CREATIVE GROUP

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eom creative group is about design, function,

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Please contact:Cyndie Wooley

415.233.3211

eom creative group 107 Water Street 2MPetaluma, CA 94952

chwooley@eomcreative.com

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Technology in Sync

Coronary Product SuiteAdvanced crossing technology for complex and workhorse cases

Integrity CORONARY STENT SYSTEM

Sprinter Family BALLOON DILATATION CATHETERS

Endeavor Sprint ZOTAROLIMUS-ELUTING CORONARY STENT SYSTEM

�e Power of Combined PerformanceMedtronic’s coronary product suite combines the balanced performance of guide catheters,

the recognised crossability of an advanced line of guidewires,

sophisticated balloon technology and revolutionary stent engineering—

creating a synchronised approach for today’s coronary interventions.

Intuition ADVANCED WORKHORSE GUIDEWIRE

Launcher GUIDE CATHETER

ProVia CROSSING GUIDEWIRE

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Art directionDesignIllustration

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Art directionDesignIllustration

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Design ProductionMedical /technical illustrationMarketing collateral

Coronary Artery Disease

Understanding Your Stent Procedure Patient Guide

Integrity®CoRoNARy STENT SySTEM

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Design ProductionMedical /technical illustrationMarketing collateral

Easy Radial curves

Universal diagnostic catheter

Additional transradialcurves

Transradial Curve FamilyLAuncHErAnDSHErPAnXGuiDEcATHETErS

Judkins Right CurveStandard curve for right coronary arteries (may be particularly useful for inferior takeoffs)

MAC CurveWorkhorse catheter for the right coronary artery

Recommended engagement techniqueUse a gentle clockwise rotation technique similar to the Judkins right coronary approach and the MAC. Pullback is required to carefully engage the artery.

Sizing suggestions:Same as for femoral approach•

Recommended engagement techniqueEmploy a Judkins engagement technique similar to the femoral approach. Apply a clockwise rotation to engage the right coronary artery.

Sizing suggestions:Same as femoral approach•

Recommended engagement techniqueEnter the root with the catheter tip facing the left coronary cusp. Once in the non-coronary cusp or the left coronary cusp, pull the wire back and apply clockwise torque. The catheter tip should deflect to the right coronary cusp and engage the right coronary artery.

Backup support is derived from the contralateral wall and sinus of valsalva.

Appropriate sizing suggestions:Lateraltakeoffandsmallroot:MAc3.0•

Superior takeoff and small root: MAC3.5/4.0•

Superior and large root: MAC4.0•

Lateralandlargeroot:MAc3.5/4.0•

Multipurpose Short Tip (MPST) CurveStandard curve for right coronary arteries (may be particularly useful for inferior takeoffs)

riGHTcOrOnArYcurvES

EBU Extra Backup CurveWorkhorse guide catheter for left coronary arteries

Recommended engagement techniqueEmploy a Judkins engagement technique similar to the femoral approach.veryfinetorquingmovementsmayberequiredtodirect the catheter toward the left coronary artery.

Sizing suggestions:Downsizethecurveby0.05fromwhatisusedforthefemoral•approach

Judkins Left CurveStandard curve for left coronary arteries (may be particularly useful for short left coronary arteries)

LEFTcOrOnArYcurvES

Recommended engagement techniqueThe EBU catheter enters the descending aorta facing the right coronary artery. Make a large J-shaped loop in the sinus of valsalva with the 0.035 J-tipped wire and advance the catheter over the wire. Apply torque to point the tip to the left coronary cusp and turn the catheter. Pull the wire back and the catheter will engage the left coronary artery.

Backup support with the transradial approach is derived from the sinus of valsalva, while EBU backup support with the femoral approach comes from the contralateral wall.

Sizing suggestions:JL35=EBu35•

JL40=EBu35•

JL50=EBu40•

GuidecathetersfromMedtronicaretheno.1choiceworldwide—andaresuitablefortransradial procedures. The majority of cases can be addressed with just a few basic curve shapes.

