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Title:
Network pharmacology analysis reveal flavonoids and diterpenoids from Andrographis
paniculata and Thespesia populnea as potential modulators of hepatitis B virus induced
hepatocellular carcinoma
Supplementary Tables
SS1 List of references for the selected medicinal plant for the treatment of hepatitis like illness
including Jaundice, Hepatitis, fever, inflammation and for hepatoprotective and antiviral
potential
SS2 List of plants with their phytocompounds and druglikeness property
SS3 Toxicity profile of phytocompounds
SS4 Overall probable targets modulated by the phytocompounds (Predicted using BindingDB)
SS5 Gene Ontology (GO) functional enrichment analysis: Regulated molecular functions of 16
protein targets modulated by the phytocompounds
SS6 GO process enrichment analysis: Molecular processes of 16 protein targets modulated by the
phytocompounds
SS7 Pathway enrichment analysis: 16 protein targets modulated 139 pathways
SS8 Role of 16 protein targets in the pathogenesis of hepatitis B viral infection and hepato cellular
carcinoma (HCC)
Supplementary Table 1: List of references for the selected medicinal plant for the treatment of hepatitis like illness including Jaundice, Hepatitis,
fever, inflammation and for hepatoprotective and antiviral potential
Medicinal Plants Ayurvedic/com
mon name
References
Achyranthes
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Strychnus
nuxvomica
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induced hepatic damage by the natural product loganin from the plant strychnos nux‐vomica: studies on isolated
hepatocytes and bile flow in rat. Phytotherapy Research: An International Journal Devoted to Pharmacological
and Toxicological Evaluation of Natural Product Derivatives, 12(6), 405-408.
Thespesia
populnea
Gansuriya Yuvaraj, P., & Subramoniam, A. (2009). Hepatoprotective property of Thespesia populnea against carbon
tetrachloride induced liver damage in rats. Journal of Basic and Clinical Physiology and Pharmacology, 20(2),
169-178.
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populnea bark extracts against carbon tetrachloride-induced liver toxicity in rats. Natural Product Sciences.
2003;9(2):83-6.
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Sunilson JA. Hepatoprotective Activity of Isolated Gossypin, a Novel Bioflavanoid from Thespesia Populnea
Linn. KPJ Medical. 2016 Nov;6(1):11.
Vernonia cinerea Monarakudumb
iya
Leelaprakash G, Mohan Dass S, Sivajothi V. Antioxidant and hepatoprotective activities of Vernonia cinerea
extract against CCl4 induced hepatotoxicity in albino rats. Int. J. Pharm. Sci. Rev. Res. 2011;10:30-4.
Nishadh A. EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF VERNONIA CINEREA (L.) LESS
AND CUMINUM CYMINUM IN CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS.
Gokilaveni C, Nishadh A, Selvi V. Ameliorative role of Vernonia cinerea in carbon tetrachloride induced hepatic
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Yadava RN, Raj M. A new antiviral flavone glycoside from Vernonia cinerea Less. Asian Journal of Chemistry.
2013;25(7):3542-4.
SS2: List of plants with their phytocompounds and druglikeness property
Abbreviations: MF Molecular formula; MW Molecular weight; HBA Hydrogen bond acceptor; HBD Hydrogen bond donor; LogP Partition co-efficient; DLS Druglikeness score
Plant name(s) Phytocompound PubChe
m CID
Canonical smiles MF MW
(g/mol)
HBA HBD LogP DLS
Achyranthes
aspera
(3R,5S)- 1,3,4,5-
Tetrahydroxycycl
ohexane
carboxylic acid
1268037 C1[C@H](C([C@H](CC1(C(=O)O)O)O)O)O C7 H12 O6 192.06 6 5 -2.52 -1.09
Achyranthes
aspera
20-
hydroxyecdysone
5459840 C[C@]12CC[C@H]3C(=CC(=O)[C@H]4[C@@]3(C[C@
@H]([C@@H](C4)O)O)C)[C@@]1(CC[C@@H]2[C@](
C)([C@@H](CCC(C)(C)O)O)O)O
C27 H44 O7 480.31 7 6 2.35 1.46
Achyranthes
aspera
3,4-
Dimethoxythioph
enol
136539 COC1=C(C=C(C=C1)S)OC C8 H10 O2
S
170.04 3 1 2.18 -1.11
Achyranthes
aspera
3,5- Dihydroxy-6-
Methyl-2,3-
Dihydro-4H-
Pyran-4-one
5091874
1
CC1=C(C(=O)[C@H](CO1)O)O C15 H15 N
O3
257.11 3 1 1.93 0.53
Achyranthes
aspera
Asarone 636822 C/C=C/C1=CC(=C(C=C1OC)OC)OC C12 H16 O3 208.11 3 0 3.23 -1.72
Achyranthes
aspera
Eugenol 3314 COC1=C(C=CC(=C1)CC=C)O C10 H12 O2 164.08 2 1 2.61 -0.6
Achyranthes
aspera
α-ionone 5282108 CC1=CCCC(C1/C=C/C(=O)C)(C)C C13 H20 O 192.15 1 0 4.05 -0.77
Achyranthes
aspera
Spathulenol 92231 C[C@@]1(CC[C@@H]2[C@@H]1[C@H]3[C@H](C3(
C)C)CCC2=C)O
C15 H24 O 220.18 1 1 4.33 -0.88
Achyranthes
aspera, Centella
asiatica
2-Furaldehyde 7362 C1=COC(=C1)C=O C5 H4 O2 96.02 2 0 0.87 -1.76
Aerva lanata 10-O-β-D-
glucopyranosylox
ycanthin-6-one
1510928
3
C1=CC2=C(C=C1O[C@H]3[C@@H]([C@H]([C@@H](
[C@H](O3)CO)O)O)O)C4=C5N2C(=O)C=CC5=NC=C4
C20 H18 N2
O7
398.11 8 4 -0.5 -0.39
Aerva lanata 6-methoxy-β
carboline-1-
propionic acid
1510928
4
COC1=CC2=C(C=C1)NC3=C2C=CN=C3CCC(=O)O C15 H14 N2
O3
270.1 4 2 2.34 0.3
Aerva lanata 10-
methoxycanthine-
6-one
(methylervine)
158928 COC1=CC2=C(C=C1)N3C(=O)C=CC4=NC=CC2=C43 C15 H10 N2
O2
250.07 3 0 2.6 -0.45
Aerva lanata 10-
hydroxycanthin-
6-one (ervine)
158929 C1=CC2=C(C=C1O)C3=C4N2C(=O)C=CC4=NC=C3 C14 H8 N2
O2
236.06 3 1 2.25 -0.44
Aerva lanata Isorhamnetin 3-
(6''-p-
coumarylglucosid
e)
4425802
5
COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)
O)O)O[C@H]4C(C([C@@H]([C@H](O4)COC(=O)/C=C
/C5=CC=C(C=C5)O)O)O)O)O
C31H28O14 624.15 14 7 2.46 0.8
Aerva lanata Isorhamnetin 5281654 COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)
O)O)O)O
C16H12O7 316.06 7 4 2.46 0.67
Aerva lanata Tiliroside 5320686 C1=CC(=CC=C1/C=C/C(=O)OC[C@@H]2[C@H]([C@
@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C
3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O
C30H26O13 594.14 13 7 2.49 0.85
Aerva lanata β-carboline-1 -
propionic acid
5375436 C1=CC=C2C(=C1)C3=C(N2)C(=NC=C3)CCC(=O)O C14H12N2
O2
240.09 3 2 2.25 0.35
Aerva lanata Isorhamnetin 3-
(3'',6''-di-p-
coumarylglucosid
e)
4425802
6
COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)
O)O)O[C@H]4C(C([C@@H]([C@H](O4)COC(=O)/C=C
/C5=CC=C(C=C5)O)O)OC(=O)/C=C/C6=CC=C(C=C6)O
)O)O
C40 H34
O16
770.18 16 7 5.06 0.97
Aerva lanata Kaempferol 3-
(3'',6''-di-p-
coumarylglucosid
e)
4425886
8
C1=CC(=CC=C1/C=C/C(=O)OCC2[C@H](C(C([C@@H
](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(
C=C5)O)O)OC(=O)/C=C/C6=CC=C(C=C6)O)O)O
C39 H32
O15
740.17 15 7 5.09 1.03
Aloe vera Aloe-Emodin 10207 C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)
CO
C15 H10 O5 270.05 5 3 1.91 0.25
Aloe vera Chrysophanic-
Acid
10208 CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O C15 H10 O4 254.06 4 2 2.89 0.1
Aloe vera Isorabaichromone 1037083
2
CC1=CC(=C(C2=C1C(=O)C=C(O2)C[C@H](C)O)[C@H
]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC(=
O)/C=C/C4=CC(=C(C=C4)O)O)OC
C29 H32
O12
572.19 12 6 1.74 1.07
Aloe vera Hydrocinnamic-
Acid
107 C1=CC=C(C=C1)CCC(=O)O C9 H10 O2 150.07 2 1 1.84 -1.2
Aloe vera Dehydroabietal 1169486
9
CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3
CC2)(C)C=O)C
C20 H28 O 284.21 1 0 5.35 0.01
Aloe vera Homonataloin 1196859
3
COC1=C(C=CC2=C1C(=O)C3=C(C2[C@H]4[C@@H]([
C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)O)
O
C21 H22
O10
434.12 10 7 -0.02 0.46
Aloe vera Trihydroxymethyl
anthraquinone
1230920
4
CC1=CC(=CC2=C1C(=O)C3=C(C2=O)C=C(C=C3O)O)
O
C15 H10 O5 270.05 5 3 2.63 -0.7
Aloe vera Pteroylglutamic-
Acid
1354447
79
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=
CN=C3C(=N2)C(=O)NC(=N3)N
C19 H19 N7
O6
441.14 9 7 -0.95 0.97
Aloe vera 2(3H)-
Benzothiazolone
13625 C1=CC=C2C(=C1)NC(=O)S2 C7 H5 N O
S
151.01 2 1 2.06 -1.07
Aloe vera Aloeresin-D 1421122
5
CC1=CC(=C(C2=C1C(=O)C=C(O2)C[C@@H](C)O)[C
@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O
C(=O)/C=C/C4=CC=C(C=C4)O)OC
C29 H32
O11
556.19 11 5 2.12 0.91
Aloe vera Coniferyl-Alcohol 1549095 COC1=C(C=CC(=C1)/C=C/CO)O C10 H12 O3 180.08 3 2 1.83 -0.58
Aloe vera 7-Hydroxyaloin 158096 C1=CC(=C(C2=C1[C@H](C3=C(C2=O)C(=CC(=C3)CO)
O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O
)O)O)O)O
C21 H22
O10
434.12 10 8 -0.69 0.5
Aloe vera Aloesin 160190 CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(=O)C)[C@H]3[C
@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O
C19 H22 O9 394.13 9 5 -1.03 0.45
Aloe vera Aloenin 162305 CC1=CC(=CC(=C1C2=CC(=CC(=O)O2)OC)O[C@H]3[
C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O
C19 H22
O10
410.12 10 5 -1.36 0.73
Aloe vera 1,8-
Dihydroxyanthrac
ene
1978601
4
C1=CC2=CC3=C(C=C2C(=C1)O)C(=CC=C3)O C14 H10 O2 210.07 2 2 3.99 -1.27
Aloe vera Glucomannan 2489272
6
C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O
[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C
@@H]3[C@H](O[C@H]([C@H]([C@H]3O)O)OC4[C@
H](O[C@H]([C@H]([C@H]4O)O)O)CO)CO)CO)O)O)O)
O
C24 H42
O21
666.22 21 14 -
10.12
0.22
Aloe vera Dibutyl-Phthalate 3026 CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC C16 H22 O4 278.15 4 0 4.76 -0.07
Aloe vera Aloe-Emodin-
Anthranol
3220 CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O
)O
C15 H10 O5 270.05 5 3 2.63 -0.72
Aloe vera Chrysamminic-
Acid
3938245 C1=C(C2=C(C(=C1[N+](=O)[O-
])O)C(=O)C3=C(C2=O)C(=CC(=C3O)[N+](=O)[O-
])[N+](=O)[O-])[N+](=O)[O-]
C14 H4 N4
O12
419.98 12 2 0.91 -0.5
Aloe vera Cinnamic-Acid 444539 C1=CC=C(C=C1)/C=C/C(=O)O C9H8O2 148.05 2 1 2.33 -1.13
Aloe vera Gamolenic-Acid 5280933 CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O C18H30O2 278.22 2 1 6.31 -0.08
Aloe vera Feralolide 5317333 CC(=O)C1=C(C=C(C=C1O)O)C[C@@H]2CC3=C(C(=C
C(=C3)O)O)C(=O)O2
C18H16O7 344.09 7 4 1.58 0.82
Aloe vera Aloesone 5317700 CC1=CC(=CC2=C1C(=O)C=C(O2)CC(=O)C)O C13H12O4 232.07 4 1 1.85 -0.23
Aloe vera Aloesol 5318230 CC1=CC(=CC2=C1C(=O)C=C(O2)CC(C)O)O C13H14O4 234.09 4 2 2.06 0.49
Aloe vera Isocitric-Acid 5318532 C([C@@H]([C@H](C(=O)O)O)C(=O)O)C(=O)O C6H8O7 192.03 7 4 -2.12 -0.56
Aloe vera Linoleic-Acid-
Ethyl-Ester
5367460 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)OCC C20H34O2 306.26 2 0 7.14 -0.74
Aloe vera Hydroxyproline 5810 C1[C@H](CN[C@@H]1C(=O)O)O C5H9NO3 131.06 4 3 1.98 -0.25
Aloe vera Hexauronic-Acid 610 C1(C(C(OC(C1O)O)C(=O)O)O)O C6H10O7 194.04 7 5 -3.01 -0.3
Aloe vera P-
Methoxybenzylac
etone
61007 CC(=O)CCC1=CC=C(C=C1)OC C11 H14 O2 178.1 2 0 2.38 -1.41
Aloe vera 4-Hydroxy-3,5-
Di-Tert-Butyl-
Benzaldehyde
73219 CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=O C15 H22 O2 234.16 2 1 4.38 -2.14
Aloe vera Isoaloeresin-D 7633250
5
CC1=CC(=C(C2=C1C(=O)C=C(O2)C[C@H](C)O)[C@H
]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC(=
O)/C=C/C4=CC=C(C=C4)O)OC
C29 H32
O11
556.19 11 5 2.12 0.91
Aloe vera Monooctylphthala
te
79362 CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)O C16 H22 O4 278.15 4 1 4.87 0.08
Aloe vera Hydroxymethylan
thraquinone
87014 C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C=C(C=C3)CO C15 H10 O3 238.06 3 1 2.67 -0.25
Aloe vera M-
Protocatechuic-
Aldehyde
8768 C1=CC(=C(C=C1C=O)O)O C7 H6 O3 138.03 3 2 1.01 -0.66
Aloe vera 2-Methyl-2-
Phytyl-6-
Chromanol
9865117 CC(C)CCCC(C)CCCC(C)CCCC1(CCC2=C(O1)C=CC(=
C2)O)C
C26 H44 O2 388.33 2 1 10.24 0.83
Aloe vera 10-Hydroxyaloin-
A
1488973
6
C1=CC2=C(C(=C1)O)C(=O)C3=C([C@]2([C@H]4[C@
@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C=C(C
=C3O)CO
C21 H22
O10
434.12 10 8 -1.49 1.05
Aloe vera 10-Hydroxyaloin-
B
1488973
7
C1=CC2=C(C(=C1)O)C(=O)C3=C([C@@]2([C@H]4[C
@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C=C
(C=C3O)CO
C21 H22
O10
434.12 10 8 -1.49 1.05
Aloe vera Elgonica-Dimer-
A
2158259
6
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2([C@H]4[C@@H]
([C@H]([C@@H]([C@H](O4)CO)O)O)O)C5=C(C6=C(
C=C5)C(=O)C7=C(C6=O)C(=CC(=C7)CO)O)O)C=C(C=
C3O)CO
C36 H30
O14
686.16 14 10 1.03 0.48
Aloe vera Aloeresin_A 1022474
58
CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(=O)C)[C@H]3[C
@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC(=O)/
C=C/C4=CC=CC=C4)O[C@H]5[C@@H]([C@H]([C@
@H]([C@H](O5)CO)O)O)O
C34 H38
O15
686.22 15 7 -0.92 0.37
Aloe vera Neoaloesin-A 1024455
77
CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(=O)C)[C@@H]3
[C@@H]([C@H]([C@H](O3)[C@@H](CO)O)O)O)O
C19 H22 O9 394.13 9 5 -1.01 0.37
Aloe vera 7-Hydroxy-8-O-
Methyl-Aloin-B
1317511
75
COC1=C(C=CC2=C1C(=O)C3=C(C2C4C(C(C(C(O4)CO
)O)O)O)C=C(C=C3O)CO)O
C22 H24
O10
448.14 10 7 -0.34 0.54
Aloe vera Diheptyl-
Phthalate
19284 CCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC C22 H34
O4
362.25 4 0 7.63 -0.13
Aloe vera Casanthranol 2098 C1=CC2=C(C(=C1)O)C(=O)C3=C(C2OC4C(C(C(C(O4)
CO)O)O)O)C=C(C=C3O)CO
C21 H22
O10
434.12 10 7 -0.74 0.77
Aloe vera Sulfoquinovosyl-
Diglyceride
5684203
0
CCCCCCCCCCCCCCCC(=O)OC(CO[C@@H]1[C@@H
]([C@H]([C@@H]([C@H](O1)CS(=O)(=O)O)O)O)O)C
OC(=O)CCC/C=C/C/C=C/C/C=C/C/C=C/C/C=C/CC
C45 H76
O12 S
840.51 12 4 9.16 0.24
Aloe vera Lysophosphatidyl
-Inositol
7375506
7
CC(=O)OC[C@@H](COP(=O)(O)OC1[C@@H]([C@H](
C([C@H]([C@H]1O)O)O)O)O)O
C11 H21
O12 P
376.08 12 7 -5.31 -0.05
Aloe vera Di-(2-
Ethylhexyl)-
Phthalate
8343 CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)C
CCC
C24 H38 O4 390.28 4 0 8.64 0.26
Aloe vera Dioctyl-Phthalate 8346 CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC
C
C24 H38 O4 390.28 4 0 8.59 -0.13
Aloe vera,
Centella asiatica
Campesterol 173183 C[C@H](CC[C@@H](C)C(C)C)[C@H]1CC[C@@H]2[
C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@
H](C4)O)C)C
C28 H48 O 400.37 1 1 8.9 0.71
Aloe vera,
Centella asiatica
Glutamic-Acid 33032 C(CC(=O)O)[C@@H](C(=O)O)N C5 H9 N O4 147.05 5 4 -2.2 0.69
Aloe vera,
Centella asiatica,
Strychnus
nuxvomica,
Vernonia cinerea,
Achyranthes
aspera, Ricinus
communis
Stigmasterol 5280794 CC[C@H](/C=C/[C@@H](C)[C@H]1CC[C@@H]2[C@
@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C
4)O)C)C)C(C)C
C29H48O 412.37 1 1 8.82 0.73
Aloe vera,
Mangifera indica
Isoleucine 6306 CC[C@H](C)[C@@H](C(=O)O)N C6 H13 N
O2
131.09 3 3 -0.45 -1.05
Aloe vera,
Mangifera indica
P-Coumaric-Acid 637542 C1=CC(=CC=C1/C=C/C(=O)O)O C9 H8 O3 164.05 3 2 2.07 -0.74
Aloe vera,
Thespesia
populnea,
Centella asiatica,
Vernonia cinerea,
Ricinus
communis,
Diospyros
montana
Beta-Sitosterol 222284 CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]
1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)
O)C)C)C(C)C
C29 H50 O 414.39 1 1 9.48 0.88
Andrographis
paniculata
14-Deoxy-11-
Oxoandrographoli
de
1015930
61
C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]
2C(=O)CC3=CC(=O)OC3)(C)CO)O
C20 H28 O5 348.19 5 2 2.00 -0.36
Andrographis
paniculata
14-Deoxy-11-
Dehydroandrogra
pholide
1541180
9
C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]
2C/C=C\3/C(=COC3=O)O)(C)CO)O
C20 H28 O5 348.19 5 3 2.56 -0.64
Andrographis
paniculata
5-Hydroxy-7,8,2'-
Trimethoxyflavon
e
5318506 COC1=CC=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)
OC)OC
C18H16O6 328.09 6 1 3.49 0.61
Andrographis
paniculata
5-Hydroxy-
7,8,2',3'-
Tetramethoxyflav
one
5319878 COC1=CC=CC(=C1OC)C2=CC(=O)C3=C(O2)C(=C(C=
C3O)OC)OC
C19H18O7 358.11 7 1 3.46 0.5
Andrographis
paniculata
Neoandrographoli
de
9848024 C[C@]1(CCC[C@@]2([C@@H]1CCC(=C)[C@H]2CCC
3=CCOC3=O)C)CO[C@H]4[C@@H]([C@H]([C@@H](
[C@H](O4)CO)O)O)O
C26 H40 O8 480.27 8 4 2.17 0.17
Andrographis
paniculata
Paniculide-A 1182148
5
CC(=CCCC1=C2[C@H](C[C@@]3([C@H]([C@H]2O)O
3)C)OC1=O)C
C15 H20 O4 264.14 4 1 1.85 -0.1
Andrographis
paniculata
Paniculide-B 1012898
23
CC(=CCCC1=C2[C@H](C[C@@]3([C@H]([C@H]2O)O
3)CO)OC1=O)C
C15 H20 O5 280.13 5 2 0.72 0.09
Andrographis
paniculata
Paniculide-C 1012898
24
CC(=CCCC1=C2[C@H](C[C@@]3([C@H](C2=O)O3)C
O)OC1=O)C
C15 H18 O5 278.12 5 1 0.72 -0.05
Andrographis
paniculata Andrographolide 5318517
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)C
O)O C20 H30 O5 350.21 5 3 2.32 -0.64
Andrographis
paniculata
14-
Deoxyandrograph
olide
1162416
1 CC12CCC(C(C1CCC(=C)C2CCC3=CCOC3=O)(C)CO)O C20 H30 O4 334.21 4 2 3.22 -0.24
Andrographis
paniculata
14-Deoxy 11,12-
didehydroandrogr
apholide 5708351
CC12CCC(C(C1CCC(=C)C2C=CC3=CCOC3=O)(C)CO)
O C20 H28 O4 332.2 4 2 3.22 -0.54
Andrographis
paniculata
Isoandrographolid
e 343585
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)C
O)O C20 H30 O5 350.21 5 3 2.32 -0.64
Andrographis
paniculata Andrographiside
4459358
3
CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)C
OC4C(C(C(C(O4)CO)O)O)O)O
C26 H40
O10 512.26 10 6 0.55 0.08
Andrographis
paniculata Andrograpanin
1166687
1 CC1(CCCC2(C1CCC(=C)C2CCC3=CCOC3=O)C)CO C20 H30 O3 318.22 3 1 4.28 -0.3
Andrographis
paniculata
14-Deoxy-11-
hydroxyandrograp
holide
9188498
7
CC12CCC(C(C1CCC(=C)C2C(CC3=CCOC3=O)O)(C)C
O)O
C20 H30 O5 350.21 5 3 2.08 -0.48
Andrographis
paniculata
Andrographolacto
ne
4420646
6
CC1=CC2=C(CCC1)C(=C(C(=C2)C)CCC3=CCOC3=O)
C C20 H24 O2 296.18 2 0 5.66 0.53
Andrographis
paniculata
19-O-acetyl-14-
deoxy-11,12-
didehydroandrogr
apholide
4617987
4
CC(=O)OCC1(C2CCC(=C)C(C2(CCC1O)C)C=CC3=CC
OC3=O)C
C22 H30 O5 374.21 5 1 3.8 -0.23
Andrographis
paniculata
Altisin 1510071
9
COC1=C(C(=CC=C1)OC)C2=CC(=O)C3=C(O2)C(=C(C
=C3O)OC)OC C19 H18 O7 358.11 7 1 2.81 0.03
Andrographis
paniculata
2'-hydroxy-5,7,8-
trimethoxyflavone
2166887
8
COC1=CC(=C(C2=C1C(=O)C=C(O2)C3=CC=CC=C3O)
OC)OC C18 H16 O6 328.09 6 1 3.9 0.2
Andrographis
paniculata
5-hydroxy-
7,8,2',3',4'-
pentamethoxyflav
one
1231547
9
COC1=C(C(=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3
O)OC)OC)OC)OC
C20 H20 O8 388.12 8 1 3.4 0.36
Andrographis
paniculata
Wightin 1244494
3
COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=C(C(=CC=
C3)O)OC)OC C18 H16 O7 344.09 7 2 3.08 0.19
Andrographis
paniculata
5-hydroxy-7,8-
dimethoxyflavano
ne
1396377
0
COC1=C(C2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O
)OC
C17 H16 O5 300.1 5 1 3.02 0.48
Andrographis
paniculata
5-hydroxy-7,8-
dimethoxyflavone
188316 COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C
3)OC C17 H14 O5 298.08 5 1 3.74 0.17
Andrographis
paniculata
Skullcapflavone I 5320399 COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=CC=C
3O)OC C17 H14 O6 314.08 6 2 3.71 0.33
Andrographis
paniculata
5-hydroxy-
7,8,2',5'-
tetramethoxyflavo
ne
1094831
8
COC1=CC(=C(C=C1)OC)C2=CC(=O)C3=C(O2)C(=C(C
=C3O)OC)OC
C19 H18 O7 358.11 7 1 3.41 0.11
Andrographis
paniculata
5,4'-dihydroxy-
7,8,2',3'-
tetramethoxyflavo
ne
1396377
7
COC1=C(C2=C(C(=C1)O)C(=O)C=C(O2)C3=C(C(=C(C
=C3)O)OC)OC)OC
C19 H18 O8 374.1 8 2 3.02 0.31
Andrographis
paniculata
Skullcapflavone II 124211 COC1=CC=CC(=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)
OC)OC)OC)O)O C19 H18 O8 374.1 8 2 3.37 -0.45
Andrographis
paniculata
Andrographidine
A
1396376
2
COC1=C(C2=C(C(=O)CC(O2)C3=CC=CC=C3)C(=C1)O
C4C(C(C(C(O4)CO)O)O)O)OC
C23 H26
O10 462.15 10 4 0.91 0.38
Andrographis
paniculata
Andrographidine
C
5318484 COC1=C(C2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(
=O)C=C(O2)C4=CC=CC=C4)OC
C23 H24
O10 460.14 1 4 1.67 0.24
Cassia auriculata Pelargonidin 5-
galactoside
4425669
8
C1=CC(=CC=C1C2=C(C=C3C(=CC(=CC3=[O+]2)O)O[
C@H]4C([C@H]([C@H](C(O4)CO)O)O)O)O)O
C21H21O10 433.11 10 7 -0.26 0.32
Centella asiatica 2,3-
Dihydrobenzofura
n
10329 C1COC2=CC=CC=C21 C8 H8 O 120.1 1 0 2.1 -1.55
Centella asiatica Epiglobulol 1185878
8
C[C@@H]1CC[C@@H]2[C@@H]1[C@H]3[C@H](C3(
C)C)CC[C@]2(C)O
C15 H26 O 222.2 1 1 4.35 -1.06
Centella asiatica Beta-
Sesquiphellandren
e
1231549
2
C[C@@H](CCC=C(C)C)[C@H]1CCC(=C)C=C1 C15 H24 204.19 0 0 5.19 -0.58
Centella asiatica 7-
Glucosylkaempfer
ol
1298560
29
C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O
C4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
)O)O
C21 H20
O12
464.1 12 8 -0.76 0.69
Centella asiatica Borneol-Acetate 1401926
6
CC(=O)O[C@H]1[C@]2(CC[C@H](C2)C1(C)C)C C12 H20 O2 196.15 2 0 3.18 -0.86
Centella asiatica Beta-Pinene 14896 CC1(C2CCC(=C)C1C2)C C10 H16 136.13 0 0 3.72 -1.41
Centella asiatica Caryophyllene-
Oxide
1742210 C[C@@]12CC[C@@H]3[C@H](CC3(C)C)C(=C)CC[C
@H]1O2
C15 H24 O 220.18 1 0 4.53 -1.43
Centella asiatica P-Vinyl-Guaiacol 332 COC1=C(C=CC(=C1)C=C)O C9 H10 O2 150.07 2 1 2.43 -0.96
Centella asiatica Delta-Cadinene 441005 CC1=C[C@H]2[C@@H](CCC(=C2CC1)C)C(C)C C15 H24 204.19 0 0 5.44 -1.07
Centella asiatica Madecassic-Acid 5153196
6
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C
@]3(C[C@H]([C@H]5[C@@]4(C[C@H]([C@@H]([C@
@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O
C30H48O6 504.35 6 5 4.63 0.69
Centella asiatica 3-
Glucosylquercetin
5280804 C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O
)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O
)O)O)O)O
C21H20O12 464.1 12 8 -0.64 0.89
Centella asiatica 3-
Glucosylkaempfer
ol
5282102 C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)
O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)
O)O)O
C21H20O11 488.1 11 7 -0.26 0.8
Centella asiatica Nerolidol 5284507 CC(=CCC/C(=C/CCC(C)(C=C)O)/C)C C15H26O 222.2 1 1 5.24 -1.03
Centella asiatica Bicycloelemene 5684278
6
CC(=C)[C@H]1[C@H]2[C@H](C2(C)C)CC[C@@]1(C)
C=C
C15H24 204.19 0 0 5.41 -1.13
