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Glomerulo-pathies

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Glomerulo-pathies

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If you meet a patient with rapidly progressive GN and alveolar

hemorrhage, suspect this condition marked by antibodies

against type IV collagen

What is Goodpasture’s

syndrome?

Patients with this diagnosis have a higher risk of malignancy,

especially solid tumors; it is also the most common cause of

nephrotic syndrome in adults

What is membranous nephropathy?

This cause of nephrotic syndrome is frequently

associated with HIV and heroin use; the “collapsing” variant is most common among African

Americans

What is focal segmental glomerulosclerosis?

Majority with this disease, marked by hematuria, proteinuria and low

complement, are Hepatitis C (+). Don’t forget to look for

palpable purpura and skin necrosis.

What is mixed cryoglobulinemia?

Often heralded by hematuria 1-3 days post-URI, this is the most common cause of GN

worldwide most prevalent in Asians and rare in blacks

What is IgA nephropathy?

What is a hypersegmented neutrophil?

(Megaloblastic anemia)

What are sickle cells?(Sickle cell anemia)

What is a Reed-Sternberg cell?

(Hodgkin’s lymphoma)

What are Howell-Jolly bodies?

(Asplenia; hemolytic, megaloblastic anemia)

What are hairy cells? (Hairy cell leukemia)

A long latency of about 30-40 years occurs from exposure to this mineral and mesothelioma

What is Asbestos?

Miners and sandblasters exposed to this crystalline mineral are at high risk for tuberculosis and

should have their PPD checked

What is Silica?

Coal worker’s pneumoconiosis+

Rheumatoid arthritis+

Multiple pulmonary nodules

What is Caplan’s syndrome?

First described in fluorescent lamp workers, this disease may present with skin and

lung nodules showing noncaseating granuloma

What is Berylliosis?

A reactive airway disease in textile mill workers exposed to

cotton dust, it presents with wheezing and causes “Monday

chest tightness” that improves at the end of the work week

What is Byssinosis?

Strawberry cervix

What is Trichomonas vaginalis infection?

Apple-core lesion

What is colon cancer?

Strawberry tongue

What is Kawasaki disease?

(also Scarlet fever)

Cherry red spot on macula

What is Tay-Sachs disease? (also Central Retinal Artery

occlusion)

Watermelon stomach

What is Gastric Antral Vascular Ectasia

(GAVE)?

Rash hour

Travel ID

Toxicology

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What is erythema migrans?

(Lyme disease)

What is pytiriasis versicolor?

What is

dermatitis herpetiformis?

What is erythema multiforme?

What is lichen planus?

From pulmonary to disseminated such as in AIDS, this mycosis can be picked up from bird and bat droppings in the Ohio and Mississippi River

valleys

What is Histoplasmosis?

The most common rickettsial infection in the US, it is

mainly transmitted by the Dermacentor tick and is

prevalent in the Southeast such as North Carolina

What is Rocky Mountain Spotted Fever?

Attention: this fungal infection that causes Valley Fever is

endemic in Arizona, California, New Mexico and

yes, West Texas!

What is Coccidioidomycosis?

Humans handling infected animals, like rabbits and deer, are accidental hosts of this zoonosis

caused by a gram-negative bacterium common in the South

Central states, primarily Arkansas

What is Tularemia?

Let’s travel this time to the tropics…this potentially fatal spirochetal

infection causes Weil’s syndrome and is acquired by exposure to the

urine of infected carrier animals such as rats

What is Leptospirosis?

Tinnitus, vertigo, respiratory alkalosis and high gap

metabolic acidosis…and in kids, Reye’s syndrome

What is aspirin toxicity?

Xanthopsia, or impaired yellow-green color perception, is a rare but characteristic adverse effect

of toxicity from this oldest cardiac drug

What is Digoxin?

Chronic intake of this psych drug can cause kidney toxicity and

nephrogenic DI

What is lithium?

Myelosuppression is a well-known hematologic adverse effect of this MRSA-fighting drug, especially when used longer than 2 weeks

What is linezolid?

Toxicity from this can cause high gap acidosis, high serum osmolality and oxalate crystals in the urine; it is

common in antifreeze

What is ethylene glycol?

Osteoarthritic growth of the proximal

interphalangeal joint

What is Bouchard’s node?

Left supraclavicularlymph node usually

suggestive of agastrointestinal neoplasm

What is Virchow’s or Troisier’s node?

Tender, red, raised lesions on the hands or feet

indicative of subacute bacterial endocarditis

What are Osler’s nodes?

First lymph nodereached by metastasizing

cancer cells

What is sentinel node?

Palpable metastatic node in the umbilicus

What is Sister Mary Joseph node?

Medical Milestones

This Scottish Nobel Prize winner accidentally discovered the world’s

first antibiotic named after the fungus from where it was isolated

Who is Sir Alexander Fleming?

Thank you for playing