solution

Gentamicin - Amphotericin B Solution

0.1% Gelatin Solution

Dulbecco’s Phosphate Buffered Saline(D-PBS)

PCS-100-030PCS-100-040PCS-100-041

PCS-100-030PCS-100-040PCS-100-041

PCS-100-030PCS-100-042

PCS-200-030PCS-200-040

PCS-200-030PCS-200-040

PCS-200-030PCS-200-041

PCS-201-030PCS-201-040PCS-201-041

PCS-201-030PCS-201-040PCS-201-041

PCS-201-030PCS-201-040PCS-201-041

PCS-300-030PCS-300-040

PCS-300-030PCS-301-040

PCS-400-030PCS-400-040

PCS-400-030PCS-400-040

PCS-400-030PCS-400-040

PCS-999-001

PCS-999-002

PCS-999-003

PCS-999-004

PCS-999-025

PCS-999-027

30-2200


DescriptionATCC® no.

Primary cells, media and reagents

Primary cell cultures more closely mimic the physiological state of cells in vivo and generate more relevant data. Traditional

attention to quality, research and science makes ATCC your most reliable source for primary cells. Each lot of cells is

performance tested for viability and growth potential; sample purity and normal morphology are also assured.

Primary cell line

PCS-100-010

PCS-100-011

PCS-100-012

PCS-200-010

PCS-200-011

PCS-200-012

PCS-201-010

PCS-201-011

PCS-201-012

PCS-300-010

PCS-301-010

PCS-400-010

PCS-400-011

PCS-400-012

Primary Umbilical Vein Endothelial Cells;Normal, Human

Primary Aortic Endothelial Cells; Normal,Human

Primary Aortic Smooth Muscle Cells; Normal,Human

Primary Epidermal Keratinocytes; Normal,Human, Neonatal

Primary Epidermal Keratinocytes; Normal,Human, Adult

Primary Epidermal Melanocytes; Normal,Human, Neonatal

Dermal Fibroblasts; Normal, Human, Neonatal

Dermal Fibroblasts; Normal, Human, Neonatal,Mitomycin-C treated

Dermal Fibroblasts; Normal, Human, Adult

Primary Bronchial/Tracheal Epithelial Cells;Normal, Human

Primary Small Airway Epithelial Cells;Normal, Human

Primary Renal Proximal Tubule EpithelialCells; Normal, Human

Primary Renal Cortical Epithelial Cells;Normal, Human

Primary Renal Mixed Epithelial Cells; Normal,Human

Recommended culture reagents

Culture reagent descriptionCatalogue no.

All ATCC products are sold subject to a material transferagreement. Appendix II details the complete document.

Additional primary cells are being added all the time.Refer to the ATCC primary cell page:www.lgcstandards-atcc.org/PrimaryCells/tabid/1516/Default.aspx

Additional culture reagents optimised for culturing primary cells

®


DescriptionSpecies Quantity Product code


Rat

Mouse

Rabbit

Human

Other species

Rat Hepatocytes in SuspensionSuspension (5 million cells) - Minimum order 2 platesSuspension, Pre-induced with 3-MethylcolanthreneSuspension, Pre-induced with Sodium PhenobarbitalIn vivo Induction Charge

Rat Hepatocytes, Pre-platedPre-plated on 35mm dish - Min 10 platesPre-plated on 60mm dish - Min 10 platesPre-plated on 100mm dish - Min 5 platesPre-plated on 6 well platePre-plated on 12 well platePre-plated on 24 well platePre-plated on 48 well platePre-plated on 96 well plate

Rat Hepatocytes Induced(3-Methycholanthrene), Pre-plated on CollagenInduced, Pre-plated on Collagen Coated 6-well PlatesInduced, Pre-plated on Collagen Coated 12-well PlatesInduced, Pre-plated on Collagen Coated 24-well PlatesInduced, Pre-plated on Collagen Coated 48-well PlatesInduced, Pre-plated on Collagen Coated 96-well PlatesIn vivo Induction Charge

Rat Hepatocytes Induced(Sodium Phenobarbital), Pre-plated on CollagenInduced, Pre-plated on Collagen Coated 6-well PlatesInduced, Pre-plated on Collagen Coated 12-well PlatesInduced, Pre-plated on Collagen Coated 24-well PlatesInduced, Pre-plated on Collagen Coated 48-well PlatesInduced, Pre-plated on Collagen Coated 96-well PlatesIn vivo Induction Charge