Centella asiatica Geraniol 637566 CC(=CCC/C(=C/CO)/C)C C10 H18 O 154.14 1 1 3.33 -1.11
Centella asiatica Nerol 643820 CC(=CCC/C(=C\CO)/C)C C10 H18 O 154.14 1 1 3.33 -1.11
Centella asiatica Linalool 6549 CC(=CCCC(C)(C=C)O)C C10 H18 O 154.14 1 1 3.25 -0.99
Centella asiatica Beta-Elemene 6918391 CC(=C)[C@@H]1CC[C@@]([C@@H](C1)C(=C)C)(C)
C=C
C15 H24 204.19 0 0 5.39 -1.15
Centella asiatica Isobrahmic-Acid 73412 C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C
@]3(C[C@H]([C@@H]5[C@@]4(C[C@H]([C@@H]([C
@@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)
O
C30 H48 O6 504.35 6 5 4.63 0.69
Centella asiatica Gamma-
Terpinene
7461 CC1=CCC(=CC1)C(C)C C10 H16 136.13 0 0 4.57 -1.61
Centella asiatica Meso-Inositol 892 C1(C(C(C(C(C1O)O)O)O)O)O C6 H12 O6 180.06 6 6 -3.61 -0.89
Centella asiatica Germacrene-D 9172365
3
C/C/1=C/CCC(=C)/C=C\[C@@H](CC1)C(C)C C15 H24 204.19 0 0 4.81 -1.71
Centella asiatica Germacrene 9548705 C/C/1=C\CC/C(=C/C[C@@H](CC1)C(=C)C)/C C15 H24 204.19 0 0 5.52 -1.81
Centella asiatica Widdrene 97829 CC1=CCC2(CCCC(C23C1C3)(C)C)C C15 H24 204.19 0 0 5.35 -1.03
Centella asiatica Isothankunic-
Acid
1230270
3
CC1CCC2(CCC3(C(=CCC4C3(CC(C5(C4(CCC(C5(C)C
O)O)C)O)O)C)C2C1C)C)C(=O)O
C30 H48 O6 504.35 6 5 4.78 0.91
Centella asiatica Madasiatic-Acid 2313222
5
CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)C)
O)O)C)O)C)C2C1C)C)C(=O)O
C30 H48 O5 488.35 5 4 5.75 0.53
Centella asiatica Brahmic-Acid 258809 CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)C
O)O)O)C)O)C)C2C1C)C)C(=O)O
C30 H48 O6 504.35 6 5 4.63 0.69
Centella asiatica,
Leucas aspera
Beta-
Caryophyllene
5281515 C/C/1=C\CCC(=C)[C@H]2CC([C@@H]2CC1)(C)C C15 H24 204.19 0 0 5.4 -1.73
Centella asiatica,
Leucas aspera
Alpha-Humulene 5281520 C/C/1=C\CC(/C=C/C/C(=C/CC1)/C)(C)C C15 H24 204.19 0 0 5.47 -1.38
Centella asiatica,
Mangifera indica
Limonene 22311 CC1=CCC(CC1)C(=C)C C10 H16 136.13 0 0 3.83 -1.51
Centella asiatica,
Pongamia
pinnata,
Diospyros
montana, Centella
asiatica
Betulic-Acid 64971 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@
H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3
(CC2)C)C)(C)C)O)C)C(=O)O
C30 H48 O3 456.36 3 2 7.65 0.31
Diospyros
montana
Allobetulin 1108073
3
C[C@@]12CC[C@@]34CCC([C@@H]([C@@H]3[C@
H]1CC[C@H]5[C@]2(CC[C@@H]6[C@@]5(CC[C@@
H](C6(C)C)O)C)C)OC4)(C)C
C30 H50
O2
442.38 2 1 7.91 -0.47
Diospyros
montana
Fucostanol 1555939
6
CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]
1(CC[C@H]3[C@H]2CCC4[C@@]3(CC[C@@H](C4)O
)C)C)C(C)C
C29 H52 O 416.4 1 1 9.52 0.35
Diospyros
montana
Mamegakinone 167673 CC1=CC2=C(C(=C1)O)C(=O)C(=CC2=O)C3=CC(=O)C
4=C(C3=O)C(=CC(=C4)C)O
C22 H14 O6 374.08 6 2 3.52 -0.48
Diospyros
montana
Ramentaceone 26905 CC1=CC2=C(C(=O)C=CC2=O)C(=C1)O C11 H8 O3 188.05 3 1 1.92 -1.02
Diospyros
montana
Euclein 308140 CC1=CC2=C(C(=C1)O)C(=O)C=C(C2=O)C3=C(C4=C(C
=C3C)C(=O)C=CC4=O)O
C22 H14 O6 374.08 6 2 3.41 -0.66
Diospyros
montana
Yerrinquinone 618938 COC1=CC(=O)C2=C(C(=CC(=C2C1=O)O)C(=O)OC)OC C14 H12 O7 292.06 7 1 1.27 -0.19
Diospyros
montana
Biramentaceone 633060 CC1=CC2=C(C(=C1)O)C(=O)C=C(C2=O)C3=CC(=O)C
4=C(C3=O)C=C(C=C4O)C
C22 H14
O6
374.08 6 2 3.52 -0.44
Diospyros
montana
Ursolic Acid 64945 C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C
@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C
)[C@@H]2[C@H]1C)C)C(=O)O
C30 H48 O3 456.36 3 2 7.84 0.65
Diospyros
montana
Betulin 72326 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@
H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3
(CC2)C)C)(C)C)O)C)CO
C30 H50 O2 442.38 2 2 7.9 -0.09
Diospyros
montana
Isodiospyrin 99298 CC1=CC2=C(C(=O)C=CC2=O)C(=C1C3=C4C(=O)C=C
C(=O)C4=C(C=C3C)O)O
C15 H15 N
O3
257.11 3 1 1.93 0.53
Diospyros
montana
Oxyallobetulin 304256 CC1(CCC23CCC4(C(C2C1OC3=O)CCC5C4(CCC6C5(C
CC(C6(C)C)O)C)C)C)C
C30 H48 O3 456.36 3 1 6.94 -0.32
Diospyros
montana
Astrantiagenin C 10494 C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@
H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(
=O)O)C)C)(C)C)O
C30 H48 O3 456.36 3 2 7.8 0.37
Diospyros
montana
Ursolic Acid 64945 C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C
@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C
)[C@@H]2[C@H]1C)C)C(=O)O
C30 H48 O3 456.36 3 2 7.84 0.65
Diospyros
montana, Aloe
vera, Pongamia
pinnata, Vernonia
cinerea, Ricinus
communis
Lupeol 259846 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@
H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3
(CC2)C)C)(C)C)O)C)C
C30 H50 O 426.39 1 1 9.02 -0.16
Diospyros
montana,
Strychnus
nuxvomica,
Ricinus communis
Alpha-Amyrin 73170 C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C
@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C
)[C@@H]2[C@H]1C)C)C
C30 H50 O 426.39 1 1 9.21 0.09
Leucas aspera Acacetin 5280442 COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O
)O
C16 H12 O5 284.07 5 2 3.41 0.52
Leucas aspera Apigenin 5280443 C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)
O
C15 H10 O5 270.05 5 3 3.06 0.77
Leucas aspera Asperphenamate 173952 C1=CC=C(C=C1)C[C@@H](COC(=O)[C@H](CC2=CC
=CC=C2)NC(=O)C3=CC=CC=C3)NC(=O)C4=CC=CC=
C4
C32 H30 N2
O4
506.22 4 2 5.45 0.1
Leucas aspera (-)-Chicanine 5336043
2
C[C@H]1[C@H]([C@H](O[C@@H]1C2=CC3=C(C=C2
)OCO3)C4=CC(=C(C=C4)O)OC)C
C20 H22 O5 342.15 5 1 5.03 -0.29
Leucas aspera Chrysoeriol 5280666 COC1=C(C=CC(=C1)C2=CC(=O)C3=C(C=C(C=C3O2)
O)O)O
C16 H12 O6 300.06 6 3 3.03 0.65
Leucas aspera Erythro-2-(4-
allyl-2,6-
dimethoxyphenox
y)-1-(4-hydroxy-
3-
methoxyphenyl)pr
opan-1-ol
2387211
2
CC(C(C1=CC(=C(C=C1)O)OC)O)OC2=C(C=C(C=C2OC
)CC=C)OC
C21 H26 O6 374.17 6 2 3.85 0.9
Leucas aspera Leucasperol B 1014036
54
C[C@@H]1CC(=O)[C@@H]2[C@@]([C@@]13CC[C@
]4(O3)CCO[C@@H]4O)(CC[C@@H](C2(C)C)O)C
C20 H32
O5
352.22 5 2 2.59 -0.05
Leucas aspera Leucasperone B 1184410
8
C[C@H]1C[C@H](C2=C([C@@]1(C)C(CC(C)(C=C)O)
O)CCC(=O)[C@]2(C)COC(=O)C)OC(=O)C
C24 H36 O7 436.25 7 2 2.76 0.64
Leucas aspera Leucasperones A 1184397
5
C[C@H]1C[C@H](C2=C([C@@]1(C)C(CC(C)(C=C)O)
OC(=O)C)CCC(=O)[C@]2(C)COC(=O)C)OC(=O)C
C26 H38 O8 478.26 8 1 3.21 0.55
Leucas aspera Leucasperoside A 1184411
2
C[C@@]1(CC[C@H]2C(=C1)C(=O)C[C@@H]3[C@@]
2(CC[C@@H](C3(C)C)O[C@H]4[C@@H]([C@H]([C@
@H]([C@H](O4)CO)O)O)O[C@H]5[C@@H]([C@H]([
C@@H]([C@H](O5)CO[C@H]6[C@@H]([C@H]([C@
@H]([C@H](O6)CO)O)O)O)O)O)O)C)C=C
C38 H60
O17
788.38 17 10 -2.96 -0.15
Leucas aspera Leucasperoside B 1184423
6
C[C@@]1(CC[C@H]2C(=C1)C(=O)C[C@@H]3[C@@]
2(CC[C@@H](C3(C)C)O[C@H]4[C@@H]([C@H]([C@
@H]([C@H](O4)CO)O)O)O[C@H]5[C@@H]([C@H]([
C@@H]([C@H](O5)CO)O)O)O)C)C=C
C32 H50
O12
626.34 12 7 -0.67 -0.07
Leucas aspera Linifolioside 1595377
9
CC1C(C(C(C(O1)OC2C(C(C(OC2OC3CCC4(C5CCC(C=
C5C(=O)CC4C3(C)C)(C)C=C)C)CO)O)O)O)O)O
C32 H50
O11
610.34 11 6 0.4 0
Leucas aspera Macelignan 1040424
5
C[C@H](CC1=CC2=C(C=C1)OCO2)[C@@H](C)CC3=
CC(=C(C=C3)O)OC
C20 H24 O4 328.17 4 1 5.79 -0.06
Leucas aspera Maslinic acid 73659 C[C@@]12CC[C@@H]3[C@@]([C@H]1CC=C4[C@]2(
CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)(C[C@H]
([C@@H](C3(C)C)O)O)C
C30 H48 O4 472.36 4 3 6.76 0.52
Leucas aspera Meso-
dihydroguaiaretic
acid
476856 C[C@H](CC1=CC(=C(C=C1)O)OC)[C@@H](C)CC2=C
C(=C(C=C2)O)OC
C20 H26
O4
330.18 4 2 5.35 -0.04
Leucas aspera Myristargenol B 5703
(greenmo
lBD)
CC(CC1=CC(=C(C=C1)O)OC)C(C)C(C2=CC(=C(C=C2)
O)OC)O
C20 H26 O5 346.18 5 3 4.27 0.89
Leucas aspera Nectandrin B 156517 C[C@@H]1[C@@H]([C@H](O[C@H]1C2=CC(=C(C=C
2)O)OC)C3=CC(=C(C=C3)O)OC)C
C20 H24 O5 344.16 5 2 4.59 -0.27
Leucas aspera,
Achyranthes
aspera, Ricinus
communis, Aloe
vera, Solanum
nigrum, Thespesia
populnea,
Centella asiatica,
Mangifera indica,
Strychnus
nuxvomica,
Vernonia cinerea
Linoleic acid 5280450 CCCCC/C=C\C/C=C\CCCCCCCC(=O)O C18H32O2 280.24 2 1 6.73 -0.08
Mangifera indica Mangiferonic-
Acid
1403447
4
C[C@H](CC/C=C(\C)/C(=O)O)[C@H]1CC[C@@]2([C
@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CCC(
=O)C5(C)C)C)C
C30 H46 O3 454.34 3 1 7.75 0.34
Mangifera indica Gibberellin A29 1460554
8
C[C@@]12C[C@H](C[C@@]3([C@@H]1[C@@H]([C
@]45[C@H]3CC[C@](C4)(C(=C)C5)O)C(=O)O)OC2=O
)O
C19 H24 O6 348.16 6 3 0.2 -0.39
Mangifera indica Dihydrozeatin 32021 CC(CCNC1=NC=NC2=C1NC=N2)CO C10 H15 N5
O
221.13 4 3 0.56 0.05
Mangifera indica Violaxanthin 448438 C/C(=C\C=C\C=C(\C=C\C=C(\C=C\[C@@]12O[C@@]1
(C[C@H](CC2(C)C)O)C)/C)/C)/C=C/C=C(/C=C/[C@@]
34O[C@@]3(C[C@H](CC4(C)C)O)C)\C
C40H56O4 600.42 4 2 10.36 -1.49
Mangifera indica Trans-Zeatin 449093 C/C(=C\CNC1=NC=NC2=C1NC=N2)/CO C10H13N5
O
219.11 4 3 0.58 -0.96
Mangifera indica Mangiferolic-
Acid
4527009
9
C[C@H](CC/C=C(\C)/C(=O)O)[C@H]1CC[C@@]2([C
@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C
@@H](C5(C)C)O)C)C
C30H48O3 456.36 3 2 8.05 0.04
Mangifera indica 23-Hydroxy-
mangiferonic acid
4527177
8
C[C@H](CC(/C=C(\C)/C(=O)O)O)[C@H]1CC[C@@]2([
C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC
C(=O)C5(C)C)C)C
C30H46O4 470.34 4 2 6.75 0.39
Mangifera indica Gibberellin A1 5280379 C[C@@]12[C@H](CC[C@@]3([C@@H]1[C@@H]([C
@]45[C@H]3CC[C@](C4)(C(=C)C5)O)C(=O)O)OC2=O
)O
C19H24O6 348.16 6 3 0.33 -0.35
Mangifera indica Gibberellin A20 5280481 C[C@@]12CCC[C@@]3([C@@H]1[C@@H]([C@]45[
C@H]3CC[C@](C4)(C(=C)C5)O)C(=O)O)OC2=O
C19H24O5 332.16 5 2 1.36 -0.52
Mangifera indica Linolenic-Acid 5280934 CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O C18H30O2 278.22 2 1 6.31 0.36
Mangifera indica 5,6-epoxy-beta-
Carotene / beta-
Carotene 5,6-
epoxide
5281231 CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(
\C)/C=C/C=C(\C)/C=C/C23C(CCCC2(O3)C)(C)C)/C)/C
C40H56O 552.43 1 0 13.05 -0.12
Mangifera indica Mangiferin 5281647 C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[
C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)
O)O
C19H18O11 422.08 11 8 -0.39 0.33
Mangifera indica 5-(Heptadec-12-
enyl)resorcinol
5281859 CCCC/C=C\CCCCCCCCCCCC1=CC(=CC(=C1)O)O C23H3O2 346.29 2 2 9 -0.95
Mangifera indica Gibberellin A19 5460209 C[C@]1(CCC[C@@]2([C@@H]1[C@@H]([C@]34[C@
H]2CC[C@](C3)(C(=C)C4)O)C(=O)O)C=O)C(=O)O
C20H26O6 326.17 6 3 1.48 -0.39
Mangifera indica Leucine 6106 CC(C)C[C@@H](C(=O)O)N C6 H13 N
O2
131.09 3 3 -0.47 -0.61
Mangifera indica Gamma-
Eudesmol
6432005 CC1=C2C[C@@H](CC[C@]2(CCC1)C)C(C)(C)O C15 H26 O 222.2 1 1 4.19 -0.07
Mangifera indica Mangiferic-Acid 6439027 CC/C=C/CCCC/C=C/CCCCCCCC(=O)O C18 H32 O2 280.24 2 1 6.68 0.36
Mangifera indica Gibberellin A3 6466 C[C@@]12[C@H](C=C[C@@]3([C@@H]1[C@@H]([C
@]45[C@H]3CC[C@](C4)(C(=C)C5)O)C(=O)O)OC2=O
)O
C19 H22 O6 346.14 6 3 -0.11 -0.51
Mangifera indica Rubrofusarin 72537 CC1=CC(=O)C2=C(C3=C(C=C(C=C3C=C2O1)OC)O)O C15 H12 O5 272.07 5 2 2.89 -0.68
Mangifera indica Cyanidin 3-
arabinoside
7407980
9
C1C(C(C(C(O1)OC2=CC3=C(C=C(C=C3[O+]=C2C4=C
C(=C(C=C4)O)O)O)O)O)O)O
C20 H19
O10
419.1 10 7 -0.07 0.38
Mangifera indica 5-
Pentadecylresorci
nol
76617 CCCCCCCCCCCCCCCC1=CC(=CC(=C1)O)O C21 H36 O2 320.27 2 2 8.5 -1.07
Mangifera indica N6-(delta2-
Isopentenyl)adeni
ne
92180 CC(=CCNC1=NC=NC2=C1NC=N2)C C10 H13
N5
203.12 3 2 1.55 -0.88
Mangifera indica Butin / 7,3',4'-
Trihydroxyflavan
one
92775 C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC(=C(C=C
3)O)O
C15 H12 O5 272.07 5 3 2.3 1.2
Mangifera indica Isomangiferolic-
Acid
1403446
5
CC(CC/C=C(\C)/C(=O)O)C1CCC2(C1(CCC34C2CCC5C
3(C4)CCC(C5(C)C)O)C)C
C30 H48 O3 456.36 3 2 8.05 0.04
Mangifera indica Myrtillin 165558 C1=C(C=C(C(=C1O)O)O)C2=[O+]C3=CC(=CC(=C3C=
C2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)
O)O)O)O)O.[Cl-]
C21 H21
O12.Cl
500.07 12 9 -0.76 0.29
Mangifera indica Petunidin 3-
glucoside
176449 COC1=CC(=CC(=C1O)O)C2=[O+]C3=CC(=CC(=C3C=
C2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)
O)O)O)O)O.[Cl-]
C22 H23
O12.Cl
514.09 12 8 -0.41 0.42
Mangifera indica Peonidin
galactoside
9181051
2
COC1=C(C=CC(=C1)C2=[O+]C3=CC(=CC(=C3C=C2O[
C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O
)O)O)O.[Cl-]
C22 H23
O11.Cl
498.09 11 7 -0.04 0.08
Phyllanthus
virgatus
Kaempferol 8-C-
sulfate
1050045
6
C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O
)S(=O)(=O)O)O)O
C15 H10
O9 S
366 9 5 0.41 0.27
Phyllanthus
virgatus
Virgatyne 1080705
1
C1OC2=C(O1)C=C(C=C2)CC(CO)(C#CC3=CC4=C(C=C
3)OCO4)O
C19 H16 O6 340.09 6 2 3.05 -1.08
Phyllanthus
virgatus
Lirioresinol B 1160410
8
COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3CO[C@H
]([C@@H]3CO2)C4=CC(=C(C(=C4)OC)O)OC
C22 H26 O8 418.16 8 2 3.14 -0.63
Phyllanthus
virgatus
3,5,7-
Trihydroxyflavon
e 3-glucoside-8-
sulfate
4425872
8
C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)
O)S(=O)(=O)O)O[C@H]4C([C@H]([C@@H](C(O4)CO)
O)O)O
C21H20O13
S
512.06 13 7 -2.08 0.22
Phyllanthus
virgatus
Hinokinin 442879 C1[C@@H]([C@H](C(=O)O1)CC2=CC3=C(C=C2)OCO
3)CC4=CC5=C(C=C4)OCO5
C20H18O6 354.11 6 0 3.88 -0.59
Pongamia
pinnata
Praecansone B 1009030
6
CC1(C=CC2=C(C(=C(C=C2O1)OC)C(=O)/C=C(/C3=CC
=CC=C3)\O)OC)C
C22H22O5 366.15 5 1 4.61 -0.23
Pongamia
pinnata
Stigmasterol-3-O-
Beta-D-
Glucopyranoside
1016898
89
CC[C@H](/C=C/[C@@H](C)[C@H]1CC[C@@H]2[C@
@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C
4)O[C@@H]5[C@@H]([C@H]([C@@H]([C@H](O5)C
O)O)O)O)C)C)C(C)C
C35 H58 O6 574.42 6 4 6.47 0.32
Pongamia
pinnata
7-
Methoxypraecans
one B
1045236
2
CC1(C=CC2=C(C(=C(C=C2O1)OC)C(=O)/C=C(/C3=CC
=CC=C3)\OC)OC)C
C23 H24 O5 380.16 5 0 4.96 -0.47
Pongamia
pinnata
Ovalichromene B 1098100
7
CC1(C=CC2=C(O1)C=CC3=C2OC(CC3=O)C4=CC5=C(
C=C4)OCO5)C
C21 H18 O5 350.12 5 0 4.42 0.07
Pongamia
pinnata
Pongamone A 1158867
8
CC(=CCOC1=C(C2=C(C=C1)C(=O)C(=CO2)C3=CC=C(
C=C3)OC)OC)C
C22 H22 O5 366.15 5 0 5.32 0.47
Pongamia
pinnata
Pongacoumestan 1213522
3
COC1=C(C=CC2=C1OC(=O)C3=C2OC4=C3C=CC(=C4
)O)O
C16 H10 O6 298.05 6 2 2.89 -0.5
Pongamia
pinnata
Pongapinone B 127022 CC(=CCC1=C2C(=C(C=C1OC)OC)C(=O)C[C@H](O2)C
3=CC4=C(C=C3)OCO4)C
C23 H24 O6 396.16 6 0 5.13 1.11
Pongamia
pinnata
Isopongaglabol 1277849
1
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=C(C=C3O)O
C=C4
C17 H10 O4 278.06 4 1 4.07 -0.17
Pongamia
pinnata
Pongachromene 1403398
5
CC1(C=CC2=C(O1)C=CC3=C2OC(=C(C3=O)OC)C4=C
C5=C(C=C4)OCO5)C
C22 H18 O6 378.11 6 0 4.96 -0.43
Pongamia
pinnata
Ponganone III 1516070
2
CC1(C=CC2=C(O1)C=CC3=C2O[C@@H](CC3=O)C4=
CC(=C(C=C4)OC)OC)C
C22 H22 O5 366.15 5 0 4.33 0.34
Pongamia
pinnata
Pongachin 155236 CC1(C=CC2=C3C(=C(C=C2O1)OC)C(=O)C[C@H](O3)
C4=CC=CC=C4)C
C21 H20 O4 336.14 4 0 4.24 0.21
Pongamia
pinnata
Candidone 157102 CC(=CCC1=C2C(=C(C=C1OC)OC)C(=O)C[C@H](O2)C
3=CC=CC=C3)C
C22 H24
O4
352.17 4 0 4.98 0.9
Pongamia
pinnata
3'-
Methoxypongapin
1583876
7
COC1=CC(=CC2=C1OCO2)C3=C(C(=O)C4=C(O3)C5=
C(C=C4)OC=C5)OC
C20 H14 O7 366.07 7 0 4.35 -0.78
Pongamia
pinnata
Pongapin 3083586 COC1=C(OC2=C(C1=O)C=CC3=C2C=CO3)C4=CC5=C
(C=C4)OCO5
C19 H12 O6 336.06 6 0 4.38 -0.54
Pongamia
pinnata
Pinnatin 5320607 COC1=C2C=COC2=CC3=C1C(=O)C=C(O3)C4=CC=CC
=C4
C18H12O4 292.07 4 0 4.42 0.24
Pongamia
pinnata
Pongapinone A 6438794 CC1(C=CC2=C(C(=C(C=C2O1)OC)C(=O)/C=C(/C3=CC
4=C(C=C3)OCO4)\O)OC)C
C23 H22 O7 410.14 7 1 4.76 -0.04
Pongamia
pinnata
Lupenone 92158 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@
H]4[C@]5(CCC(=O)C([C@@H]5CC[C@]4([C@@]3(C
C2)C)C)(C)C)C)C
C30 H48 O 424.37 1 0 8.72 0.37
Ricinus communis Corilagin 73568 C1[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC
(=O)C3=CC(=C(C(=C3)O)O)O)O)OC(=O)C4=CC(=C(C(
=C4C5=C(C(=C(C=C5C(=O)O1)O)O)O)O)O)O)O
C27 H22
O18
634.08 18 11 -2.2 0.83
Ricinus communis Ellagic acid 5281855 C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)O
C2=O)O)O
C14 H6 O8 302.01 8 4 1.02 -0.98
Ricinus communis Ent-
Copalyldiphospha
te
5280897 C/C(=C\COP(=O)(O)OP(=O)(O)O)/CC[C@@H]1C(=C)C
C[C@H]2[C@]1(CCCC2(C)C)C
C20 H36 O7
P2
450.19 7 3 3.14 -0.2
Ricinus communis Gentisic acid 3469 C1=CC(=C(C=C1O)C(=O)O)O C7 H6 O4 154.03 4 3 0.93 0.79
Ricinus communis Kaempferol 3-
xyloside
4425891
2
C1[C@H](C(C([C@@H](O1)OC2=C(OC3=CC(=CC(=C
3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O
C20 H18
O10
418.09 10 6 0.39 1.06
Ricinus communis Methyl indole-3-
acetate
74706 COC(=O)CC1=CNC2=CC=CC=C21 C11 H11 N
O2
189.08 2 1 1.97 -1.36
Ricinus communis Naringenin 7-(2-
p-
Coumaroylglucosi
de)
4260792
1
C1C(OC2=CC(=CC(=C2C1=O)O)O[C@H]3C([C@H]([C
@@H](C(O3)CO)O)O)OC(=O)/C=C/C4=CC=C(C=C4)O
)C5=CC=C(C=C5)O
C30 H28
O12
580.16 12 6 2.15 1.17
Ricinus communis Reynoutrin 5320863 C1[C@H]([C@@H]([C@H](C(O1)OC2=C(OC3=CC(=C
C(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
C20 H18
O11
434.08 11 7 0.01 1.2
Ricinus communis Ricinine 10666 CN1C=CC(=C(C1=O)C#N)OC C8 H8 N2
O2
164.06 3 0 -0.13 -1.02
Ricinus communis Ricinitin 4425902
4
CC(=O)OCC1[C@H]([C@@H](C([C@@H](O1)O[C@H
]2[C@H](C(O[C@H](C2O)OC3=C(OC4=CC(=CC(=C4C
3=O)O)O)C5=CC=C(C=C5)O)CO)O)O)O)O
C29 H32
O17
652.16 17 9 -2.04 0.91
Ricinus communis Rutin 5280805 C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C
@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=C(
OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O
)O)O)O)O)O
C27 H30
O16
610.15 16 10 -1.87 1.1
Ricinus
communis,
Centella asiatica
1,8-Cineole 2758 CC1(C2CCC(O1)(CC2)C)C C10 H18 O 154.14 1 0 2.93 -1.06
Ricinus
communis,
Vernonia cinerea
Beta Amyrin 73145 C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@
@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]1C
C(CC2)(C)C)C
C30 H50 O 426.39 1 1 9.17 -0.23
Solanum nigrum Solasodine 442985 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5
(CC[C@@H](C6)O)C)C)C)NC1
C27H43NO
2
413.33 2 2 5.53 0.01
Solanum nigrum 2(S)-2-
Aminoadipic-
Acid
92136 C(C[C@@H](C(=O)O)N)CC(=O)O C6 H11 N
O4
161.07 5 4 -1.71 0.08
Solanum nigrum Diosgenin 99474 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5
(CC[C@@H](C6)O)C)C)C)OC1
C27 H42 O3 414.31 3 1 6.39 -0.04
Solanum nigrum Tigogenin 99516 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC[C@@H]6[C
@@]5(CC[C@@H](C6)O)C)C)C)OC1
C27 H44 O3 416.33 3 1 6.43 -0.67
Solanum nigrum Solasonine 119247 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5
(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@H]([C
@H](O7)CO)O)O[C@H]8[C@@H]([C@H]([C@@H]([C
@H](O8)CO)O)O)O)O[C@H]9[C@@H]([C@@H]([C@
H]([C@@H](O9)C)O)O)O)C)C)C)NC1
C45 H73 N
O16
883.49 17 10 -0.46 0.22
Solanum nigrum Desgalactotigonin 162401 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC[C@@H]6[C
@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C
@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@H]([C@@
H]([C@H](O8)CO)O)O[C@H]9[C@@H]([C@H]([C@@
H](CO9)O)O)O)O[C@H]2[C@@H]([C@H]([C@@H]([
C@H](O2)CO)O)O)O)O)O)C)C)C)OC1
C50 H82
O22
1034.5
3
22 12 -2.32 -0.31
Solanum nigrum Solanine 262500 CC1CCC2C(C3C(N2C1)CC4C3(CCC5C4CC=C6C5(CC
C(C6)OC7C(C(C(C(O7)CO)O)OC8C(C(C(C(O8)CO)O)O
)O)OC9C(C(C(C(O9)C)O)O)O)C)C)C
C45 H73 N
O15
867.5 16 9 -0.7 0.33
Solanum nigrum,
Solanum nigrum
Solamargine 73611 C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C
[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5
(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([
C@H](O7)CO)O[C@H]8[C@@H]([C@@H]([C@H]([C
@@H](O8)C)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C
@H]([C@@H](O9)C)O)O)O)C)C)C)NC1
C15 H15 N
O3
257.11 3 1 1.93 0.53
Strychnus
nuxvomica
Vomicine 101595 CN1CC[C@]23[C@@H]4[C@H]5[C@@H](CC2=O)C(=
CCO[C@H]5CC(=O)N4C6=C3C=CC=C6O)C1
C22 H24 N2
O4
380.17 5 1 1.85 0.99
Strychnus
nuxvomica
Pseudo-Alpha-
Colubrine
1020673
18
COC1=CC2=C(C=C1)[C@]34CCN5[C@]3(C[C@@H]6[
C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5)O
C22 H24 N2
O4
380.14 5 1 1.14 0.8
Strychnus
nuxvomica
Condylocarpine 1091425
5
C/C=C\1/[C@@H]2CCN3[C@H]1[C@]4(CC3)C5=CC=
CC=C5NC4=C2C(=O)OC
C20 H22 N2
O2
322.17 3 1 3.55 0.98
Strychnus
nuxvomica
Isostrychnine 1102411
3
C1CN2C/C(=C/CO)/[C@@H]3C[C@H]2[C@@]14[C@
@H]5C3=CCC(=O)N5C6=CC=CC=C46
C21 H22 N2
O2
334.17 3 1 2.92 0.75
Strychnus
nuxvomica
Brucine-N-Oxide 1112245
2
COC1=C(C=C2C(=C1)[C@]34CC[N+]5([C@H]3C[C@
@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C
6C5)[O-])OC
C23 H26
N2 O5
410.18 5 0 1.75 0.38
Strychnus
nuxvomica
Novacine 1231441
4
CN1CC[C@]23[C@@H]4[C@H]5[C@@H](CC2=O)C(=
CCO[C@H]5CC(=O)N4C6=CC(=C(C=C36)OC)OC)C1
C24 H28 N2
O5
424.2 6 0 2.29 0.68
Strychnus
nuxvomica
C-Mavacurine 1347166
52
C/C=C\1/C[N+]2(CCC3=C4[C@@H]2C[C@@H]1C(N4
C5=CC=CC=C35)CO)C
C20 H25 N2
O
309.2 1 1 2.81 0.89
Strychnus
nuxvomica
Secologanin 161276 COC(=O)C1=CO[C@H]([C@@H]([C@@H]1CC=O)C=
C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)
O)O)O
C17 H24
O10
388.14 10 4 -1.97 -0.13
Strychnus
nuxvomica
Hydroxystrychnin
e
167851 C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C
@H]3C[C@H]2C61C7=C5C=CC(=C7)O
C21 H22 N2
O3
350.16 4 1 1.51 0.72
Strychnus
nuxvomica
Pseudostrychnine 2172344
6
C1CN2CC3=CCOC4CC(=O)N5C6C4C3CC2(C61C7=CC
=CC=C75)O
C21 H22 N2
O3
350.16 4 1 1.05 0.77
Strychnus
nuxvomica
Beta-Colubrine 251890 COC1=CC2=C(C=C1)N3[C@@H]4[C@]25CCN6[C@H]
5C[C@@H]7[C@H]4[C@H](CC3=O)OCC=C7C6
C22 H24 N2
O3
364.18 4 0 1.86 0.48
Strychnus
nuxvomica
Pseudobrucine 3083630 COC1=C(C=C2C(=C1)[C@]34CCN5[C@]3(C[C@@H]6
[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5)O
)OC
C23 H26 N2
O5
410.18 6 1 1.11 0.74
