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Thursday, October 2, 2014
Title: Genetic DisordersLT: I will be able to explain the inheritance
of various genetic disorders.Do Now:
1. What is the difference between an autosomal disorder and a sex linked disorder?
2. Analyze the pedigree below and answer the following:
The characteristic indicated by the blackened figures is probably: a. Dominant. b. Recessive. c. Non-dominant. d. Sex-linked recessive.
Pedigree Question #1 to Ask…
• What is the mode of inheritance?– Autosomal dominant: the disorder is a dominant trait, only one affected allele must be inherited to show the phenotype
– Autosomal recessive: the disorder is a recessive trait and offspring must inherit TWO recessive alleles to show the phenotype
– Sex Linked: the disorder is LINKED to the X chromosome and is inherited when the affected X or two affected X chromosomes are passed on
Autosomal Dominant Disorders:
• Affects males and females equally
• Both genders can pass the trait• Later generations will be affected
• Rarely skips a generation– Achondroplasia (dwarfism)– Huntington’s Disease– Marfan Disease
Sex Linked Disorders
• Affects males more than females• Only females can be carriers• Can be passed from either parent*
• Most are recessive–Duchenne Muscular Dystrophy–Colorblindness–Hemophilia
Autosomal Recessive Disorders
• Affects both genders equally• Can skip generations• Both genders can be carriers–Cystic Fibrosis–Sickle Cell Anemia–Tay-Sachs
Today’s Activity:
• You and a partner will research ONE inherited genetic disorder.
• You will use that research to identify FIVE FAST FACTS about the disorder.
• You will then read a scenario about a family that has a history of that disorder.
• Using the scenario, you will create a pedigree that accurately represents the family history of that disorder.
• You will then answer the questions posed.• Your final assessment of mastery will be a POSTER and PRESENTATION* of that poster to the class.
Poster Requirements:
• Disorder Name: BOLD, NEAT, CLEAR
• Five Facts• Pedigree: CORRECT, CLEAR, NEAT
• @ least ONE Punnett Square you ran
• Scenario attached*My walls are bare… I’d like to change that!
Thursday, October 2, 2014
Title: Pedigrees and Genetic Disorders
LT: I will be able to trace the inheritance of a trait within a
family.
Do Now: Why would it be important to be
able to track the inheritance of a trait across multiple generations
of a family?
Today’s Agenda
1.You will record live notes about PEDIGREES and GENETIC DISORDERS.
2.You will receive a practice worksheet about pedigrees to complete as homework, DUE tomorrow.
Friday, October 3, 2014
• Do Now: Using the pedigree, determine which mode of inheritance (autosomal dominant, autosomal recessive, sex linked) the trait follows. Explain your choice. Then, determine the genotype of person X.
LT: I will be able to track the inheritance of a trait within multiple generations of a family using a pedigree.
Today’s Agenda1.You will continue your genetic investigation of a family history and a genetic disorder.
2.DUE at END of class:1.Completed poster2.Don’t forget to turn in your
purple pedigree homework!
Friday, October 3, 2014
• Do Now: DRAW THE PEDIGREE!
• Using the pedigree, determine:– What is the relationship between U, V and W?
– What is the phenotype of X?
– What is the genotype of Y?
Title: Pedigrees – Mode of InheritanceLT: I will be able to track the inheritance of a trait within multiple generations of a family using a pedigree.
Today’s Agenda1.You will record quick notes about PEDIGREES and GENETIC DISORDERS.
2.You will work with your lab group to create a pedigree about a family and their history of a genetic disorder.
3.Don’t forget!!! Turn in your pedigree homework from last night!
Pedigree Question #1 to Ask…
• What is the mode of inheritance?– Autosomal dominant: the disorder is a dominant trait, only one affected allele must be inherited to show the phenotype
– Autosomal recessive: the disorder is a recessive trait and offspring must inherit TWO recessive alleles to show the phenotype
– Sex Linked: the disorder is LINKED to the X chromosome and is inherited when the affected X or two affected X chromosomes are passed on
Autosomal Dominant Disorders:
• Affects males and females equally
• Both genders can pass the trait• Later generations will be affected
• Rarely skips a generation– Achondroplasia (dwarfism)– Huntington’s Disease– Marfan Disease
Sex Linked Disorders
• Affects males more than females• Only females can be carriers• Can be passed from either parent*
• Most are recessive–Duchenne Muscular Dystrophy–Colorblindness–Hemophilia