Mouse Hepatocytes in SuspensionSuspension (5 million cells) - Minimum order 2 plates

Mouse Hepatocytes, Pre-platedPre-plated on 6 Well PlatePre-plated on 12 Well PlatePre-plated on 24 Well PlatePre-plated on 48 Well PlatePre-plated on 96 Well Plate

Rabbit Hepatocytes, SuspensionRabbit - Suspension - 10 million cells

Rabbit Hepatocytes, Pre-platedPre-plated on 6 Well PlatePre-plated on 12 Well PlatePre-plated on 24 Well PlatePre-plated on 48 Well PlatePre-plated on 96 Well Plate

Available on request. Please contact your localLGC Standards office for further information anddelivery schedules.

Available on request.

2 plate10 plates2 plates

10 plates10 plates5 plates6 well plate12 well plate24 well plate24 well plate96 well plate

6 well plate12 well plate24 well plate48 well plate96 well plate


10 plate


1 plate


ABC-SUSPRHABC-SUSP-RHMCABC-SUSP-RHPBABC-INDN-CHGE

ABC-35PCC-RHABC-60PCC-RHABC-100PCC-RHABC-06WPCCRHABC-12WPCCRHABC-24WPCCRHABC-48WPCCRHABC-96WPCCRH

ABC-6WPCC-RHMCABC-12WPCC-RHMCABC-24WPCC-RHMCABC-48WPCC-RHMCABC-96WPCC-RHMCABC-INDN-CHGE

ABC- 6WPCC-RHPBABC-12WPCC-RHPBABC-24WPCC-RHPBABC-48WPCC-RHPBABC-96WPCC-RHPBABC-INDN-CHGE

ABC-SUSPMH

ABC-06WPCCMHABC-12WPCCMHABC-24WPCCMHABC-48WPCCMHABC-96WPCCMH

ABC-SUSPZH

ABC-06WPCCZHABC-12WPCCZHABC-24WPCCZHABC-48WPCCZHABC-96WPCCZH

Ultra-pure solvents fromLGC Standards

Ultra HPLC (UHPLC) requires solvents of superiorquality in order to achieve the optimum performanceof the instrument and columns.

UHPLC can provide very significant increases inresolution, speed, and sensitivity, compared toconventional HPLC. To ensure these benefits arerealised, and so gain the full benefits of investment insuch sophisticated technology, solvents of the highestpurity are required.

The range of Optigrade® solvents from LGC Standards hasbeen designed to support high resolution and sensitivity forUHPLC and MS by tightly controlling the trace metal impurities,organic impurities and particle levels. Also available are selectedbuffers for mobile phase preparation, and several blends of waterand acetonitrile with formic acid, acetic acid and trifluoroacetic acid.

LGC Standards Optigrade® solvents combine:• The highest specification for UV• Low gradient shift• Minimal peak impurities• Lowest ionic background for MS detection

Our Optigrade® solvents for UHPLC and MS:• Are micro filtered at 0.1 µm• Have a residue of max 1ppm following evaporation• Are packed under inert gas for improved shelf life• Provided with MSDS and certificate of analysis


Introduction

Optigrade® – High purity solvents for HPLC

High performance liquid chromatography is now

an essential analytical tool especially in the areas

of research and development, pharmaceutical

quality control and analysis in the food and

environmental sectors. This technique demands

the highest quality solvents to allow reproducible

separations. The basic requirements include a

high UV-transmission factor, low particle levels,

slight acidity and alkalinity coupled with low levels

of water and other non-volatile components. In

addition there must be consistency between

batches.

Solvents for LC/MS

The presence of alkali and alkaline earth metals

in the mobile phase when using LC/MS can make

the interpretation of the mass spectrum very

difficult. LGC Standards offers solvents designed

for this technique with extremely low levels of

these metals at 0.1 ppm and less.

Solvents for Ultra HPLC (UHPLC)

ULTRA HPLC (UHPLC) requires solvents of

superior quality. A new range of high purity

Optigrade® solvents from LGC Standards has

been designed to allow high resolution and

sensitivity. Such Ultra HPLC solvents combine

the highest specification for: UV, low gradient

shift, minimal peak impurities and lowest ionic

background for MS detection. All Ultra HPLC

solvents are micro filtered at 0.1 µm, have a

residue following evaporation of max 1 ppm

and are packed under inert gas for improved

shelf life. Also available are selected buffers for

mobile phase preparation and several blends of

water and acetonitrile with formic acid, acetic

acid and trifluoroacetic acid.

