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TO FEEL & STAY MORE TO FEEL & STAY MORE YOUTHFULYOUTHFUL
Our Skin
Understanding Our Skin Structure -
Hypodermis• The skin is made up of 3 layers.
• The bottom or deepest layer of the skin is the hypodermis. It is made up of fatty tissue that cushions & supports the two layers of skin above it.
• The middle layer of skin
• It contains collagen & elastin which give the
skin its form, shape & elasticity.
Understanding Our Skin Structure - Dermis
• The collagen & elastin in young, healthy skin are constantly renewed.
• Older skin tends to sag & wrinkle because the collagen & elastin are damaged & not renewed as often.
• The dermis is also where the blood capillaries, hair follicles, sweat & oil glands are found.
• As we age, oil glands become less active, causing skin to become drier & more prone to the formation of fine lines.
Understanding Our Skin Structure - Dermis
• The top layer of the skin
• This is where the critical function of cell renewal takes place.
Understanding Our Skin Structure - Epidermis
Skin Renew Process• New skin cells are born at the base & slowly move upward,
losing moisture & flattening out as they rise until they form a paper thin barrier at the top of the epidermis.
• The cells in younger skin are replaced about every 15-30 days. But as we age, this process takes twice as
long.
Skin Renew ProcessThis indispensable new barrier
protects skin from
moisture loss and
environmental dam
age.
RESULTING IN
Major Factors affecting our skin to age
(1) Sun
- 80% of visible skin ageing is due to UV light exposure.
- the UV light damages moisture barrier in the epidermis & elastin and
collagen in the dermis.
- resulting in skin loses its elasticity, forming of fine lines and wrinkles
formation of dark spots on the skin as skin produces excess melanin.
Damage to the moisture barrier
Skin produces excess melanin
Elastin & Collagen damaged
(2) Hormonal Ageing
- The first five years following menopause, the skin loses up to 30% of its
supportive collagen fibres.
- As a result, the skin becomes thinner, skin becomes less capable of
storing moisture, becomes drier and wrinkles deepen.
- Now, the skin is more prone to damages caused by free radicals as the
cell renewal process slows down.
(3) Pollution
- Airborne pollutants such as dirt and
dust, present in most modern environments,
especially in densely populated or
industrialized areas – are harmful to the skin.
Major Factors affecting our skin to age
(4) Air-Conditioning
- Dry, dehydrate the skin, leaving epidermis dry.
- Dehydration damages the skin’s barrier function and increases evaporation of dermal
moisture.
(5) Sleep
- Sleep deprivation leads to dull complexion & dark, puffy under-eye circles.
- Skin tend to premature lines and wrinkles.
Major Factors affecting our skin to age
(6) Stress
- Anxiety and anger will increase sebum production in the skin.
(7) Alcohol
- Drinking in excess leads to skin dehydration and robs the body’s nutrients
(Vitamin A,B,C and the minerals magnesium & zinc.)
(8) Smoking
- Smoking reduces the supply of blood to the skin’s surface, restricting the flow of
essential nutrients.
- Skin dull and greyish in colour
- Smokers tend to have thinner skin & premature appearance of
lines and wrinkles.
Major Factors affecting our skin to age
(A) Wrinkle
- UVR causes wrinkle and melanin to form.
- UVA penetrate into the dermis to damage the collagen.
- UV induce production of free radical (O2) species (ROS) & matrix metalloproteinases
(MMP)
- (O2) present in our cell can form harmful radical (ROS).
The Ageing Process
UVA penetrate into dermis –
damage collagen
ROS
ROS
ROS
MMP
MMP
MMP
The Ageing Process
ROS
ROS
MMP
MMP
MMP
Antioxidant attenuates the ROS & MMP & allow skin to regenerate properly
Antioxidants
Anti-oxidants
Anti-oxidants
Anti-oxidants
SUPERFOODS ! FOR BEAUTY ON THE INSIDE OUT
3-in-1 formula
(Radiant Skin + Breast Firming + Antioxidant)
Perfect Combination Of
PRESENTING…
BEUCOGEN COLLAGEN(Product Benefits)
1. Repair body cell
2. Improve skin fairness
3. Restore skin cell elasticity
4. Reduce fine lines & pigmentation
5. Retain skin moisture content
6. Smoothen skin
7. Eliminate free radicals
8. Prevent cell oxidation
9. Firm up breasts
10. Antioxidant
Active Ingredients
(For Skin)
Hydrolysed Marine Collagen• Collagen is main protein surrounding every cell. 6% of body weight.
• Collagen is one the long, fibrous structural protein.
• Main component of cartilage, ligaments, tendons, bone & skin.
