TIMETABLE 1 BIOINFORMATICS_14 (Advanced Biological Chemistry) 1. Introductory remarks on biochemical information resources

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  • TIMETABLE 1 BIOINFORMATICS_14 (Advanced Biological Chemistry) 1. Introductory remarks on biochemical information resources
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  • Assisted by: Andrea Bernini [email protected]@unisi.it Ottavia Spiga [email protected]@unisi.it Simone Gardini [email protected][email protected] Powerpoint slides to be downloaded from: http://www.sienabiografix.it/edu BIOINFORMATICS_14 (Advanced Biological Chemistry) Academic year 2014-2015 Neri Niccolai 3 1. Introductory remarks on biochemical information resources
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  • 4 BIOINFORMATICS_14 (Advanced Biological Chemistry) http://www.sienabiografix.it/edu
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  • 5 syllabus: 1.Introductory remarks on biochemical information resources 2.Nucleic acids and proteins in one and more dimensions 3.Retrieving information from nucleotide and amino acid sequences 4.3D structure predictions of RNAs and proteins 5.Bioinformatics for pathogen protection 6.Practicals on Immuno-Bioinformatics BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources written test
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  • 6 TEXTBOOK BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources
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  • 7 TEXTBOOK BIOINFORMATICS_14 1. Introductory remarks on biochemical information resources
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  • Automatic procedures Robotics exploring Life in post-genomic era 8 1. Introductory remarks on biochemical information resources
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  • Databank 1 Databank 2 Databank 4 Databank 5 Databank 3 Databank n Bioinformatics Bioknowledge huge amount of data distributed in databank exploring Life in post-genomic era 9 1. Introductory remarks on biochemical information resources
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  • 10 1. Introductory remarks on biochemical information resources exploring Life in post-genomic era
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  • 11 1. Introductory remarks on biochemical information resources exploring Life in post-genomic era databanks+Bioinformatics= biological knowledge
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  • Bioinformatics genome + algorithm * Sequence Alignment Gene localization Genome reconstruction from fragments Protein structure alignment protein structure prediction prediction of gene expression prediction of protein-protein interaction * algorithm = an algorithm is a step-by-step procedure for calculations. Algorithms are used for calculation, data processing, and automated reasoning. An algorithm is an effective method expressed as a finite list of well-defined instructions for calculating a function. 12 2. Nucleic acids and proteins in one and more dimensions
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  • millions or billions of times 13 (deoxy)nucleotide base DNA 4 bases base TACTG 1. Introductory remarks on biochemical information resources
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  • From tens to thousands 14 RNA 4 bases base Uracil U 1. Introductory remarks on biochemical information resources
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  • 15 1. Introductory remarks on biochemical information resources
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  • 16 1. Introductory remarks on biochemical information resources
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  • hydrogen carbon oxygen sulphur nitrogen amino acid + 1 2 3 M L K 4 A 5 W 6 R 7 F 8 D 9 Q Thousands of times more often 100 - 500 17 1. Introductory remarks on biochemical information resources
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  • 18 1. Introductory remarks on biochemical information resources
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  • 19 http://www.slideshare.net/BlazeDreamTech/website-vs-portal 1. Introductory remarks on biochemical information resources
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  • 20 1. Introductory remarks on biochemical information resources
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  • 21 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 22 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 23 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 24 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 25 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 26 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 27 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal
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  • 28 1. Introductory remarks on biochemical information resources Guided tour of NCBI portal