Reagents / sorbents

Code Product Unit

SC-4592-A005 ICN-Aluminia A - Super I (acid) 500 g(50 - 200 µm)

SC-4568-A005 ICN-Alumina B - Super I (basic) 500 g(50 - 200 µm)

SC-4181-B005 FLORISIL® (Standard), 60 - 100 mesh 500 g(150 - 250 µm)

SC-4181-S010 FLORISIL® (Standard), 60 - 100 mesh 10 kg(150 - 250 µm)

SC-9982-B010 Silica gel 60 (63 - 200 µm) 1 kg

SC-9950-B005 Sodium sulfate anhydrous, 500 gfor analysis (ACS), powder

SC-9950-B025 Sodium sulfate anhydrous, 2.5 kgfor analysis (ACS), powder

SC-8024-B005 Sodium sulfate anhydrous, 500 gfor analysis (ACS), in granular form

SC-8024-B025 Sodium sulfate anhydrous, 2.5 kgfor analysis (ACS), in granular form

Ion pair reagents

Code Product Unit

SC-5330-F025 1-Butanesulfonic acid sodium salt for HPLC 25 g

SC-5330-F100 1-Butanesulfonic acid sodium salt for HPLC 100 g

SC-5650-F025 1-Decanesulfonic acid sodium salt for HPLC 25 g

SC-5650-F100 1-Decanesulfonic acid sodium salt for HPLC 100 g

SC-5430-F025 1-Dodecanesulfonic acid sodium salt for HPLC 25 g

SC-5430-F100 1-Dodecanesulfonic acid sodium salt for HPLC 100 g

SC-5230-F025 1-Heptanesulfonic acid sodium salt for HPLC 25 g

SC-5230-F100 1-Heptanesulfonic acid sodium salt for HPLC 100 g

SC-5550-F025 1-Hexanesulfonic acid sodium salt for HPLC 25 g

SC-5550-F100 1-Hexanesulfonic acid sodium salt for HPLC 100 g

SC-5150-F025 1-Octanesulphonic acid sodium salt for HPLC 25 g

SC-5150-F100 1-Octanesulphonic acid sodium salt for HPLC 100 g

SC-5730-F025 1-Pentanesulfonic acid sodium salt for HPLC 25 g

SC-5730-F100 1-Pentanesulfonic acid sodium salt for HPLC 100 g



LC-MS additives

Code Product Unit

SO-9685-B001 Ammonium acetate ULC-MS Optigrade® 100 g

CAS number 631-61-8

Assay (GC, on anhydrous basis) 99 % min.

Water (KF) 0.1 % max.

Filter test (1M in water) Passes test

pH (1M in water) 6.0-7.5

Transmissionat 260 nm (1M in water) 96 %at 280 nm (1M in water) 98 %

Chloride (Cl) 0.0005% max.Sulfate (SO4) 001% max.

Al 1 ppm max.Ca 5 ppm max.Fe 1 ppm max.K 5 ppm max.Mg 1 ppm max.Na 5 ppm max.

SO-9679-B001 Formic acid ULC-MS Optigrade® 100 mL

UN 1779

CAS number 64-18-6

Assay (T, on anhydrous basis) 99 % min.

Water (KF) 1 % max.

Residue after evaporation 0.001 % w/w max.

Color (APHA) 10 max.

Gradient specificationHPLC gradient at 254 nm - H. Peak 0.005 AU max.HPLC gradient at 254 nm - Drift 0.02 AU max.

Transmissionat 260 nm 15 % min.at 270 nm 83 % min.at 280 nm 90 % min.at 300 nm 97 % min.at 320 nm 98 % min.

SO-9668-B001 Trifluoroacetic acid ULC-MS Optigrade® 100 mL

UN 2699

CAS number 76-05-1

Assay (T) 99.95 % min.



Color (APHA) 10 max.


Fluorescence at 254 nm (25%, as quinine) 1 ppb max.Fluorescence at 365 nm (25%, as quinine) 1 ppb max.

Transmissionat 260 nm 10 % min.at 270 nm 79 % min.at 280 nm 93 % min.at 300 nm 95 % min.at 320 nm 96 % min.


Code Product Unit

Acetone

SO-2435-B010 Acetone HPLC Optigrade® 1 L

SO-2435-B010 Acetone HPLC Optigrade® 2.5 L

SO-2435-B010 Acetone HPLC Optigrade® 4 L

UN 1090

CAS number 67-64-1

C3H6O

Assay 99.5 % min.Water 0.5 % max.Non-volatile matter 0.0005 % max.

