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2009 PDR GUIDE TO DRUG INTERACTIONS, SIDE EFFECTS AND INDICATIONS FOR TINNITUS
AMERICAN TINNITUS ASSOCIATION P.O. Box 5 • Portland, OR 97207-0005 • 503-248-9985 • 800-634-8978
As listed in the 2009 Physicians’ Desk Reference Companion Guide When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these listed drugs can be found in the 2009 Physicians’ Desk Reference (PDR). PDR page numbers follow the drug names on this list.
A
Abelcet Injection……………………………………………..……. Accutane Capsules……………………………..……………..….. Aceon Tablets (2 mg, 4 mg, 8 mg) (1.5%)….…………. Actiq (1% or greater)…………..………………….….…..……. Aggrenox Capsules (less than 1%)……………………..…..
Agrylin Capsules (1% - 5%)…………………………..……. Alferon N Injection (one patient)…………………..………… Aloxi Injection (less than 1%)…………………………………. Ambien Tablets (infrequent)……………………...…………… Ambien CR Tablets (infrequent to 1%)……………………. Amerge Tablets (infrequent)…………………………...….….
Anaprox Tablets (3% - 9%)……………………...…..……. Anaprox DS Tablets (3% - 9%)…………….…….….……
Anzemet Injection (infrequently)………………………..…… Anzemet Tablets (infrequently)……………………….……... Aricept Tablets (infrequent)………………………….………... Aricept ODT Tablets (infrequent)…………………………….. Asacol Delayed-Release Tablets……………………….…..… Atacand HCT (0.5% or greater)………….…………………… Atripla Tablets………………………………………………………. Atrovent Nasal Spray 0.06% (less than 1%) ………..... Avelox (less than 0.1%) ………………………………………… Axert Tablets (rare)…………………..…………………..…….
B Bayer Aspirin ……………………………………..………………… Biaxin/Biaxin XL…………………………………………….…….… Bicillin C-R Injectable Suspension…………………………… Bicillin L-A Injection ……………………………………………….
C Campral Tablets (infrequent)……………………………….. Capastat Sulfate for Injection……………………………….. Carbatrol Capsules………..…………………………….…….…. Cardene I.V. (rare) ………………………………………..……. Cardizem LA Extended Release Tablets (less than 2%) …………………………………… Celebrex Capsules (0.1% - 1.9%)…………….…….…...… Celexa (infrequent)……………………………….…….…….....
CellCept Capsules (3% to less than 20%)……………. CellCept Intravenous (3% to less than 20%)………… CellCept Oral Suspension (3% to less than 20%)…. CellCept Tablets (3% to less than 20%)……………….
Chantix Tablets (infrequent)………………………………….. Cialis Tablets (less than 2%)…………………………………… Cipro I.V. (1% or less)………………………………..………... Cipro (less than 1%) ……………………………………………. Cipro XR Tablets ………………..……………………………..…. Clinoril Tablets (greater than 1%)……….……….………... Combigan Ophthalmic Solution ……………………………… Copaxone for Injection (at least 2%)……………………… Coreg Tablets (greater than 0.1% - 1%)………..…..….. Coreg CR Extended-Release Capsules (0.1% to less than or equal to 1%) ………………….. Cosopt Sterile Ophthalmic Solution………………….……... Cozaar Tablets (less than 1%) ………………………….….. Cubicin…………………………………………………….……....…. Cuprimine Capsules ………………………………………………. Cymbalta Delayed-Release Capsules (Infrequent)……..
1134 2607 3038 959 819
3017 1726 1059 2692 2696 1301 2632 2632 2701 2704 1062 1062 2579 642 938 836
2803 2431
750 411
1775 1777
1158 1791 3019 1093
421
2979 1160 2622 2622 2622 2622 2511 1792 2817 2810 2823 1962 553
3110 1387
1393 1969 1973 995
1986 1801
D
Dapsone Tablets USP………………………………..…….…… Demadex Injection….……....…….…….…………………….. Demadex Tablets ………………………………………………..
Depakote ER Tablets (greater than 1% - 7%)……. Diovan HCT Tablets (greater than 0.2%)…………….….. Doxil Injection (less than 1%)…………………….……..…..
E EC-Naprosyn Delayed-Release Tablets (3%-9%)……
Edecrin…………………………………………………………….…. Effexor XR Extended-Release Tablets (frequent)…….. Eldepryl Capsules……………………………………………..….. Elmiron Capsules (less than or equal to 1%)……..….…
Emend Capsules (3.7%)………………………………..….. Emend for Injection (3.7%) ……………………………….