The transradial approach has advantages for both diagnostic and interventional procedures, including: Reduced bleeding Lowered vascular complications Early ambulation Reduced costs

Generalguidemanipulationtip:Thetransradialapproachcaninvolvemoretortuositythanthefemoralapproach.Guidemanipulationfromtheradialartery requires small clockwise and counterclockwise torquing movements. A fingertip technique is recommended rather than the wrist technique routinely used for the femoral approach.

The brachial curve shape, available in the SiteSeer® angiographic catheter, can be used as a universal diagnostic catheter for right and left angiographies.

Medtronic Offers a Full Line of Transradial Curves

Clear pocket

ALr12

IMA

MRESS

Easy Radial left

Hockey Stick

rrAD

Easy Radial left long tip

MrADiAL

Easy Radial left short tip

LArA

Easy Radial right

MAC3030

Easy Radial right short tip

What is the rationale for renal denervation?

The nerves leading in and out of the kidneys play a central role in sympathetic nervous system (SNS) hyperactivation, which is an established contributor to hypertension (high blood pressure).* The SNS connects the brain, heart, blood vessels and kidneys—each of which plays an important role in the regulation of the body’s blood pressure. Surgical disruption of sympathetic nerves has been a proven method for lowering blood pressure.† Renal denervation with the Symplicity® renal denervation system from Medtronic represents a breakthrough and first-of-its-kind device, currently under investigation in the United States for uncontrolled hypertension; a significant global healthcare problem affecting approximately 1.2 billion people worldwide and directly associated with increased risks of heart attacks, stroke, heart failure, kidney disease and death.‡

How does renal denervation work?

Renal denervation reduces activity of the renal sympathetic nerves, which is central to blood pressure regulation. It is a minimally invasive procedure that modulates the output of the sympathetic nerves located outside the renal artery walls.§

What is the procedure?

The Symplicity renal denervation system accomplishes renal denervation using a system consisting of a proprietary generator and a flexible catheter. The catheter is introduced through the femoral artery in the upper thigh and is threaded up into the renal artery near each kidney. Once in place, the tip of the catheter delivers low-power, radiofrequency (RF) energy according to a proprietary algorithm, or pattern, to modulate the surrounding sympathetic nerves. After energy delivery in mulitple locations along each artery, the Symplicty® catheter is removed—there is no permanent implant.

Renal DeneRvation WitH tHe Symplicity® Renal DeneRvation SyStem

Symplicity Htn-4 Trial

Caution: The Symplicity Renal Denervation System is an investigational device. Limited by US law to investigational use.

Renal Denervation (RDN) CATheTeR-bASed TReATMeNT FOR UNCONTROlled hypeRTeNSION

Refer to the Instructions for Use (IFU) for full product information.

The Symplicity G3™ generator, an integral part of the Symplicity™ renal denervation system, is designed to deliver precisely controlled radiofrequency (RF) energy treatments using either the Symplicity Spyral™ catheter or the Symplicity Flex™ catheter

PRODUCT DESCRIPTION The Symplicity G3 generator is an automatically-controlled electrosurgical generator that produces RF energy according to a programmed algorithm. During energy delivery, power is continuously monitored and controlled based on temperature and impedance measured at the electrode-tissue interface to ensure proper operation.

The Symplicity G3 generator consists of:• Generator• Optional foot switch

MATERIALSGENERATOR • Painted and nonpainted sheet metal

• Polycarbonate/acrylonitrile butadiene styrene blend (external covers)• Krapton thermoplastic elastomer (cord management strap)• Glass (projected capacitance touchscreen)

FOOT SWITCH • Painted sheet metal• PVC (foot switch hose)• Nylon

CABLE REGION LENGTH (mm) PRODUCT CODE

AC POWER CABLE USA 3.0 PRT075-1

ALTERNATE AC POWER CABLE EU 2.5 PRT075-2

India 2.5 PRT075-3

Australia 2.5 PRT075-4

UK/Ireland 2.5 PRT075-5

Italy 2.5 PRT075-6

Switzerland 2.5 PRT075-7

Israel 2.5 PRT075-8

Denmark 2.5 PRT075-9

SIZESGENERATOR • Dimensions of 29.9 cm × 36.7 cm × 18.9 cm (11.8 in. × 14.5 in. × 7.45 in.)