Filtered through 0.2 µm

1 L = 0.792 kg (at 20°C)

Optical absorbance Wavelength1.0 max. 330 nm0.1 340 nm0.05 350 nm0.01 370 nm

Acetonitrile

SO-2856-B010 Acetonitrile HPLC Optigrade® 1 L

SO-2856-B025 Acetonitrile HPLC Optigrade® 2.5 L

SO-2856-B040 Acetonitrile HPLC Optigrade® 4 L

UN 1648

CAS number 75-05-8

C2H3N

Assay 99.8 % min.Water 0.02 % max.Non-volatile matter 0.0003 % max.


1 L = 0.783 kg (at 20°C)

Optical absorbance Wavelength1.0 max. 190 nm0.1 200 nm0.05 210 nm0.02 220 nm0.01 230 nm0.005 235 nm




Code Product Unit

SO-9340-B010 Acetonitrile for LC-MS Optigrade® 1 L

SO-9340-B025 Acetonitrile for LC-MS Optigrade® 2.5 L

UN 1648

CAS number 75-05-8

C2H3N

Assay 99.8 % min.

Water 0.02 % max.

Non-volatile matter 0.0003 % max.


1 L = 0.783 kg (at 20°C)

Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.

Transmissionat 195 nm 78 % min.at 200 nm 95 % min.at 220 nm 98 % min.at 240 nm 99 % min.

SO-9640-B010 Acetonitrile ULC-MS Optigrade® 1 L

UN 1648

CAS number 75-05-8

C2H3N

Assay (GC, on anhydrous basis) 99.97 % min.



Acidity (as acetic acid) 0.001 % max.

Alkalinity (as ammonia) 0.0001 % max.

Color (APHA) 5 max.

Gradient specificationHPLC gradient at 210 nm - Drift 0.006 AU max.HPLC gradient at 254 nm - Drift 0.002 AU max.HPLC gradient at 210 nm - H. Peak 0.001 AU max.HPLC gradient at 254 nm - H. Peak 0.0003 AU max.

Fluorescence at 254 nm (as quinine) 0.3 ppb max.Fluorescence at 365 nm (as quinine) 0.3 ppb max.

1 L = 0.792 kg (at 20°C)

Transmissionat 191 nm 30 % min.at 195 nm 85 % min.at 200 nm 97 % min.at 215 nm 98 % min.at >230 nm 99 % min.

Al 20 ppb max.Ca 50 ppb max.Fe 20 ppb max.K 50 ppb max.Mg 20 ppb max.Na 100 ppb max.

Microfiltered through 0.1 µm/bottled under inert gas.


Code Product Unit

SO-4680-B025 Acetonitrile 0.1 % formic acid ULC-MS Optigrade® 2.5 L

UN 1648

CAS number 75-05-8

C2H3N

Assay 0.095-0.105 %


Purity of ACN (GC) 99.97 % min.

Purity of formic acid 99.0% min.

Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.


Transmissionat 210 nm 5 % min.at 230 nm 15 % min.at 254 nm 90 % min.

Al 30 ppb max.Ca 100 ppb min.Fe 50 ppb min.K 100 ppb min.Mg 30 ppb min.Na 100 ppb min.


SO-4680-B025 Acetonitrile 0.1 % acetic acid ULC-MS Optigrade® 2.5 L

UN 1648

CAS number 75-05-8

C2H3N

Assay 0.095-0.105 %


Purity of acetic acid (GC) 99.9 % min.









Code Product Unit

SO-4692-B025 Acetonitrile 0.1 % trifluoroacetic acid ULC-MS Optigrade® 2.5 L

UN 1648

CAS number 75-05-8

C2H3N

Assay 0.095-0.105 %



Purity of trifluoroacetic acid 99.95 % min.

Gradient specificationHPLC gradient at 254 nm - H. Peak 0.0002 AU max.





Chloroform

SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 1 L

SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 2.5 L

SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 4 L

UN 1888

CAS number 67-66-3

CHCl3

Assay 99.9 % min.

Water 0.03 % max.



1 L = 1.475 kg (at 20°C)

stabilised with 50 - 200 ppm amylene

Optical absorbance Wavelength1.0 max 245 nm0.15 255 nm0.05 260 nm0.02 270 nm0.01 290 nm


Code Product Unit

Cyclohexane

SO-9052-B010 Cyclohexane HPLC Optigrade® 1 L

SO-9052-B025 Cyclohexane HPLC Optigrade® 2.5 L

UN 1145

CAS number 110-82-7

C6H12

Assay 99.5 % min.

