The Vincent Memorial Hospital Foundation

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The support of The Vincent Memorial Hospital Foundation is a vital resource for Mass General’s Vincent Department of Obstetrics and Gynecology. In times of dwindling federal grants, rising expenses and tighter clinical margins, this funding allows our faculty and staf f to lead in clinical care and discovery and continue our commitment to train the next generation of specialists and subspecialists in our field.

These funds have helped the Vincent Center for Reproductive Biology become a renowned center for basic science research in OB/GYN, both by providing seed grants to individuals while also supporting the laboratory’s infrastructure. In addition, VMHF contributions support the fellowship training of the next generation of OB/GYN physician-scientists focused on gynecologic cancers, high-risk pregnancies, infertility, and pelvic floor disorders and incontinence.

My partner in all these ef forts is the VMHF Board, which includes a collection of diverse and remarkable individuals who of fer more than just financial support. As we shape our path forward, this 18-member Board is a rich source of wisdom, of fering invaluable guidance and perspective.

Founded over a century ago, the Vincent Memorial Hospital and its more than 75-year connection to Mass General remains central to OB/GYN care, research and training at Mass General. We value our shared history, celebrate our present collaboration and look forward to a vibrant future as we continue our incredible partnership. Thank you for all you do and allow us to do.

JEFFREY L. ECKER, MDChief, Vincent Department of Obstetrics and Gynecology, Massachusetts General HospitalJoe Vincent Meigs Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School

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Message from the Chief

What the Vincent Foundationmeans to Mass General today

The year 2018 marked a major milestone in the distinguished history of Vincent Memorial Hospital. Thoughtful and thorough deliberations that spanned more than two years culminated in the Board of Trustees’ decision to add the word “Foundation” to the corporation’s name.

The new name — The Vincent Memorial Hospital Foundation, Inc. — communicates the progression of our nonprofit organization from its 1891 beginnings as a Boston hospital for working women to a charitable endowment dedicated to advancing the health of all women.

To showcase the Vincent Memorial Hospital Foundation’s new name and vibrant ongoing mission, we have completely updated our website. It highlights the foundation’s support of two key initiatives in the Vincent Department of Obstetrics and Gynecology at Massachusetts General

Hospital — laboratory research in the Vincent Center for Reproductive Biology (VCRB), and the training of tomorrow’s leaders in obstetrics and gynecology. It also features stories about donors, patients and outreach events.

In addition, a newly launched quarterly e-newsletter focuses on what’s new at the Vincent — discoveries by faculty, profiles of clinical research fellows and studies by postdoctoral fellows, who work side-by-side with research faculty on innovations streaming from the VCRB. A total of 85 studies were published in 2018 by Vincent OB/GYN clinical and research faculty, advancing new directions in women’s care.

Through our website, eNews and outreach events, we’re excited to engage the general public in the work emanating from the Vincent, a world leader in obstetrics and gynecology. We thank you for your ongoing and enthusiastic support.

DAVID E. WALKER CATHERINE S. AUSTIN Chair Vice Chair

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A new era in women’s health

1891Vincent Memorial Hospital (VMH) is founded by friends of Mary Ann Vincent, a generous Boston actress. Grace Wolcott, MD, and Lena V. Ingraham, MD, are the first doctors of this freestanding 12-bed facility for women in need, originally located at 44 Chambers St. in Boston, near Massachusetts General Hospital.

1948The VMH moves to the newly completed Vincent Burnham Building.

2018The nonprofit corporation formally becomes The Vincent Memorial Hospital Foundation to better reflect its role as a funding organization while recognizing its distinguished heritage as a hospital for women. A new website and eNews are launched.

1908The VMH moves to a larger facility on South Huntington Ave. in Boston.

1941Recognizing the tremendous potential of merging the VMH with the broad resources of Mass General, the VMH relocates to the Mass General campus, where it becomes the gynecology service while retaining its own hospital identity and staff.

1988When the clinical services of the VMH become part of Mass General, the VMH continues as an independent charitable organization focused on supporting OB/GYN research and training at Mass General’s Vincent Department of Obstetrics and Gynecology.