Strychnus
nuxvomica
Icajine 3083907 CN1CC[C@]23[C@@H]4[C@H]5[C@@H](CC2=O)C(=
CCO[C@H]5CC(=O)N4C6=CC=CC=C36)C1
C22 H24 N2
O3
364.18 4 0 2.23 0.92
Strychnus
nuxvomica
4-Deoxyloganin 440906 C[C@H]1CC[C@H]2[C@@H]1[C@@H](OC=C2C(=O)
OC)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C
O)O)O)O
C17 H26 O9 374.16 9 4 -0.94 0.74
Strychnus
nuxvomica
Strychnine 441071 C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C
@H]3C[C@H]2[C@@]61C7=CC=CC=C75
C21 H22 N2
O2
334.17 3 0 1.77 0.54
Strychnus
nuxvomica
Brucine 442021 COC1=C(C=C2C(=C1)[C@]34CCN5[C@H]3C[C@@H]
6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5)
OC
C23 H26 N2
O4
394.19 5 0 1.83 0.5
Strychnus
nuxvomica
Strychnicine 633307 CN1CCC23C4C5C(CC2=O)C(=CCOC5CC(=O)N4C6=C
3C=CC=C6O)C1
C22 H24 N2
O4
380.17 5 1 1.85 0.99
Strychnus
nuxvomica
Geissoschizine 6443046 C/C=C\1/CN2CCC3=C([C@@H]2C[C@@H]1/C(=C/OC
)/C(=O)OC)NC4=CC=CC=C34
C22 H26 N2
O3
366.19 4 1 2.85 0.58
Strychnus
nuxvomica
3-Methoxyicajine 7145339
9
CN1CC[C@]23[C@@H]4[C@H]5[C@@H](CC2=O)C(=
C(CO[C@H]5CC(=O)N4C6=CC=CC=C36)OC)C1
C23 H26 N2
O4
394.19 5 0 1.74 1
Strychnus
nuxvomica
Strychnine-N-6-
Oxide
73393 C1C[N+]2(CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]
4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75)[O-]
C21 H22 N2
O3
350.16 3 0 1.69 0.41
Strychnus
nuxvomica
Loganin 87691 C[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2
C(=O)OC)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](
O3)CO)O)O)O)O
C17 H26
O10
390.15 10 5 -1.98 0.98
Strychnus
nuxvomica
Loganic-Acid 89640 C[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2
C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O
3)CO)O)O)O)O
C16 H24
O10
376.14 10 6 -2.33 1.26
Strychnus
nuxvomica
Cycloartenol 92110 C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC
[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C
5(C)C)O)C)C
C30 H50 O 426.39 1 1 9.22 -0.31
Strychnus
nuxvomica
Diaboline 321983 CC(=O)N1C2C3C4CC5C2(CCN5CC4=CCOC3O)C6=CC
=CC=C61
C21 H24 N2
O3
352.18 4 1 0.93 0.85
Thespesia
populnea
Kaempferol-7-
Glucoside
1009518
0
C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O[C
@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
)O)O)O
C21H20O11 448.1 11 7 -0.26 0.81
Thespesia
populnea
Mansonones C 21742 CC1=C2C(=C(C=C1)C(C)C)C=C(C(=O)C2=O)C C15 H16
O2
228.12 2 0 3.52 0
Thespesia
populnea
Mansonones D 3083888 CC1COC2=C1C3=C(C(=C2)C)C(=O)C(=O)C(=C3)C C15 H14 O3 242.09 3 0 3.05 -0.41
Thespesia
populnea
Gossypol 3503 CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C
(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O
C30 H30
O8
518.19 8 6 5.7 -1.23
Thespesia
populnea
Herbacetin 5280544 C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O
)O)O)O
C15H10O7 302.04 7 5 1.99 0.63
Thespesia
populnea
Gossypetin 5280647 C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)
O)O)O)O)O
C15H10O8 318 8 6 1.61 0.62
Thespesia
populnea
Thespesone 5321934 CC1COC2=C1C3=C(C(=C2)C)C(=O)C(=O)C(=C3O)C C15H14O4 258.09 4 1 2.48 -0.43
Thespesia
populnea
Mansonones E 94303 CC1COC2=C(C(=O)C(=O)C3=C(C=CC1=C32)C)C C15 H14 O3 242.09 3 0 2.37 -0.55
Thespesia
populnea
Populneol 2775187 CC(=O)C1=C(C=CC=C1OCC2=CC=CC=C2)O C15 H14 O3 242.09 3 1 2.81 -0.05
Thespesia
populnea
Thespone 5321935 CC1=CC2=C(C(=CC3=C2C(=CO3)C)C)C(=O)C1=O C15 H12 O3 240.08 3 0 3.3 -0.8
Thespesia
populnea,
Centella asiatica,
Mangifera indica,
Aerva lanata,
Ricinus communis
Kaempferol 5280863 C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)
O)O
C15H10O6 286.05 6 4 2.49 0.77
Thespesia
populnea,
Centella asiatica,
Mangifera indica,
Aerva lanata,
Ricinus communis
Quercetin 5280343 C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O
)O)O)O
C15 H10 O7 302.04 7 5 2.11 0.93
Vernonia cinerea Luteolin-7-Mono-
Beta-D-Glucoside
5280637 C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O[C
@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
)O)O)O
C21H20O11 448.1 11 7 -0.07 0.86
Vernonia cinerea Vernolic-Acid 6449780 CCCCC[C@@H]1[C@@H](O1)C/C=C\CCCCCCCC(=O
)O
C18 H32
O3
296.24 3 1 6.03 -0.96
Vernonia cinerea Lupeol-Acetate 92157 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@
H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3
(CC2)C)C)(C)C)OC(=O)C)C)C
C32 H52 O2 468.4 2 0 9.45 0.32
Phytocompound Gene ID P-value (>0.7)2-Methyl-2-Phytyl-6-Chromanol ALOX5 0.72-Methyl-2-Phytyl-6-Chromanol CNR1 0.72-Methyl-2-Phytyl-6-Chromanol CNR2 0.72-Methyl-2-Phytyl-6-Chromanol ESR1 0.722-Methyl-2-Phytyl-6-Chromanol ESR1 0.722-Methyl-2-Phytyl-6-Chromanol HRH3 0.722-Methyl-2-Phytyl-6-Chromanol PPARG 0.72-Methyl-2-Phytyl-6-Chromanol PPARA 0.72-Methyl-2-Phytyl-6-Chromanol PHLPP1 0.872-Methyl-2-Phytyl-6-Chromanol AKT1 0.873-Glucosylkaempferol ADORA1 0.73-Glucosylkaempferol ADORA3 0.73-Glucosylkaempferol AKR1B1 0.863-Glucosylkaempferol ADRA2A 0.873-Glucosylkaempferol ALOX5 0.713-Glucosylkaempferol CA12 0.843-Glucosylkaempferol CA2 0.883-Glucosylkaempferol CA4 0.843-Glucosylkaempferol CA7 0.843-Glucosylkaempferol PDE5A 0.863-Glucosylkaempferol CHRM5 0.853-Glucosylkaempferol CYP3A 0.783-Glucosylkaempferol EGFR 0.73-Glucosylkaempferol IL2RA 0.763-Glucosylkaempferol ALPI 0.813-Glucosylkaempferol NOX4 0.873-Glucosylkaempferol HPA 0.913-Glucosylkaempferol PTPN1 0.973-Glucosylkaempferol RPS6KA3 0.773-Glucosylkaempferol F10 0.843-Glucosylkaempferol TNF 0.763-Glucosylquercetin ADORA1 0.73-Glucosylquercetin ADORA3 0.73-Glucosylquercetin AKR1B1 0.893-Glucosylquercetin ADRA2A 0.893-Glucosylquercetin ALOX5 0.73-Glucosylquercetin CA12 0.843-Glucosylquercetin CA2 0.873-Glucosylquercetin CA4 0.843-Glucosylquercetin CA7 0.843-Glucosylquercetin PDE5A 0.853-Glucosylquercetin CHRM5 0.883-Glucosylquercetin CYP3A 0.793-Glucosylquercetin EGFR 0.73-Glucosylquercetin IL2RA 0.793-Glucosylquercetin ALPI 0.843-Glucosylquercetin NOX4 0.893-Glucosylquercetin HPA 0.943-Glucosylquercetin PTPN1 1
SS4: Overall probable targets modulated by the phytocompounds (Predicted using BindingDB)
35 Phytocompounds predicted to modulate 206 targets
3-Glucosylquercetin RPS6KA3 0.773-Glucosylquercetin F10 0.863-Glucosylquercetin TNF 0.795-Hydroxy-782'3'-Tetramethoxyflavone ALOX12 0.715-Hydroxy-782'3'-Tetramethoxyflavone FASN 0.725-Hydroxy-782'3'-Tetramethoxyflavone ACHE 0.75-Hydroxy-782'3'-Tetramethoxyflavone ADORA1 0.775-Hydroxy-782'3'-Tetramethoxyflavone ADORA3 0.745-Hydroxy-782'3'-Tetramethoxyflavone ADORA2A 0.715-Hydroxy-782'3'-Tetramethoxyflavone AKR1B1 0.885-Hydroxy-782'3'-Tetramethoxyflavone ALR2 0.75-Hydroxy-782'3'-Tetramethoxyflavone AKR1B1 0.745-Hydroxy-782'3'-Tetramethoxyflavone GAA 0.75-Hydroxy-782'3'-Tetramethoxyflavone MAOB 0.75-Hydroxy-782'3'-Tetramethoxyflavone ALOX12 0.75-Hydroxy-782'3'-Tetramethoxyflavone ALOX15 0.75-Hydroxy-782'3'-Tetramethoxyflavone ALOX5 0.75-Hydroxy-782'3'-Tetramethoxyflavone CYP19A1 0.745-Hydroxy-782'3'-Tetramethoxyflavone AHR 0.75-Hydroxy-782'3'-Tetramethoxyflavone ABCG2 0.745-Hydroxy-782'3'-Tetramethoxyflavone AURKB 0.745-Hydroxy-782'3'-Tetramethoxyflavone NTRK2 0.725-Hydroxy-782'3'-Tetramethoxyflavone CA12 0.785-Hydroxy-782'3'-Tetramethoxyflavone CA2 0.785-Hydroxy-782'3'-Tetramethoxyflavone CA4 0.725-Hydroxy-782'3'-Tetramethoxyflavone CA7 0.785-Hydroxy-782'3'-Tetramethoxyflavone CBR1 0.75-Hydroxy-782'3'-Tetramethoxyflavone CISD1 0.75-Hydroxy-782'3'-Tetramethoxyflavone CDK1 0.715-Hydroxy-782'3'-Tetramethoxyflavone CDK5 0.715-Hydroxy-782'3'-Tetramethoxyflavone CDK6 0.715-Hydroxy-782'3'-Tetramethoxyflavone PTGS1 0.725-Hydroxy-782'3'-Tetramethoxyflavone CYP1A1 0.75-Hydroxy-782'3'-Tetramethoxyflavone CYP1B1 0.745-Hydroxy-782'3'-Tetramethoxyflavone TOP1 0.725-Hydroxy-782'3'-Tetramethoxyflavone NT5E 0.745-Hydroxy-782'3'-Tetramethoxyflavone ELAVL3 0.745-Hydroxy-782'3'-Tetramethoxyflavone INHA 0.745-Hydroxy-782'3'-Tetramethoxyflavone EGFR 0.75-Hydroxy-782'3'-Tetramethoxyflavone HSD17B2 0.75-Hydroxy-782'3'-Tetramethoxyflavone GSK3B 0.725-Hydroxy-782'3'-Tetramethoxyflavone GLO1 0.745-Hydroxy-782'3'-Tetramethoxyflavone HGF 0.745-Hydroxy-782'3'-Tetramethoxyflavone TNKS 0.75-Hydroxy-782'3'-Tetramethoxyflavone TNKS2 0.75-Hydroxy-782'3'-Tetramethoxyflavone IGF1R 0.745-Hydroxy-782'3'-Tetramethoxyflavone PSIP1 0.745-Hydroxy-782'3'-Tetramethoxyflavone DNPEP 0.745-Hydroxy-782'3'-Tetramethoxyflavone KIT 0.75-Hydroxy-782'3'-Tetramethoxyflavone MMP12 0.725-Hydroxy-782'3'-Tetramethoxyflavone MAOA 0.745-Hydroxy-782'3'-Tetramethoxyflavone OPRM1 0.815-Hydroxy-782'3'-Tetramethoxyflavone NOX4 0.745-Hydroxy-782'3'-Tetramethoxyflavone NR0B1 0.7
5-Hydroxy-782'3'-Tetramethoxyflavone ABCB1 0.75-Hydroxy-782'3'-Tetramethoxyflavone PIK3CG 0.745-Hydroxy-782'3'-Tetramethoxyflavone UBE3A 0.745-Hydroxy-782'3'-Tetramethoxyflavone PIM1 0.745-Hydroxy-782'3'-Tetramethoxyflavone NEU1 0.785-Hydroxy-782'3'-Tetramethoxyflavone SI 0.75-Hydroxy-782'3'-Tetramethoxyflavone SYN1 0.755-Hydroxy-782'3'-Tetramethoxyflavone TERT 0.765-Hydroxy-782'3'-Tetramethoxyflavone F10 0.75-Hydroxy-782'3'-Tetramethoxyflavone TTR 0.725-Hydroxy-782'3'-Tetramethoxyflavone TYR 0.765-Hydroxy-782'3'-Tetramethoxyflavone LCK 0.75-Hydroxy-782'3'-Tetramethoxyflavone FLT3 0.725-Hydroxy-782'3'-Tetramethoxyflavone AXL 0.745-Hydroxy-782'3'-Tetramethoxyflavone KDR 0.75-Hydroxy-782'3'-Tetramethoxyflavone XDH 0.725-Hydroxy-782'-Trimethoxyflavone ALOX12 0.75-Hydroxy-782'-Trimethoxyflavone AKR1C3 0.75-Hydroxy-782'-Trimethoxyflavone FASN 0.75-Hydroxy-782'-Trimethoxyflavone ACHE 0.75-Hydroxy-782'-Trimethoxyflavone ADORA1 0.815-Hydroxy-782'-Trimethoxyflavone ADORA3 0.785-Hydroxy-782'-Trimethoxyflavone ADORA2A 0.765-Hydroxy-782'-Trimethoxyflavone AKR1B1 0.865-Hydroxy-782'-Trimethoxyflavone ALR2 0.75-Hydroxy-782'-Trimethoxyflavone AKR1B1 0.715-Hydroxy-782'-Trimethoxyflavone GAA 0.725-Hydroxy-782'-Trimethoxyflavone MAOA 0.75-Hydroxy-782'-Trimethoxyflavone ALOX12 0.725-Hydroxy-782'-Trimethoxyflavone ALOX15 0.725-Hydroxy-782'-Trimethoxyflavone ALOX5 0.725-Hydroxy-782'-Trimethoxyflavone CYP19A1 0.75-Hydroxy-782'-Trimethoxyflavone AHR 0.745-Hydroxy-782'-Trimethoxyflavone ABCG2 0.715-Hydroxy-782'-Trimethoxyflavone AURKB 0.715-Hydroxy-782'-Trimethoxyflavone NTRK2 0.765-Hydroxy-782'-Trimethoxyflavone BCHE 0.715-Hydroxy-782'-Trimethoxyflavone CA12 0.725-Hydroxy-782'-Trimethoxyflavone CA2 0.725-Hydroxy-782'-Trimethoxyflavone CA4 0.75-Hydroxy-782'-Trimethoxyflavone CA7 0.725-Hydroxy-782'-Trimethoxyflavone CBR1 0.75-Hydroxy-782'-Trimethoxyflavone CSNK2A1 0.75-Hydroxy-782'-Trimethoxyflavone CISD1 0.745-Hydroxy-782'-Trimethoxyflavone BCHE 0.75-Hydroxy-782'-Trimethoxyflavone CDK1 0.75-Hydroxy-782'-Trimethoxyflavone CDK5 0.75-Hydroxy-782'-Trimethoxyflavone CDK6 0.75-Hydroxy-782'-Trimethoxyflavone PTGS1 0.75-Hydroxy-782'-Trimethoxyflavone CFTR 0.75-Hydroxy-782'-Trimethoxyflavone CYP1A1 0.745-Hydroxy-782'-Trimethoxyflavone CYP2C9 0.715-Hydroxy-782'-Trimethoxyflavone TOP1 0.75-Hydroxy-782'-Trimethoxyflavone DRD2 0.7
5-Hydroxy-782'-Trimethoxyflavone NT5E 0.715-Hydroxy-782'-Trimethoxyflavone ELAVL3 0.715-Hydroxy-782'-Trimethoxyflavone INHA 0.715-Hydroxy-782'-Trimethoxyflavone EGFR 0.75-Hydroxy-782'-Trimethoxyflavone HSD17B1 0.75-Hydroxy-782'-Trimethoxyflavone HSD17B2 0.745-Hydroxy-782'-Trimethoxyflavone ESR1 0.75-Hydroxy-782'-Trimethoxyflavone GSK3B 0.75-Hydroxy-782'-Trimethoxyflavone GLO1 0.715-Hydroxy-782'-Trimethoxyflavone HGF 0.715-Hydroxy-782'-Trimethoxyflavone TNKS 0.75-Hydroxy-782'-Trimethoxyflavone TNKS2 0.75-Hydroxy-782'-Trimethoxyflavone IGF1R 0.715-Hydroxy-782'-Trimethoxyflavone PSIP1 0.715-Hydroxy-782'-Trimethoxyflavone DNPEP 0.715-Hydroxy-782'-Trimethoxyflavone KIT 0.745-Hydroxy-782'-Trimethoxyflavone MMP12 0.75-Hydroxy-782'-Trimethoxyflavone MAOA 0.715-Hydroxy-782'-Trimethoxyflavone OPRM1 0.865-Hydroxy-782'-Trimethoxyflavone NOX4 0.715-Hydroxy-782'-Trimethoxyflavone NR0B1 0.745-Hydroxy-782'-Trimethoxyflavone ABCB1 0.725-Hydroxy-782'-Trimethoxyflavone PIK3CG 0.715-Hydroxy-782'-Trimethoxyflavone UBE3A 0.715-Hydroxy-782'-Trimethoxyflavone PIM1 0.715-Hydroxy-782'-Trimethoxyflavone NEU1 0.755-Hydroxy-782'-Trimethoxyflavone SIGMAR1 0.75-Hydroxy-782'-Trimethoxyflavone SI 0.725-Hydroxy-782'-Trimethoxyflavone SYN1 0.725-Hydroxy-782'-Trimethoxyflavone TERT 0.745-Hydroxy-782'-Trimethoxyflavone F10 0.75-Hydroxy-782'-Trimethoxyflavone TTR 0.75-Hydroxy-782'-Trimethoxyflavone TYR 0.745-Hydroxy-782'-Trimethoxyflavone LCK 0.75-Hydroxy-782'-Trimethoxyflavone FLT3 0.75-Hydroxy-782'-Trimethoxyflavone AXL 0.715-Hydroxy-782'-Trimethoxyflavone KDR 0.75-Hydroxy-782'-Trimethoxyflavone XDH 0.85-Hydroxy-782'-Trimethoxyflavone XDH 0.7Aloe-Emodin ACHE 0.7Aloe-Emodin MAOA 0.71Aloe-Emodin BCL2 0.72Aloe-Emodin ALOX5 0.82Aloe-Emodin CYP19A1 0.76Aloe-Emodin CSNK2A1 0.85Aloe-Emodin ESR1 0.85Aloe-Emodin HPN 0.75Aloe-Emodin MCL1 0.72Aloe-Emodin LIMK1 0.73Aloe-Emodin LCK 0.73Aloenin IL2RA 0.7Aloenin F10 0.7Aloenin TNF 0.7Cyanidin 3-arabinoside AKR1B1 0.87
Cyanidin 3-arabinoside ADRA2A 0.87Cyanidin 3-arabinoside CA12 0.75Cyanidin 3-arabinoside CA2 0.85Cyanidin 3-arabinoside CA4 0.75Cyanidin 3-arabinoside CA7 0.75Cyanidin 3-arabinoside PDE5A 0.75Cyanidin 3-arabinoside CHRM5 0.85Cyanidin 3-arabinoside CYP3A 0.76Cyanidin 3-arabinoside IL2RA 0.72Cyanidin 3-arabinoside ALPI 0.81Cyanidin 3-arabinoside NOX4 0.87Cyanidin 3-arabinoside HPA 0.83Cyanidin 3-arabinoside PTPN1 0.89Cyanidin 3-arabinoside RPS6KA3 0.73Cyanidin 3-arabinoside F10 0.92Cyanidin 3-arabinoside TNF 0.72Feralolide ALK 0.7Feralolide MAP2K1 0.7Feralolide MAP2K2 0.7Feralolide MAP2K6 0.7Feralolide MAP2K7 0.7Feralolide MAP2K2 0.7Feralolide SLC12A5 0.7Feralolide ESR1 0.71Feralolide PTK2 0.7Feralolide FLT1 0.7Feralolide HSP90AA1 0.7Feralolide MAPKAPK5 0.7Feralolide KIT 0.7Feralolide MAPK1 0.7Feralolide NOX4 0.7Feralolide PDGFRB 0.7Feralolide PDGFRB 0.7Feralolide ACVRL1 0.7Feralolide LCK 0.7Feralolide FLT3 0.7Feralolide FLT1 0.7Feralolide KDR 0.7Gossypetin ALOX12 0.91Gossypetin AKR1C3 0.7Gossypetin FASN 0.85Gossypetin ACHE 0.7Gossypetin ADORA1 0.77Gossypetin ADORA3 0.73Gossypetin ADORA2A 0.87Gossypetin AKR1B1 0.85Gossypetin GAA 0.7Gossypetin MAOA 0.7Gossypetin MAOA 0.73Gossypetin AR 0.73Gossypetin ALOX12 0.8Gossypetin ALOX15 0.8Gossypetin ALOX5 0.8Gossypetin CYP19A1 0.79
Gossypetin AHR 0.89Gossypetin ABCG2 0.94Gossypetin AURKB 0.94Gossypetin NTRK2 0.82Gossypetin BACE1 0.7Gossypetin CA12 0.9Gossypetin CA2 0.9Gossypetin CA4 0.85Gossypetin CA7 0.9Gossypetin CBR1 0.76Gossypetin CSNK2A1 0.79Gossypetin CISD1 0.89Gossypetin PDE5A 0.76Gossypetin CDK1 0.94Gossypetin CDK2 0.74Gossypetin CDK5 0.91Gossypetin CDK6 0.91Gossypetin PTGS1 0.85Gossypetin CFTR 0.79Gossypetin CYP1A1 0.77Gossypetin CYP2C9 0.94Gossypetin OPRD1 0.7Gossypetin TOP1 0.85Gossypetin NT5E 0.94Gossypetin ELAVL3 0.94Gossypetin INHA 0.94Gossypetin EGFR 0.87Gossypetin HSD17B1 0.79Gossypetin HSD17B2 0.89Gossypetin ESR1 0.79Gossypetin GABRA1 0.7Gossypetin GSK3B 0.85Gossypetin GLO1 0.94Gossypetin HGF 0.94Gossypetin TNKS 0.79Gossypetin TNKS2 0.79Gossypetin IGF1R 0.94Gossypetin PSIP1 0.94Gossypetin ACP1 0.7Gossypetin DNPEP 0.94Gossypetin KIT 0.79Gossypetin MMP12 0.85Gossypetin MAOA 0.94Gossypetin OPRM1 0.8Gossypetin NOX4 0.94Gossypetin NR0B1 0.79Gossypetin OPRD1 0.7Gossypetin ABCB5 0.77Gossypetin ABCB1 0.7Gossypetin PIK3CG 0.94Gossypetin PDE5A 0.7Gossypetin PGF 0.7Gossypetin UBE3A 0.94Gossypetin PIM1 0.94
Gossypetin NEU1 1Gossypetin SLC6A3 0.7Gossypetin SI 0.8Gossypetin SYN1 0.96Gossypetin TERT 0.7Gossypetin F10 0.86Gossypetin TTR 0.85Gossypetin TYR 0.91Gossypetin LCK 0.7Gossypetin FLT3 0.85Gossypetin AXL 0.94Gossypetin VEGFA 0.7Gossypetin KDR 0.87Gossypetin XDH 0.83Herbacetin ALOX12 0.86Herbacetin AKR1C3 0.73Herbacetin FASN 0.81Herbacetin ACHE 0.7Herbacetin ADORA1 0.7Herbacetin ADORA3 0.76Herbacetin ADORA2A 0.91Herbacetin AKR1B1 0.81Herbacetin GAA 0.73Herbacetin MAOA 0.73Herbacetin MAOB 0.7Herbacetin AR 0.7Herbacetin ALOX12 0.84Herbacetin ALOX15 0.84Herbacetin ALOX5 0.84Herbacetin CYP19A1 0.83Herbacetin AHR 0.94Herbacetin ABCG2 0.89Herbacetin AURKB 0.89Herbacetin NTRK2 0.86Herbacetin BACE1 0.7Herbacetin CA12 0.85Herbacetin CA2 0.85Herbacetin CA4 0.81Herbacetin CA7 0.85Herbacetin CBR1 0.8Herbacetin CES1 0.7Herbacetin CSNK2A1 0.83Herbacetin CISD1 0.94Herbacetin PDE5A 0.72Herbacetin CDK1 0.86Herbacetin CDK2 0.7Herbacetin CDK5 0.86Herbacetin CDK6 0.86Herbacetin PTGS1 0.81Herbacetin CFTR 0.83Herbacetin CYP1A1 0.7Herbacetin CYP1A1 0.7Herbacetin CYP2C9 0.7Herbacetin OPRD1 0.7
Herbacetin TOP1 0.81Herbacetin NT5E 0.89Herbacetin ELAVL3 0.89Herbacetin INHA 0.89Herbacetin EGFR 0.83Herbacetin HSD17B1 0.83Herbacetin HSD17B2 0.94Herbacetin ESR1 0.83Herbacetin GABRA1 0.7Herbacetin GSK3B 0.81Herbacetin GLO1 0.89Herbacetin HGF 0.89Herbacetin TNKS 0.7Herbacetin TNKS2 0.7Herbacetin IGF1R 0.89Herbacetin PSIP1 0.89Herbacetin ACP1 0.7Herbacetin DNPEP 0.89Herbacetin KIT 0.83Herbacetin MMP12 0.81Herbacetin MAOA 0.89Herbacetin OPRM1 0.83Herbacetin NOX4 0.89Herbacetin NR0B1 0.83Herbacetin OPRD1 0.7Herbacetin ABCB5 0.81Herbacetin ABCB1 0.7Herbacetin PIK3CG 0.89Herbacetin PDE5A 0.71Herbacetin PGF 0.7Herbacetin UBE3A 0.89Herbacetin PIM1 0.89Herbacetin NEU1 0.95Herbacetin SLC6A3 0.7Herbacetin SI 0.84Herbacetin SYN1 0.9Herbacetin TERT 0.7Herbacetin F10 0.82Herbacetin TTR 0.81Herbacetin TYR 0.86Herbacetin LCK 0.7Herbacetin FLT3 0.81Herbacetin AXL 0.89Herbacetin VEGFA 0.7Herbacetin KDR 0.83Herbacetin XDH 0.87Isorhamnetin FASN 0.91Isorhamnetin ACHE 0.85Isorhamnetin ADORA1 0.7Isorhamnetin ADORA3 0.8Isorhamnetin ADORA2A 0.7Isorhamnetin AKR1B1 0.87Isorhamnetin GAA 0.94Isorhamnetin MAOA 0.7
Isorhamnetin AR 0.81Isorhamnetin ALOX12 0.73Isorhamnetin ALOX15 0.77Isorhamnetin ALOX5 0.77Isorhamnetin CYP19A1 0.77Isorhamnetin AHR 0.79Isorhamnetin ABCG2 0.89Isorhamnetin AURKB 0.94Isorhamnetin NTRK2 0.94Isorhamnetin BACE1 0.73Isorhamnetin CA12 0.7Isorhamnetin CA2 1Isorhamnetin CA4 1Isorhamnetin CA7 0.85Isorhamnetin CBR1 1Isorhamnetin CSNK2A1 0.76Isorhamnetin CISD1 0.79Isorhamnetin PDE5A 0.89Isorhamnetin CDK1 0.77Isorhamnetin CDK2 0.91Isorhamnetin CDK5 0.74Isorhamnetin CDK6 0.91Isorhamnetin PTGS1 0.91Isorhamnetin PTGS1 0.85Isorhamnetin CFTR 0.71Isorhamnetin CYP1A1 0.79Isorhamnetin CYP2C9 0.71Isorhamnetin OPRD1 0.94Isorhamnetin TOP1 0.7Isorhamnetin SLC6A3 0.85Isorhamnetin NT5E 0.71Isorhamnetin ELAVL3 0.94Isorhamnetin INHA 0.94Isorhamnetin EGFR 0.94Isorhamnetin HSD17B1 0.86Isorhamnetin HSD17B2 0.79Isorhamnetin ESR1 0.89Isorhamnetin GABRA1 0.79Isorhamnetin GSTO1 0.7Isorhamnetin GSK3B 0.7Isorhamnetin GLO1 0.85Isorhamnetin HGF 0.94Isorhamnetin TNKS 0.94Isorhamnetin TNKS2 0.79Isorhamnetin IGF1R 0.92Isorhamnetin PSIP1 0.94Isorhamnetin DNPEP 0.94Isorhamnetin KIT 0.94Isorhamnetin MMP12 0.79Isorhamnetin MAOA 0.85Isorhamnetin OPRM1 0.94Isorhamnetin NOX4 0.76Isorhamnetin NR0B1 0.94Isorhamnetin OPRD1 0.8
Isorhamnetin ABCB5 0.7Isorhamnetin ABCB1 0.78Isorhamnetin PIK3CG 0.7Isorhamnetin PDE5A 0.94Isorhamnetin PGF 0.73Isorhamnetin UBE3A 0.7Isorhamnetin PIM1 0.94Isorhamnetin NEU1 0.94Isorhamnetin SLC6A3 0.9Isorhamnetin SI 0.7Isorhamnetin SYN1 0.77Isorhamnetin TERT 0.92Isorhamnetin F10 0.82Isorhamnetin TTR 0.85Isorhamnetin TYR 0.85Isorhamnetin ABL1 0.82Isorhamnetin LCK 0.7Isorhamnetin FLT3 0.7Isorhamnetin AXL 0.85Isorhamnetin VEGFA 0.94Isorhamnetin TEK 0.7Isorhamnetin XDH 0.7Isorhamnetin XDH 0.83Isorhamnetin ALOX12 0.85Kaempferol 8-C-sulfate ADORA1 0.7Kaempferol 8-C-sulfate ADORA3 0.7Kaempferol 8-C-sulfate ADORA2A 0.7Kaempferol 8-C-sulfate AHR 0.7Kaempferol 8-C-sulfate CA12 0.7Kaempferol 8-C-sulfate CA4 0.7Kaempferol 8-C-sulfate CA7 0.7Kaempferol 8-C-sulfate CISD1 0.7Kaempferol 8-C-sulfate CYP1A1 0.7Kaempferol 8-C-sulfate CYP1A1 0.7Kaempferol 8-C-sulfate CYP2C9 0.7Kaempferol 8-C-sulfate EGFR 0.7Kaempferol 8-C-sulfate HSD17B2 0.7Kaempferol 8-C-sulfate TYR 0.7Kaempferol 8-C-sulfate LCK 0.7Kaempferol-7-Glucoside ADORA1 0.7Kaempferol-7-Glucoside ADORA3 0.7Kaempferol-7-Glucoside ALDH2 0.71Kaempferol-7-Glucoside AKR1B1 0.76Kaempferol-7-Glucoside AKR1B1 0.78Kaempferol-7-Glucoside ADRA2A 0.78Kaempferol-7-Glucoside ALOX5 0.7Kaempferol-7-Glucoside CA12 0.71Kaempferol-7-Glucoside CA2 0.79Kaempferol-7-Glucoside CA4 0.71Kaempferol-7-Glucoside CA7 0.71Kaempferol-7-Glucoside PDE5A 0.73Kaempferol-7-Glucoside CHRM5 0.76Kaempferol-7-Glucoside CYP3A 0.7Kaempferol-7-Glucoside EGFR 0.74
