Upload
others
View
0
Download
0
Embed Size (px)
Citation preview
Nina Mian, Head of Biomedical Informatics Advanced Analytics Center, AstraZeneca April 2015
Patient-Centered Analytics Tools and technologies to enable patient centered insight
The Advanced Analytics Centre Transforming drug development decision making through applied data science
Patient centered…
analytics?
3
Deliver actionable insights to
AstraZeneca and patients
Solicit and acquire
patient views & data
Derive insight from
data: analytics
Challenges you might have come across...
5
..and why we need to resolve them
Motivation to do great things for patients Motivation to do great things for patients
Impact of disease Status of current treatment
Unmet need Endpoints that matter
Recruitment & retention Reducing missing data Adherence + efficacy
Benefit-Risk (tolerability) Transparency
True patient journey Patient group education
and advocacy Brand awareness Medicines Access
Improved health outcomes & experiences
6
http://commons.wikimedia.org/wiki/Category:Hype_cycle
Tools & Technologies Peak of Inflated Expectation
Data & Insights Active and passive
PRO/ PRE
Blogs
Forums
YouTube Searches
Biomarkers
Podcasts
Location and
movement
Mobile
Social
Wearable Consumer reports Patient
health record
PatientsLikeMe
7
Ovarian Cancer – “In your own words”
8
Total # 30 (56.3 ± 9.2 y.o) Caucasian females BRCA+ n = 4 BRCA - n = 11 BRCA Unknown n = 15
Treatment pathway
• Structured
• Longitudinal
• Targeted additional data
• Fast
•Account for bias
(population, recall)
•Where the patients
already are
9
The approach
Patient centric learning Listening, and understanding what patients are willing to share
10
“I spent Sunday in bed shaking off a headache and feeling unwell.”
“Still there has been no return of the swelling to my ankle or foot and No discomfort while eating. So I'm in pretty good shape really ”
“I'm not doing an awful lot because of the fatigue that is really quite, quite overwhelming.”
“the taste of the pills is unpleasant even though they are in the mouth for only a couple of seconds, ...”
“the rash is gone from my face and is greatly reduced on my chest” ... “My skin continues to be dry but is responding to XXX and is not a problem.”
Insight to Interpretation
11
Safety
Skin Gastrointestinal
Dry skin Pimply rash Diarrhoea Constipation
• Characterisation of issues
• Impact
• Management
Informed medical teams
Informed patients
Gives our patients a voice, and us a way to listen, so that we can strengthening the link between our science and patient-driven needs
12
How does it help the patients? How does it help us?
Finalist: Customer Innovator Award
Me&My: Global Patient and Physician Support
Key Modules •Patient Profiling based on behaviour and disease state
• guides messaging strategy and other interventions
•Data Collection from Patients •Integration of devices for adherence support and detecting change in disease state •Devices to collect physiological data •Patient reported outcomes
•Supported self management •Individualised messages based on data collected •Content from medically valid sources •Goal setting and tracking •Decision support •Links to HCP and HCP services
15
Navigating the trough of disillusionment
> Patients making medical decisions… > New methods of data capture… > Holistic view of patient experience
htt
ps:/
/ww
w.a
icu
re.c
om
/
htt
ps:/
/ww
w.t
hera
no
s.c
om
/
Patient +
Provider +
Payer +
Pharma
http://www.thecyranosmccann.com/
Improved health outcomes & experience
Acknowledgements
Jenny Royle, Patient Safety Åsa Strom, Clinical informatics, R&D Information Stephanie Roberts, Advanced Analytics Center Christelle Gendrin, Advanced Analytics Center Amrik Mahal, R&D Information Lili Peng, R&D Information Donal Landers, Early Clinical Development Andrew Hughes, Early Clinical Development Shirley Spratt, Patient Safety Katarina Halling, PRO Group Daniel Eek, PRO Group Lisa Banks, Intelligent Pharmaceuticals Matt Bonam , Intelligent Pharmaceuticals Jan Frövenholt, R&D Information Sarah Keegans, Intelligent Pharmaceuticals Our partners at PLM and many other collaborators.
17
Confidentiality Notice
This file is private and may contain confidential and proprietary information. If you have received this file in error, please notify us and remove
it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the
contents of this file is not permitted and may be unlawful. AstraZeneca PLC, 2 Kingdom Street, London, W2 6BD, UK, T: +44(0)20 7604 8000,
F: +44 (0)20 7604 8151, www.astrazeneca.com
18