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2011Achieving an academic goal set in 1977, a fourth OB/GYN subspecialty fellowship is added at Mass General. Today, with continuing support from the VMHF, 12 young physician-scientists pursue the demanding subspecialty training that will help them become tomorrow’s leaders in academic medicine (see page 4).

1995The VMH provides significant funding to launch the Vincent Center for Reproductive Biology, a state-of-the-art laboratory where Vincent faculty and fellows explore how cells normally work and what goes wrong in gynecologic cancers, infertility, premature delivery, infections and other conditions unique to women’s health (see page 3).

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Training Tomorrow’s Leaders

Seeking innovative solutionsIn fellowships supported by The Vincent Memorial Hospital Foundation, young physician-scientists pursue demanding training to become tomorrow’s leaders in OB/GYN. The Vincent fellows below are exploring key issues in women’s care.

For more information on the 12 physicians serving Vincent OB/GYN fellowships, please visit our website: vincentmemorial.org/training.

“This year, the biggest fundamental change in our gynecologic cancer research initiative has been creating an organized leadership group representing surgery, medicine and basic research,” said Eric Eisenhauer, MD (at lef t in photo), the new chief of the Division of Gynecologic Cancer, who joined the Vincent Department of Obstetrics and Gynecology in September 2018.

Meeting weekly in the Vincent Center for Reproductive Biology (VCRB), the Gynecologic Oncology Leadership Group also includes scientist Bo Rueda, PhD (at center), director of the VCRB, who conducts basic research in gynecologic cancer and also oversees an extensive tumor bank, a treasure trove for lab investigators.

The third specialist is medical oncologist David Spriggs, MD (right), director of the Gynecologic Cancer Program at the Mass General Cancer Center, who offers systemic treatment options such as chemotherapy and immunotherapy for women’s cancers.

In addition, a forum of approximately 15 physicians and scientists from Mass General and MIT meets monthly. Together, they are speeding the translation of lab discoveries into new therapies — a “bench to bedside” discovery cycle called translational research. It involves many intricate steps. Lab findings about molecules, genes and cells are leveraged to identify possible drug interventions, which are tested in cell lines, then animals and possibly human patients.

A key goal is to develop immunotherapies for ovarian cancer. Diagnosed in 20,000 U.S. women each year, ovarian cancer causes more deaths than any other gynecologic cancer.

“To create effective immunotherapies, scientists must understand the mechanisms the immune system normally uses to surveil the body for cancer and how cancer cells fool the immune system into ignoring them,” said Dr. Eisenhauer. “One aim of immunotherapy is to block cancer cells’ ability to avoid the immune system, allowing the immune system to recognize and destroy cancer cells as foreign invaders.”

At the heart of this approach is personalized medicine. All ovarian cancer patients at Mass General undergo genetic testing for nine hereditary mutations, including BRCA1 and BRAC2. Treatments are tailored to their genetic profile as well as robust responses to multi-modality protocols emerging from clinical studies nationwide.

There is considerable reason for hope. “Thirty years ago, the life expectancy of a woman with ovarian cancer was less than two years,” said Dr. Eisenhauer. “Today, effective surgery and novel medical therapies allow patients to live on average six to 10 years, and emerging treatments promise to push that out even further.”

“Many of these positive results are possible because of The Vincent Memorial Hospital Foundation, which for nearly 25 years has provided funding for the VCRB and resources for Vincent fellows and trainees,” he said. “The Vincent’s support is making a huge difference.”

Research Advances

Conquering women’s cancersA new leadership group at Massachusetts General Hospital is coordinating an all-out effort to conquer cancers of the female reproductive system — from early detection to personalized treatment options.

Preventing pre-term birthKaitlyn Edelson, MD, in Maternal-Fetal Medicine, is studying pathways that trigger pre-term labor. She is investigating how placental DNA fragments called telomeres shorten as a woman approaches her due date. This shortening appears to be one of the triggers that starts labor. By better understanding how telomeres shorten in pre-term labor, we can begin to develop interventions that prevent pre-term birth.