Kaempferol-7-Glucoside IL2RA 0.71Kaempferol-7-Glucoside ALPI 0.74Kaempferol-7-Glucoside NOX4 0.78Kaempferol-7-Glucoside HPA 0.76Kaempferol-7-Glucoside PTPN1 0.8Kaempferol-7-Glucoside RPS6KA3 0.7Kaempferol-7-Glucoside F10 0.8Kaempferol-7-Glucoside TNF 0.91Luteolin-7-Mono-Beta-D-Glucoside ACHE 0.7Luteolin-7-Mono-Beta-D-Glucoside ALDH2 0.74Luteolin-7-Mono-Beta-D-Glucoside AKR1B1 0.72Luteolin-7-Mono-Beta-D-Glucoside ADRA2A 0.76Luteolin-7-Mono-Beta-D-Glucoside ALOX5 0.7Luteolin-7-Mono-Beta-D-Glucoside CA1 0.7Luteolin-7-Mono-Beta-D-Glucoside CA12 0.7Luteolin-7-Mono-Beta-D-Glucoside CA2 0.75Luteolin-7-Mono-Beta-D-Glucoside CA4 0.7Luteolin-7-Mono-Beta-D-Glucoside CA7 0.7Luteolin-7-Mono-Beta-D-Glucoside CA9 0.7Luteolin-7-Mono-Beta-D-Glucoside PDE5A 0.7Luteolin-7-Mono-Beta-D-Glucoside CHRM5 0.75Luteolin-7-Mono-Beta-D-Glucoside CYP3A 0.7Luteolin-7-Mono-Beta-D-Glucoside SLC6A3 0.7Luteolin-7-Mono-Beta-D-Glucoside EGFR 0.77Luteolin-7-Mono-Beta-D-Glucoside IL2RA 0.74Luteolin-7-Mono-Beta-D-Glucoside ALPI 0.73Luteolin-7-Mono-Beta-D-Glucoside NOX4 0.76Luteolin-7-Mono-Beta-D-Glucoside HPA 0.74Luteolin-7-Mono-Beta-D-Glucoside PTPN1 0.78Luteolin-7-Mono-Beta-D-Glucoside RPS6KA3 0.7Luteolin-7-Mono-Beta-D-Glucoside F10 0.77Luteolin-7-Mono-Beta-D-Glucoside TNF 1Myrtillin AKR1B1 0.87Myrtillin ADRA2A 0.89Myrtillin CA12 0.76Myrtillin CA2 0.87Myrtillin CA4 0.76Myrtillin CA7 0.76Myrtillin CA9 0.7Myrtillin PDE5A 0.77Myrtillin CHRM5 0.87Myrtillin CYP3A 0.78Myrtillin IL2RA 0.75Myrtillin ALPI 0.84Myrtillin NOX4 0.89Myrtillin HPA 0.85Myrtillin PTPN1 0.9Myrtillin RPS6KA3 0.75Myrtillin F10 0.94Myrtillin TNF 0.75Neoandrographolide F7 0.7Neoandrographolide KLF5 0.77Neoandrographolide ATP1A1 0.75Neoandrographolide ATP1A2 0.75
Neoandrographolide RORC 0.75Neoandrographolide PTGS1 0.7Neoandrographolide PPP2R5A 0.7Neoandrographolide PTPN1 0.7Neoandrographolide PTPRA 0.7Neoandrographolide ATP1A2 0.7Neoandrographolide SLCO1B1 0.7Neoandrographolide STAT3 0.75Neoandrographolide TTL 0.7Neoandrographolide XDH 0.7Paniculide-B PTGS1 0.7Paniculide-B DDIT3 0.7Paniculide-B IARS 0.7Paniculide-B NDUFA9 0.7Paniculide-B CHRNB2 0.73Paniculide-B PRKCB 0.7Paniculide-B PRKCA 0.71Paniculide-B FNTA 0.7Paniculide-B PRKCA 0.7Paniculide-B PRKCD 0.7Paniculide-B PRKCQ 0.7Paniculide-B PRKCA 0.7Paniculide-B PRKCE 0.7Paniculide-B PRKCH 0.7Paniculide-B PRKCG 0.7Paniculide-B F2RL1 0.7Paniculide-B ATP2A2 0.73Paniculide-B ATP2A1 0.7Paniculide-B SCN2A 0.73Paniculide-B PCSK7 0.7Paniculide-B TTL 0.7Pelargonidin 5-galactoside ALDH2 0.7Pelargonidin 5-galactoside AKR1B1 0.71Pelargonidin 5-galactoside ADRA2A 0.73Pelargonidin 5-galactoside CA1 0.7Pelargonidin 5-galactoside CA12 0.7Pelargonidin 5-galactoside CA2 0.7Pelargonidin 5-galactoside CA4 0.74Pelargonidin 5-galactoside CA7 0.74Pelargonidin 5-galactoside CA9 0.7Pelargonidin 5-galactoside CHRM5 0.71Pelargonidin 5-galactoside EGFR 0.7Pelargonidin 5-galactoside IL2RA 0.7Pelargonidin 5-galactoside ALPI 0.7Pelargonidin 5-galactoside NOX4 0.73Pelargonidin 5-galactoside HPA 0.7Pelargonidin 5-galactoside PTPN1 0.74Pelargonidin 5-galactoside RPS6KA3 0.71Pelargonidin 5-galactoside F10 0.87Pelargonidin 5-galactoside TNF 0.81Peonidin galactoside AKR1B1 0.85Peonidin galactoside ADRA2A 0.88Peonidin galactoside CA12 0.75Peonidin galactoside CA2 0.86
Peonidin galactoside CA4 0.75Peonidin galactoside CA7 0.75Peonidin galactoside CA9 0.7Peonidin galactoside PDE5A 0.76Peonidin galactoside CHRM5 0.86Peonidin galactoside CYP3A 0.77Peonidin galactoside IL2RA 0.73Peonidin galactoside ALPI 0.82Peonidin galactoside NOX4 0.88Peonidin galactoside HPA 0.84Peonidin galactoside PTPN1 0.88Peonidin galactoside RPS6KA3 0.74Peonidin galactoside F10 0.93Peonidin galactoside TNF 0.73Petunidin 3-glucoside AKR1B1 0.85Petunidin 3-glucoside ADRA2A 0.87Petunidin 3-glucoside CA12 0.76Petunidin 3-glucoside CA2 0.86Petunidin 3-glucoside CA4 0.76Petunidin 3-glucoside CA7 0.76Petunidin 3-glucoside CA9 0.7Petunidin 3-glucoside PDE5A 0.76Petunidin 3-glucoside CHRM5 0.86Petunidin 3-glucoside CYP3A 0.77Petunidin 3-glucoside IL2RA 0.74Petunidin 3-glucoside ALPI 0.83Petunidin 3-glucoside NOX4 0.87Petunidin 3-glucoside HPA 0.83Petunidin 3-glucoside PTPN1 0.88Petunidin 3-glucoside RPS6KA3 0.75Petunidin 3-glucoside F10 0.94Petunidin 3-glucoside TNF 0.74Pinnatin AKR1C3 0.7Pinnatin FASN 0.7Pinnatin ACHE 0.73Pinnatin ADORA1 0.7Pinnatin ADORA3 0.71Pinnatin ADORA2A 0.73Pinnatin ADRB2 0.73Pinnatin AKR1B1 0.7Pinnatin AKR1B1 0.7Pinnatin AKR1B1 0.7Pinnatin GAA 0.7Pinnatin MAOA 0.72Pinnatin MAOB 0.7Pinnatin AR 0.7Pinnatin ALOX12 0.7Pinnatin ALOX15 0.78Pinnatin ALOX15 0.78Pinnatin ALOX5 0.78Pinnatin CYP19A1 0.78Pinnatin AHR 0.76Pinnatin ABCG2 0.71Pinnatin AURKB 0.7
Pinnatin NTRK2 0.7Pinnatin APP 0.71Pinnatin CA12 0.7Pinnatin CA2 0.7Pinnatin CA4 0.7Pinnatin CA7 0.73Pinnatin CBR1 0.7Pinnatin CES1 0.79Pinnatin CSNK2A1 0.7Pinnatin CISD1 0.76Pinnatin BCHE 0.71Pinnatin CDK1 0.7Pinnatin CDK5 0.7Pinnatin CDK6 0.7Pinnatin PTGS1 0.7Pinnatin CFTR 0.73Pinnatin CYP1A1 0.71Pinnatin CYP2C9 0.71Pinnatin TOP1 0.7Pinnatin DRD2 0.73Pinnatin NT5E 0.7Pinnatin ELAVL3 0.7Pinnatin INHA 0.7Pinnatin EGFR 0.7Pinnatin HSD17B1 0.7Pinnatin HSD17B2 0.76Pinnatin ESR1 0.71Pinnatin GSK3B 0.76Pinnatin GLO1 0.73Pinnatin HGF 0.7Pinnatin TNKS 0.7Pinnatin TNKS2 0.71Pinnatin IGF1R 0.7Pinnatin PSIP1 0.7Pinnatin DNPEP 0.7Pinnatin KIT 0.7Pinnatin MMP12 0.76Pinnatin MAOA 0.73Pinnatin OPRM1 0.7Pinnatin MSH3 0.71Pinnatin NOX4 0.7Pinnatin NR0B1 0.7Pinnatin ABCB1 0.76Pinnatin PPARG 0.73Pinnatin PIK3CG 0.7Pinnatin UBE3A 0.7Pinnatin PIM1 0.7Pinnatin SYN1 0.7Pinnatin SI 0.72Pinnatin TERT 0.78Pinnatin F10 0.7Pinnatin TTR 0.7Pinnatin TYR 0.73Pinnatin LCK 0.7
Pinnatin FLT3 0.7Pinnatin AXL 0.73Pinnatin XDH 0.7Pinnatin AKR1B1 0.73Pongamone A ACHE 0.7Pongamone A ALDH2 0.77Pongamone A ALOX5 0.7Pongamone A CYP19A1 0.7Pongamone A CA12 0.7Pongamone A CA7 0.7Pongamone A BCHE 0.7Pongamone A DRD5 0.7Pongamone A EGFR 0.7Pongamone A MIF 0.7Pongamone A ABCB1 0.8Pongamone A S1PR1 0.7Pongamone A AKR1B1 0.7Pongamone A PKIA 0.72Tiliroside AKR1B1 0.76Tiliroside ADRA2A 0.78Tiliroside CA12 0.78Tiliroside CA2 0.97Tiliroside CA4 0.78Tiliroside CA7 0.97Tiliroside PDE5A 0.97Tiliroside CHRM5 0.79Tiliroside CYP3A 0.79Tiliroside IL2RA 0.9Tiliroside ALPI 0.7Tiliroside NOX4 0.77Tiliroside HPA 0.78Tiliroside PTPN1 0.84Tiliroside RPS6KA3 0.87Tiliroside F10 0.75Tiliroside TNF 0.77Tiliroside MDH1 0.7Andrographiside ATP5F1B 0.7Andrographiside NR1H4 0.7Andrographiside CHS1 0.7Andrographiside F7 0.7Andrographiside ITGA4 0.7Andrographiside IARS1 0.7Andrographiside KLF5 0.7Andrographiside MRP1 0.7Andrographiside ATP1A1 0.7Andrographiside ATP1A2 0.7Andrographiside ATP1A1 0.7Andrographiside RORC 0.7Andrographiside ABCB1 0.7Andrographiside PRKCB 0.7Andrographiside PRKCA 0.7Andrographiside PTGS1 0.7Andrographiside PRKCA 0.7Andrographiside PRKCD 0.7
Andrographiside PRKCT 0.7Andrographiside PRKCE 0.7Andrographiside PRKCH 0.7Andrographiside PRKCG 0.7Andrographiside PRKC 0.7Andrographiside PP2CB 0.7Andrographiside PTPN1 0.7Andrographiside ATP2A2 0.7Andrographiside PTPA 0.7Andrographiside PPP2R5D 0.7Andrographiside PPP2CA 0.7Andrographiside PPP1CC 0.7Andrographiside ATP1A2 0.7Andrographiside SLCO1A4 0.7Andrographiside SLCO1B1 0.7Andrographiside STAT3 0.7Andrographiside XDH 0.7Altisin ALOX12 0.7Altisin AKR1C3 0.7Altisin FASN 0.7Altisin ACHE 0.7Altisin ADORA1 0.82Altisin ADORA3 0.78Altisin ADORA2A 0.75Altisin AKR1B1 0.86Altisin ALR2 0.7Altisin AKR1B1 0.71Altisin GAA 0.72Altisin MAOA 0.75Altisin MAOB 0.71Altisin ALOX12 0.72Altisin ALOX15 0.72Altisin ALOX15 0.72Altisin ALOX5 0.72Altisin AHR 0.74Altisin ABCG2 0.71Altisin AURKB 0.71Altisin NTRK2 0.76Altisin BCHE 0.71Altisin CA12 0.72Altisin CA2 0.72Altisin CA4 0.7Altisin CA7 0.72Altisin CBR1 0.7Altisin CSNK2A1 0.7Altisin CISD1 0.74Altisin BCHE 0.7Altisin CDK1 0.71Altisin CDK1 0.7Altisin CDK5 0.7Altisin CDK6 0.7Altisin PTGS1 0.7Altisin CFTR 0.7Altisin CYP19A1 0.7
Altisin CYP1A1 0.7Altisin CYP1A1 0.74Altisin CYP2C9 0.72Altisin gyrB 0.7Altisin TOP1 0.7Altisin D2R 0.7Altisin Nt5e 0.71Altisin ELAVL3 0.71Altisin INHA 0.71Altisin EGFR 0.7Altisin HSD17B1 0.7Altisin HSD17B2 0.74Altisin ESR 0.7Altisin GSK3B 0.7Altisin GLO1 0.71Altisin HGF 0.71Altisin GAG-POL 0.72Altisin IGF1R 0.71Altisin PSIP1 0.71Altisin DNPEP 0.71Altisin KIT 0.73Altisin MMP12 0.7Altisin MAOA 0.71Altisin OPRM1 0.87Altisin NOX4 0.71Altisin NR0B1 0.74Altisin ABCB1 0.73Altisin PIK3CG 0.71Altisin E6AP 0.71Altisin NEU1 0.75Altisin SIGMAR1 0.7Altisin SI 0.72Altisin SYN1 0.72Altisin TERT 0.74Altisin F10 0.7Altisin TTR 0.7Altisin TYR 0.74Altisin LCK 0.7Altisin FLT3 0.7Altisin UFO 0.71Altisin XDH 0.8Altisin XDH 0.72'-hydroxy-5,7,8- trimethoxyflavone ALOX12 0.72'-hydroxy-5,7,8- trimethoxyflavone AKR1C3 0.72'-hydroxy-5,7,8- trimethoxyflavone FASN 0.72'-hydroxy-5,7,8- trimethoxyflavone ACHE 0.72'-hydroxy-5,7,8- trimethoxyflavone ADORA1 0.832'-hydroxy-5,7,8- trimethoxyflavone ADORA3 0.772'-hydroxy-5,7,8- trimethoxyflavone ADORA2A 0.762'-hydroxy-5,7,8- trimethoxyflavone AKR1B1 0.872'-hydroxy-5,7,8- trimethoxyflavone ALR2 0.732'-hydroxy-5,7,8- trimethoxyflavone AKR1B1 0.722'-hydroxy-5,7,8- trimethoxyflavone GAA 0.72'-hydroxy-5,7,8- trimethoxyflavone MAOA 0.76
2'-hydroxy-5,7,8- trimethoxyflavone MAOB 0.722'-hydroxy-5,7,8- trimethoxyflavone DHTR 0.72'-hydroxy-5,7,8- trimethoxyflavone ALOX12 0.732'-hydroxy-5,7,8- trimethoxyflavone ALOX15 0.732'-hydroxy-5,7,8- trimethoxyflavone ALOX15 0.732'-hydroxy-5,7,8- trimethoxyflavone ALOX5 0.732'-hydroxy-5,7,8- trimethoxyflavone AHR 0.752'-hydroxy-5,7,8- trimethoxyflavone ABCG2 0.722'-hydroxy-5,7,8- trimethoxyflavone AURKB 0.722'-hydroxy-5,7,8- trimethoxyflavone NTRK2 0.772'-hydroxy-5,7,8- trimethoxyflavone CA12 0.732'-hydroxy-5,7,8- trimethoxyflavone CA2 0.732'-hydroxy-5,7,8- trimethoxyflavone CA4 0.72'-hydroxy-5,7,8- trimethoxyflavone CA7 0.732'-hydroxy-5,7,8- trimethoxyflavone CBR1 0.712'-hydroxy-5,7,8- trimethoxyflavone CSNK2A1 0.712'-hydroxy-5,7,8- trimethoxyflavone CISD1 0.752'-hydroxy-5,7,8- trimethoxyflavone BCHE 0.72'-hydroxy-5,7,8- trimethoxyflavone CDK1 0.722'-hydroxy-5,7,8- trimethoxyflavone CDK1 0.72'-hydroxy-5,7,8- trimethoxyflavone CDK5 0.72'-hydroxy-5,7,8- trimethoxyflavone CDK6 0.72'-hydroxy-5,7,8- trimethoxyflavone PTGS1 0.72'-hydroxy-5,7,8- trimethoxyflavone CFTR 0.712'-hydroxy-5,7,8- trimethoxyflavone CYP19A1 0.712'-hydroxy-5,7,8- trimethoxyflavone CYP1A1 0.712'-hydroxy-5,7,8- trimethoxyflavone CYP1A1 0.742'-hydroxy-5,7,8- trimethoxyflavone CYP2C9 0.732'-hydroxy-5,7,8- trimethoxyflavone gyrB 0.72'-hydroxy-5,7,8- trimethoxyflavone TOP1 0.72'-hydroxy-5,7,8- trimethoxyflavone D2R 0.72'-hydroxy-5,7,8- trimethoxyflavone Nt5e 0.722'-hydroxy-5,7,8- trimethoxyflavone ELAVL3 0.722'-hydroxy-5,7,8- trimethoxyflavone INHA 0.722'-hydroxy-5,7,8- trimethoxyflavone EGFR 0.72'-hydroxy-5,7,8- trimethoxyflavone HSD17B1 0.712'-hydroxy-5,7,8- trimethoxyflavone HSD17B2 0.752'-hydroxy-5,7,8- trimethoxyflavone ESR 0.712'-hydroxy-5,7,8- trimethoxyflavone GSK3B 0.72'-hydroxy-5,7,8- trimethoxyflavone GLO1 0.722'-hydroxy-5,7,8- trimethoxyflavone HGF 0.722'-hydroxy-5,7,8- trimethoxyflavone GAG-POL 0.732'-hydroxy-5,7,8- trimethoxyflavone IGF1R 0.722'-hydroxy-5,7,8- trimethoxyflavone PSIP1 0.722'-hydroxy-5,7,8- trimethoxyflavone DNPEP 0.722'-hydroxy-5,7,8- trimethoxyflavone KIT 0.742'-hydroxy-5,7,8- trimethoxyflavone MMP12 0.72'-hydroxy-5,7,8- trimethoxyflavone MAOA 0.722'-hydroxy-5,7,8- trimethoxyflavone OPRM1 0.882'-hydroxy-5,7,8- trimethoxyflavone NOX4 0.722'-hydroxy-5,7,8- trimethoxyflavone NR0B1 0.752'-hydroxy-5,7,8- trimethoxyflavone ABCB5 0.72'-hydroxy-5,7,8- trimethoxyflavone ABCB1 0.752'-hydroxy-5,7,8- trimethoxyflavone PIK3CG 0.72
2'-hydroxy-5,7,8- trimethoxyflavone PDE5A 0.72'-hydroxy-5,7,8- trimethoxyflavone E6AP 0.722'-hydroxy-5,7,8- trimethoxyflavone NEU1 0.762'-hydroxy-5,7,8- trimethoxyflavone SIGMAR1 0.72'-hydroxy-5,7,8- trimethoxyflavone SI 0.732'-hydroxy-5,7,8- trimethoxyflavone SYN1 0.732'-hydroxy-5,7,8- trimethoxyflavone TERT 0.752'-hydroxy-5,7,8- trimethoxyflavone F10 0.72'-hydroxy-5,7,8- trimethoxyflavone TTR 0.712'-hydroxy-5,7,8- trimethoxyflavone TYR 0.752'-hydroxy-5,7,8- trimethoxyflavone LCK 0.72'-hydroxy-5,7,8- trimethoxyflavone FLT3 0.72'-hydroxy-5,7,8- trimethoxyflavone UFO 0.722'-hydroxy-5,7,8- trimethoxyflavone XDH 0.782'-hydroxy-5,7,8- trimethoxyflavone XDH 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALOX12 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone FASN 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone ACHE 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ADORA1 0.765-hydroxy-7,8,2',3',4'- pentamethoxyflavone ADORA3 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone ADORA2A 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone AKR1B1 0.895-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALR2 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone AKR1B1 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone GAA 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone MAOA 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone MAOB 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALOX12 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALOX15 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALOX15 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone ALOX5 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone AHR 0.715-hydroxy-7,8,2',3',4'- pentamethoxyflavone ABCG2 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone AURKB 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone NTRK2 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone CA12 0.795-hydroxy-7,8,2',3',4'- pentamethoxyflavone CA2 0.795-hydroxy-7,8,2',3',4'- pentamethoxyflavone CA4 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone CA7 0.795-hydroxy-7,8,2',3',4'- pentamethoxyflavone CISD1 0.715-hydroxy-7,8,2',3',4'- pentamethoxyflavone BCHE 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone CDK1 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone CDK1 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone CDK5 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone CDK6 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone PTGS1 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone CYP19A1 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone CYP1A1 0.775-hydroxy-7,8,2',3',4'- pentamethoxyflavone CYP1A1 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone CYP2C9 0.795-hydroxy-7,8,2',3',4'- pentamethoxyflavone gyrB 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone TOP1 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone Nt5e 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone ELAVL3 0.75
5-hydroxy-7,8,2',3',4'- pentamethoxyflavone INHA 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone EGFR 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone HSD17B2 0.715-hydroxy-7,8,2',3',4'- pentamethoxyflavone GSK3B 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone GLO1 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone HGF 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone GAG-POL 0.765-hydroxy-7,8,2',3',4'- pentamethoxyflavone IGF1R 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone PSIP1 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone DNPEP 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone KIT 0.725-hydroxy-7,8,2',3',4'- pentamethoxyflavone MMP12 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone MAOA 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone OPRM1 0.835-hydroxy-7,8,2',3',4'- pentamethoxyflavone NOX4 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone NR0B1 0.715-hydroxy-7,8,2',3',4'- pentamethoxyflavone ABCB1 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone PIK3CG 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone E6AP 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone NEU1 0.795-hydroxy-7,8,2',3',4'- pentamethoxyflavone SI 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone SYN1 0.765-hydroxy-7,8,2',3',4'- pentamethoxyflavone TERT 0.775-hydroxy-7,8,2',3',4'- pentamethoxyflavone F10 0.75-hydroxy-7,8,2',3',4'- pentamethoxyflavone TTR 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone TYR 0.775-hydroxy-7,8,2',3',4'- pentamethoxyflavone LCK 0.785-hydroxy-7,8,2',3',4'- pentamethoxyflavone FLT3 0.735-hydroxy-7,8,2',3',4'- pentamethoxyflavone UFO 0.755-hydroxy-7,8,2',3',4'- pentamethoxyflavone XDH 0.775-hydroxy-7,8,2',3',4'- pentamethoxyflavone XDH 0.73Wightin ALOX12 0.72Wightin AKR1C3 0.7Wightin FASN 0.73Wightin ACHE 0.7Wightin ADORA1 0.78Wightin ADORA3 0.75Wightin ADORA2A 0.73Wightin AKR1B1 0.9Wightin ALR2 0.7Wightin AKR1B1 0.75Wightin GAA 0.7Wightin MAOA 0.73Wightin MAOB 0.7Wightin ALOX12 0.7Wightin ALOX15 0.7Wightin ALOX15 0.7Wightin ALOX5 0.7Wightin AHR 0.71Wightin ABCG2 0.75Wightin AURKB 0.75Wightin NTRK2 0.73Wightin CA12 0.76Wightin CA2 0.76
Wightin CA4 0.73Wightin CA7 0.76Wightin CBR1 0.7Wightin CSNK2A1 0.7Wightin CISD1 0.71Wightin BCHE 0.7Wightin CDK1 0.75Wightin CDK1 0.72Wightin CDK5 0.72Wightin CDK6 0.72Wightin PTGS1 0.73Wightin CFTR 0.7Wightin CYP19A1 0.7Wightin CYP1A1 0.74Wightin CYP1A1 0.71Wightin CYP2C9 0.76Wightin gyrB 0.7Wightin TOP1 0.73Wightin Nt5e 0.75Wightin ELAVL3 0.75Wightin INHA 0.75Wightin EGFR 0.7Wightin HSD17B1 0.7Wightin HSD17B2 0.71Wightin ESR 0.7Wightin GSK3B 0.73Wightin GLO1 0.75Wightin HGF 0.75Wightin GAG-POL 0.76Wightin IGF1R 0.75Wightin PSIP1 0.75Wightin DNPEP 0.75Wightin KIT 0.71Wightin MMP12 0.73Wightin MAOA 0.75Wightin OPRM1 0.83Wightin NOX4 0.75Wightin NR0B1 0.71Wightin ABCB1 0.7Wightin PIK3CG 0.75Wightin E6AP 0.75Wightin NEU1 0.79Wightin SI 0.7Wightin SYN1 0.76Wightin TERT 0.78Wightin F10 0.7Wightin TTR 0.7Wightin TYR 0.78Wightin LCK 0.7Wightin FLT3 0.73Wightin UFO 0.75Wightin XDH 0.77Wightin XDH 0.735-hydroxy-7,8-dimethoxyflavanone AKR1C3 0.72
5-hydroxy-7,8-dimethoxyflavanone FABG 0.75-hydroxy-7,8-dimethoxyflavanone FASN 0.75-hydroxy-7,8-dimethoxyflavanone PGD 0.75-hydroxy-7,8-dimethoxyflavanone ACHE 0.795-hydroxy-7,8-dimethoxyflavanone ALPL 0.75-hydroxy-7,8-dimethoxyflavanone FUT7 0.75-hydroxy-7,8-dimethoxyflavanone MAOB 0.75-hydroxy-7,8-dimethoxyflavanone ARG1 0.75-hydroxy-7,8-dimethoxyflavanone APP 0.75-hydroxy-7,8-dimethoxyflavanone BACE1 0.75-hydroxy-7,8-dimethoxyflavanone CA1 0.815-hydroxy-7,8-dimethoxyflavanone CA12 0.75-hydroxy-7,8-dimethoxyflavanone CA2 0.815-hydroxy-7,8-dimethoxyflavanone CA4 0.845-hydroxy-7,8-dimethoxyflavanone CA7 0.75-hydroxy-7,8-dimethoxyflavanone COX1 0.75-hydroxy-7,8-dimethoxyflavanone CYP19A1 0.815-hydroxy-7,8-dimethoxyflavanone CYP2C9 0.855-hydroxy-7,8-dimethoxyflavanone D2R 0.75-hydroxy-7,8-dimethoxyflavanone DNMT1 0.75-hydroxy-7,8-dimethoxyflavanone gyrB 0.75-hydroxy-7,8-dimethoxyflavanone DYRK1A 0.75-hydroxy-7,8-dimethoxyflavanone DYRK1A 0.75-hydroxy-7,8-dimethoxyflavanone EDNRA 0.75-hydroxy-7,8-dimethoxyflavanone EDNRB 0.75-hydroxy-7,8-dimethoxyflavanone ELAVL3 0.75-hydroxy-7,8-dimethoxyflavanone INHA 0.75-hydroxy-7,8-dimethoxyflavanone ESR 0.75-hydroxy-7,8-dimethoxyflavanone ESR 0.715-hydroxy-7,8-dimethoxyflavanone FASN 0.75-hydroxy-7,8-dimethoxyflavanone G6PD 0.75-hydroxy-7,8-dimethoxyflavanone HGF 0.75-hydroxy-7,8-dimethoxyflavanone HSP90 0.835-hydroxy-7,8-dimethoxyflavanone GAG-POL 0.75-hydroxy-7,8-dimethoxyflavanone sssIM 0.75-hydroxy-7,8-dimethoxyflavanone GRM5 0.75-hydroxy-7,8-dimethoxyflavanone NOS3 0.75-hydroxy-7,8-dimethoxyflavanone NFKB 0.75-hydroxy-7,8-dimethoxyflavanone ABCB1 0.75-hydroxy-7,8-dimethoxyflavanone PPARG 0.725-hydroxy-7,8-dimethoxyflavanone SERPINE1 0.75-hydroxy-7,8-dimethoxyflavanone PTPN1 0.715-hydroxy-7,8-dimethoxyflavanone AKT1 0.75-hydroxy-7,8-dimethoxyflavanone Mex5 0.75-hydroxy-7,8-dimethoxyflavanone SLCO2B1 0.755-hydroxy-7,8-dimethoxyflavanone SQLE 0.75-hydroxy-7,8-dimethoxyflavanone TERT 0.75-hydroxy-7,8-dimethoxyflavanone SHBG 0.815-hydroxy-7,8-dimethoxyflavanone F10 0.75-hydroxy-7,8-dimethoxyflavanone STAT1 0.75-hydroxy-7,8-dimethoxyflavanone TTR 0.75-hydroxy-7,8-dimethoxyflavanone TYR 0.75-hydroxy-7,8-dimethoxyflavanone XDH 0.75-hydroxy-7,8-dimethoxyflavanone XBP1 0.71
5-hydroxy-7,8-dimethoxyflavone ALOX12 0.75-hydroxy-7,8-dimethoxyflavone FASN 0.735-hydroxy-7,8-dimethoxyflavone ACHE 0.75-hydroxy-7,8-dimethoxyflavone ADORA1 0.815-hydroxy-7,8-dimethoxyflavone ADORA3 0.775-hydroxy-7,8-dimethoxyflavone ADORA2A 0.785-hydroxy-7,8-dimethoxyflavone AKR1B1 0.925-hydroxy-7,8-dimethoxyflavone ALR2 0.715-hydroxy-7,8-dimethoxyflavone AKR1B1 0.735-hydroxy-7,8-dimethoxyflavone GAA 0.725-hydroxy-7,8-dimethoxyflavone MAOA 0.785-hydroxy-7,8-dimethoxyflavone MAOB 0.775-hydroxy-7,8-dimethoxyflavone DHTR 0.765-hydroxy-7,8-dimethoxyflavone ALOX12 0.85-hydroxy-7,8-dimethoxyflavone ALOX15 0.85-hydroxy-7,8-dimethoxyflavone ALOX15 0.85-hydroxy-7,8-dimethoxyflavone ALOX5 0.85-hydroxy-7,8-dimethoxyflavone AHR 0.765-hydroxy-7,8-dimethoxyflavone ABCG2 0.735-hydroxy-7,8-dimethoxyflavone AURKB 0.735-hydroxy-7,8-dimethoxyflavone NTRK2 0.855-hydroxy-7,8-dimethoxyflavone CA12 0.735-hydroxy-7,8-dimethoxyflavone CA2 0.735-hydroxy-7,8-dimethoxyflavone CA4 0.735-hydroxy-7,8-dimethoxyflavone CA7 0.735-hydroxy-7,8-dimethoxyflavone CBR1 0.785-hydroxy-7,8-dimethoxyflavone CSNK2A1 0.765-hydroxy-7,8-dimethoxyflavone CISD1 0.765-hydroxy-7,8-dimethoxyflavone CDK1 0.735-hydroxy-7,8-dimethoxyflavone CDK1 0.75-hydroxy-7,8-dimethoxyflavone CDK5 0.75-hydroxy-7,8-dimethoxyflavone CDK6 0.75-hydroxy-7,8-dimethoxyflavone PTGS1 0.735-hydroxy-7,8-dimethoxyflavone CFTR 0.765-hydroxy-7,8-dimethoxyflavone CYP19A1 0.765-hydroxy-7,8-dimethoxyflavone CYP1A1 0.745-hydroxy-7,8-dimethoxyflavone CYP1A1 0.85-hydroxy-7,8-dimethoxyflavone CYP2C9 0.735-hydroxy-7,8-dimethoxyflavone gyrB 0.75-hydroxy-7,8-dimethoxyflavone TOP1 0.735-hydroxy-7,8-dimethoxyflavone HTR2 0.75-hydroxy-7,8-dimethoxyflavone Nt5e 0.735-hydroxy-7,8-dimethoxyflavone ELAVL3 0.735-hydroxy-7,8-dimethoxyflavone INHA 0.735-hydroxy-7,8-dimethoxyflavone EGFR 0.75-hydroxy-7,8-dimethoxyflavone HSD17B1 0.765-hydroxy-7,8-dimethoxyflavone HSD17B2 0.765-hydroxy-7,8-dimethoxyflavone ESR 0.765-hydroxy-7,8-dimethoxyflavone GSK3B 0.735-hydroxy-7,8-dimethoxyflavone GLO1 0.735-hydroxy-7,8-dimethoxyflavone HGF 0.735-hydroxy-7,8-dimethoxyflavone GAG-POL 0.745-hydroxy-7,8-dimethoxyflavone IGF1R 0.735-hydroxy-7,8-dimethoxyflavone PSIP1 0.73
