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Thyroid Dysfunction: A Functional Medicine Perspective
Dr. Wayne Sodano, D.C., D.A.B.C.I.
Physiologic Effects of Thyroid Hormones
•Development•Growth•Metabolism
Metabolism
Thyroid hormones stimulate diverse metabolic activities in most tissues, leading to an increase in basal metabolic rate and,
therefore, controls body temperature
Lipid metabolism:
Plasma concentrations of cholesterol and triglycerides are inversely correlated with thyroid hormone levels – one diagnostic indication of hypothyroidism is increased
blood cholesterol concentration.
Carbohydrate metabolism:
Thyroid hormones stimulate almost all aspects of carbohydrate
metabolism, including enhancement of insulin-dependent entry of
glucose into cells and increased gluconeogenesis and glycogenolysis
to generate free glucose.
Growth: The growth-promoting effect of thyroid hormones is intimately intertwined with that of growth hormone.
Hormone-Receptor Bindingand Interactions with DNA
Thyroid hormones enter the cell by facilitated diffusion.
Thyroid Hormone Receptors
Receptor for thyroid hormones are members of a large family of nuclear receptors that include those
of the steroid hormones. They function as hormone-activated transcription factors and thereby act by modulating gene expression.
Constructing Thyroid Hormones
The synthesis occurs in three major steps.
1. Accumulation of raw materialsTyrosinesIodide (I¯):
2. Fabrication or synthesis of the hormones on a backbone or scaffold of precursor
3. Release of the free hormones from the scaffold and secretion into blood
HCH
tyrosine
Thyroid peroxidase
diiodotyrosine
O
II
I I
HO
HCH
thyroxine
Thyroglobulin Thyroid peroxidase
I
I
HO HO
HOHCH
I
I
I
I
I
I
HOHCH
HCH H
C=H
Thyroid-Binding Globulin
TBG is the major thyroid hormone protein carrier. It is primarily produced in
the liver and is affected by liver dysfunction.
TRH
TSH
Thyroid Gland95% T4
5% T3
~ 95%
5 deiodinase
rT3Inactive(45%)
T3Active(35%)
5’ deiodinase(Se)
Hypothalamus Pituitary
Liver or Kidney
Cell Nucleus
5’ –Deiodinase Inhibitors
Selenium deficiencyInadequate protein, excess carbohydrates
High insulinChronic illnessStress (cortisol)
Cd, Hg, Pb, and other toxinsCompromised liver or kidney
Impaired glucuronidationImpaired sulfation
Hypothalamus
Anterior Pituitary
Severe Stress Cold Circadian rhythms
( - ) (+) (+)
Somatostatin TRH
( - ) (+)
TSH
(+)
Thyroid
( - )
T4
T3
Excess I.
I.(+)
Thioureylenes
( - )
( - )
Factors That Regulate Thyroid Hormone Secretion
Assessing Metabolic Energy
Sub-optimal thyroid and adrenal functions are the most common causes of low metabolic
energy. Both present with low body temperature and although some signs and
symptoms are shared by both, many are not.
Metabolic Temperature Graph
Patient HistoryPhysical Exam
Past Medical RecordsCurrent Lab Tests
-Standard-Functional (ASI)
Fix Adrenals First
ASI Test
Liver
Kidney
LiverGI Dysfunction
Kidney
Temp Graph UnstableTAS Favors Adrenal Dysfunction
Temp Graph StableTAS Favors Thyroid Dysfunction
Treat ThyroidLiver
GI DysfunctionKidney
Thyroid/Adrenal Symptom SurveyTemperature Graph
Functional Medicine Thyroid
Algorithm
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