The Lighter Side The Way They Work (To the Tune of ‘‘The Way We Were’’) h S Received for publication, January 28, 2011 Kevin Ahern† From the Department of Biochemistry & Biophysics, Oregon State University, Corvallis, Oregon, 97331 Enzymes Mighty powerhouse peptides Cause reactions to go faster In the cell’s insides Tiny substrates Bring about an induced ﬁt Enzyme structure is affect-ed By what binds to it Can it be that it’s just simple zen? How the enzymes activate If they bind effector, will they go To an R-State, T-State? Folding Gives the mechanistic might To three-D arrangement Of the active site Enzymes Have a bias they can’t hide Hydrophobic side chains are Mostly found inside So it’s the structure For celebrating Whenever there’s debating The way they work The way they work Copyright Ó 2011 Kevin Ahern h S Additional supporting information (an .mp3 ﬁle of this song) may be found in the online version of this article. †To whom correspondence should be addressed. Tel.: 541- 737-2305. E-mail: [email protected]. This paper is available on line at http://www.bambed.org DOI 10.1002/bmb.20525 331 Q 2011 by The International Union of Biochemistry and Molecular Biology BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION Vol. 39, No. 4, pp. 331, 2011

The way they work (to the tune of “the way we were”)

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Page 1: The way they work (to the tune of “the way we were”)

The Lighter Side

The Way They Work (To the Tune of ‘‘The Way We Were’’)hS

Received for publication, January 28, 2011

Kevin Ahern†

From the Department of Biochemistry & Biophysics, Oregon State University, Corvallis, Oregon, 97331

EnzymesMighty powerhouse peptidesCause reactions to go fasterIn the cell’s insides

Tiny substratesBring about an induced fitEnzyme structure is affect-edBy what binds to it

Can it be that it’s just simple zen?How the enzymes activateIf they bind effector, will they goTo an R-State, T-State?

FoldingGives the mechanistic mightTo three-D arrangementOf the active site

EnzymesHave a bias they can’t hideHydrophobic side chains areMostly found inside

So it’s the structureFor celebratingWhenever there’s debatingThe way they workThe way they work

may be found in the online version of this article.† To whom correspondence should be addressed. Tel.: 541-

737-2305. E-mail: [email protected].

This paper is available on line at http://www.bambed.org DOI 10.1002/bmb.20525331

Q 2011 by The International Union of Biochemistry and Molecular Biology BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Vol. 39, No. 4, pp. 331, 2011

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