THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER · THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER 1-3 March 2018 Palazzo Bernabei, ... Valentina Lancellotta,

THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER

1-3 March 2018 Palazzo Bernabei, Assisi - Italy

Under the patronage

AIMS- to identify grey zones in daily clinical practice in breast cancer treatment by detecting

where the evidence is not so firm, - to brainstorm on issues in combined treatment modalities,- to identify affordable trial proposals to address the issues and put them forward to the

scientific community, public and private sponsors - to promote cure and enhance patients’ quality of life.

METHOD

To achieve these aims the Meeting will take the following steps:

1. The Scientific Organizers (SO) nominated an international Expert Board (EB) and identified the

main clinical situations demanding investigation;

2. The SO chose the Chairs and Speakers for each topic;

3. Clinical cases with questions on treatment options were prepared;

4. The EB voted on different clinical choices in a monkey questionnaire before the meeting;

5. At the meeting, on Day 1 (Thursday afternoon, 1 March 2018), the EB will:

a) discuss the monkey survey results and the outstanding clinical issues

b) select the trial proposals to be debated on the following days

6. On Day 2 (Friday, 2 March 2018), trial proposals will be presented and debated by the EB.

Meeting attendees, who will act as the first validation group, will comment on the proposals

from their perspective. Moreover, potential public and private research sponsors will attend and

decide whether they are interested in funding the research proposals.

7. On Day 3 (Saturday, 3 March 2018), the EB will

a) review protocol drafts to outline the final proposals

b) deliver a set of trial proposals for each topic, each of which will include:

1. Aim

2. Primary and secondary endpoints

3. Patient selection

4. Treatment modalities to be tested

5. Research method: prospective study (expected benefit should be defined so as to

set the accrual number and timing) or large data base collection

c) plan the outline of the white paper to be written about ATTM and trial proposals

d) set topics for future meetings.

TOPICS1. Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy2. Therapeutic options in ductal carcinoma in situ3. De-escalated therapies in early breast cancer

Participants: Expert Board

Morning: arrival; welcome lunch

14.00 - 14.30 Meeting aims and methodology: Why this meeting? Why this methodology? What follow-up? Philip Poortmans, Cynthia Aristei, Vincenzo Valentini

14.30 – 15.30 Report the results of the clinical case monkey questionnaire - Topics 1,2 and 3

Room A:

15.30 - 19.00 Topic 1 : Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci

15.30 - 15.35 Monkey-survey results and on-site tele-voting Elisabetta Perrucci

15.35 - 15.55 Review the main evidence Icro Meattini

15.55 - 16.15 Review ongoing clinical trials Liesbeth Boersma

16.15 - 16.30 Discussion

16.30 - 17.00 Coffee Break

17.00 - 19.00 Scouting for trial proposal: which goal? All Expert Board Group

Room B :

15.30 - 19.00 Topic 2 : Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi

15.30 - 15.35 Monkey-survey results and on-site tele-voting Fabio Marazzi

15.35 - 15.55 Review the main evidence Angel Montero Luis

15.55 – 16.15 Review ongoing clinical trials Cristina Leonardi



PROGRAM

Thursday, 1 March 2018 Thursday, 1 March 2018


Room C :

15.30 - 19.00 Topic 3: De-escalated therapies in early breast cancer

Team Chairs: Ugur Selek, Raphael Pfeffer

Secretary: Valeria Masiello

15.30 - 15.35 Monkey-survey results and on-site tele-voting Valeria Masiello

15.35 - 15.55 Review the main evidence Pierfrancesco Franco

15.55 - 16.15 Review ongoing clinical trials Vassilis Kouloulias




19.00 - 20.00 Presentations of working group proposals

Friday, 2 March 2018

9.00 - 9.15 Aims and methodology of the day Philip Poortmans , Cynthia Aristei, Vincenzo Valentini9.15 - 9.35 Lecture: Epidemiology of breast cancer Philip Poortmans9.35 - 9.55 Lecture: Biological subtypes and their impact on survival Cynthia Aristei9.55 - 10.15 Lecture: Learning from large data base in breast cancer: state of the art Vincenzo Valentini