Understanding infertilityCaitlin R. Sacha, MD, in Reproductive Endocrinology and Infertility, is studying anti-Müllerian hormone (AMH), a hormone used to assess women’s ovarian function, or egg reserve. But it is not fully understood how AMH levels vary between follicles and over time for women with different infertility diagnoses. In addition to increasing knowledge of AMH physiology in the ovary, these studies will help determine if AMH in follicular fluid is a valuable predictor of embryo quality.

Identif ying protective microbesPatricia Hudson, MD, in Female Pelvic Medicine and Reconstructive Surgery, is investigating the effects of “good” protective vaginal bacteria on the “bad” bacteria that cause urinary tract infections (UTIs), focusing on strategies to control or eliminate pathogens associated with UTIs. She also has been studying the effects of these protective vaginal bacteria on the healing of vaginal cells.

Optimizing patient careKatelyn Dorney, MD, in Gynecologic Oncology, focuses on improving care for patients at Mass General, with special attention to identifying, analyzing and optimizing organizational processes to meet standards of quality. As part her Vincent fellowship, she has been a Partners Population Health Leadership Fellow, helping to create the Partners Hospice Collaborative Network, which focuses on improving the quality of care at the end of life.

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Vincent Memorial Hospital Foundation Statement of Activities for the Years Ended September 30, 2018 and 2017Sources of Revenue 2018 2017 Annual Contributions* $111,101 $75,325

Income from endowment 578,317 550,513

Endowment transfer to support Operating Expenses 567,865 472,511

Total revenue $1,257,283 $1,098,349

Operating Expenses Vincent Center for Reproductive Biology support $600,000 $500,000

Teaching and research support 250,000 250,000

Program and project support 100,000 55,000

VincenTech, LLC 3,790 17,972

Support services (marketing, investment fees, audit) 293,546 262,676

Board of Managers grants and program expense 9,947 12,701

Total expenses $1,257,283 $1,098,349

Percentage of endowment Net Assets 3.8% 3.6%used to fund Operating Expenses

Net Assets, beginning $29,760,999 $26,985,862

Net Assets, ending $30,343,587 $29,760,999

*Annual Contributions include only those gif ts made directly through the VMHF to benefit the Vincent Department of OB/GYN. Additional support is also solicited and channeled through the Mass General Development Of fice to benefit the Department.

The VMHF is a public charity that supports programs for the care and treatment of women at the Vincent Department of Obstetrics and Gynecology at Massachusetts General Hospital. It is a 501(c)(3) tax-exempt charitable organization that is separate and distinct from Mass General. The figures shown reflect the audited financial statements of the VMHF.

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VMHF funding supports the futurePlease visit the VMHF website to see how gifts of all sizes, both large and small, are working together to advance women’s health. Donations may be made online or mailed to Vincent Memorial Hospital Foundation, 55 Fruit Street, FND 516, Boston, MA 02114. Our deepest appreciation for supporting the future of women’s healthcare.

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VMHF DonorsJanuar y 1, 2018, through December 31, 2018The donor list below recognizes gif ts made to The Vincent Memorial Hospital Foundation. It does not include gif ts benefiting Mass General’s Vincent Department of Obstetrics and Gynecology that are processed through the Mass General Development Of fice.

FOUNDATIONS, TRUSTS AND CORPORATIONSMacPherson Fund, Inc.

Milbank FoundationEdward Lee & Slocumb Hollis

Perry Foundation James O. Robbins Family Charitable Lead

Annuity Trust

Sanofi Foundation for North America

WestWind Foundation

INDIVIDUALSMr. & Mrs. Charles A. AustinMrs. Hope Lincoln Baker Mr. & Mrs. William R. Baker, Jr. Mrs. Robert Bannish Mr. Brant C. Binder

Mrs. Elizabeth CampanellaMrs. Ann CorcoranMs. Elizabeth R. ColtMrs. W. Pearce Coues Mrs. Winthrop DowMr. William Ebsworth & Dr. Anandi Pratap Mrs. Paul Evans Mrs. Richard FeeneyMr. & Mrs. Peter R. GatesLawrence Gennari, Esq., & Denise Pelletier, Esq. Mrs. Eizabeth P. HealdMs. Mary Kay HolderMr. & Mrs. James F. Hunnewell, Jr.Miss Sally D. Hurlbut Mr. & Mrs. F. Gardner Jackson, Jr.Miss C. Winston Jenkins Mrs. Bret JordanMrs. James KesslerMrs. Walter O. LaBonte, Jr.