• Made up of three polypeptide strands, twisted together & stabilized by hydrogen bonds
• More than 28 types of collagen. Over 90% of collagen are of type 1,2,3,&4
• Collagen 1- skin, tendon, vascular, ligature, organ , bone
• Collagen 2- cartilage
• Collagen 3- reticular fiber found in artery walls, skin, intestines & uterus
• Collagen 4 – form bases of cell basement membrane
• After age 25, collagen synthesis reduce at a rate of 1.5% and reduce into half after age of 60, skin become thinner & less firm
• Characteristics of marine collagen in Ladies Collagen:-
* Marine Low Molecular Collagen
* Average Molecular Weight 3,000Da – the lighter the molecular weight (< 5,000Da) increases absorption.
* High solubility
* High digestion by human enzyme
* Low moisture absorption
* Less fish smell & taste white fine powder.
* Easy handling
(3,000mg)
L-Arginine• Key building block to repair damaged tissue & bone
• Improve blood circulation
• Help in wound healing
• Positive immune modulating – anticancer effects
• Generate muscle mass
• Reduce body fat
(200mg)
L-Lysine
• Amino acid for growth & tissue repair
(one of the nine essential amino acid which the body can’t produce ourselves, have to take from food)
• Produce antibodies, hormones, enzymes, collagen formation
• Assist calcium absorption
• Lowering cholesterol
(200mg)
Active Ingredients
(Firming)
Soy Extract (Isoflavonoid)
• Isoflavones = phytoestrogen(plant hormone) which resembles human estrogen in chemical structure.
• Functions to firm skin & breast and balancing the hormone.
• Contain 40% isoflavonoid which helps in :
- Prevention of breast cancer- Prevent osteoporosis- bone- Ease menopause symptoms – hot flushes- Reduce heart disease risk
(200mg)
Soy Protein
• High source of protein which subsequently increases our protein in the body
• Functions to provide protein to rebuild cell
(2,000mg)
Oligo (oligosaccharides )
• Decrease gastrointestinal transit time
• Helps to encourage the growth of friendly bacteria
• Improves constipation & diarrhea
(2,400mg)
Active Ingredients
(Antioxidant)
• An antioxidant as it protects the body against oxidative stress • Vitamin C in combination with collagen, allows the collagen
molecule to assume its triple helix structure and making vitamin C essential to the development and maintenance of scar tissue, blood vessels, and cartilage.
Vitamin C
Sources of Vitamin C :
Citrus Fruits eg. Oranges, grapefruitRose hips are particularly high in
vitamin C
(50mg)
Manufacturing Flow Chart
(Marine Collagen)
Marine Hydrolyzed collagenMarine Hydrolyzed collagen
Spray DryingSpray Drying
SterilizationSterilization
ConcentrationConcentration
FiltrationFiltration
Enzymatic HydrolysisEnzymatic Hydrolysis
PurificationPurification
Extraction (by hot water)Extraction (by hot water)
Acid treatmentAcid treatment
DegreasingDegreasing
100% fish skin (bone, skin, cartilage, scale)100% fish skin (bone, skin, cartilage, scale)
ENZYMATIC HYDROLYSIS:1) SHORT CHAIN PEPTIDES2) LOW MOLECULAR WEIGHT,3000D3) NO FISHY ODOUR 4) NEUTRAL TASTE5) GOOD SOLUBILITY IN WATER6) CLEAR SOLUTION7) HIGH AMINO ACID PROFILE
Double Blind Placebo (Clinical Evaluation)
Examining for :
1) Moisture content of skin surface
2) Skin elasticity
3) Flexibility of skin
4) Microscopic 3D skin surface analysis
5) Statistical analysis – the difference before and after (Non-parametric Mann-Whitney test with placebo)
(P-value of less than 0.05 was taken as significant difference)
Double Blind Clinical Evaluation
• 21 women
• Age 13.3 – 34.1 years old
• Dry & rough skin
• Drinks 5g of Collagen per day for 4 weeks
Test Result : Moisture content
0
5
10
15
20
25
30
35
40
45
mo
istu
re c
on
ten
t%
MM placebo
before after 2 weeks after 4 weeks
This shows the increase of moisture
content of skin surface by approx.
60%
Test Result : Flexibility of Skin
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
flexi
bilit
y %
MM placebo
before after 2 weeks after 4 weeks
This shows that the flexibility of skin had
increased by approx.
48%
Before treatment
After 4 weeks treatment
Test Result : Microscopic Skin Surface Analysis
BEFORE
AFTER
Conclusion – Test Analysis
• Increase of moisture content
• Increase of skin flexibility
• Improvement of skin conditions
• Certificate of safety - no side effect was observed
CERTIFICATION
2) HALAL CERTIFIED
3) HACCP CERTIFICATION 4) GOOD MANUFACTURING PRACTICE
5) ISO CERTIFIED
CONTACT DETAILSZENOTEC PHARMA (M) SDN. BHD.
+603- 5122 3050
No.34-2, Jalan Anggerik Vanilla R31/R,40460 Shah Alam,Selangor Darul Ehsan
&