Water 0.02 % max.



1 L = 0.779 kg (at 20°C)


Cyclopentane

SO-6157-B010 Cyclopentane HPLC Optigrade® 1 L

UN 1146

CAS number 287-92-3

C5H10

Assay 75 % min.

Water 0.005 % max.



1 L = 0.751 kg (at 20°C)

Optical absorbance Wavelength1.0 max 200 nm0.3 215 nm0.02 225 nm0.005 300 nm

Dichloromethane

SO-4879-B010 Dichloromethane HPLC Optigrade® (stab. with amylene) 1 L

SO-4879-B025 Dichloromethane HPLC Optigrade® (stab. with amylene) 2.5 L

SO-4879-B040 Dichloromethane HPLC Optigrade® (stab. with amylene) 4 L

UN 1593

CAS number 75-09-2

CH2Cl2

Assay 99.8 % min.

Water 0.02 % max.



1 L = 1.335 kg (at 20°C)

stabilised with 60 - 100 ppm amylene





Code Product Unit

Diethyl ether

SO-9012-B010 Diethyl ether HPLC Optigrade® (stab. with ethanol) 1 L

SO-9012-B025 Diethyl ether HPLC Optigrade® (stab. with ethanol) 2.5 L

UN 1155

CAS number 60-29-7

C4H10O

Assay 99.0 % min.

Water 0.01 % max.


Peroxide 5 ppm max.


1 L = 0.713 kg (at 20°C)

stabilised with 2 % ethanol

Optical absorbance Wavelength1.0 max 215 nm0.3 230 nm0.08 254 nm0.04 270 nm0.02 280 nm0.005 300 nm

SO-2854-B010 Diethyl ether HPLC Optigrade® (not stabilised) 1 L

UN 1155

CAS number 60-29-7

C4H10O

Assay 99.0 % min.

Water 0.01 % max.


Peroxide 5 ppm max.


1 L = 0.713 kg (at 20°C)

not stabilised

Optical absorbance Wavelength1.0 max 215 nm0.08 254 nm0.02 280 nm


Code Product Unit

N.N-Dimethylacetamide

SO-5407-B025 N.N-Dimethylacetamide HPLC Optigrade® 2.5 L

SO-5407-B040 N.N-Dimethylacetamide HPLC Optigrade® 4 L

CAS number 127-19-5

C4H9NO

Assay 99.0 % min.

Water 0.03 % max.



1 L = 0.937 kg (at 20°C)


N.N-Dimethylformamide

SO-5356-B025 N.N-Dimethylformamide HPLC Optigrade® 2.5 L

SO-5356-B040 N.N-Dimethylformamide HPLC Optigrade® 4 L

UN 2265

CAS number 68-12-2

C3H7NO

Assay 99.7 % min.

Water 0.05 % max.



1 L = 0.951 kg (at 20°C)





Code Product Unit

1.4-Dioxan

SO-9002-B010 1.4-Dioxan HPLC Optigrade® (not stabilised) 1 L

SO-9002-B025 1.4-Dioxan HPLC Optigrade® (not stabilised) 2.5 L

UN 1165

CAS number 123-91-1

C4H8O2

Assay 99.5 % min.

Water 0.05 % max.



1 L = 1.034 kg (at 20°C)

not stabilised


Ethanol

SO-9063-B010 Ethanol HPLC Optigrade® 1 L

SO-9063-B025 Ethanol HPLC Optigrade® 2.5 L

UN 1170

CAS number 64-17-5

C2H5OH

Assay 99.7 % min.

Water 0.1 % max.



1 L = 0.789 kg (at 20°C)

Optical absorbance Wavelength0.7 max 210 nm0.1 240 nm0.01 260 nm

2-Ethoxyethanol

SO-2925-B025 2-Ethoxyethanol HPLC Optigrade® 2.5 L

UN 1171

CAS number 110-80-5

C4H10O2

Assay 99.5 % min.

Water 0.08 % max.



1 L = 0.932 kg (at 20°C)



Code Product Unit

Ethyl acetate

SO-3442-B010 Ethyl acetate HPLC Optigrade® 1 L

SO-3442-B025 Ethyl acetate HPLC Optigrade® 2.5 L

SO-3442-B040 Ethyl acetate HPLC Optigrade® 4 L

UN 1173

CAS number 141-78-6

CH3COOC2H5

Assay 99.5 % min.

