The University Of Western Ontario - Zhejiang Universityche.zju.edu.cn/attachments/2011-09/07-1317289028-48655.pdf · The University Of Western Ontario . ... Downstream Processing

The University Of Western Ontario Faculty of Engineering

DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING

CBE 4404A - Downstream Processing in Pharmaceutical Manufacturing

Course Outline 2010-2011

The objective of this course is to introduce upper year chemical/biochemical engineering students to pharmaceutical manufacturing. An overview of the pharmaceutical industry and its regulations will be presented followed by the basic concepts of the major manufacturing methods and their component unit operations. Examples of the manufacturing of selected pharmaceutical drugs will be presented.

Objectives

CBE 3322A/B, CBE 3323A/B, CBE 3324A/B, CBE 3325A/B. Prerequisites

Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you will be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites.

None Corequisites

None Antirequisites

3 lecture hours, 1 tutorial hour, 0.5 course. Contact Hours

Dr. L. Briens (TEB 449) Telephone: 519-661-2111 ext: 88849 email: Instructor

[email protected]

Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: Undergraduate Assistant

[email protected]

Ryan Logan, email: Teaching Assistants

[email protected] Craig Mara, email: [email protected]

mailto:[email protected]�




CBE 4404A Course Outline 2

None Required Texts

Course notes will be available for download from the course website. Course Notes

None Laboratory Notes

None Reference Texts

None Laboratory

SI, FPS, and CGS units will be used. Units

General Learning Objectives

Knowledge Base x Individual Work x Ethics and Equity x

Problem Analysis x Team Work Economics and Project Management

Investigation x Communication x Life-Long Learning x Design x Professionalism

Engineering Tools x Impact on Society x

Specific Learning Objectives

1. Overview of the pharmaceutical industry 2. Regulations and Safety Issues 3. Mixing a. Functions and characteristics of the components of pharmaceutical mixtures b. Principles of mixing c. Types of mixers d. Monitoring mixing 4. Granulation a. Dry granulation b. Wet granulation c. Oven drying d. Fluid bed drying e. Monitoring granulation and drying


5. Tabletting a. Functions and stages of the tablet compression process b. Overview of tabletting equipment c. Examination of dies and punches 6. Coating a. Principles of coating b. Coating materials c. Spray coating d. Fluid bed coating 7. Encapsulation a. Manufacture of hard-shell capsules b. Manufacture of soft gel capsules 8. New directions in pharmaceuticals

The final course mark will be determined as follows: Evaluation

Assignments 15% Project 35% Final Examination 50%

1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is more than 50% or the aggregate mark.

Notes

2) Assignments are to be handed in electronically through WebCT/OWL. Late assignments will receive a mark of zero. 3) For the project, each student will be assigned a pharmaceutical drug to investigate. The project will include the drug history, drug use, drug effectiveness, potential drug side effects, components of the drug and their functions and characteristics, and a proposed manufacturing pathway with evaluation and preliminary design.

In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years.

Repeating All Components of the Course

In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission.

Use of English


Attendance Attendance in all lectures, tutorials and laboratories is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors.


Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 60% Engineering Design = 40% September 8, 2010 / af

The University of Western Ontario Faculty of Engineering DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING

CBE 4407A - Solid Waste Treatment Course Outline for 2010-2011 Description This course covers principles of solid waste treatment using chemical and biological methods, with emphasis on waste volume reduction at the source and recycling. Classification of solid wastes, incineration, fluidized chemical reactors and bioreactors for solid waste treatment, chemical and biological oxidation of solids, chemical and biological treatment of hazardous compounds in soil. Prerequisites CBE 3323A/B, CBE 2220A/B, CBE 3301A/B, CBE 3315A/B or GPE 3315A/B, CBE 3322A/B or GPE 3322A/B, CBE 3325A/B. Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Corequisite None Antirequisite None Contact Hours 3 lecture hours, 1 tutorial hour, 0.5 course. Instructor Dr. M. Ray (TEB 443) Telephone: 519-661-2111 ext: 81273 email: [email protected] Undergraduate Assistant Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: [email protected] Teaching Assistants Rifath Sharmin, email: [email protected] Required Text None Course Notes Course notes will be available for download from the course website or provided by the Instructor.




CBE 4407A Course Outline 2 Lab Notes None References Texts Handbook of Solid Waste Management, 2nd edition, George Tchobanoglous and Frank Kreith, 2nd

Solid Waste Engineering, P. A. Vesilind, W. A. Worrell and D. R. Reinhart, Thomson Learning, 2002.

edition, McGraw-Hill, 2002.