• Weight of 9.1 kg (excluding any accessories)• 10.4 in. (26.4 cm) display screen

PERFORMANCEGENERATOR • RF power output to a maximum of 8.0 W (for treatment with Symplicity Flex catheter)

• Delivers energy if measured impedance is >100 ohms and <500 ohms (for treatment with Symplicity Flex catheter)

• RF power output to a maximum of 6.5 W (for treatment with Symplicity Spyral catheter)• Delivers energy if measured impedance is >100 ohms and <1200 ohms (for treatment with

Symplicity Spyral catheter)• Input power of 100 to 240 V ~, 50 to 60 Hz universal power supply

STERILISATION PROCESS • Generator shall not be sterilised

LATEX • Not present

PHTHALATE • Not present

ANIMAL SUBSTANCE • Not present

AC power connector

TECHNICAL SPECIFICATIONS

Symplicity G3™

RENAL DENERVATION GENERATOR

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Transradial Curve Family

Medtronic Vascular3576 Unocal PlaceSanta Rosa, CA 95403USATel: +1.707.525.0111

www.medtronic.comMedtronic BVEarl Bakkenstraat 106422 PJ HeerlenThe NetherlandsTel: +31.45.566.8000Fax: +31.45.566.8668

Indications for Use: Medtronic guiding catheters are designed to provide a pathway through which therapeutic devices are introduced. The guiding catheters are intended to be used in the coronary or peripheral vascular system.

Adverse effects: Use of guiding catheters may give rise to the following complications: hemorrhage or hematoma, allergic reaction to contrast medium, infection, embolism, vessel or heart dissection, perforation, vessel spasm, thrombosis, myocardial infarction, stroke, death and vascular occlusion.

Refer to Instructions for Use supplied with the device for indications, warnings, precautions, and adverse effects.

CAUTION: Federal (USA) law restricts this device to sale by or on the order of a physician.

Test data on file at Medtronic, Inc. Bench test results may not be indicative of clinical performance. The curve recommendations in this guide are not meant to replace patient-specific clinical judgment.

Sherpa NX Guide Catheter

• Twodistalsegmentstoprovideoptionsforguideengagement

• Softtipanddistalsleevetofacilitateeaseofengagement

• AdvancedHDPElinerforsmooth,low-frictiondevicepassage

Launcher Guide Catheter

• Largelumenswithnoperformancetradeoffs

• Flexibledistalsegmenttoengagetheguideforbackup

• Supportivesecondarycurve

Choosing a transradial curve should be simple. We can help.Medtronic is the worldwide leader in guide catheters. Medtronic is the worldwide leader in guide catheters. When it comes to choosing a transradial guide catheter, the choice should be simple—Medtronic. Our family of guide catheters is appropriate for transradial procedures, allowing you to navigate a variety of anatomies. A broad range of radial shapes is available—and custom lengths and shapes can be ordered—to satisfy the majority of cases.

A Full Line of Guide Catheters Medtronic’s multiple guide catheter platforms provide options for guide engagement.

Supportive secondary curve

Mid-range flexibility

LAuncHEr®AnDSHErPAnXGuiDEcATHETErS

Medtronic’s complete line of guide catheters incorporates full-wall technology. The unique shaft construction optimizes the balance between a large lumen and robust performance, and offers excellent kink resistance and curve retention.

Unique Full-Wall Technology

The inner and outer jackets encapsulate the flat braid wire, affording thinner, stronger walls.

Outer jacket

More polymerEncapsulated braid wire

Flat braid wire

Inner jacket

Medtronic Ordering Information Contact your Medtronic sales representative.