Water 0.05 % max.



1 L = 0.897 kg (at 20°C)


SO-9345-B010 Ethyl acetate for LC-MS Optigrade® 1 L

SO-9345-B025 Ethyl acetate for LC-MS Optigrade® 2.5 L

UN 1173

CAS number 141-78-6

CH3COOC2H5

Assay 99.5 % min.

Water 0.05 % max.



1 L = 0.897 kg (at 20°C)


Transmissionat 260 nm 70 % min.at 280 nm 99 % min.




Code Product Unit

n-Heptane

SO-5139-B010 n-Heptane HPLC Optigrade® 1 L

SO-5139-B025 n-Heptane HPLC Optigrade® 2.5 L

SO-5139-B040 n-Heptane HPLC Optigrade® 4 L

UN 1206

CAS number 142-82-5

C7H16

Assay 95.0 % min.

Water 0.02 % max.



1 L = 0.685 kg (at 20°C)


n-Hexane

SO-5167-B010 n-Hexane HPLC Optigrade® 1 L

SO-5167-B025 n-Hexane HPLC Optigrade® 2.5 L

SO-5167-B040 n-Hexane HPLC Optigrade® 4 L

UN 1208

CAS number 110-54-3

C6H14

Assay (of C6-isomers) 99.8 % min.

Water 0.1 % max.



1 L = 0.659 kg (at 20°C)


Iso-Hexane

SO-9043-B025 Iso-Hexane HPLC Optigrade® 2.5 L

UN 1208

CAS number 107-83-5

C6H14

Assay (of C6-isomers) 95.0 % min.

Water 0.01 % max.


1 L = 0.653 kg (at 20°C)



Code Product Unit

MethanolSO-3041-B010 Methanol HPLC Optigrade® 1 L

SO-3041-B025 Methanol HPLC Optigrade® 2.5 L

SO-3041-B040 Methanol HPLC Optigrade® 4 L

UN 1230

CAS number 67-56-1

CH3OH

Assay 99.9 % min.

Water 0.05 % max.



1 L = 0.792 kg (at 20°C)


This solvent in glass bottles fulfills the specifications according to chapter 4 of the European Pharmacopoeia.

SO-9658-B010 Methanol ULC-MS Optigrade® 1 L

UN 1230

CAS number 67-56-1

CH3OH

Assay (GC, on anhydrous basis) 99.98 % min.


Residue after evaporation 0.0001 %w/w max.

Acidity (as acetic acid) 0.002 % max.

Alkalinity (as ammonia) 0.0001 % max.

Color (APHA) 5 max.

Gradient specificationHPLC gradient at 220 nm - Drift 0.01 AU max.HPLC gradient at 235 nm - Drift 0.005 AU max.HPLC gradient at 220 nm - H. Peak 0.004 AU max.HPLC gradient at 235 nm - H. Peak 0.002 AU max.


1 L = 0.783 kg (at 20°C)







Code Product Unit

SO-9356-B010 Methanol for LC-MS Optigrade® 1 L

SO-9356-B025 Methanol for LC-MS Optigrade® 2.5 L

UN 1230

CAS number 67-56-1

CH3OH

Assay 99.9 % min.

Water 0.05 % max.



1 L = 0.792 kg (at 20°C)



Methyl-tert-butyl ether

SO-5398-B025 Methyl-tert-butyl ether HPLC Optigrade® 2.5 L

UN 2398

CAS number 1634-04-4

C5H12O

Assay 99.7 % min.

Water 0.05 % max.



1 L = 0.742 kg (at 20°C)


n-Nonane

SO-4436-B010 n-Nonane HPLC Optigrade® 1 L

UN 1920

CAS number 111-84-2

C9H20

Assay 95 % min.

Water 0.01 % max.



1 L = 0.719 kg (at 20°C)



Code Product Unit

n-Pentane

SO-9081-B010 n-Pentane HPLC Optigrade® 1 L

UN 1265

CAS number 109-66-0

C5H12

Assay 95.0 % min.

Water 0.01 % max.



1 L = 0.626 kg (at 20°C)


Propan-1-ol

SO-5351-B025 Propan-1-ol HPLC Optigrade® 2.5 L

UN 1274

CAS number 71-23-8

CH3CH2CH2OH

Assay 99.8 % min.

Water 0.05 % max.