5-hydroxy-7,8-dimethoxyflavone DNPEP 0.735-hydroxy-7,8-dimethoxyflavone KIT 0.85-hydroxy-7,8-dimethoxyflavone MMP12 0.735-hydroxy-7,8-dimethoxyflavone MAOA 0.735-hydroxy-7,8-dimethoxyflavone OPRM1 0.945-hydroxy-7,8-dimethoxyflavone NOX4 0.735-hydroxy-7,8-dimethoxyflavone NR0B1 0.815-hydroxy-7,8-dimethoxyflavone ABCB5 0.75-hydroxy-7,8-dimethoxyflavone ABCB1 0.795-hydroxy-7,8-dimethoxyflavone PIK3CG 0.735-hydroxy-7,8-dimethoxyflavone E6AP 0.735-hydroxy-7,8-dimethoxyflavone NEU1 0.775-hydroxy-7,8-dimethoxyflavone SYN1 0.725-hydroxy-7,8-dimethoxyflavone SI 0.85-hydroxy-7,8-dimethoxyflavone SYN1 0.745-hydroxy-7,8-dimethoxyflavone TERT 0.795-hydroxy-7,8-dimethoxyflavone F10 0.75-hydroxy-7,8-dimethoxyflavone TTR 0.765-hydroxy-7,8-dimethoxyflavone TYR 0.795-hydroxy-7,8-dimethoxyflavone LCK 0.75-hydroxy-7,8-dimethoxyflavone FLT3 0.735-hydroxy-7,8-dimethoxyflavone UFO 0.735-hydroxy-7,8-dimethoxyflavone XDH 0.85-hydroxy-7,8-dimethoxyflavone XDH 0.73Skullcapflavone I ALOX12 0.71Skullcapflavone I AKR1C3 0.72Skullcapflavone I FASN 0.71Skullcapflavone I ACHE 0.7Skullcapflavone I ADORA1 0.81Skullcapflavone I ADORA3 0.78Skullcapflavone I ADORA2A 0.78Skullcapflavone I AKR1B1 0.89Skullcapflavone I AKR1B1 0.7Skullcapflavone I AKR1B1 0.73Skullcapflavone I GAA 0.7Skullcapflavone I MAOA 0.78Skullcapflavone I MAOA 0.73Skullcapflavone I DHTR 0.71Skullcapflavone I ALOX12 0.74Skullcapflavone I ALOX15 0.74Skullcapflavone I ALOX15 0.74Skullcapflavone I ALOX5 0.74Skullcapflavone I AHR 0.76Skullcapflavone I ABCG2 0.73Skullcapflavone I AURKB 0.73Skullcapflavone I NTRK2 0.79Skullcapflavone I CA12 0.74Skullcapflavone I CA2 0.74Skullcapflavone I CA4 0.71Skullcapflavone I CA7 0.74Skullcapflavone I CBR1 0.73Skullcapflavone I CSNK2A1 0.72Skullcapflavone I CISD1 0.76Skullcapflavone I BCHE 0.7
Skullcapflavone I CDK1 0.73Skullcapflavone I CDK1 0.71Skullcapflavone I CDK5 0.71Skullcapflavone I CDK6 0.71Skullcapflavone I PTGS1 0.71Skullcapflavone I CFTR 0.72Skullcapflavone I CYP19A1 0.72Skullcapflavone I CYP1A1 0.72Skullcapflavone I CYP1A1 0.76Skullcapflavone I CYP2C9 0.74Skullcapflavone I gyrB 0.7Skullcapflavone I TOP1 0.71Skullcapflavone I Nt5e 0.73Skullcapflavone I ELAVL3 0.73Skullcapflavone I INHA 0.73Skullcapflavone I EGFR 0.7Skullcapflavone I HSD17B1 0.72Skullcapflavone I HSD17B2 0.76Skullcapflavone I ESR 0.72Skullcapflavone I GSK3B 0.71Skullcapflavone I GLO1 0.73Skullcapflavone I HGF 0.73Skullcapflavone I GAG-POL 0.75Skullcapflavone I IGF1R 0.73Skullcapflavone I PSIP1 0.73Skullcapflavone I DNPEP 0.73Skullcapflavone I KIT 0.76Skullcapflavone I MMP12 0.71Skullcapflavone I MAOA 0.73Skullcapflavone I OPRM1 0.89Skullcapflavone I NOX4 0.73Skullcapflavone I NR0B1 0.76Skullcapflavone I ABCB5 0.71Skullcapflavone I ABCB1 0.74Skullcapflavone I PIK3CG 0.73Skullcapflavone I PDE5A 0.7Skullcapflavone I E6AP 0.73Skullcapflavone I NEU1 0.78Skullcapflavone I SYN1 0.7Skullcapflavone I SI 0.74Skullcapflavone I SYN1 0.75Skullcapflavone I TERT 0.76Skullcapflavone I F10 0.7Skullcapflavone I TTR 0.72Skullcapflavone I TYR 0.76Skullcapflavone I LCK 0.7Skullcapflavone I FLT3 0.71Skullcapflavone I UFO 0.73Skullcapflavone I XDH 0.8Skullcapflavone I XDH 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone ALOX12 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone FASN 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone ACHE 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ADORA1 0.78
5-hydroxy-7,8,2',5'- tetramethoxyflavone ADORA3 0.745-hydroxy-7,8,2',5'- tetramethoxyflavone ADORA2A 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone AKR1B1 0.885-hydroxy-7,8,2',5'- tetramethoxyflavone AKR1B1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone AKR1B1 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone GAA 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone MAOA 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone MAOA 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ALOX12 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ALOX15 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ALOX15 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ALOX5 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone AHR 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ABCG2 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone AURKB 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone NTRK2 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone CA12 0.775-hydroxy-7,8,2',5'- tetramethoxyflavone CA2 0.775-hydroxy-7,8,2',5'- tetramethoxyflavone CA4 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone CA7 0.775-hydroxy-7,8,2',5'- tetramethoxyflavone CBR1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone CISD1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone CDK1 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone CDK1 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone CDK5 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone CDK6 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone PTGS1 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone CYP19A1 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone CYP1A1 0.765-hydroxy-7,8,2',5'- tetramethoxyflavone CYP1A1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone CYP2C9 0.775-hydroxy-7,8,2',5'- tetramethoxyflavone gyrB 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone TOP1 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone Nt5e 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone ELAVL3 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone INHA 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone EGFR 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone HSD17B2 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone GSK3B 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone GLO1 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone HGF 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone GAG-POL 0.745-hydroxy-7,8,2',5'- tetramethoxyflavone IGF1R 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone PSIP1 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone DNPEP 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone KIT 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone MMP12 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone MAOA 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone OPRM1 0.815-hydroxy-7,8,2',5'- tetramethoxyflavone NOX4 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone NR0B1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone ABCB1 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone PIK3CG 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone E6AP 0.73
5-hydroxy-7,8,2',5'- tetramethoxyflavone NEU1 0.775-hydroxy-7,8,2',5'- tetramethoxyflavone SI 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone SYN1 0.745-hydroxy-7,8,2',5'- tetramethoxyflavone TERT 0.765-hydroxy-7,8,2',5'- tetramethoxyflavone F10 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone TTR 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone TYR 0.765-hydroxy-7,8,2',5'- tetramethoxyflavone LCK 0.75-hydroxy-7,8,2',5'- tetramethoxyflavone FLT3 0.715-hydroxy-7,8,2',5'- tetramethoxyflavone UFO 0.735-hydroxy-7,8,2',5'- tetramethoxyflavone XDH 0.765-hydroxy-7,8,2',5'- tetramethoxyflavone XDH 0.715,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ALOX12 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone FASN 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ACHE 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ADORA1 0.765,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ADORA3 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ADORA2A 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone AKR1B1 0.95,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone AKR1B1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone AKR1B1 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone GAA 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone MAOA 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone MAOB 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ALOX12 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ALOX15 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ALOX15 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ALOX5 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone AHR 0.725,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ABCG2 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone AURKB 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone NTRK2 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CA12 0.795,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CA2 0.795,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CA4 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CA7 0.795,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CSNK2A1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CISD1 0.725,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone BCHE 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CDK1 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CDK1 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CDK5 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CDK6 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone PTGS1 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CFTR 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CYP19A1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CYP1A1 0.785,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CYP1A1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone CYP2C9 0.795,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone gyrB 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone TOP1 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone Nt5e 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ELAVL3 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone INHA 0.75
5,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone EGFR 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone HSD17B1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone HSD17B2 0.725,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ESR 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone GSK3B 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone GLO1 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone HGF 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone GAG-POL 0.775,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone IGF1R 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone PSIP1 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone DNPEP 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone KIT 0.715,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone MMP12 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone MAOA 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone OPRM1 0.835,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone NOX4 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone NR0B1 0.725,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone ABCB1 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone PIK3CG 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone PDE5A 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone E6AP 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone NEU1 0.795,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone SI 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone SYN1 0.775,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone TERT 0.785,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone F10 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone TTR 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone TYR 0.785,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone LCK 0.75,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone FLT3 0.735,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone UFO 0.755,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone XDH 0.785,4'-dihydroxy-7,8,2',3'- tetramethoxyflavone XDH 0.73Andrographidine A CA12 0.7Andrographidine A CA4 0.7Andrographidine A CA7 0.7Andrographidine A CYP2C9 0.7Andrographidine A HSP90 0.7Andrographidine A SGLT2 0.73Andrographidine A SLCO2B1 0.7Andrographidine C ACHE 0.7Andrographidine C ALDH2 0.7Andrographidine C AKR1B1 0.7Andrographidine C AKR1B1 0.7Andrographidine C ADRA2A 0.7Andrographidine C ALOX5 0.7Andrographidine C CA12 0.7Andrographidine C CA2 0.7Andrographidine C CA4 0.7Andrographidine C CA7 0.7Andrographidine C PDE5A 0.7Andrographidine C CHRM5 0.7Andrographidine C CYP3A 0.7Andrographidine C EGFR 0.71
Andrographidine C IL2RA 0.7Andrographidine C ALPI 0.7Andrographidine C NOX4 0.7Andrographidine C HPA 0.7Andrographidine C PTPN1 0.72Andrographidine C RPS6KA3 0.7Andrographidine C F10 0.74Andrographidine C TNF 0.83
GO ID Molecular function Gene count FDR Gene IDsGO:0004672 protein kinase activity 12 4.94E-13 AKT1, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCGGO:0016772 transferase activity, transferring phosphorus-containing groups 13 6.78E-13 AKT1, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TERT
GO:0004674 protein serine/threonine kinase activity 10 1.15E-11 AKT1, CDK1, CDK2, CDK6, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCGGO:0005524 ATP binding 11 3.69E-08 AKT1, CDK1, CDK2, CDK6, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCGGO:0004698 calcium-dependent protein kinase C activity 3 2.41E-07 PRKCA, PRKCB, PRKCGGO:1901363 heterocyclic compound binding 15 4.49E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0004712 protein serine/threonine/tyrosine kinase activity 4 5.23E-07 AKT1, MAP2K1, MAPK1, PRKCGGO:0097159 organic cyclic compound binding 15 5.23E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0019902 phosphatase binding 5 1.69E-06 AKT1, BCL2, EGFR, MAPK1, STAT3GO:0035173 histone kinase activity 3 3.19E-06 CDK1, PRKCA, PRKCBGO:0005515 protein binding 15 6.21E-06 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3,
TERT, TNFGO:0042802 identical protein binding 9 1.57E-05 AKT1, BCL2, EGFR, HGF, IGF1R, MAPK1, STAT3, TERT, TNFGO:0019903 protein phosphatase binding 4 1.80E-05 AKT1, BCL2, EGFR, STAT3GO:0030332 cyclin binding 3 1.80E-05 CDK1, CDK2, CDK6GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3 1.85E-05 CDK1, CDK2, CDK6GO:0035403 histone kinase activity (H3-T6 specific) 2 2.08E-05 PRKCA, PRKCBGO:0004713 protein tyrosine kinase activity 4 6.80E-05 EGFR, HGF, IGF1R, MAP2K1GO:0019899 enzyme binding 9 8.25E-05 AKT1, BCL2, EGFR, HGF, MAPK1, PRKCA, PRKCB, STAT3, TNFGO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2 0.00014 CDK1, MAPK1GO:0004708 MAP kinase kinase activity 2 0.0004 MAP2K1, MAPK1GO:0019901 protein kinase binding 5 0.00042 AKT1, EGFR, MAPK1, PRKCB, STAT3GO:0008134 transcription factor binding 5 0.00045 BCL2, MAPK1, PRKCB, STAT3, TERTGO:0005102 signaling receptor binding 7 0.00046 EGFR, HGF, IGF1R, PRKCA, PRKCB, STAT3, TNFGO:0051721 protein phosphatase 2A binding 2 0.0012 AKT1, BCL2GO:0005488 binding 16 0.0014 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0043167 ion binding 12 0.0015 AKT1, CDK1, CDK2, CDK6, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TERT
GO:0046983 protein dimerization activity 6 0.0016 AKT1, BCL2, EGFR, HGF, STAT3, TERTGO:0003682 chromatin binding 4 0.0024 CDK1, EGFR, PRKCB, STAT3GO:0005080 protein kinase C binding 2 0.003 AKT1, PRKCBGO:0060089 molecular transducer activity 6 0.003 CDK1, CDK2, CDK6, EGFR, IGF1R, STAT3GO:0004714 transmembrane receptor protein tyrosine kinase activity 2 0.0044 EGFR, IGF1RGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 2 0.0053 EGFR, HGFGO:0001618 virus receptor activity 2 0.0062 CDK1, EGFRGO:0098772 molecular function regulator 6 0.007 AKT1, BCL2, EGFR, HGF, MAP2K1, TNFGO:0035258 steroid hormone receptor binding 2 0.0081 PRKCB, STAT3GO:0042562 hormone binding 2 0.0081 EGFR, IGF1RGO:0047485 protein N-terminus binding 2 0.0113 MAP2K1, TERTGO:0016922 nuclear receptor binding 2 0.0116 PRKCB, STAT3GO:0042803 protein homodimerization activity 4 0.012 AKT1, BCL2, STAT3, TERTGO:0005178 integrin binding 2 0.0134 EGFR, PRKCAGO:0019838 growth factor binding 2 0.0141 EGFR, IGF1RGO:0002020 protease binding 2 0.0158 BCL2, TNFGO:0046982 protein heterodimerization activity 3 0.0229 BCL2, EGFR, HGFGO:0003677 DNA binding 6 0.0281 BCL2, EGFR, MAPK1, STAT3, TERT, TNFGO:0008022 protein C-terminus binding 2 0.0295 MAP2K1, TERTGO:0005088 Ras guanyl-nucleotide exchange factor activity 2 0.0439 EGFR, HGF
SS5: Gene Ontology (GO) functional enrichment analysis: Regulated molecular functions of 16 protein targets modulated by the phytocompounds
Abbreviations: GO Gene Ontology; FDR False discovery rate16 protein targets associated with HBV infection and HCC modulates 46 molecular functions
GO ID Molecular process Gene count FDR Gene IDsGO:0006468 protein phosphorylation 14 3.75E-14 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
TNFGO:0016310 phosphorylation 15 3.75E-14 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TNFGO:0008284 positive regulation of cell population proliferation 13 1.21E-12 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAPK1, PRKCA, STAT3, TERT, TNFGO:0035556 intracellular signal transduction 14 1.90E-11 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3,
TNFGO:0018193 peptidyl-amino acid modification 12 1.97E-11 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCGGO:0042127 regulation of cell population proliferation 14 1.97E-11 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, STAT3, TERT,
TNFGO:0018107 peptidyl-threonine phosphorylation 7 7.35E-11 AKT1, BCL2, CDK1, MAP2K1, MAPK1, PRKCA, PRKCBGO:0018105 peptidyl-serine phosphorylation 8 1.16E-10 AKT1, BCL2, CDK1, CDK2, MAPK1, PRKCA, PRKCB, PRKCGGO:0032879 regulation of localization 15 1.24E-10 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3,
TERT, TNFGO:2000145 regulation of cell motility 11 3.65E-10 AKT1, BCL2, CDK6, EGFR, HGF, IGF1R, MAPK1, PRKCA, STAT3, TERT, TNFGO:0043066 negative regulation of apoptotic process 11 6.64E-10 AKT1, BCL2, CDK1, EGFR, HGF, IGF1R, PRKCA, PRKCG, STAT3, TERT, TNFGO:0007346 regulation of mitotic cell cycle 10 7.69E-10 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, MAP2K1, PRKCA, TERT, TNFGO:0045595 regulation of cell differentiation 13 7.69E-10 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT, TNF
GO:0048583 regulation of response to stimulus 16 7.69E-10 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNF
GO:0080135 regulation of cellular response to stress 10 7.69E-10 AKT1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCG, TERT, TNFGO:0031399 regulation of protein modification process 13 1.01E-09 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCG, STAT3, TNF
GO:1902531 regulation of intracellular signal transduction 13 1.09E-09 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TNF
GO:1902533 positive regulation of intracellular signal transduction 11 1.25E-09 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TNFGO:2000045 regulation of G1/S transition of mitotic cell cycle 7 1.52E-09 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, TERTGO:0001932 regulation of protein phosphorylation 12 1.62E-09 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, STAT3, TNFGO:0030335 positive regulation of cell migration 9 1.62E-09 AKT1, BCL2, EGFR, HGF, IGF1R, MAPK1, PRKCA, TERT, TNFGO:0071900 regulation of protein serine/threonine kinase activity 9 2.69E-09 AKT1, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, TNFGO:0030334 regulation of cell migration 10 3.15E-09 AKT1, BCL2, EGFR, HGF, IGF1R, MAPK1, PRKCA, STAT3, TERT, TNFGO:0048523 negative regulation of cellular process 16 3.22E-09 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0009967 positive regulation of signal transduction 12 3.26E-09 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT, TNFGO:0042981 regulation of apoptotic process 12 3.38E-09 AKT1, BCL2, CDK1, EGFR, HGF, IGF1R, MAP2K1, PRKCA, PRKCG, STAT3, TERT, TNFGO:0048584 positive regulation of response to stimulus 13 4.38E-09 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNF
GO:0051726 regulation of cell cycle 11 4.41E-09 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, MAP2K1, PRKCA, STAT3, TERT, TNFGO:0032872 regulation of stress-activated MAPK cascade 7 8.92E-09 AKT1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, TNFGO:0051054 positive regulation of DNA metabolic process 7 8.92E-09 AKT1, CDK1, CDK2, EGFR, HGF, MAPK1, PRKCGGO:0048522 positive regulation of cellular process 16 1.06E-08 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0051173 positive regulation of nitrogen compound metabolic process 14 1.21E-08 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT,
TNFGO:0080134 regulation of response to stress 11 1.48E-08 AKT1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCG, TERT, TNFGO:0045935 positive regulation of nucleobase-containing compound metabolic process12 1.57E-08 AKT1, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, PRKCG, STAT3, TERT, TNFGO:0001934 positive regulation of protein phosphorylation 10 1.61E-08 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, STAT3, TNFGO:0009966 regulation of signal transduction 14 1.61E-08 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT,
TNFGO:0048708 astrocyte differentiation 5 1.61E-08 CDK6, EGFR, MAP2K1, MAPK1, STAT3GO:0031325 positive regulation of cellular metabolic process 14 1.73E-08 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT,
TNFGO:0010604 positive regulation of macromolecule metabolic process 14 1.87E-08 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT,
TNFGO:0008283 cell population proliferation 9 2.35E-08 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, STAT3, TNFGO:1901698 response to nitrogen compound 10 2.35E-08 AKT1, CDK1, CDK2, EGFR, IGF1R, MAPK1, PRKCG, STAT3, TERT, TNFGO:2000026 regulation of multicellular organismal development 12 2.62E-08 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, PRKCA, PRKCB, STAT3, TERT, TNFGO:0048699 generation of neurons 11 3.08E-08 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, STAT3, TERTGO:0046686 response to cadmium ion 5 3.32E-08 AKT1, CDK1, EGFR, MAPK1, TERTGO:0043408 regulation of MAPK cascade 9 3.34E-08 AKT1, CDK1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, TNFGO:0009895 negative regulation of catabolic process 7 3.65E-08 AKT1, BCL2, EGFR, HGF, PRKCG, STAT3, TNFGO:1903829 positive regulation of cellular protein localization 7 4.62E-08 AKT1, BCL2, CDK1, EGFR, MAPK1, TERT, TNFGO:0010001 glial cell differentiation 6 5.53E-08 AKT1, CDK6, EGFR, MAP2K1, MAPK1, STAT3GO:0051240 positive regulation of multicellular organismal process 11 6.42E-08 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, PRKCA, PRKCB, STAT3, TERT, TNFGO:0051239 regulation of multicellular organismal process 13 9.64E-08 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT, TNF
GO:0051171 regulation of nitrogen compound metabolic process 16 9.89E-08 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNF
GO:0010033 response to organic substance 13 1.06E-07 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAPK1, PRKCA, PRKCG, STAT3, TERT, TNF
GO:0043405 regulation of MAP kinase activity 7 1.19E-07 CDK1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, TNFGO:0007399 nervous system development 12 1.23E-07 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCG, STAT3, TERTGO:0071902 positive regulation of protein serine/threonine kinase activity 7 1.23E-07 AKT1, CDK1, EGFR, HGF, MAP2K1, MAPK1, TNFGO:1901699 cellular response to nitrogen compound 8 1.31E-07 AKT1, CDK2, EGFR, IGF1R, MAPK1, STAT3, TERT, TNFGO:0032147 activation of protein kinase activity 7 1.38E-07 AKT1, CDK1, EGFR, HGF, MAP2K1, MAPK1, TNFGO:0080090 regulation of primary metabolic process 16 1.38E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0014070 response to organic cyclic compound 9 1.44E-07 AKT1, BCL2, CDK1, EGFR, MAPK1, PRKCG, STAT3, TERT, TNFGO:0050790 regulation of catalytic activity 12 1.44E-07 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, STAT3, TERT, TNFGO:0000302 response to reactive oxygen species 6 1.47E-07 AKT1, BCL2, CDK1, CDK2, EGFR, MAPK1GO:0044093 positive regulation of molecular function 11 1.51E-07 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0007165 signal transduction 15 1.58E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TNFGO:0060255 regulation of macromolecule metabolic process 16 1.62E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0031323 regulation of cellular metabolic process 16 1.64E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0051049 regulation of transport 11 1.64E-07 AKT1, BCL2, CDK1, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TERT, TNFGO:0051094 positive regulation of developmental process 10 1.79E-07 AKT1, BCL2, CDK1, HGF, MAP2K1, PRKCA, PRKCB, STAT3, TERT, TNFGO:0010557 positive regulation of macromolecule biosynthetic process 11 1.85E-07 AKT1, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0016572 histone phosphorylation 4 2.14E-07 CDK1, CDK2, PRKCA, PRKCBGO:0051716 cellular response to stimulus 16 2.18E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0048732 gland development 7 2.79E-07 AKT1, BCL2, EGFR, HGF, MAP2K1, MAPK1, TNFGO:0031328 positive regulation of cellular biosynthetic process 11 2.91E-07 AKT1, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0034599 cellular response to oxidative stress 6 3.24E-07 AKT1, BCL2, CDK1, CDK2, EGFR, MAPK1
SS6: GO process enrichment analysis: Molecular processes of 16 protein targets modulated by the phytocompounds
Abbreviations: GO Gene Ontology; FDR False discovery rate16 protein targets associated with HBV infection and HCC modulates 599 molecular processes
GO:0043085 positive regulation of catalytic activity 10 3.24E-07 AKT1, BCL2, CDK1, EGFR, HGF, MAP2K1, MAPK1, STAT3, TERT, TNFGO:0044260 cellular macromolecule metabolic process 16 3.36E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0060968 regulation of gene silencing 5 3.57E-07 CDK2, EGFR, MAP2K1, STAT3, TERTGO:2001237 negative regulation of extrinsic apoptotic signaling pathway 5 3.71E-07 AKT1, BCL2, HGF, TERT, TNFGO:0032501 multicellular organismal process 16 4.09E-07 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0006950 response to stress 13 4.80E-07 AKT1, BCL2, CDK1, CDK2, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNF
GO:0042221 response to chemical 14 5.20E-07 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCG, STAT3, TERT, TNF
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand4 5.20E-07 AKT1, BCL2, TERT, TNFGO:0065009 regulation of molecular function 13 5.69E-07 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNF
GO:0007568 aging 6 6.33E-07 AKT1, BCL2, CDK1, MAP2K1, STAT3, TERTGO:1903508 positive regulation of nucleic acid-templated transcription 10 7.06E-07 AKT1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0043406 positive regulation of MAP kinase activity 6 7.51E-07 CDK1, EGFR, HGF, MAP2K1, MAPK1, TNFGO:0034614 cellular response to reactive oxygen species 5 7.61E-07 AKT1, CDK1, CDK2, EGFR, MAPK1GO:0060341 regulation of cellular localization 8 8.91E-07 AKT1, BCL2, CDK1, EGFR, MAP2K1, MAPK1, TERT, TNFGO:0010035 response to inorganic substance 7 9.81E-07 AKT1, BCL2, CDK1, CDK2, EGFR, MAPK1, TERTGO:0009892 negative regulation of metabolic process 12 1.04E-06 AKT1, BCL2, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, PRKCG, STAT3, TERT, TNFGO:0051254 positive regulation of RNA metabolic process 10 1.05E-06 AKT1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway7 1.06E-06 AKT1, EGFR, HGF, IGF1R, MAPK1, PRKCA, STAT3GO:0033135 regulation of peptidyl-serine phosphorylation 5 1.13E-06 AKT1, BCL2, EGFR, HGF, TNFGO:0043410 positive regulation of MAPK cascade 7 1.25E-06 CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, TNFGO:0045786 negative regulation of cell cycle 7 1.31E-06 BCL2, CDK1, CDK2, CDK6, EGFR, MAP2K1, TNFGO:0010468 regulation of gene expression 14 1.42E-06 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT,
TNFGO:0009894 regulation of catabolic process 8 1.66E-06 AKT1, BCL2, EGFR, HGF, PRKCA, PRKCG, STAT3, TNFGO:0000187 activation of MAPK activity 5 1.68E-06 CDK1, HGF, MAP2K1, MAPK1, TNFGO:0050678 regulation of epithelial cell proliferation 6 1.73E-06 AKT1, CDK6, EGFR, PRKCA, STAT3, TNFGO:0060284 regulation of cell development 8 1.73E-06 AKT1, BCL2, CDK1, HGF, MAP2K1, STAT3, TERT, TNFGO:0009611 response to wounding 7 1.84E-06 BCL2, CDK1, EGFR, MAPK1, PRKCA, PRKCB, PRKCGGO:0032768 regulation of monooxygenase activity 4 2.00E-06 AKT1, EGFR, TERT, TNFGO:0010243 response to organonitrogen compound 8 2.18E-06 AKT1, CDK1, EGFR, IGF1R, MAPK1, PRKCG, STAT3, TNFGO:0007275 multicellular organism development 14 2.34E-06 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCG, STAT3, TERT,
TNFGO:0045766 positive regulation of angiogenesis 5 2.37E-06 HGF, PRKCA, PRKCB, STAT3, TERTGO:1901701 cellular response to oxygen-containing compound 8 2.54E-06 AKT1, CDK1, CDK2, EGFR, IGF1R, MAPK1, STAT3, TNFGO:0042493 response to drug 8 2.61E-06 BCL2, CDK1, CDK2, EGFR, MAPK1, PRKCG, STAT3, TNFGO:0032880 regulation of protein localization 8 2.62E-06 AKT1, BCL2, CDK1, EGFR, MAPK1, PRKCA, TERT, TNFGO:0010038 response to metal ion 6 2.66E-06 AKT1, BCL2, CDK1, EGFR, MAPK1, TERTGO:0007077 mitotic nuclear envelope disassembly 3 2.69E-06 CDK1, PRKCA, PRKCBGO:0045597 positive regulation of cell differentiation 8 2.71E-06 AKT1, BCL2, HGF, MAP2K1, PRKCA, STAT3, TERT, TNFGO:2000377 regulation of reactive oxygen species metabolic process 5 2.78E-06 AKT1, BCL2, EGFR, STAT3, TNFGO:0010628 positive regulation of gene expression 10 3.16E-06 AKT1, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, STAT3, TERT, TNFGO:0007569 cell aging 4 3.43E-06 BCL2, CDK1, MAP2K1, TERTGO:0030278 regulation of ossification 5 3.78E-06 BCL2, CDK6, HGF, MAPK1, TNFGO:1900182 positive regulation of protein localization to nucleus 4 3.99E-06 AKT1, CDK1, MAPK1, TERTGO:0022603 regulation of anatomical structure morphogenesis 8 4.00E-06 BCL2, HGF, MAP2K1, PRKCA, PRKCB, STAT3, TERT, TNFGO:0045787 positive regulation of cell cycle 6 4.49E-06 AKT1, CDK1, CDK2, EGFR, PRKCA, TERTGO:0038127 ERBB signaling pathway 4 4.57E-06 AKT1, EGFR, MAPK1, PRKCAGO:1901215 negative regulation of neuron death 5 4.71E-06 AKT1, BCL2, PRKCG, STAT3, TERTGO:1901700 response to oxygen-containing compound 9 5.24E-06 AKT1, BCL2, CDK1, CDK2, EGFR, IGF1R, MAPK1, STAT3, TNFGO:0010605 negative regulation of macromolecule metabolic process 11 5.38E-06 AKT1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, PRKCG, STAT3, TERT, TNFGO:0045893 positive regulation of transcription, DNA-templated 9 5.38E-06 AKT1, CDK2, EGFR, HGF, MAP2K1, MAPK1, STAT3, TERT, TNFGO:0019219 regulation of nucleobase-containing compound metabolic process13 5.83E-06 AKT1, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNF
GO:0070920 regulation of production of small RNA involved in gene silencing by RNA3 5.95E-06 EGFR, MAP2K1, TERTGO:0048731 system development 13 5.96E-06 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCG, STAT3, TERT, TNF
GO:0048661 positive regulation of smooth muscle cell proliferation 4 6.42E-06 AKT1, EGFR, TERT, TNFGO:0045596 negative regulation of cell differentiation 7 6.57E-06 BCL2, CDK6, EGFR, MAPK1, STAT3, TERT, TNFGO:0060147 regulation of posttranscriptional gene silencing 4 6.63E-06 EGFR, MAP2K1, STAT3, TERTGO:0060966 regulation of gene silencing by RNA 4 6.63E-06 EGFR, MAP2K1, STAT3, TERTGO:0048585 negative regulation of response to stimulus 9 6.71E-06 AKT1, BCL2, CDK6, EGFR, HGF, IGF1R, PRKCB, TERT, TNFGO:0010827 regulation of glucose transmembrane transport 4 7.47E-06 AKT1, PRKCB, TERT, TNFGO:0070887 cellular response to chemical stimulus 11 7.87E-06 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAPK1, STAT3, TERT, TNFGO:0001892 embryonic placenta development 4 8.06E-06 AKT1, EGFR, MAP2K1, MAPK1GO:0051248 negative regulation of protein metabolic process 8 8.12E-06 AKT1, CDK6, EGFR, HGF, IGF1R, PRKCG, STAT3, TNFGO:0030154 cell differentiation 12 9.17E-06 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, STAT3, TERT, TNFGO:0033554 cellular response to stress 9 9.47E-06 AKT1, BCL2, CDK1, CDK2, EGFR, MAP2K1, MAPK1, TERT, TNFGO:0061024 membrane organization 7 9.47E-06 AKT1, BCL2, CDK1, EGFR, PRKCA, PRKCB, STAT3GO:0050767 regulation of neurogenesis 7 9.50E-06 AKT1, BCL2, CDK1, HGF, MAP2K1, STAT3, TERTGO:2000637 positive regulation of gene silencing by miRNA 3 9.59E-06 EGFR, MAP2K1, STAT3GO:0010608 posttranscriptional regulation of gene expression 6 9.61E-06 AKT1, MAPK1, PRKCA, STAT3, TERT, TNFGO:0031329 regulation of cellular catabolic process 7 1.05E-05 AKT1, BCL2, HGF, PRKCA, PRKCG, STAT3, TNFGO:0031330 negative regulation of cellular catabolic process 5 1.06E-05 AKT1, BCL2, HGF, PRKCG, STAT3GO:0006807 nitrogen compound metabolic process 16 1.26E-05 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0045930 negative regulation of mitotic cell cycle 5 1.26E-05 BCL2, CDK1, CDK2, EGFR, TNFGO:0009968 negative regulation of signal transduction 8 1.34E-05 AKT1, BCL2, EGFR, HGF, IGF1R, PRKCB, TERT, TNFGO:0007166 cell surface receptor signaling pathway 10 1.39E-05 AKT1, BCL2, EGFR, HGF, IGF1R, MAPK1, PRKCA, PRKCB, STAT3, TNFGO:0045637 regulation of myeloid cell differentiation 5 1.39E-05 CDK6, PRKCA, PRKCB, STAT3, TNFGO:0033138 positive regulation of peptidyl-serine phosphorylation 4 1.57E-05 AKT1, BCL2, EGFR, TNFGO:0071417 cellular response to organonitrogen compound 6 1.57E-05 AKT1, EGFR, IGF1R, MAPK1, STAT3, TNFGO:0032770 positive regulation of monooxygenase activity 3 1.79E-05 AKT1, TERT, TNFGO:0071407 cellular response to organic cyclic compound 6 1.94E-05 AKT1, EGFR, MAPK1, STAT3, TERT, TNFGO:0051172 negative regulation of nitrogen compound metabolic process 10 2.11E-05 AKT1, CDK2, CDK6, EGFR, HGF, IGF1R, PRKCG, STAT3, TERT, TNFGO:0007049 cell cycle 8 2.39E-05 CDK1, CDK2, CDK6, HGF, MAP2K1, MAPK1, PRKCA, PRKCBGO:0007417 central nervous system development 7 2.52E-05 AKT1, BCL2, CDK6, EGFR, MAP2K1, MAPK1, STAT3GO:0030168 platelet activation 4 2.52E-05 MAPK1, PRKCA, PRKCB, PRKCGGO:0031663 lipopolysaccharide-mediated signaling pathway 3 2.52E-05 AKT1, MAPK1, TNFGO:0035270 endocrine system development 4 2.52E-05 AKT1, CDK6, MAP2K1, MAPK1GO:0060674 placenta blood vessel development 3 2.52E-05 AKT1, MAP2K1, MAPK1GO:0071276 cellular response to cadmium ion 3 2.52E-05 AKT1, EGFR, MAPK1GO:0001936 regulation of endothelial cell proliferation 4 2.61E-05 AKT1, PRKCA, STAT3, TNFGO:0044238 primary metabolic process 16 2.65E-05 AKT1, BCL2, CDK1, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TERT, TNFGO:0002684 positive regulation of immune system process 7 2.85E-05 AKT1, BCL2, MAPK1, PRKCA, PRKCB, STAT3, TNFGO:0051050 positive regulation of transport 7 3.05E-05 AKT1, BCL2, CDK1, EGFR, MAPK1, TERT, TNFGO:0050853 B cell receptor signaling pathway 3 3.11E-05 BCL2, MAPK1, PRKCB
GO:0062013 positive regulation of small molecule metabolic process 4 3.15E-05 AKT1, CDK1, STAT3, TNFGO:0045936 negative regulation of phosphate metabolic process 6 3.27E-05 AKT1, CDK6, HGF, IGF1R, STAT3, TNFGO:0045740 positive regulation of DNA replication 3 3.31E-05 CDK1, CDK2, EGFRGO:0035408 histone H3-T6 phosphorylation 2 3.33E-05 PRKCA, PRKCBGO:0009605 response to external stimulus 9 3.44E-05 AKT1, BCL2, CDK6, EGFR, HGF, MAP2K1, MAPK1, PRKCA, TNFGO:0006915 apoptotic process 7 3.45E-05 AKT1, BCL2, CDK1, MAPK1, PRKCA, PRKCB, TNFGO:0031324 negative regulation of cellular metabolic process 10 3.45E-05 AKT1, BCL2, CDK2, CDK6, HGF, IGF1R, PRKCG, STAT3, TERT, TNFGO:0035690 cellular response to drug 5 3.45E-05 CDK1, CDK2, EGFR, MAPK1, TNFGO:0022414 reproductive process 8 3.53E-05 AKT1, BCL2, CDK1, CDK2, EGFR, MAP2K1, MAPK1, STAT3GO:0000165 MAPK cascade 5 4.13E-05 EGFR, HGF, MAP2K1, MAPK1, TNFGO:0031400 negative regulation of protein modification process 6 4.18E-05 AKT1, CDK6, HGF, IGF1R, PRKCG, TNFGO:2000112 regulation of cellular macromolecule biosynthetic process 12 4.18E-05 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0002682 regulation of immune system process 8 4.33E-05 AKT1, BCL2, CDK6, MAPK1, PRKCA, PRKCB, STAT3, TNFGO:0031099 regeneration 4 5.34E-05 BCL2, CDK1, EGFR, HGFGO:0000278 mitotic cell cycle 6 5.70E-05 CDK1, CDK2, CDK6, HGF, PRKCA, PRKCBGO:0048538 thymus development 3 5.88E-05 BCL2, MAP2K1, MAPK1GO:0070849 response to epidermal growth factor 3 5.88E-05 AKT1, EGFR, MAPK1GO:0016043 cellular component organization 13 6.03E-05 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, IGF1R, MAPK1, PRKCA, PRKCB, STAT3, TERT, TNF
GO:0050999 regulation of nitric-oxide synthase activity 3 6.20E-05 AKT1, EGFR, TERTGO:0032269 negative regulation of cellular protein metabolic process 7 6.33E-05 AKT1, CDK6, HGF, IGF1R, PRKCG, STAT3, TNFGO:0001775 cell activation 7 6.72E-05 BCL2, EGFR, MAPK1, PRKCA, PRKCB, PRKCG, STAT3GO:0060711 labyrinthine layer development 3 6.94E-05 AKT1, MAP2K1, MAPK1GO:0034097 response to cytokine 7 7.13E-05 AKT1, BCL2, HGF, MAPK1, PRKCA, STAT3, TNFGO:0070201 regulation of establishment of protein localization 6 7.38E-05 BCL2, CDK1, EGFR, MAPK1, PRKCA, TNFGO:0040008 regulation of growth 6 7.40E-05 AKT1, BCL2, CDK1, EGFR, STAT3, TNFGO:0090170 regulation of Golgi inheritance 2 7.43E-05 MAP2K1, MAPK1GO:0035094 response to nicotine 3 7.63E-05 BCL2, MAPK1, TNFGO:0008285 negative regulation of cell population proliferation 6 7.70E-05 BCL2, CDK6, MAP2K1, STAT3, TERT, TNFGO:0046328 regulation of JNK cascade 4 7.73E-05 AKT1, EGFR, IGF1R, TNFGO:0060429 epithelium development 7 7.85E-05 AKT1, BCL2, CDK1, CDK6, EGFR, MAP2K1, MAPK1GO:0030030 cell projection organization 7 8.35E-05 AKT1, BCL2, CDK1, EGFR, IGF1R, MAPK1, PRKCAGO:0050679 positive regulation of epithelial cell proliferation 4 9.13E-05 AKT1, EGFR, PRKCA, STAT3GO:0065008 regulation of biological quality 11 9.71E-05 AKT1, BCL2, CDK6, EGFR, MAPK1, PRKCA, PRKCB, PRKCG, STAT3, TERT, TNFGO:1904951 positive regulation of establishment of protein localization 5 9.71E-05 BCL2, CDK1, EGFR, MAPK1, TNFGO:0051241 negative regulation of multicellular organismal process 7 9.78E-05 BCL2, CDK6, EGFR, HGF, STAT3, TERT, TNFGO:0071241 cellular response to inorganic substance 4 0.0001 AKT1, CDK2, EGFR, MAPK1GO:0048608 reproductive structure development 5 0.00011 AKT1, BCL2, EGFR, MAP2K1, MAPK1GO:0009888 tissue development 8 0.00012 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1GO:0018108 peptidyl-tyrosine phosphorylation 4 0.00012 EGFR, HGF, IGF1R, MAP2K1GO:0032101 regulation of response to external stimulus 6 0.00012 EGFR, HGF, MAP2K1, PRKCA, PRKCG, TNFGO:0040011 locomotion 7 0.00012 CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, TNFGO:0048568 embryonic organ development 5 0.00012 AKT1, EGFR, MAP2K1, MAPK1, TNFGO:0071310 cellular response to organic substance 9 0.00012 AKT1, BCL2, EGFR, HGF, IGF1R, MAPK1, STAT3, TERT, TNFGO:0006974 cellular response to DNA damage stimulus 6 0.00013 AKT1, BCL2, CDK1, CDK2, MAPK1, TNFGO:0046777 protein autophosphorylation 4 0.00013 AKT1, EGFR, IGF1R, PRKCGGO:0048513 animal organ development 10 0.00013 AKT1, BCL2, CDK1, CDK6, EGFR, HGF, MAP2K1, MAPK1, STAT3, TNFGO:0060440 trachea formation 2 0.00013 MAP2K1, MAPK1GO:0070141 response to UV-A 2 0.00013 AKT1, EGFRGO:0070374 positive regulation of ERK1 and ERK2 cascade 4 0.00013 EGFR, MAP2K1, PRKCA, TNFGO:0051896 regulation of protein kinase B signaling 4 0.00014 AKT1, EGFR, HGF, TNFGO:0046324 regulation of glucose import 3 0.00016 AKT1, TERT, TNFGO:0051128 regulation of cellular component organization 9 0.00016 AKT1, BCL2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCG, TNFGO:0035295 tube development 6 0.00018 BCL2, EGFR, MAP2K1, MAPK1, PRKCA, TNFGO:0042060 wound healing 5 0.00018 EGFR, MAPK1, PRKCA, PRKCB, PRKCGGO:0042326 negative regulation of phosphorylation 5 0.00018 AKT1, CDK6, HGF, IGF1R, STAT3GO:0009636 response to toxic substance 5 0.00019 BCL2, CDK1, MAPK1, STAT3, TNFGO:0030279 negative regulation of ossification 3 0.00019 BCL2, CDK6, TNFGO:0060020 Bergmann glial cell differentiation 2 0.00019 MAP2K1, MAPK1GO:0060693 regulation of branching involved in salivary gland morphogenesis2 0.00019 HGF, TNFGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA2 0.00019 EGFR, MAP2K1GO:0010507 negative regulation of autophagy 3 0.00021 AKT1, BCL2, HGFGO:0051252 regulation of RNA metabolic process 11 0.00021 AKT1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, PRKCB, STAT3, TERT, TNFGO:1900407 regulation of cellular response to oxidative stress 3 0.00021 AKT1, HGF, TNFGO:0033993 response to lipid 6 0.00022 AKT1, BCL2, EGFR, MAPK1, STAT3, TNFGO:1903426 regulation of reactive oxygen species biosynthetic process 3 0.00024 AKT1, STAT3, TNFGO:0009725 response to hormone 6 0.00026 AKT1, BCL2, EGFR, IGF1R, STAT3, TNFGO:0031100 animal organ regeneration 3 0.00026 CDK1, EGFR, HGFGO:0009887 animal organ morphogenesis 6 0.00028 BCL2, EGFR, MAP2K1, MAPK1, STAT3, TNFGO:0050673 epithelial cell proliferation 3 0.00029 MAP2K1, MAPK1, TNFGO:0045927 positive regulation of growth 4 0.0003 AKT1, BCL2, CDK1, EGFRGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity3 0.00032 AKT1, CDK6, EGFRGO:0009719 response to endogenous stimulus 7 0.00032 AKT1, BCL2, EGFR, IGF1R, MAPK1, STAT3, TNFGO:0022402 cell cycle process 6 0.00032 CDK1, CDK2, CDK6, MAP2K1, PRKCA, PRKCBGO:0034762 regulation of transmembrane transport 5 0.00032 AKT1, BCL2, PRKCB, TERT, TNFGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus2 0.00032 AKT1, MAPK1GO:0006928 movement of cell or subcellular component 7 0.00033 CDK1, EGFR, HGF, MAP2K1, MAPK1, PRKCA, TNFGO:0001938 positive regulation of endothelial cell proliferation 3 0.00034 AKT1, PRKCA, STAT3GO:0045639 positive regulation of myeloid cell differentiation 3 0.00034 PRKCA, STAT3, TNFGO:0007610 behavior 5 0.00036 BCL2, EGFR, MAPK1, PRKCG, STAT3GO:0021782 glial cell development 3 0.00036 AKT1, CDK6, EGFRGO:0022612 gland morphogenesis 3 0.0004 BCL2, EGFR, TNFGO:2000379 positive regulation of reactive oxygen species metabolic process3 0.0004 AKT1, EGFR, TNFGO:0002363 alpha-beta T cell lineage commitment 2 0.00041 BCL2, STAT3GO:0030182 neuron differentiation 6 0.00041 BCL2, EGFR, MAP2K1, MAPK1, PRKCA, STAT3GO:0042635 positive regulation of hair cycle 2 0.00041 TERT, TNFGO:0014066 regulation of phosphatidylinositol 3-kinase signaling 3 0.00042 EGFR, HGF, MAPK1GO:0043467 regulation of generation of precursor metabolites and energy 3 0.00042 AKT1, CDK1, STAT3GO:1903047 mitotic cell cycle process 5 0.00042 CDK1, CDK2, CDK6, PRKCA, PRKCBGO:2000134 negative regulation of G1/S transition of mitotic cell cycle 3 0.00042 BCL2, CDK1, CDK2GO:0009653 anatomical structure morphogenesis 8 0.00043 BCL2, EGFR, HGF, MAP2K1, MAPK1, PRKCA, STAT3, TNFGO:0071345 cellular response to cytokine stimulus 6 0.00043 AKT1, BCL2, HGF, MAPK1, STAT3, TNFGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment2 0.00045 BCL2, STAT3GO:0048009 insulin-like growth factor receptor signaling pathway 2 0.00045 AKT1, IGF1RGO:0048534 hematopoietic or lymphoid organ development 5 0.00045 BCL2, MAP2K1, MAPK1, STAT3, TNFGO:0006606 protein import into nucleus 3 0.00047 AKT1, STAT3, TNFGO:0051179 localization 12 0.00047 AKT1, BCL2, CDK1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0072593 reactive oxygen species metabolic process 3 0.00049 AKT1, BCL2, EGFRGO:0048638 regulation of developmental growth 4 0.00054 AKT1, BCL2, CDK1, STAT3GO:0048468 cell development 7 0.00055 AKT1, BCL2, CDK1, CDK6, EGFR, MAPK1, PRKCAGO:0071496 cellular response to external stimulus 4 0.00056 AKT1, BCL2, EGFR, MAPK1