Knowledge Base X Individual Work X Ethics and Equity X

Problem Analysis X Team Work Economics and Project Management X

Investigation X Communication X Life-Long Learning X Design X Professionalism X

Engineering Tools X Impact on Society X

Topics • Integrated solid waste management • Sources and classification of solid wastes • Refuse collection systems • Processing of solid waste • Materials separation • Combustion and energy recovery • Design principles of fluidized and non-fluidized incinerator reactors • Biological and enzymatic kinetics of solid waste biodegradation and bio-oxidation • Current issues in solid waste management Evaluation The final mark will be calculated as follows:

Assignments 30% Midterm 30% Final exam 40%

The final examination will be closed book. Note 1. Students must pass the final examination to pass this course. Students who fail the final

examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.

2. Assignments are to be handed into the CBE 4407A locker (#464) in TEB on the specified due date provided by the Instructor.

CBE 4407A Course Outline 3 Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests and examinations for the improper use of English. Additionally, poorly written work with the exception of final examinations may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal.

CBE 4407A Course Outline 4 Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 50% Engineering Design = 50% September 8, 2010 / af

The University of Western Ontario Faculty of Engineering


Course Outline 2010-2011 CBE 4415 - CHEMICAL ENGINEERING PROJECT

Description Selection and investigation of an engineering problem. Analytical and/or experimental work is carried out by individual students or project groups under the supervision of a faculty member. Progress reports and a final engineering report are prepared; each student must deliver a public lecture. Prerequisites Completion of third year of the Chemical Engineering program. Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Corequisites None Antirequisites None Contact Hours As determined by the individual advisor. Instructor Dr. W. Wan (TEB 433) Telephone: 519-661-2111 ext. 88440 email: [email protected] Undergraduate Assistant Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: [email protected] Required Texts Given the versatility of the projects involved, there is no single textbook which can cover all the course material. Selected textbooks and other references are suggested by the advisor and the course coordinator on an individual basis.



CBE 4415 Course Outline 2

Course Notes None Laboratory Notes None Reference Texts Reference texts will be suggested by the advisor and the course coordinator on an individual basis. In addition, the following is suggested to all students: L. Finkelstein, Jr. Pocket Book of Technical Writing for Engineers and Scientists. McGraw Hill, Toronto. 2000. Laboratory 6 laboratory hours, 1.0 course. Units SI units and as appropriate for each individual project. General Learning Objectives


Problem Analysis X Team Work Economics and Project Management X



Specific Learning Objectives At the end of this topic, students should be able to: • Define and devise an approach to solve a chemical engineering problem. • Search and review the literature to help develop a plan to solve the problem. • Acquire the computational or experimental skills required to solve the problem. • Acquire oral communication skills. Students are required to give an oral presentation to a

panel of examiners. • Acquire written communication skills. Students are required to submit a proposal, a

progress report, an abstract for the oral presentation and a final formal report. Evaluation The final course mark will be determined as follows: Proposal 5% Progress report 5% Abstract for oral presentation 5% Oral presentation 20%


Formal report 65% The oral presentation will be given to a panel of examiners. The oral presentation mark will be an average of the marks given by the panel of examiners. All other marks are the responsibility of the individual advisor. Due dates are as follows: Proposal October 19, 2009 Progress report January 5, 2010 Abstract March 22, 2010 4th

Formal report April 6, 2010 Year Presentation Days March 25, 2010

Students must turn in all laboratory reports, and achieve a passing grade in the laboratory component, to pass this course. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking.


Conduct: Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Complementary Studies = 25% Engineering Science = 50% Engineering Design = 25% CBE 4415 REPORT REQUIREMENTS Proposal The proposal should not be more than two pages long and contain the following sections:

Introduction - to provide the background information. Objectives - to outline the proposed project and the objectives. Methodology - to lay down the technical approaches to be employed in solving the

problems, including the proposed experiments/simulations, experimental apparatus, analytical methods, data processing, etc.

Milestones - to provide a list of important tasks and the anticipated completion date.


Progress Report The progress report must:

• Summarize the progress made since the start of the project. • Using the task list presented in the proposal, report on the progress of each task. • Discuss any outstanding problem and plans for its resolution. • Highlight and justify any deviation from the original plan. • Provide an updated plan and task list.