1 L = 0.804 kg (at 20°C)





Code Product Unit

Propan-2-ol

SO-3043-B010 Propan-2-ol HPLC Optigrade® 1 L

SO-3043-B025 Propan-2-ol HPLC Optigrade® 2.5 L

SO-3043-B040 Propan-2-ol HPLC Optigrade® 4 L

UN 1219

CAS number 67-63-0

C3H8O

Assay 99.5 % min.

Water 0.05 % max.



1 L = 0.786 kg (at 20°C)


SO-9352-B010 Propan-2-ol for LC-MS Optigrade® 1 L

SO-9352-B025 Propan-2-ol for LC-MS Optigrade® 2.5 L

UN 1219

CAS number 67-63-0

C3H8O

Assay 99.5 % min.

Water 0.05 % max.



1 L = 0.786 kg (at 20°C)




Code Product Unit

Tetrahydrofuran

SO-2858-B010 Tetrahydrofuran HPLC Optigrade® (not stabilised) 1 L

SO-2858-B025 Tetrahydrofuran HPLC Optigrade® (not stabilised 2.5 L

SO-2858-B040 Tetrahydrofuran HPLC Optigrade® (not stabilised) 4 L

UN 2056

CAS number 109-99-9

C4H8O

Assay 99.8 % min.

Water 0.03 % max.



1 L = 0.887 kg (at 20°C)

not stabilised


SO-9364-B010 Tetrahydrofuran for LC-MS Optigrade® (not stabilised) 1 L

SO-9364-B025 Tetrahydrofuran for LC-MS Optigrade® (not stabilised) 2.5 L

UN 2056

CAS number 109-99-9

C4H8O

Assay 99.8 % min.

Water 0.03 % max.



1 L = 0.887 kg (at 20°C)

not stabilised






Code Product Unit

Toluene

SO-4483-B010 Toluene HPLC Optigrade® 1 L

SO-4483-B025 Toluene HPLC Optigrade® 2.5 L

SO-4483-B040 Toluene HPLC Optigrade® 4 L

UN 1294

CAS number 108-88-3

C7H8

Assay 99.7 % min.

Water 0.03 % max.


1 L = 0.866 kg (at 20°C)


2,2,4-Trimethylpentane

SO-6043-B010 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 1 L

SO-6043-B025 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 2.5 L

SO-6043-B040 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 4 L

UN 1262

CAS number 540-84-1

C8H18

Assay 99.5 % min.

Water 0.02 % max.



1 L = 0.690 kg (at 20°C)



Code Product Unit

Water

SO-6795-B025 Water HPLC Optigrade® 2.5 L

SO-6795-B040 Water HPLC Optigrade® 4 L


H2O

Fluorescence at 254 nm (as quinine) 0.1 ppb max.

Fluorescence at 365 nm (as quinine) 0.1 ppb max.

Non-volatile matter 1 mg/L max.


pH 5.0 - 8.0

This solvent in glass bottles fulfills the specifications according to chapter 4 of the European Pharmacopoeia.

SO-9662-B010 Water ULC-MS Optigrade® 1 L


H2O


Acidity (as Acetic acid) 0.002 % max.

Alkalinity (as Ammonia) 0.00005 % max.

Resistivity (at manuf.) 18.2 Mohm*cm min.

Gradient specificationHPLC gradient at 210 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - H. Peak 0.0005 AU max.


TOC 10 ppb max.

Filter test Passes test



SO-4661-B025 Water 0.1 % formic acid ULC-MS Optigrade® 2.5 L

Assay 0.095-0.105 %

Purity of formic acid (GC) 99.0 % min.









Code Product Unit

SO-4667-B025 Water 0.1 % acetic acid ULC-MS Optigrade® 2.5 L

Assay 0.095-0.105 %

pH 3.2-3.4

Purity of acetic acid (GC) 99.9 % min.






SO-4673-B025 Water 0.1 % trifluoroacetic acid ULC-MS Optigrade® 2.5 L

Assay 0.095-0.105 %

Purity of trifluoroacetic acid (GC) 99.95 % min.






SO-9368-B010 Water for LC-MS Optigrade® 1 L

SO-9368-B025 Water for LC-MS Optigrade® 2.5 L


H2O

Fluorescence (as quinine at 450 nm) 1x10-7 g max.

Non-volatile matter 1 mg/L max.

pH 5.0 - 8.0



Transmissionat 200 nm - 400 nm 99 % min.


Appendix I

FDA drug development guidance, reference:

http://www.fda.gov/Drugs/DevelopmentAp-

provalProcess/DevelopmentResources/Drug

InteractionsLabeling/ucm081177.htm

Drug Development and Drug Interactions:

Table of Substrates, Inhibitors and Inducers.