GO:2000010 positive regulation of protein localization to cell surface 2 0.00056 AKT1, TNFGO:0045667 regulation of osteoblast differentiation 3 0.00061 CDK6, HGF, TNFGO:0030155 regulation of cell adhesion 5 0.00062 AKT1, BCL2, CDK6, PRKCA, TNFGO:0045780 positive regulation of bone resorption 2 0.00062 EGFR, PRKCAGO:0051223 regulation of protein transport 5 0.00062 CDK1, EGFR, MAPK1, PRKCA, TNFGO:0090201 negative regulation of release of cytochrome c from mitochondria2 0.00062 AKT1, HGFGO:2000773 negative regulation of cellular senescence 2 0.00062 CDK6, TERTGO:0000902 cell morphogenesis 5 0.00063 BCL2, EGFR, HGF, MAPK1, PRKCAGO:0120036 plasma membrane bounded cell projection organization 6 0.00063 BCL2, CDK1, EGFR, IGF1R, MAPK1, PRKCAGO:0002761 regulation of myeloid leukocyte differentiation 3 0.00065 CDK6, PRKCA, TNFGO:0034763 negative regulation of transmembrane transport 3 0.00065 AKT1, PRKCB, TNFGO:2000641 regulation of early endosome to late endosome transport 2 0.00066 MAP2K1, MAPK1GO:1905477 positive regulation of protein localization to membrane 3 0.00067 AKT1, BCL2, EGFRGO:0006417 regulation of translation 4 0.00069 AKT1, MAPK1, STAT3, TNFGO:0010829 negative regulation of glucose transmembrane transport 2 0.00073 PRKCB, TNFGO:0033365 protein localization to organelle 5 0.00073 AKT1, CDK1, STAT3, TERT, TNFGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 3 0.00074 AKT1, PRKCB, TNFGO:0019221 cytokine-mediated signaling pathway 5 0.00075 AKT1, BCL2, HGF, STAT3, TNFGO:0006355 regulation of transcription, DNA-templated 10 0.00076 AKT1, CDK2, EGFR, HGF, MAP2K1, MAPK1, PRKCB, STAT3, TERT, TNFGO:0010256 endomembrane system organization 4 0.00076 AKT1, CDK1, PRKCA, PRKCBGO:0051000 positive regulation of nitric-oxide synthase activity 2 0.00077 AKT1, TERTGO:0060716 labyrinthine layer blood vessel development 2 0.00077 AKT1, MAPK1GO:0048565 digestive tract development 3 0.00079 BCL2, EGFR, TNFGO:0051704 multi-organism process 8 0.00082 AKT1, BCL2, CDK1, CDK6, EGFR, MAPK1, STAT3, TNFGO:0045944 positive regulation of transcription by RNA polymerase II 6 0.00085 AKT1, EGFR, HGF, STAT3, TERT, TNFGO:0048762 mesenchymal cell differentiation 3 0.00085 BCL2, HGF, MAPK1GO:0050995 negative regulation of lipid catabolic process 2 0.0009 AKT1, TNFGO:0060322 head development 5 0.00093 BCL2, CDK6, EGFR, MAP2K1, MAPK1GO:0051130 positive regulation of cellular component organization 6 0.00094 BCL2, HGF, IGF1R, MAP2K1, MAPK1, TNFGO:0030878 thyroid gland development 2 0.00097 MAP2K1, MAPK1GO:0051222 positive regulation of protein transport 4 0.00098 CDK1, EGFR, MAPK1, TNFGO:0043524 negative regulation of neuron apoptotic process 3 0.00099 BCL2, PRKCG, TERTGO:0051384 response to glucocorticoid 3 0.00099 BCL2, EGFR, TNFGO:0009411 response to UV 3 0.001 AKT1, BCL2, EGFRGO:0033043 regulation of organelle organization 6 0.001 AKT1, BCL2, HGF, MAP2K1, MAPK1, TNFGO:0042176 regulation of protein catabolic process 4 0.001 AKT1, EGFR, PRKCG, TNFGO:0071456 cellular response to hypoxia 3 0.001 AKT1, BCL2, TERTGO:0045785 positive regulation of cell adhesion 4 0.0011 AKT1, CDK6, PRKCA, TNFGO:0045931 positive regulation of mitotic cell cycle 3 0.0011 CDK1, PRKCA, TERTGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II2 0.0011 STAT3, TERTGO:0002376 immune system process 8 0.0012 AKT1, BCL2, IGF1R, MAP2K1, MAPK1, PRKCB, STAT3, TNFGO:0010389 regulation of G2/M transition of mitotic cell cycle 3 0.0012 CDK1, CDK2, CDK6GO:0010821 regulation of mitochondrion organization 3 0.0012 AKT1, BCL2, HGFGO:0030162 regulation of proteolysis 5 0.0012 AKT1, HGF, PRKCG, STAT3, TNFGO:0052548 regulation of endopeptidase activity 4 0.0012 AKT1, HGF, STAT3, TNFGO:0070371 ERK1 and ERK2 cascade 2 0.0012 MAP2K1, MAPK1GO:0070570 regulation of neuron projection regeneration 2 0.0012 HGF, MAP2K1GO:0006996 organelle organization 9 0.0013 AKT1, BCL2, CDK1, CDK2, PRKCA, PRKCB, STAT3, TERT, TNFGO:0007435 salivary gland morphogenesis 2 0.0013 EGFR, TNFGO:0051090 regulation of DNA-binding transcription factor activity 4 0.0013 AKT1, MAPK1, PRKCB, TNFGO:0051897 positive regulation of protein kinase B signaling 3 0.0013 EGFR, HGF, TNFGO:0072594 establishment of protein localization to organelle 4 0.0013 AKT1, STAT3, TERT, TNFGO:0014002 astrocyte development 2 0.0014 CDK6, EGFRGO:0030307 positive regulation of cell growth 3 0.0014 AKT1, BCL2, EGFRGO:0001933 negative regulation of protein phosphorylation 4 0.0015 AKT1, CDK6, HGF, IGF1RGO:0007005 mitochondrion organization 4 0.0015 AKT1, BCL2, STAT3, TERTGO:0030212 hyaluronan metabolic process 2 0.0015 AKT1, HGFGO:0030324 lung development 3 0.0015 EGFR, MAP2K1, MAPK1GO:0038128 ERBB2 signaling pathway 2 0.0015 EGFR, PRKCAGO:0048639 positive regulation of developmental growth 3 0.0015 AKT1, BCL2, CDK1GO:0060416 response to growth hormone 2 0.0015 AKT1, STAT3GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors2 0.0016 BCL2, TNFGO:1904707 positive regulation of vascular smooth muscle cell proliferation 2 0.0016 TERT, TNFGO:0014065 phosphatidylinositol 3-kinase signaling 2 0.0017 AKT1, IGF1RGO:0043029 T cell homeostasis 2 0.0017 AKT1, BCL2GO:0043086 negative regulation of catalytic activity 5 0.0017 AKT1, CDK6, HGF, IGF1R, TNFGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity2 0.0017 AKT1, EGFRGO:0045907 positive regulation of vasoconstriction 2 0.0017 AKT1, EGFRGO:0072359 circulatory system development 5 0.0017 AKT1, CDK1, MAP2K1, MAPK1, PRKCAGO:0090322 regulation of superoxide metabolic process 2 0.0017 EGFR, TNFGO:1903580 positive regulation of ATP metabolic process 2 0.0017 CDK1, STAT3GO:0031641 regulation of myelination 2 0.0018 AKT1, HGFGO:0043243 positive regulation of protein complex disassembly 2 0.0018 IGF1R, TNFGO:0043491 protein kinase B signaling 2 0.0018 AKT1, TNFGO:0048812 neuron projection morphogenesis 4 0.0018 BCL2, EGFR, MAPK1, PRKCAGO:0051051 negative regulation of transport 4 0.0018 AKT1, BCL2, PRKCB, TNFGO:0110111 negative regulation of animal organ morphogenesis 2 0.0018 BCL2, TNFGO:0014911 positive regulation of smooth muscle cell migration 2 0.0019 BCL2, TERTGO:0031667 response to nutrient levels 4 0.0019 AKT1, BCL2, EGFR, MAPK1GO:0051707 response to other organism 5 0.0019 AKT1, BCL2, CDK6, MAPK1, TNFGO:1901031 regulation of response to reactive oxygen species 2 0.0019 HGF, TNFGO:0001568 blood vessel development 4 0.002 AKT1, MAP2K1, MAPK1, PRKCAGO:0031018 endocrine pancreas development 2 0.0021 AKT1, CDK6GO:0032715 negative regulation of interleukin-6 production 2 0.0021 HGF, TNFGO:0006357 regulation of transcription by RNA polymerase II 8 0.0022 AKT1, CDK2, EGFR, HGF, PRKCB, STAT3, TERT, TNFGO:0006954 inflammatory response 4 0.0022 AKT1, EGFR, STAT3, TNFGO:0008104 protein localization 7 0.0022 AKT1, CDK1, EGFR, PRKCB, STAT3, TERT, TNFGO:0034613 cellular protein localization 6 0.0022 AKT1, CDK1, EGFR, STAT3, TERT, TNFGO:0051234 establishment of localization 10 0.0022 AKT1, BCL2, CDK2, EGFR, HGF, MAPK1, PRKCB, STAT3, TERT, TNFGO:0060627 regulation of vesicle-mediated transport 4 0.0022 MAP2K1, MAPK1, PRKCG, TNFGO:0071229 cellular response to acid chemical 3 0.0022 AKT1, EGFR, TNFGO:0071356 cellular response to tumor necrosis factor 3 0.0022 AKT1, MAPK1, TNFGO:0071363 cellular response to growth factor stimulus 4 0.0022 AKT1, EGFR, HGF, MAPK1GO:0071364 cellular response to epidermal growth factor stimulus 2 0.0022 AKT1, EGFRGO:1905953 negative regulation of lipid localization 2 0.0022 AKT1, TNFGO:0071396 cellular response to lipid 4 0.0023 AKT1, EGFR, MAPK1, TNFGO:0006935 chemotaxis 4 0.0024 HGF, MAP2K1, MAPK1, PRKCAGO:0042307 positive regulation of protein import into nucleus 2 0.0024 CDK1, MAPK1GO:0045429 positive regulation of nitric oxide biosynthetic process 2 0.0024 AKT1, TNFGO:0090276 regulation of peptide hormone secretion 3 0.0024 EGFR, PRKCA, TNFGO:1904407 positive regulation of nitric oxide metabolic process 2 0.0024 AKT1, TNF
GO:0046326 positive regulation of glucose import 2 0.0025 AKT1, TERTGO:0048678 response to axon injury 2 0.0025 BCL2, CDK1GO:2000027 regulation of animal organ morphogenesis 3 0.0025 BCL2, HGF, TNFGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process3 0.0026 AKT1, HGF, TNFGO:0043393 regulation of protein binding 3 0.0026 AKT1, BCL2, TERTGO:0045668 negative regulation of osteoblast differentiation 2 0.0026 CDK6, TNFGO:0048870 cell motility 5 0.0026 CDK1, EGFR, HGF, MAP2K1, TNFGO:0060425 lung morphogenesis 2 0.0026 MAP2K1, MAPK1GO:1903202 negative regulation of oxidative stress-induced cell death 2 0.0026 AKT1, HGFGO:0001503 ossification 3 0.0027 AKT1, BCL2, EGFRGO:0007423 sensory organ development 4 0.0027 BCL2, EGFR, MAPK1, STAT3GO:0044057 regulation of system process 4 0.0027 AKT1, EGFR, HGF, PRKCAGO:0045646 regulation of erythrocyte differentiation 2 0.0027 CDK6, STAT3GO:0009059 macromolecule biosynthetic process 9 0.0029 AKT1, CDK1, CDK2, EGFR, MAPK1, PRKCB, STAT3, TERT, TNFGO:0038083 peptidyl-tyrosine autophosphorylation 2 0.0029 EGFR, IGF1RGO:0045184 establishment of protein localization 6 0.0029 AKT1, EGFR, PRKCB, STAT3, TERT, TNFGO:0046622 positive regulation of organ growth 2 0.0029 AKT1, CDK1GO:0048546 digestive tract morphogenesis 2 0.0029 BCL2, EGFRGO:0060324 face development 2 0.0029 MAP2K1, MAPK1GO:0035194 posttranscriptional gene silencing by RNA 2 0.0031 STAT3, TERTGO:0042592 homeostatic process 6 0.0031 AKT1, BCL2, EGFR, MAPK1, STAT3, TERTGO:2000378 negative regulation of reactive oxygen species metabolic process2 0.0031 BCL2, STAT3GO:0002763 positive regulation of myeloid leukocyte differentiation 2 0.0033 PRKCA, TNFGO:0007173 epidermal growth factor receptor signaling pathway 2 0.0033 AKT1, EGFRGO:0097305 response to alcohol 3 0.0033 AKT1, CDK1, STAT3GO:0007611 learning or memory 3 0.0034 EGFR, MAPK1, PRKCGGO:0045739 positive regulation of DNA repair 2 0.0034 EGFR, PRKCGGO:0050730 regulation of peptidyl-tyrosine phosphorylation 3 0.0034 EGFR, HGF, STAT3GO:1903078 positive regulation of protein localization to plasma membrane 2 0.0034 AKT1, EGFRGO:0048146 positive regulation of fibroblast proliferation 2 0.0035 CDK6, EGFRGO:0048878 chemical homeostasis 5 0.0035 AKT1, BCL2, EGFR, MAPK1, STAT3GO:0051276 chromosome organization 5 0.0035 CDK1, CDK2, PRKCA, PRKCB, TERTGO:0043536 positive regulation of blood vessel endothelial cell migration 2 0.0036 AKT1, PRKCAGO:0061180 mammary gland epithelium development 2 0.0036 AKT1, MAPK1GO:0016032 viral process 4 0.0037 CDK1, EGFR, MAPK1, STAT3GO:0071375 cellular response to peptide hormone stimulus 3 0.0037 AKT1, IGF1R, STAT3GO:0006955 immune response 6 0.0038 BCL2, IGF1R, MAPK1, PRKCB, STAT3, TNFGO:0031647 regulation of protein stability 3 0.0039 BCL2, MAPK1, TERTGO:0034502 protein localization to chromosome 2 0.0039 CDK1, TERTGO:0051091 positive regulation of DNA-binding transcription factor activity 3 0.0039 AKT1, PRKCB, TNFGO:0006469 negative regulation of protein kinase activity 3 0.004 AKT1, CDK6, IGF1RGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2 0.004 CDK1, CDK2GO:0032870 cellular response to hormone stimulus 4 0.004 AKT1, EGFR, IGF1R, STAT3GO:0044772 mitotic cell cycle phase transition 3 0.004 CDK1, CDK2, CDK6GO:0008637 apoptotic mitochondrial changes 2 0.0041 AKT1, BCL2GO:0050778 positive regulation of immune response 4 0.0041 BCL2, MAPK1, PRKCB, TNFGO:0071230 cellular response to amino acid stimulus 2 0.0041 EGFR, TNFGO:0009628 response to abiotic stimulus 5 0.0042 AKT1, BCL2, EGFR, TERT, TNFGO:0045664 regulation of neuron differentiation 4 0.0042 AKT1, BCL2, HGF, MAP2K1GO:0014031 mesenchymal cell development 2 0.0043 BCL2, MAPK1GO:0009615 response to virus 3 0.0046 BCL2, CDK6, TNFGO:1901992 positive regulation of mitotic cell cycle phase transition 2 0.0046 CDK1, TERTGO:0090068 positive regulation of cell cycle process 3 0.0047 CDK1, CDK2, TERTGO:0033555 multicellular organismal response to stress 2 0.0049 BCL2, PRKCGGO:0006970 response to osmotic stress 2 0.005 EGFR, TNFGO:0010629 negative regulation of gene expression 6 0.005 AKT1, CDK2, MAP2K1, STAT3, TERT, TNFGO:0031397 negative regulation of protein ubiquitination 2 0.005 AKT1, PRKCGGO:0051881 regulation of mitochondrial membrane potential 2 0.005 AKT1, BCL2GO:2000573 positive regulation of DNA biosynthetic process 2 0.005 HGF, MAPK1GO:0022607 cellular component assembly 7 0.0051 BCL2, CDK1, CDK2, IGF1R, PRKCA, TERT, TNFGO:0040014 regulation of multicellular organism growth 2 0.0051 BCL2, STAT3GO:0045844 positive regulation of striated muscle tissue development 2 0.0051 BCL2, CDK1GO:0050764 regulation of phagocytosis 2 0.0051 PRKCG, TNFGO:1901224 positive regulation of NIK/NF-kappaB signaling 2 0.0051 EGFR, TNFGO:0007249 I-kappaB kinase/NF-kappaB signaling 2 0.0052 AKT1, TNFGO:0001942 hair follicle development 2 0.0053 BCL2, EGFRGO:0007420 brain development 4 0.0053 BCL2, CDK6, EGFR, MAP2K1GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage2 0.0053 BCL2, TNFGO:0030855 epithelial cell differentiation 4 0.0053 AKT1, CDK1, CDK6, MAP2K1GO:0032103 positive regulation of response to external stimulus 3 0.0053 EGFR, PRKCA, TNFGO:0046902 regulation of mitochondrial membrane permeability 2 0.0053 BCL2, STAT3GO:0046889 positive regulation of lipid biosynthetic process 2 0.0055 AKT1, TNFGO:0097190 apoptotic signaling pathway 3 0.0055 BCL2, PRKCA, TNFGO:0010721 negative regulation of cell development 3 0.0056 BCL2, STAT3, TERTGO:0046677 response to antibiotic 3 0.0059 BCL2, CDK1, STAT3GO:0007098 centrosome cycle 2 0.0061 CDK1, CDK2GO:0071260 cellular response to mechanical stimulus 2 0.0061 AKT1, EGFRGO:0002521 leukocyte differentiation 3 0.0063 BCL2, STAT3, TNFGO:0042058 regulation of epidermal growth factor receptor signaling pathway2 0.0063 AKT1, EGFRGO:0008286 insulin receptor signaling pathway 2 0.0066 AKT1, IGF1RGO:0043331 response to dsRNA 2 0.0066 MAPK1, TERTGO:0030641 regulation of cellular pH 2 0.0067 BCL2, MAPK1GO:0045833 negative regulation of lipid metabolic process 2 0.0068 AKT1, TNFGO:0045069 regulation of viral genome replication 2 0.007 BCL2, TNFGO:0032386 regulation of intracellular transport 3 0.0074 CDK1, MAP2K1, MAPK1GO:0006952 defense response 5 0.0075 AKT1, BCL2, EGFR, STAT3, TNFGO:0045666 positive regulation of neuron differentiation 3 0.0075 BCL2, HGF, MAP2K1GO:0050727 regulation of inflammatory response 3 0.0075 EGFR, HGF, TNFGO:0051336 regulation of hydrolase activity 5 0.0075 AKT1, EGFR, HGF, STAT3, TNFGO:1901655 cellular response to ketone 2 0.0076 AKT1, EGFRGO:0008593 regulation of Notch signaling pathway 2 0.0077 EGFR, STAT3GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process2 0.0077 AKT1, HGFGO:0007409 axonogenesis 3 0.0079 BCL2, MAPK1, PRKCAGO:0046718 viral entry into host cell 2 0.0079 CDK1, EGFRGO:0051345 positive regulation of hydrolase activity 4 0.0079 AKT1, EGFR, STAT3, TNFGO:0045862 positive regulation of proteolysis 3 0.008 AKT1, STAT3, TNFGO:0062014 negative regulation of small molecule metabolic process 2 0.008 AKT1, STAT3GO:0045861 negative regulation of proteolysis 3 0.0081 AKT1, HGF, PRKCGGO:2001243 negative regulation of intrinsic apoptotic signaling pathway 2 0.0085 AKT1, BCL2GO:0019953 sexual reproduction 4 0.0086 AKT1, BCL2, CDK1, STAT3GO:0046649 lymphocyte activation 3 0.0086 BCL2, PRKCB, STAT3