Mrs. David Lee Mrs. Josiah K. Lilly, III Mrs. Ian LoringMrs. Kristen Miller MahoneyMrs. Benjamin McClearyMrs. James Mead Ms. Sarah P. Meigs Mrs. David L. MurphyMs. Jane Brooks RobbinsMrs. Eve Ross RobertsLaura Saltonstall, MD, & Alex SaltonstallMrs. George Sprague The Hon. & Mrs. Richard G. StearnsMrs. Marshall Taylor Ms. D. Higgins ThompsonMr. & Mrs. Michael E.F. TreacyMr. & Mrs. David E. Walker Mr. & Mrs. Monte J. WallaceMrs. Thomas H.P. Whitney, Jr.

VMHF LeadershipVMHF BOARD OF TRUSTEESMr. David E. Walker, ChairMrs. Catherine S. Austin, Vice ChairMrs. Hope Lincoln Baker, ClerkMr. Peter R. Gates, Treasurer Mr. Brant BinderMr. William R. EbsworthMr. Lawrence H. GennariDr. Matina S. HornerMrs. James F. Hunnewell, Jr. Mr. F. Gardner Jackson, Jr.Mrs. Kristen Miller MahoneyMs. Sarah P. Meigs Mrs. Patricia F. Ribakof f Mrs. Eve Ross Roberts Dr. Laura SaltonstallHon. Richard G. Stearns Mrs. Michael E.F. TreacyMrs. Thomas H.P. Whitney, Jr.

LIFE TRUSTEESMrs. William S. FriendMrs. John J. States

EX-OFFICIOMrs. Mary Lotuf f Feeny, President Vincent Memorial Hospital Foundation Board of Managers

VMHF BOARD OF MANAGERSMrs. Mary Lotuf f Feeny, PresidentMrs. David Bailey Lee, First Vice PresidentMrs. Marshall Taylor, Second Vice President Mrs. James E. Kessler, TreasurerMrs. Robert Bannish, Corresponding SecretaryMrs. David L. Murphy, Recording SecretaryMrs. Catherine S. AustinMrs. Elizabeth M. CampanellaMrs. Daniel CorcoranMrs. W. Pearce Coues Mrs. Paul EvansMrs. William S. FriendRev. Patricia HandlossMs. Mary Kay HolderMiss Sally D. HurlbutMs. C. Winston JenkinsMrs. Eric H. JohnsonMrs. Bret D. JordanMrs. Rosanna LaBonte Mrs. Josiah K. Lilly, IIIMrs. Ian K. Loring Mrs. Benjamin P. McClearyMrs. James G. MeadMs. Sarah P. MeigsMrs. George R. SpragueMrs. John J. States Mrs. Kilman K. Steele Mrs. Michael F. Wynne-Willson

HONORARY MEMBERSMrs. David AmesMrs. Lewis H. ClarkMrs. Winthrop G. Dow, Jr.Mrs. William S. Olney

Dr. Matina Souretis Horner, a VMHF Trustee, was honored in 2018 by the MGH Institute of Health Professions, which has established an endowed professorship in her name in recognition of her 27 years of board service, including chairing the board from 1995–2005. During her distinguished career in education, which included serving as president of Radclif fe College, she has made major contributions to women's studies and to the advancement of the health professions.

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The Vincent Memorial Hospital Foundation, Inc. Massachusetts General Hospital 55 Fruit Street, FND 516 Boston, MA 02114

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COVER IMAGESLef t: Nurses providing patient care, Eaton Ward, original Vincent Memorial Hospital, 1906Right: Vincent fellow managing women's cancer care, Phillips House, Ellison Building, Mass General, 2019Background (original at lef t): Using Alcian blue (pH 2.5)-periodic acid–Schif f (AB-PAS) staining, this image shows expression of mucin in colorectal cells, serving as a positive control to identify mucinous ovarian cancer in experimental models. Image by VCRB Investigator Cheng Wang, PhD

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