9.55 - 10.15 Question time All participants

10.20 -10.35 Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci

10.20-10.15 Case presentation (on-site televoting) Elisabetta Perrucci

10.35 - 10.55 Review the main evidence Icro Meattini

10.55 -11.15 Coffee Break

11.15 - 11.35 Review ongoing clinical trials Liesbeth Boersma

11.35 - 12.30 Trial proposal presentation by working group delegates

12.30 - 13.00 Voting to rank trial proposals All participants

13.00 - 13.15 Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi

13.00-13.15 Case presentation (on-site televoting) Fabio Marazzi

13.15 - 13.35 Review the main evidence Angel Montero Luis

13.35 - 14.30 Lunch

14.30 - 14.50 Review ongoing clinical trials Cristina Leonardi



16.15 - 16.30 De-escalated therapies in early breast cancer Team Chairs: Ugur Selek, Raphael Pfeffer Secretary: Valeria Masiello

16.15 - 16.30 Case presentation (on-site televoting) Valeria Masiello

16.30 - 16.50 Review the main evidence Pierfrancesco Franco


17.10 - 17.30 Review ongoing clinical trials Vassilis Kouloulias



18.30 -18.45 Closing Remarks Philip Poortmans, Cynthia Aristei, Vincenzo Valentini

Saturday, 3 March 2018

Participants: Expert Board

9.00 - 9.45 Finalize Trial Proposals for Topic 1


10.30- 11.00 Coffee Break


11.45 - 12.15 Plan outline of white paper and propose topics for next meeting

12.15 - 12.30 Closing remarks

Scientific Organizers: Philip Poortmans, Cynthia Aristei, Vincenzo Valentini

Executive Committee:Scientific organisers, Meritxell Arenas, Céline Bourgier, Orit Kaidar-Person, Icro Meattini Advisory members from Northern Europe: Liesbeth Boersma (NL), Charlotte Coles (UK), Birgitte Offersen (DK)

Expert Board (apart from the executive Ctee):France: Bruno Cutuli (Reims), Sofia Rivera (Villejuif )Spain: Angel Montero Luis (Madrid)Portugal: Lurdes Trigo (Oporto)Greece: Vassilis Kouloulias (Athens)Turkey: Ugur Selek (MD Anderson, Istanbul)Israel: Raphael Pfeffer (Ramat-Gan)Italy: Antonella Ciabattoni, Lorenzo Falcinelli, Pierfrancesco Franco, Giovanni Frezza, Domenico Genovesi, Marco Krengli, Valentina Lancellotta, Cristina Leonardi, Fabio Marazzi, Valeria Masiello, Nadia Pasinetti, Elisabetta Perrucci, Luigi Pirtoli, Riccardo Santoni, Daniela Smaniotto, Vincenzo Tombolini, Cristiana Vidali

Local Organizers:

Lorenzo Falcinelli, Valentina Lancellotta, Fabio Marazzi, Valeria Masiello, Elisabetta Perrucci, Daniela Smaniotto

Expert Board Group 1Liesbeth Boersma Bruno CutuliDomenico GenovesiMarco KrengliValentina LancellottaIcro MeattiniBirgitte OffersenElisabetta Perrucci Riccardo SantoniLurdes Trigo

Expert Board Group 2 Meritxell ArenasCéline BourgierLorenzo Falcinelli Cristina LeonardiFabio MarazziAngel Montero LuisSofia RiveraDaniela Smaniotto Vincenzo TomboliniCristiana Vidali

Expert Board Group 3 Antonella CiabattoniCharlotte ColesPierfrancesco FrancoGiovanni FrezzaVassilis KoulouliasValeria MasielloNadia PasinettiRaphael PfefferLuigi PirtoliUgur Selek ORGANIZING SECRETARIATCONSULTA UMBRIA SRLTel. +39 075 5000066fax +39 075 5153466E-mail : [email protected]

NOTE

Sponsored by:

ULTIMATE GOAL:TO BE BACK HOME WITH

A TRIAL PROPOSALIN YOUR POCKET !

Documents

THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER · THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER 1-3 March 2018 Palazzo Bernabei, ... Valentina Lancellotta,