The progress report, including references, should not be longer than ten pages. Informative Abstract The abstract should contain no more than 200 words, and summarize the most important aspect of your project including the objectives, the methodology, results, discussions and conclusions. Final Report This should be a formal technical report, conforming to the usual requirements for a standard technical report. The suggest sections include:

- Title, Table of contents, Lists of Figures and Tables. - Acknowledgements - Introduction - Project Outline and Objectives - Theory (if appropriate) - Methodology - Experiment Apparatus - Experimental Procedures - Data Analysis - Computer simulation or model prediction (if any) - Results and discussions - Conclusions - Recommendations - Nomenclature - References - Appendix: calibration, raw data, computer program, etc.


CBE 415

FINAL PROJECT REPORT

2 BOUND COPIES

DUE: To be determined

IN

ROOM TBA

PRINTING AND BINDING INSTRUCTIONS (SEE BELOW):

COMMISSARY COPY CENTRE - GRAPHIC SERVICES Saugeen-Maitland (RECOMMENDED)

THEY WILL MAKE COPIES AND BIND YOUR REPORT


HOURS: 8:00 a.m. - 8:00 p.m.

THIS IS AN EXAMPLE OF THE COVER OF YOUR FINAL REPORT

TO BE PRINTED ON 'COUGAR WHITE' COVER STOCK

CLEAR COVER ON THE FRONT

COUGAR WHITE COVER STOCK ON THE BACK

WHITE BINDING ON THE SIDES


'TITLE OF PROJECT'

by

'Student's Name'

Department of Chemical and Biochemical Engineering

CBE 4415 - Chemical and Biochemical Engineering Project Report

In partial fulfillment of the requirements for the degree


of

Bachelor of Engineering

Date: Faculty Advisor:



CBE 4421A – Biomaterials Engineering

Course Outline 2010-2011 Description Biomaterials engineering includes elements of medicine, biology, chemistry, physics, and materials and chemical engineering. It can be applied for almost every part of biomedical-device design. This course aims at the integration of fundamental-processing-application. Three major topics are: 1) fundamental biomaterials and biocompatible; 2) Biomaterials manufacturing and characterization; and 3) application of biomaterials in artificial organs, dental implant, ophthalmologic applications, etc. Due to the quick change in the biomaterials engineering, this course will also provide a review of up-to-date novel biomaterials research and development. This course is for senior undergraduates from various disciplines of biological science, chemical engineering, materials and biochemical engineering. Prerequisites Engineering Science 1021A/B. Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Corequisites None Antirequisites None Contact Hours 3 lecture hours, 1 tutorial hour, 0.5 course. Instructor Dr. J. Zhang (TEB 465) Telephone: 519-661-2111 ext: 88322; email: [email protected] Undergraduate Assistant Marilyn Tudhope (TEB 477) Telephone: 519-661-2131 email: [email protected]



CBE 4421A Course Outline 2 Teaching Assistants Long-Yan Chen, email: [email protected] Required Texts Biomaterials: an introduction. Park, Joon, Lakes, R. S., Springer, NY. 2007. Course Notes Course notes will be available for download from the course website. Laboratory Notes None Reference Text Advanced Biomaterials: Fundamentals, Processing, and Applications. Ed. Bikramjit Basu, Dhirendraa S. Katti, and Ashok Kumar, John Wiley & Sons, Inc., Hoboken, New Jersey. 2009. Laboratory None Units SI and other engineering units will be used. General Learning Objectives


Problem Analysis X Team Work X Economics and Project Management

Investigation X Communication X Life-Long Learning Design X Professionalism X



1. To control the fundamental requirement of biomaterials and biocompatibility 2. To interpret the ability of biomaterials perform and the host response 3. To be familiar with the common types of materials and implant device currently utilized

in the surgical practice of medicine 4. To learn the manufacturing process of biomaterials, e.g. metals, ceramics, and polymers 5. To obtain the concepts of design biomaterials and devices. 6. To have the knowledge on how to achieve desired implant properties and performance

by using the principles of biomaterials engineering. 7. To know the regulation and ethical concerns for biomaterials and medical devices.