Emsam Transdermal System (frequent)…………………. Engerix-B Vaccine….…………………………………………….. Equerto Extented-Release Capsules………………….……. Evoxac Capsules (less than 1%)……………………………. Exelon Capsules (frequent)……………………………………. Exelon Oral Solution (frequent)……………………………… Exelon Patch (infrequent)…………………………………..… Exforge Tablets (greater than 0.1% but less than 1%) …………….
F Fabrazyme for Intravenous Infusion (8%) ………….
Fansidar Tablets…………………………………………………… Flumadine (0.3 to 1%) …………………………………………. Frova Tablest (frequent)………………………………………… Furosemide Tablets ………………………………………………
G Gabitril Tablets (frequent)……………………………………... Gantrisin Pediatric Suspension………………………………. Gengraf Capsules (1% to less than 3%)………………… Geodon Capsules (infrequent)………………………....…… Gleevec Tablets (infrequent)……………………..………….
I Imitrex Nasal Spray ……………………………………………. Indocin (greater 1%)…………….…………….………………
Intron A for Injection (less than 5%)……………………
K Kaletra (less than 2%)……………………………….…………
L Lamictal (1.1%)……………………………………………….…… Levaquin…………………………………….………………………… Levaquin in 5% Dextrose Injection………………………… Levitra Tablets (less than 2%)……………………………… Lexapro Oral Suspension (frequent)……………………… Lexapro Tablets (frequent)…………………………………… Lidoderm Patch…………………………………………………… Lipitor Tablets (less than 2%)………………………………… Lunesta Tablets (infrequent)…………………………………. Lyrica Capsules (greater than or equal to 1%)…………
1746 2630 2630 423
2216 2378
2632 698
3195 3052 2435 1992 1999 905
1409 3174 1013 2229 2233 2233
2238
1241 2636 1167 1111 2186
973 2638 435
2520 2255
1470 2024 2859
452
1488 2416 2416 2876 1174 1174 1114 2501 2994 2527
M
Marinol Capsules (less than 1%)………………………………….. Maxalt Tablets (infrequent)…………………………………………. Maxalt-MLT Oral Disintegrating Tablets (infrequent) ………… Meridia Capsules…………………………………………………………… Miacalcin Nasal Spray (less than 1%)..…………………………… Micardis Tablets (more than 0.3%)….…………….……..……….. Micardis HCT Tablets…………………………………….….….……….. Mirapex Tablets (greater than or equal to 1%)……………….. Mobic Oral Suspension (less than 2%) …………………………… Mobic Tablets (less than 2%)……………….…………….…..…….. Mustargen for Injection (infrequent)………………….……….…..
N Nadolol Tablets (1 to 5 of 1000 patients) ….………….……
Nalfon Capsules (4.5%)...…………………………..…….…… Namenda (infrequent)…..………………….……………………...
Naprosyn Suspension (3% to 9%) ………………………….. Naprosyn Tablets (3% to 9%)……………………………….
Neoral Oral Solution (1% to less than 3%) ………………. Neoral Soft Geletin Capsules (1% to less than 3%)……. Neupro Transdermal System ……………………………………….. Nexavar Tablets (uncommon) …………………………….…… Nexium Delayed-Release Capsules (less than 1%) ……… Nexium I.V. (less than 1%)……………………………………… Nexium Delayed-Release Oral Suspension (less than 1%)… Noroxin Tablets………………………………………………….. Norvir (less than 2%) …………………………………………….…
O Orthoclone OKT3 Sterile Solution …….…..……………….…… OxyContin Tablets (less than 1%) …………………………. …
P Parnate Tablets…………………………………..……………….…… Paxil (frequent)………………………………………………………… Paxil CR Controlled-Release Tablets (frequent)……….…… Pepcid Tablets(infrequent)………………………………………….. Pepto-Bismol Original Liquid, Maximum Strength Liquid,
Original and Cherry Tablets, Chewable Tablets and Easy-To Swallow Caplets…………………………………
Percocet Tablets……………………………………………………….. Percodan Tablets………………………………………………………. Pletal Tablets (less than 2%)……..……………..………………. Primaxin I.M. …….…..…….…..……………………..………..……. Primaxin I.V. (less than 0.2%)……………………..………..….. Prinivil Tablets (0.3% to 1.0%)…….……………….………..…. Prinzide Tablets (0.3% to 1%) ……..………..…….….…….... Pristiq Extended-Release Tablets (1% to 2%)………………
Prograf Capsules and Injections (3% to 15%)………….. Protonix Delayed-Release Oral Suspension (less than 1%)… Protonix Delayed-Release Tablets (less than 1%)… Protonix I.V. (less than 1%) ……….………………………...…. Proventil HFA Inhalation Aerosol (less than 3%)….…….. Prozac Weekly Capsules (frequent)………………………………. Prozac Pulvules and Liquid (frequent)…..……….…………… Pylera Capsules………………………………………………………..