CYP Enzymes, in vitro

Table 1: Chemical inhibitors for in vitro

experiments* (9/25/2006)

Table 2: Preferred and acceptable chemical

substrates for in vitro experiments*

(9/25/2006)

Table 3: Chemical Inducers for in vitro

experiments* (5/1/2006)

P-gp Transporters

Table 9: Acceptable in vitro P-gp substrates*

(5/1/2006)

Table 10: In vitro P-gp inhibitors* (5/1/2006)

* Please note that the FDA states that these lists are notexhaustive. All care has been taken to provide a truerepresentation of the information in these tables withinthis catalogue.


Appendix II



LGC Standards, Queens Road, Teddington, Middlesex TW11 0LY, UK


No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical,including photocopying, recording or any retrieval system, without the written permission of the copyright holder.© LGC Limited, 2009. All rights reserved. 2280/CF/1009

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Patrick Henry

4 Manor LodgeMagherafeltCounty DerryBT45 6QL

Tel: +44 (0)28 7930 0078Mobile: 07921 872595Email: [email protected]

Italy

LGC Standards S.r.l.Via Venezia, 2320099 Sesto San GiovanniITALY

Tel: +39 02 2412 6830Fax: +39 02 2412 6831Email: [email protected]

Poland

LGC Standards Sp. z o.o.ul. M. Konopnickiej 1Dziekanów Lesny05-092 LOMIANKI

Tel: +48 (0)22 751 31 40Fax: +48 (0)22 751 58 45Email: [email protected]

Bangalore office

LGC Promochem India Private LimitedFourth FloorVITC Model Export Bhavan14th Cross, IV PhasePeenya Industrial AreaBangalore 560 058INDIA

Tel: (PABX): +91-80-6701-2000Fax: +91-80-6701-2046Email: [email protected]

Mumbai office

LGC Promochem India Private Limited401-D, DeltaHiranandani GardensPowaiMUMBAI 400076

Tel: +91-22-2570 0244 / 6044

Hyderabad office

LGC Promochem India Private Limited#8-3-1029, Flat No. 601"Gayatri Nest" ApartmentsSprnager ColonyHyderabad 500 073INDIA

Tel: +91-40-2373 6378

Romania

LGC Standards GmbHStr. Muncitorilor nr.1/2400424 Cluj-NapocaROMANIA

Tel/Fax: +40-364-116890Mobil: +40-749-255121Email: [email protected]

Russia

Dr Svetlana Buchaka

LGC Standards Sp. z o.o.Sankt-Peterburgskij prosp. 60APetershofSaint-Petersburg 198516RUSSIA

Tel: +7(812)935-1180Email: [email protected]

Spain

LGC Standards S.L.UC/Salvador Espriu 59, 2º planta08005 BarcelonaESPAÑA

Tel: +34 93 308 4181Fax: +34 93 307 3612Email: [email protected]

Sweden

LGC Standards ABAlbanoliden 5, 4 trapporBox 1737SE-501 17 BORÅSSWEDEN

Tel: +46 (0)33 20 90 60Fax: +46 (0)33 20 90 79Email: [email protected]

Turkey

LGC Standards GmbHTürkiye (Istanbul) Irtibat BürosuGözteps mah. Gülden sok. Nurten apt. No:26/4Ciftehavuzlar/KadiköyTURKEY

Direct tel / fax: 0090 216 360 0870Mobile: 0090 530 880 3390Email: [email protected]

United Kingdom

Head officeLGC StandardsQueens RoadTeddingtonMiddlesexTW11 0LYUNITED KINGDOM

Tel: +44 (0)20 8943 8480Fax: +44 (0)20 8943 7554Email: [email protected]

For ATCC sales orders and enquiries, please contact:

Tel: +44 (0)20 8943 8489Fax: +44 (0)20 8943 8405Email (Sales): [email protected] (Technical): [email protected]

United States (LGC: North American Markets)

David KrostVice President, North American Markets

5853 Post Road, Suite 201BEast Greenwich, RI 02818USA

Tel: 001 401 398 7892Fax: 001 401 398 7893Email: [email protected]

Documents

ToolsforADME/Tox - Főoldal · 6 ADME/Toxanalyses AsADME/Toxanalysesbecomemoreadvanced andreliableintermsofaccuracyandprediction, anincreaseintheirusageisexpectedduringthe