CBE 4421A Course Outline 3 Topics (topics and outline are subject to adjustments and changes) 1. Biomaterials and Biocompatibility

- Introduction to biomaterials - Biocompatibility and Host response - Experiment evaluation of biocompatibility

2. Structure and Properties of Artificial Biomaterials

- Bonding and crystal structure of metals and ceramics - Bio-polymers and types of polymerization - Composite materials - Physical, chemical, and mechanical properties of biomaterials

3. Structure and Properties of Biological Materials

- Extracellular matrix - Hard and soft tissues - Interaction between cells and materials

4. Manufacture processing of biomaterials

-Metal processing -Ceramic processing -Polymer processing -Surface treatment

5. Biomaterials Design and Characterization

- Metallic Implant Materials - Ceramic Implant Materials - Polymeric Implant Materials - Composite Implant Materials

6. Application of Biomaterials:

- Artificial organs - Dental implant - Ophthalmologic applications - Tissue Response to Implants

7. Commercialization of Implants - Regulations and regulatory testing - Ethics of biomaterials and implants

Evaluation The final course mark will be determined as follows: Assignments 30% Quizzes and project 15%

CBE 4421A Course Outline 4 Final exam 55% Final examination will be closed book. Only non-programmable pocket calculators will be permitted. Note 1) Students must pass the final examination to pass this course. Students who fail the final

examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.

2) Assignments are to be handed into CBE 4421A locker (#462) located in TEB on the specified due date provided by the Instructor.

Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English: In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Attendance in all lectures, tutorials and laboratories is mandatory. Any student, who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations.

CBE 4421A Course Outline 5 Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct: Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems: Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructors in tutorial sessions. Office hours will be arranged for the students to see the instructors and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Design = 35% Engineering Science = 65% September 8, 2010 / af



CBE 4423A – Tissue Engineering


Tissue Engineering integrates principles of engineering and life sciences towards the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues. The course will cover the applications of engineering design concepts and molecular cell biology in order to design biological substitutes to restore, maintain or improve tissue and organ function.

Description

This is a 4Course Structure

th

year Chemical Engineering undergraduate course toggled with BME 9526, a graduate-level course in Biomedical Engineering. Undergraduate and Graduate students attend the same lecture, and write the same exam. However, graduate students will work an extra individual project as part of the graduate course requirement.

CBE 2290A/B or Biology 1222 or 1223, CBE 2221A/B, CBE 3322A/B, CBE 3324A/B. Prerequisites


None Corequisites

None Antirequisites


Dr. K. Mequanint (TEB 439) Telephone: 519-661-2111 ext: 88573 email: Instructor

[email protected]


[email protected]




Dawit Seifu, email: Teaching Assistants

[email protected]

None Required Text

Some skeletal lecture notes will be available for download from the course website. Course Notes

None Laboratory Notes

Bernhard Palsson and Sangeeta Bhatia. Tissue Engineering, Pearson Prentice Hall, 2004. Reference Texts

Ronald Fournier. Basic Transport Phenomena in Biomedical Engineering. 2nd

Robert Lanza, Robert Langer, Joesph Vacanti. Principles of Tissue Engineering. 2

Edn. Taylor and Francis. 2007.

nd

Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter. Molecular Biology of The Cell. Taylor and Francis. 4

ed., Academic Press, 2000.

th

Edition, 2002.

None Laboratory

SI and other engineering units will be used. Units


Knowledge Base Individual Work Ethics and Equity

Problem Analysis X Team Work Economics and Project Management

Investigation Communication Life-Long Learning X Design Professionalism


The modern chemical engineer needs a strong fundamental understanding of engineering principles applied to life sciences. The application of engineering design principles, combined with basic knowledge of molecular cell biology and materials science will be covered in this course to provide students with a broad overview of the field of Tissue Engineering.

Objectives



The objectives of the course are to introduce: • the application of engineering principles combined with basic knowledge of molecular

cell biology and materials science to provide the students with a broad overview of the field of tissue engineering.

• the basics of tissue engineering, including cell-matrix interaction, cell migration and growth, mechanical regulation, bioreactors, tissue preservation, and immunomodulation/isolation. Due to the exponential growth this field has had over the last decade it is impossible to cover detail aspects of tissue engineering but particular applications of tissue engineering will be shown through selected examples from literature.

• applications of mass transport to Tissue Engineering approaches. • methods in analyzing and designing targeted engineered tissue products, evaluation of

tissue from a design perspective, scaffolding of cells using synthetic and natural materials, genetic engineering techniques, and cell seeding and transplantation. Engineered tissues for replacing vascular vessels, heart valves, cartilage, bone, skin etc. will be presented and discussed throughout the course.

• Introduction to Tissue Engineering Topics

• Fundamentals of Therapeutic Tissue Engineering • Cell Physiology and Function • The Extracellular Matrix • Cell adhesion, migration and the cytoskeleton role • Scaffolds for Tissue Engineering • Mass Transport and Bioreactors • Specific Applications of Tissue Engineered constructs • Emerging Technologies


Assignments = 20% Mid-term exam = 25% Final exam = 55% Both examinations will be closed book. Only non-programmable calculators will be permitted. Note1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is more than 50% or the aggregate mark.