(Continued on next page)
3163 2056 2056 475
2274 852 854 857 863 863
2492
2192 2508 1180 2632 2632 2280 2280 3149 784 645 652 645
2069 489
2387 2589
1532 1535 1544 2075
2564 1127 1130 2481 2080 2083 2087 2092 3247 622
3254 3254 3257 2914 1852 1852 714
Please consult with your physician before making any changes in medication.
[email protected] • www.ata.org
2009 PDR GUIDE TO DRUG INTERACTIONS,
SIDE EFFECTS AND INDICATIONS FOR TINNITUS
As listed in the 2009 Physicians’ Desk Reference Companion Guide
When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these listed drugs can be found in the 2009 Physicians’ Desk Reference (PDR). PDR page numbers follow the drug names on this list.
R Recombivax HB (less than 1%)……….……………….………… Requip Tablets (infrequent)……...….…………………………… Romazicon Injection (less than 1%) …………………………… Rythmol Tablets (less than 1% to 2%)……………………… Rythmol SR Capsules ……………………..………………….……..
S St. Joseph 81 mg Aspirin Chewable and
Enteric Coated Tablets …………………………….…….. Salagen Tablets (1% to 2%)……………………………………… Sandimmune (2% or less) …………………………………….….. Solodyn Extended Release Tablets (2%) …………………….
Soriatane Capsules (less than 1% to 10%)...………...... Sular Extended-Release Tablets (less than or equal or 1%)…………………………………. Sustiva Capsules (less than 2%)…….…………….……………. Sustiva Tablets (less than 2%) …………………………………. Symbyax Capsules (frequent)…..………………………………..
2107 1561 2646 1586 1590
1903 1082 2296 1938 3062
2975 930 930
1871
T Tarka Tablets (less frequent)………….……………………. Teveten Tablets (less than 1%)……………………..……. Teveten HCT Tablets (less than 1%) …………………….. Timoptic Sterile Ophthalmic Solution……………………… Timoptic in Ocudose…………………………………………… Timoptic-XE Sterile Ophthalmic Gel Forming Solution………………………….…. Toprol-XL Tablets……………….…..…………………..…….. Treximet Tablets…………………………………………………. Tricor Tablets …………………………………………………….
Trisenox Injection (5%)….………………………………… Twinrix Vaccine………………………………………..………
U Ultram ER Extended-Release Tablets (1% to greater than 5%)………………………………….
V Venlaflaxine Hydrochloride Tablets (2%)…………………. Vicoprofen Tablets (less than 3%)…………….…….…....
Voltaren Tablets (1% to 10%)…..………….…….…….. Voltaren-XR Tablets (1% to 10%)……….……….….….
W Wellbutrin Tablets…….…..………………..…………….……. 511 1648
Wellbutrin SR Sustained-Release Tablets 515 (5% to 6%) …………………………………………… 517 1653
Wellbutrin XL Extended-Release Tablets 2121 (3% to 6%)………………..…………..……………. 2124 1659
X 2125
Xifaxan Tablets (less than 2%) ……………………………. 666 2682 Xyrem Oral Solution (5.9%)……………………………….. 1616 1766
520 Z 986
Zomig Tablets (infrequent) ………………………………… 1628 694 Zomig Nasal Spray (infrequent)……….……………………. 689 Zomig-ZMT Tablets ….……….…………………….…..…….. 694 Zonegran Capsules (frequent)………………………….….. 1089 Zosyn for Injection (1% or less)……………….………..... 2428 3284 Zyban Sustained-Release Tablets (1%)….……….…..…. 1692 Zyprexa Tablets (infrequent)……………………………….. 1883 Zyprexa ZYDIS Orally Disintegrating Tablets 2199
(infrequent) …………………………………………. 533 1883 Zyrtec Chewable Tablets (less than 2%)……………….. 2334 1920 Zyrtec Syrup (less than 2%)…………………………………. 2337 1920 Zyrtec Tablets (less than 2%)…..…………………………. 1920 Zyrtec-D 12 Hour Extended Relief Tablets
(less than 2%) …..…….………………………….. 1923
Please consult with your physician before making any changes in medication. ( Described in PDR for Nonprescription Drugs) (Incidence data in parenthesis : 3% or more)
AMERICAN TINNITUS ASSOCIATION P.O. Box 5 • Portland, OR 97207-0005 • 503-248-9985 • 800-634-8978
[email protected] • www.ata.org