GO:0022407 regulation of cell-cell adhesion 3 0.009 AKT1, PRKCA, TNFGO:0014013 regulation of gliogenesis 2 0.0093 CDK1, TERTGO:0035051 cardiocyte differentiation 2 0.0094 CDK1, MAPK1GO:0043588 skin development 3 0.0094 BCL2, EGFR, MAP2K1GO:0043900 regulation of multi-organism process 3 0.0094 BCL2, PRKCA, TNFGO:0046854 phosphatidylinositol phosphorylation 2 0.0094 EGFR, HGFGO:0022037 metencephalon development 2 0.0095 BCL2, MAP2K1GO:0001952 regulation of cell-matrix adhesion 2 0.0097 BCL2, CDK6GO:0051403 stress-activated MAPK cascade 2 0.01 MAPK1, TNFGO:0034645 cellular macromolecule biosynthetic process 8 0.0102 AKT1, CDK1, CDK2, EGFR, MAPK1, PRKCB, STAT3, TERTGO:0016477 cell migration 4 0.0104 CDK1, EGFR, HGF, TNFGO:0045727 positive regulation of translation 2 0.0105 MAPK1, TNFGO:0042542 response to hydrogen peroxide 2 0.0108 BCL2, CDK1GO:0006006 glucose metabolic process 2 0.011 AKT1, TNFGO:0043488 regulation of mRNA stability 2 0.011 AKT1, PRKCAGO:0007268 chemical synaptic transmission 3 0.0113 AKT1, MAPK1, PRKCGGO:0008544 epidermis development 3 0.0113 BCL2, EGFR, MAP2K1GO:0007155 cell adhesion 4 0.0116 BCL2, EGFR, PRKCA, TNFGO:0045598 regulation of fat cell differentiation 2 0.0121 AKT1, TNFGO:0050729 positive regulation of inflammatory response 2 0.0121 EGFR, TNFGO:0042177 negative regulation of protein catabolic process 2 0.0122 EGFR, PRKCGGO:0098609 cell-cell adhesion 3 0.0122 BCL2, EGFR, TNFGO:0050680 negative regulation of epithelial cell proliferation 2 0.0124 CDK6, TNFGO:0060359 response to ammonium ion 2 0.0124 MAPK1, PRKCGGO:0000082 G1/S transition of mitotic cell cycle 2 0.0126 CDK2, CDK6GO:0000086 G2/M transition of mitotic cell cycle 2 0.0126 CDK1, CDK2GO:0001889 liver development 2 0.0126 EGFR, HGFGO:0050708 regulation of protein secretion 3 0.0126 EGFR, PRKCA, TNFGO:0030177 positive regulation of Wnt signaling pathway 2 0.013 EGFR, TERTGO:0032355 response to estradiol 2 0.013 EGFR, STAT3GO:0050806 positive regulation of synaptic transmission 2 0.013 EGFR, MAPK1GO:1901796 regulation of signal transduction by p53 class mediator 2 0.0135 AKT1, CDK2GO:0051346 negative regulation of hydrolase activity 3 0.0136 AKT1, HGF, TNFGO:0071901 negative regulation of protein serine/threonine kinase activity 2 0.0136 AKT1, CDK6GO:0045321 leukocyte activation 4 0.0137 BCL2, MAPK1, PRKCB, STAT3GO:0010975 regulation of neuron projection development 3 0.0139 AKT1, HGF, MAP2K1GO:0010675 regulation of cellular carbohydrate metabolic process 2 0.014 AKT1, STAT3GO:0045471 response to ethanol 2 0.0142 CDK1, STAT3GO:0034329 cell junction assembly 2 0.0144 BCL2, PRKCAGO:0009267 cellular response to starvation 2 0.0147 BCL2, MAPK1GO:0051092 positive regulation of NF-kappaB transcription factor activity 2 0.0156 PRKCB, TNFGO:0043271 negative regulation of ion transport 2 0.0158 AKT1, BCL2GO:0042113 B cell activation 2 0.0162 BCL2, PRKCBGO:0007010 cytoskeleton organization 4 0.0166 BCL2, CDK1, CDK2, TNFGO:1903034 regulation of response to wounding 2 0.0168 MAP2K1, PRKCAGO:0007050 cell cycle arrest 2 0.017 CDK6, MAP2K1GO:0051235 maintenance of location 2 0.0171 AKT1, TNFGO:0051301 cell division 3 0.0171 CDK1, CDK2, CDK6GO:0007507 heart development 3 0.0173 CDK1, MAP2K1, MAPK1GO:0043409 negative regulation of MAPK cascade 2 0.0187 AKT1, IGF1RGO:0010950 positive regulation of endopeptidase activity 2 0.0188 STAT3, TNFGO:0050865 regulation of cell activation 3 0.0191 AKT1, BCL2, PRKCAGO:0021543 pallium development 2 0.0196 CDK6, EGFRGO:1902532 negative regulation of intracellular signal transduction 3 0.0198 AKT1, BCL2, IGF1RGO:0045216 cell-cell junction organization 2 0.0207 BCL2, PRKCAGO:0042593 glucose homeostasis 2 0.0209 AKT1, STAT3GO:0050796 regulation of insulin secretion 2 0.0216 PRKCA, TNFGO:0007565 female pregnancy 2 0.0234 AKT1, BCL2GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2 0.0234 HGF, STAT3GO:0010638 positive regulation of organelle organization 3 0.0237 BCL2, MAPK1, TNFGO:0051146 striated muscle cell differentiation 2 0.0237 AKT1, CDK1GO:0007267 cell-cell signaling 4 0.0239 AKT1, HGF, MAPK1, PRKCGGO:0006810 transport 8 0.0241 AKT1, BCL2, CDK2, HGF, MAPK1, PRKCB, STAT3, TNFGO:0061136 regulation of proteasomal protein catabolic process 2 0.0243 AKT1, PRKCGGO:0097237 cellular response to toxic substance 2 0.0267 CDK1, TNFGO:1903039 positive regulation of leukocyte cell-cell adhesion 2 0.0284 AKT1, TNFGO:0006260 DNA replication 2 0.0286 CDK1, CDK2GO:0043583 ear development 2 0.0288 BCL2, MAPK1GO:0043065 positive regulation of apoptotic process 3 0.0294 AKT1, BCL2, TNFGO:0003008 system process 5 0.0307 AKT1, BCL2, EGFR, MAPK1, PRKCGGO:0035239 tube morphogenesis 3 0.0307 BCL2, EGFR, PRKCAGO:0045732 positive regulation of protein catabolic process 2 0.0319 AKT1, TNFGO:0055080 cation homeostasis 3 0.0324 BCL2, EGFR, MAPK1GO:0007411 axon guidance 2 0.0327 MAPK1, PRKCAGO:0051129 negative regulation of cellular component organization 3 0.0327 AKT1, HGF, TNFGO:0098771 inorganic ion homeostasis 3 0.0341 BCL2, EGFR, MAPK1GO:0007281 germ cell development 2 0.035 AKT1, BCL2GO:0030100 regulation of endocytosis 2 0.035 PRKCG, TNFGO:0045926 negative regulation of growth 2 0.0365 BCL2, TNFGO:0030336 negative regulation of cell migration 2 0.037 BCL2, STAT3GO:1903311 regulation of mRNA metabolic process 2 0.0372 AKT1, PRKCAGO:0050714 positive regulation of protein secretion 2 0.0377 EGFR, TNFGO:0050877 nervous system process 4 0.0399 AKT1, EGFR, MAPK1, PRKCGGO:0090596 sensory organ morphogenesis 2 0.0399 MAPK1, STAT3GO:0048511 rhythmic process 2 0.0403 EGFR, PRKCGGO:0010976 positive regulation of neuron projection development 2 0.0406 HGF, MAP2K1GO:0006959 humoral immune response 2 0.0407 BCL2, TNFGO:0051253 negative regulation of RNA metabolic process 4 0.0428 CDK2, STAT3, TERT, TNFGO:0050768 negative regulation of neurogenesis 2 0.043 STAT3, TERTGO:0051251 positive regulation of lymphocyte activation 2 0.043 AKT1, BCL2GO:0009410 response to xenobiotic stimulus 2 0.0435 EGFR, PRKCGGO:0002250 adaptive immune response 2 0.0489 PRKCB, STAT3GO:0048871 multicellular organismal homeostasis 2 0.0498 BCL2, STAT3
SS7: Pathway enrichment analysis: 16 protein targets modulated 139 pathways
KEGG
ID
Pathway Genes
within
pathway
FDR Gene ID
hsa01521 EGFR tyrosine kinase inhibitor resistance 11 6.37E-21 AKT1, BCL2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3
hsa05200 Pathways in cancer 14 8.77E-19 AKT1, BCL2, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA,
PRKCB, PRKCG, STAT3, TERT
hsa05161 Hepatitis B 11 1.07E-18 AKT1, BCL2, CDK2, CDK6, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TNF
hsa05225 Hepatocellular carcinoma 11 3.43E-18 AKT1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
TERT
hsa04066 HIF-1 signaling pathway 10 4.37E-18 AKT1, BCL2, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3
hsa05205 Proteoglycans in cancer 11 1.53E-17 AKT1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG,
STAT3, TNF
hsa05223 Non-small cell lung cancer 9 2.85E-17 AKT1, CDK6, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3
hsa05214 Glioma 9 3.20E-17 AKT1, CDK6, EGFR, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04510 Focal adhesion 10 1.95E-15 AKT1, BCL2, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa05206 MicroRNAs in cancer 9 2.07E-14 BCL2, CDK6, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, STAT3
hsa04010 MAPK signaling pathway 10 7.51E-14 AKT1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TNF
hsa04015 Rap1 signaling pathway 9 2.54E-13 AKT1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04071 Sphingolipid signaling pathway 8 3.22E-13 AKT1, BCL2, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TNF
hsa04151 PI3K-Akt signaling pathway 10 3.22E-13 AKT1, BCL2, CDK2, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA
hsa04014 Ras signaling pathway 9 5.60E-13 AKT1, EGFR, HGF, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04150 mTOR signaling pathway 8 1.52E-12 AKT1, IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TNF
hsa05218 Melanoma 7 1.52E-12 AKT1, CDK6, EGFR, HGF, IGF1R, MAP2K1, MAPK1
hsa05226 Gastric cancer 8 1.52E-12 AKT1, BCL2, CDK2, EGFR, HGF, MAP2K1, MAPK1, TERT
hsa04012 ErbB signaling pathway 7 3.28E-12 AKT1, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04540 Gap junction 7 4.26E-12 CDK1, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa05215 Prostate cancer 7 8.39E-12 AKT1, BCL2, CDK2, EGFR, IGF1R, MAP2K1, MAPK1
hsa04933 AGE-RAGE signaling pathway in diabetic
complications
7 8.58E-12 AKT1, BCL2, MAPK1, PRKCA, PRKCB, STAT3, TNF
hsa05231 Choline metabolism in cancer 7 8.58E-12 AKT1, EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04725 Cholinergic synapse 7 1.81E-11 AKT1, BCL2, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04068 FoxO signaling pathway 7 5.04E-11 AKT1, CDK2, EGFR, IGF1R, MAP2K1, MAPK1, STAT3
hsa04370 VEGF signaling pathway 6 5.23E-11 AKT1, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04730 Long-term depression 6 5.53E-11 IGF1R, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa05212 Pancreatic cancer 6 1.75E-10 AKT1, CDK6, EGFR, MAP2K1, MAPK1, STAT3
hsa05165 Human papillomavirus infection 8 3.45E-10 AKT1, CDK2, CDK6, EGFR, MAP2K1, MAPK1, TERT, TNF
hsa04666 Fc gamma R-mediated phagocytosis 6 4.70E-10 AKT1, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04914 Progesterone-mediated oocyte maturation 6 6.23E-10 AKT1, CDK1, CDK2, IGF1R, MAP2K1, MAPK1
hsa01522 Endocrine resistance 6 6.41E-10 AKT1, BCL2, EGFR, IGF1R, MAP2K1, MAPK1
hsa04919 Thyroid hormone signaling pathway 6 1.87E-09 AKT1, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04650 Natural killer cell mediated cytotoxicity 6 2.80E-09 MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG, TNF
hsa05224 Breast cancer 6 7.30E-09 AKT1, CDK6, EGFR, IGF1R, MAP2K1, MAPK1
hsa04921 Oxytocin signaling pathway 6 7.67E-09 EGFR, MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04720 Long-term potentiation 5 8.86E-09 MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04218 Cellular senescence 6 9.49E-09 AKT1, CDK1, CDK2, CDK6, MAP2K1, MAPK1
hsa04664 Fc epsilon RI signaling pathway 5 1.04E-08 AKT1, MAP2K1, MAPK1, PRKCA, TNF
hsa05164 Influenza A 6 1.39E-08 AKT1, MAP2K1, MAPK1, PRKCA, PRKCB, TNF
hsa05210 Colorectal cancer 5 3.10E-08 AKT1, BCL2, EGFR, MAP2K1, MAPK1
hsa04912 GnRH signaling pathway 5 3.57E-08 EGFR, MAP2K1, MAPK1, PRKCA, PRKCB
hsa04916 Melanogenesis 5 5.84E-08 MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa05143 African trypanosomiasis 4 8.09E-08 PRKCA, PRKCB, PRKCG, TNF
hsa05145 Toxoplasmosis 5 9.32E-08 AKT1, BCL2, MAPK1, STAT3, TNF
hsa04726 Serotonergic synapse 5 1.04E-07 MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04960 Aldosterone-regulated sodium reabsorption 4 1.04E-07 MAPK1, PRKCA, PRKCB, PRKCG
hsa04114 Oocyte meiosis 5 1.18E-07 CDK1, CDK2, IGF1R, MAP2K1, MAPK1
hsa04270 Vascular smooth muscle contraction 5 1.31E-07 MAP2K1, MAPK1, PRKCA, PRKCB, PRKCG
hsa04140 Autophagy - animal 5 1.62E-07 AKT1, BCL2, IGF1R, MAP2K1, MAPK1
hsa04926 Relaxin signaling pathway 5 1.92E-07 AKT1, EGFR, MAP2K1, MAPK1, PRKCA
hsa05160 Hepatitis C 5 1.96E-07 AKT1, EGFR, MAPK1, STAT3, TNF
hsa04915 Estrogen signaling pathway 5 2.06E-07 AKT1, BCL2, EGFR, MAP2K1, MAPK1
hsa04210 Apoptosis 5 2.18E-07 AKT1, BCL2, MAP2K1, MAPK1, TNF
hsa04550 Signaling pathways regulating pluripotency
of stem cells
5 2.38E-07 AKT1, IGF1R, MAP2K1, MAPK1, STAT3
hsa04072 Phospholipase D signaling pathway 5 2.97E-07 AKT1, EGFR, MAP2K1, MAPK1, PRKCA
hsa04934 Cushing's syndrome 5 3.78E-07 CDK2, CDK6, EGFR, MAP2K1, MAPK1
hsa05213 Endometrial cancer 4 4.58E-07 AKT1, EGFR, MAP2K1, MAPK1
hsa05230 Central carbon metabolism in cancer 4 6.96E-07 AKT1, EGFR, MAP2K1, MAPK1
hsa05221 Acute myeloid leukemia 4 7.25E-07 AKT1, MAP2K1, MAPK1, STAT3
hsa04062 Chemokine signaling pathway 5 7.95E-07 AKT1, MAP2K1, MAPK1, PRKCB, STAT3
hsa05211 Renal cell carcinoma 4 7.95E-07 AKT1, HGF, MAP2K1, MAPK1
hsa04917 Prolactin signaling pathway 4 8.12E-07 AKT1, MAP2K1, MAPK1, STAT3
hsa05167 Kaposi's sarcoma-associated herpesvirus
infection
5 8.12E-07 AKT1, CDK6, MAP2K1, MAPK1, STAT3
hsa05203 Viral carcinogenesis 5 8.12E-07 CDK1, CDK2, CDK6, MAPK1, STAT3
hsa04662 B cell receptor signaling pathway 4 8.72E-07 AKT1, MAP2K1, MAPK1, PRKCB
hsa05169 Epstein-Barr virus infection 5 1.01E-06 AKT1, BCL2, CDK1, CDK2, STAT3
hsa05220 Chronic myeloid leukemia 4 1.10E-06 AKT1, CDK6, MAP2K1, MAPK1
hsa05222 Small cell lung cancer 4 2.26E-06 AKT1, BCL2, CDK2, CDK6
hsa04713 Circadian entrainment 4 2.32E-06 MAPK1, PRKCA, PRKCB, PRKCG
hsa05146 Amoebiasis 4 2.38E-06 PRKCA, PRKCB, PRKCG, TNF
hsa04660 T cell receptor signaling pathway 4 2.87E-06 AKT1, MAP2K1, MAPK1, TNF
hsa04620 Toll-like receptor signaling pathway 4 3.17E-06 AKT1, MAP2K1, MAPK1, TNF
hsa04931 Insulin resistance 4 3.77E-06 AKT1, PRKCB, STAT3, TNF
hsa04668 TNF signaling pathway 4 3.85E-06 AKT1, MAP2K1, MAPK1, TNF
hsa04724 Glutamatergic synapse 4 4.37E-06 MAPK1, PRKCA, PRKCB, PRKCG
hsa04722 Neurotrophin signaling pathway 4 4.94E-06 AKT1, BCL2, MAP2K1, MAPK1
hsa04380 Osteoclast differentiation 4 6.31E-06 AKT1, MAP2K1, MAPK1, TNF
hsa04728 Dopaminergic synapse 4 7.04E-06 AKT1, PRKCA, PRKCB, PRKCG
hsa05162 Measles 4 8.06E-06 AKT1, CDK2, CDK6, STAT3
hsa04261 Adrenergic signaling in cardiomyocytes 4 9.44E-06 AKT1, BCL2, MAPK1, PRKCA
hsa04723 Retrograde endocannabinoid signaling 4 1.17E-05 MAPK1, PRKCA, PRKCB, PRKCG
hsa05219 Bladder cancer 3 1.17E-05 EGFR, MAP2K1, MAPK1
hsa04630 Jak-STAT signaling pathway 4 1.57E-05 AKT1, BCL2, EGFR, STAT3
hsa04961 Endocrine and other factor-regulated
calcium reabsorption
3 1.66E-05 PRKCA, PRKCB, PRKCG
hsa05152 Tuberculosis 4 2.02E-05 AKT1, BCL2, MAPK1, TNF
hsa04020 Calcium signaling pathway 4 2.33E-05 EGFR, PRKCA, PRKCB, PRKCG
hsa05031 Amphetamine addiction 3 4.07E-05 PRKCA, PRKCB, PRKCG
hsa04115 p53 signaling pathway 3 4.58E-05 CDK1, CDK2, CDK6
hsa04920 Adipocytokine signaling pathway 3 4.73E-05 AKT1, STAT3, TNF
hsa01524 Platinum drug resistance 3 4.87E-05 AKT1, BCL2, MAPK1
hsa05140 Leishmaniasis 3 4.87E-05 MAPK1, PRKCB, TNF
hsa04520 Adherens junction 3 4.97E-05 EGFR, IGF1R, MAPK1
hsa04971 Gastric acid secretion 3 5.12E-05 PRKCA, PRKCB, PRKCG
hsa04918 Thyroid hormone synthesis 3 5.27E-05 PRKCA, PRKCB, PRKCG
hsa04911 Insulin secretion 3 7.82E-05 PRKCA, PRKCB, PRKCG
hsa04970 Salivary secretion 3 8.28E-05 PRKCA, PRKCB, PRKCG
hsa04727 GABAergic synapse 3 8.76E-05 PRKCA, PRKCB, PRKCG
hsa05032 Morphine addiction 3 9.56E-05 PRKCA, PRKCB, PRKCG
hsa04750 Inflammatory mediator regulation of TRP
channels
3 9.76E-05 PRKCA, PRKCB, PRKCG
hsa04064 NF-kappa B signaling pathway 3 9.97E-05 BCL2, PRKCB, TNF
hsa04925 Aldosterone synthesis and secretion 3 9.97E-05 PRKCA, PRKCB, PRKCG
hsa04972 Pancreatic secretion 3 0.0001 PRKCA, PRKCB, PRKCG
hsa04070 Phosphatidylinositol signaling system 3 0.00011 PRKCA, PRKCB, PRKCG
hsa05142 Chagas disease (American
trypanosomiasis)
3 0.00012 AKT1, MAPK1, TNF
hsa04670 Leukocyte transendothelial migration 3 0.00016 PRKCA, PRKCB, PRKCG
hsa04110 Cell cycle 3 0.00021 CDK1, CDK2, CDK6
hsa04371 Apelin signaling pathway 3 0.00026 AKT1, MAP2K1, MAPK1
hsa04910 Insulin signaling pathway 3 0.00026 AKT1, MAP2K1, MAPK1
hsa05418 Fluid shear stress and atherosclerosis 3 0.00026 AKT1, BCL2, TNF
hsa04310 Wnt signaling pathway 3 0.00031 PRKCA, PRKCB, PRKCG
hsa04217 Necroptosis 3 0.00039 BCL2, STAT3, TNF
hsa04022 cGMP-PKG signaling pathway 3 0.00043 AKT1, MAP2K1, MAPK1
hsa04621 NOD-like receptor signaling pathway 3 0.00047 BCL2, MAPK1, TNF
hsa05020 Prion diseases 2 0.00053 MAP2K1, MAPK1
hsa05168 Herpes simplex infection 3 0.00059 CDK1, CDK2, TNF
hsa05216 Thyroid cancer 2 0.00064 MAP2K1, MAPK1
hsa04024 cAMP signaling pathway 3 0.00072 AKT1, MAP2K1, MAPK1
hsa04973 Carbohydrate digestion and absorption 2 0.0008 AKT1, PRKCB
hsa04810 Regulation of actin cytoskeleton 3 0.00082 EGFR, MAP2K1, MAPK1
hsa04930 Type II diabetes mellitus 2 0.00094 MAPK1, TNF
hsa05144 Malaria 2 0.00097 HGF, TNF
hsa05014 Amyotrophic lateral sclerosis (ALS) 2 0.0011 BCL2, TNF
hsa05166 HTLV-I infection 3 0.0014 AKT1, TERT, TNF
hsa04060 Cytokine-cytokine receptor interaction 3 0.0016 EGFR, HGF, TNF
hsa04213 Longevity regulating pathway - multiple
species
2 0.0016 AKT1, IGF1R
hsa05321 Inflammatory bowel disease (IBD) 2 0.0016 STAT3, TNF
hsa05133 Pertussis 2 0.0022 MAPK1, TNF
hsa04350 TGF-beta signaling pathway 2 0.0027 MAPK1, TNF
hsa04211 Longevity regulating pathway 2 0.0031 AKT1, IGF1R
hsa04657 IL-17 signaling pathway 2 0.0033 MAPK1, TNF
hsa04659 Th17 cell differentiation 2 0.004 MAPK1, STAT3
hsa04152 AMPK signaling pathway 2 0.0054 AKT1, IGF1R
hsa04611 Platelet activation 2 0.0056 AKT1, MAPK1
hsa05034 Alcoholism 2 0.0074 MAP2K1, MAPK1
hsa04932 Non-alcoholic fatty liver disease (NAFLD) 2 0.008 AKT1, TNF
hsa05010 Alzheimer's disease 2 0.01 MAPK1, TNF
hsa04360 Axon guidance 2 0.0105 MAPK1, PRKCA
hsa04144 Endocytosis 2 0.0196 EGFR, IGF1R
Gene ID Role of geneAKT1 RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine- protein kinases called the AKT kinase, and which regulate many processes including
metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. The replication of hepatitis B virus (HBV) modulated by the phosphatidylinositol 3‑kinase (PI3K)‑RAC‑α serine/threonine‑protein kinase (AKT)‑serine/threonine‑protein kinase mTOR (mTOR) pathway. The Large envelope protein of HBV activates the PI3K-AKT siganlling pathway and act as a tumorigenesis factor. Hepatitis B X Interacting Protein activates the PI3K-AKT pathway and act as a balancing factor between HBV replication and cell survival (Xiang et al 2018; Park et al 2000) . RAC-beta serine/threonine-protein kinase 2 (AKT2) regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis (https://pubchem.ncbi.nlm.nih.gov/protein/P31751)
EGFR Epidermal growth factor receptor; EGFR is a host-entry cofactor triggering NTCP-mediated hepatitis B virus internalization (Iwamoto et al 2019)IGF1R Insulin-like growth factor I receptor; HBx-mediates upregulation of IGF-2 and IGF-1R expression, changes in IGF binding proteines expression levels have been associated with HBV
infection and progression of HCC (Nielsen et al 2018)CDK1 Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase (Cheng et al 2009). Host CDK activities are likely required
for HBV cccDNA synthesis (Bao et al 2019)CDK6 A novel long noncoding RNA (lncRNA) DBH-AS1 involved in the HBx-mediated hepatocarcinogenesis. The levels of DBH-AS1 were positively correlated with hepatitis B surface
antigen (HBsAg) and tumor size in HCC tissues. Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. Furthermore, DBH-AS1 was shown to activate MAPK pathway. DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in HCC. Study suggests that DBH-AS1 acts as an oncogene for HCC (Huang et al 2015)
HGF Hepatocyte growth factor (HGF) is a driver of Hepatitis B indiced HCC progression and serve as an effective biomarker for Met-targeted therapy. Targeting the Met pathway in hepatitis B–induced HCC is a therapeutic approach. Overexpression of HGF causes HCC (Xie et al 2013)
TERT Hepatitis B X Interacting Protein (HBXIP) upregulates the expression and activity of hTERT in hepatoma cells, suggesting that hTERT associated with hepatocellular carcinoma (Zhang et al 2006). Importantly, researchers discovered that 68% of HCC cases had telomerase reverse transcriptase (TERT) genetic alterations, including promoter mutation, focal amplification, and viral genome integration, and they recognized TERT as a central regulator of hepatocarcinogenesis (Tornesello et al 2016)
BCL2 Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Bcl-2 proteins are key cellular targets of HBx during HBV pathogenesis (Gang et al 2012)
CDK2 Hepatitis B X Interacting Protein (HBx) activates the cyclin A promoter, induce cyclin A–cyclin-dependent kinase 2 complexes, and promote cycling of growth-arrested cells into G1 through a pathway involving activation of Src tyrosine kinases. HBx stimulation of Src kinases and cyclin gene expression was found to force growth-arrested cells to transit through G1 but to stall at the junction with S phase, which may be important for viral replication. Sterile alpha motif and histidine–aspartic acid domain containing protein 1 (SAMHD1) is a component of innate immune system, SAMHD1 phosphorylation, mediated by cyclin-dependent kinases CDK1 and CDK2 is required for the resection of nascent DNA strands at stalled replication forks and may act as a switch between the nuclease and dNTPase functions that regulate HBV cccDNA genesis and regulation of deoxyribonucleoside triphosphate levels required for host and viral DNA synthesis (Bouchard et al 2001)
STAT3 Signal transducer and activator of transcription 3; HBV activates STAT3 signaling in hepatocytes to foster its own replication but also to prevent apoptosis of infected cells. This very likely supports HBV-related carcinogenesis (Hosel et al 2017)
MAPK1, MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1/2; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK1/2 can support the hepatocyte proliferation and this cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma by HBV (Guégan et al 2012). HBx and LHBs Pres2 proteins trigger activation of c-Raf-1/MEK kinase cascade, leading to the transcriptional-activator function which is essential for HBV gene expression. Inhibition of HBx- and LHBs-dependent activation of c-Raf-1/MEK interfere with cell viability and could be a target for the future generation of antivirals (Stockl et al 2003).
PRKCB Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as oxidative stress-induced apoptosis, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1. PKC involved in cell growth, differentiation, and carcinogenesis. Overexpression of wild-type or mutant PKC may lead to disordered cell growth and transformation. HBx interacts with a PKC-binding protein, XAP3, transactivating the PKC signaling pathway. HBX increases the level of endogenous PKC and subsequently activate AP-1 and NF-κB transcription factors may contribute to different cellular fates such as transformation, differentiation, survival, and apoptosis (Ma et al 2011)
TNF Tumor necrosis factor; Interaction between TNF-α C863T polymorphisms and HBV infection associated with progression of HCC (Xiao et al 2016)PRKCA, PRKCG Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of
cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell. Protein kinase C gamma type; Large envelope protein of HBV promotes hepatocellular carcinoma by triggering a PKC-ERK signaling pathway
Xiang et al 2018 Xiang K, Wang B. Role of the PI3K‑AKT‑mTOR pathway in hepatitis B virus infection and replication. Molecular medicine reports. 2018 Mar 1;17(3):4713-9.Park et al 2000 Park US, Park SK, Lee YI, Park JG, Lee YI. Hepatitis B virus-X protein upregulates the expression of p21 wafl/cipl and prolongs G1→ S transition via a p53-independent pathway in
human hepatoma cells. Oncogene. 2000 Jul;19(30):3384-94.Iwamoto et al 2019 Iwamoto M, Saso W, Sugiyama R, Ishii K, Ohki M, Nagamori S, Suzuki R, Aizaki H, Ryo A, Yun JH, Park SY. Epidermal growth factor receptor is a host-entry cofactor triggering
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SS8: Role of 16 protein targets in the pathogenesis of hepatitis B viral infection and hepato cellular carcinoma (HCC)
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