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Tom Strachan • Andrew Read
Human Molecular Genetics Fourth Edition
Genetics for Dummies 2016
Molecular Genetics I
Robert Kraaij, PhD [email protected]
6th (2014) 1st (1983) 3rd (1994) 4th (2002) 5th (2007) 2nd (1989)
Molecular Biology of the Cell (MBoC)
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Human Molecular Genetics Fourth Edition
The central dogma:
DNA - RNA - protein
DNA and RNA structure
DNA and RNA structure
RNA
DNA
tri-phosphate
ribose mono-phosphate
base
deoxyribose
DNA and RNA structure
5 different bases
DNA and RNA structure
GC content is an important feature of DNA
DNA and RNA structure
DNA and RNA structure
5’ 3’
1953: Double-Helix Model of DNA
James D. Watson and Francis Crick
from wikipedia.org
DNA and RNA structure
secondary structure of RNA
Replication
DNA-dependent DNA polymerase
Transcription
DNA-dependent RNA polymerase
Translation
tRNA
ribosome
Translation
Translation
Protein structure
Protein structure
Protein structure
Protein structure
Protein structure
Protein structure
Protein structure
Protein structure
secondary
structures
Protein structure
secondary
structures
Protein structure
tertiary
structures
Protein structure
non-permanent bonds
Protein structure
disulfide bond
Protein structure
Hemoglobin and carbon monoxide
o
Questions
• DNA, RNA and protein structure
• Replication
• Transcription
• Translation
Human Molecular Genetics Fourth Edition
Gene expression
promoter polyadenylation
signal
cap site
poly A tail
5’ UTR 3’ UTR start codon stop codon
Post translational modifications
Questions
• Gene expression
Human Molecular Genetics Fourth Edition
Copyright © Garland Science 2011
Genetic variation
Chromosomes
Mitosis
Meiosis
Meiosis
Single Nucleotide Variation (SNV)
Questions
• Genetic variations
Human Molecular Genetics Fourth Edition
Mendelian vs Complex Genetics
Mendelian vs Complex Disease
Mendelian Disease
Complex Disease
Questions
• Mendelian genetics
• Complex genetics