Transradial Curve FamilyLAuncHErAnDSHErPAnXGuiDEcATHETErS

CurveLauncher Sherpa NX Active Sherpa NX Balanced

5 F 6 F 5 F 6 F 6 F

EBU

LA5EBu30 LA6EBu30 SA5EBU30 SA6EBU30 SB6EBU30

LA5EBu35 LA6EBu36 SA5EBU35 SA6EBU35 SB6EBU35

LA5EBu375 LA6EBu376 SA5EBU375 SA6EBU375 SB6EBU375

LA5EBu40 LA6EBu40 SA5EBU40 SA6EBU40 SB6EBU40

LA5EBu45 LA6EBu46 SA5EBU45 SA6EBU45 SB6EBU45

LA5EBu50 LA6EBu60 SA5EBU50 SA6EBU50 SB6EBU50

LArA LA5LArA LA6LArA SA5LArA SA6LArA SB6LArA

ALr12 LA5ALr12 LA6ALr12 SA5ALr12 SA6ALr12 SB6ALr12

MrADiAL LA5MrADiAL LA6MrADiAL SA5MrADiAL SA6MrADiAL SB6MrADiAL

MRESS LA5MrESS LA6MrESS SA5MRESS SA6MRESS SB6MRESS

rrAD LA5rrAD LA6rrAD SA5rrAD SA6rrAD SB6rrAD

MAC

LA5MAc30 LA6MAc30 SA5MAC30 SA6MAC30 SB6MAC30

LA5MAc35 LA6MAc36 SA5MAC35 SA6MAC35 SB6MAC35

LA5MAc375 LA6MAc376 SA5MAC375 SA6MAC375 SB6MAC375

LA5MAc40 LA6MAc40 SA5MAC40 SA6MAC40 SB6MAC40

LA5MAc45 LA6MAc46 SA5MAC45 SA6MAC45 SB6MAC45

MAC3030 LA5MAc3030 LA6MAc3030 SA5MAC3030 SA6MAC3030 SB6MAC3030

HOCKEY STICK

LA5HSi LA6HSi SA5HSI SA6HSI SB6HSI

LA5HSii LA6HSii SA5HSII SA6HSII SB6HSII

LA5HSrEL LA6HSrEL SA5HSrEL SA6HSrEL SB6HSrEL

LA5HSiii LA6HSiii SA5HSIII SA6HSIII SB6HSIII

MuLTiPurPOSE LA5MPST LA6MPST SA5MPST SA6MPST SB6MPST

IMA LA5iMA LA6iMA SA5IMA SA6IMA SB6IMA

EASYrADiALLEFT

LA5ErADL LA6ErADL SA5ErADL SA6ErADL SB6ErADL

LA5ErADLLT LA6ErADLLT SA5ErADLLT SA6ErADLLT SB6ErADLLT

LA5ErADLST LA6ErADLST SA5ErADLST SA6ErADLST SB6ErADLST

EASYrADiALriGHTLA5ErADr LA6ErADr SA5ErADr SA6ErADr SB6ErADr

LA5ErADrST LA6ErADrST SA5ErADrST SA6ErADrST SB6ErADrST

Curve Catalog Number French Size Length (cm)

BrAcHiAL3.5(one sidehole)

4A0052 4 80

5A0052 5 80

6A0054 6 80

4A0034 4 100

5A0034 5 100

6A0036 6 100

BrAcHiAL4.0(one sidehole)

4A0053 4 80

5A0053 5 80

6A0055 6 80

4A0035 4 100

5A0035 5 100

6A0037 6 100

BrAcHiAL4.5(one sidehole)

4A0054 4 80

5A0054 5 80

6A0056 6 80

4A0036 4 100

5A0036 5 100

6A0038 6 100

To further simplify your transradial approach needs, Medtronic offers the following brachial curve shapes that can be used for left and right angiographies.

For further information, please call and/or consult Medtronic at the toll-free numbers or websites listed below:

Mid-range flexibility

Soft tip

Supportive secondary curve

Mid-range flexibility

Supportive secondary curve

Soft tip

Active flexibility

Sherpa NX Active Sherpa NX Balanced

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Illustration Infographics

Age >18 years

Not pregnant

In-office systolic blood pressure≥160 mmHg

If type 2 diabetes mellitus in-office systolic blood pressure ≥150 mmHg

24hr ABPM ≥135 mmHg

Number of antihypertensive drugs, including a diuretic ≥3(adequate and maximally tolerated doses)

eGFR ≥45 ml/min/1.73 m²

Symplicity™

RENAL DENERVATION SYSTEM

RDN Screening Tool

www.medtronicRDN.com

DESIGN MATTERS

CREATIVE GROUP

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DESIGN MATTERS