2) Assignments are to be handed in to the CBE 4423A locker (#456) in TEB on the specified due date provided by the instructor.





Use of English

Attendance Attendance in all lectures, tutorials and labs is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others.


Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor by appointment. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Science = 45% Engineering Science = 35% Engineering Design = 20% September 8, 2010 / af



CBE 4493A – POLYMER ENGINEERING


The basics of polymer science and engineering are covered. The theory of macromolecules, macromolecular chemistry and fundamentals of polymerization are discussed. Specific manufacturing processes and polymer types are considered.

Description

CBE 2206A/B and CBE 2207A/B or the former 2216 or Chemistry 2213A/B and Chemistry 2223B or GPE 2213A/B and GPE 2214A/B.

Prerequisites

Unless you have either the prerequisites for this course or written special permission from your Dean to enroll in it, you will be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites.

None Corequisites

Chemistry 3320A/B. Antirequisite


Dr. W. Wan (TEB 433) Telephone: 519-661-2111 ext: 88440 email: Instructor

[email protected]


[email protected]

Darcy Small, email: Teaching Assistant

[email protected]

Polymer Science and Technology, J.R. Fried, 2Required Text

nd

edition, Prentice Hall, 2003.





None Course Notes

Lab notes will be provided by the faculty member. Laboratory Notes

Encyclopedia of Polymer Science and Engineering, Wiley-Interscience, 1988. Reference Texts

SI and other engineering units will be used. Units



Problem Analysis x Team Work Economics and Project Management

Investigation x Communication x Life-Long Learning x Design x Professionalism


At the end of this course students should: Specific Learning Objectives

• Have a sound understanding of the structures of several polymers and where polymers are used in our everyday life.

• Understand natural, synthetic and ‘green’ polymers and their impact on environmental sustainability.

• Understand the average distribution of molecular weights of polymers, (Mn, Mw and Mz

• Be able to understand the kinetics of step-growth and chain-growth polymerizations and copolymerizations, Mayo-Lewis equation, free-radical polymerizations (e.g. emulsion, suspension and solution, polymerization), and catalysis (e.g. Ziegler-Natta and metallocene polymerization).

) the polydispersity index, and how to measure molecular weights and molecular weight distributions by different methods.

• Understand the effect of chemical structure on polymer properties, crosslinking, polymer crystallinity, molecular weight, the glass transition temperature, tacticity, nonlinear polymers, composites, and natural polymers.

• Understand the mechanical and visco-elastic properties of polymers. • Understand flow behaviour of polymeric fluids (viscometric flow and the theories of

shear-viscosity). • Understand the thermal, acoustic, permeability, optical, and electrical properties of

polymers.


• Have a sound knowledge of the principals of polymer processing, including extrusion, injection molding, blow molding and fiber spinning.

• Understand the engineering applications of polymers.


Assignments 20% Midterm Examination 30% Final Examination 50%

Please note that both examinations will be closed book.

(1) Students must pass each examination to pass this course. Students who failed either of the exams will be assigned 48% if the aggregate mark is more than 50%, or the aggregate mark.

Note

(2) Assignments are to be handed in the CBE 4493A locker (#456) in TEB on the specified due date provided by the Instructor.




Use of English

Attendance Attendance in all lectures, tutorials and laboratories is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar).


Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notices Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 70 % Engineering Design = 30 % September 14, 2010 / af

The University of Western Ontario Faculty of Engineering DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING CBE 4497 - Chemical Process and Plant Design


A design is prepared for a full-scale chemical process. It involves sizing of major pieces of equipment, an estimate of the requirements for materials and energy, and calculation of different costs. The course requires integration of knowledge and skills learned and derived from other courses in the curriculum. Problem formulation, alternative design solutions and professional decision making are emphasized.

Description

ObjectivesBased on case study format, this course introduces students to chemical process synthesis and analysis and equipment sizing through creative problem solving and teamwork while applying basic principles in chemical engineering and economics learned in other courses in the curriculum. The general objectives are for the student to become able to:

• apply engineering and professional judgement to propose solutions to open-ended design

problems; • formulate problems and apply decision making to evaluate design alternatives; • identify safety, environmental, social, legal and economic issues, and their impact on design

decisions; • develop strong technical communication skills in order to present and defend technical

information and design decisions in both written and oral format; and • recognize the need for continual (life-long) learning to keep abreast of new developments

and information that could affect decisions related to design, modifications and improvements in chemical processes.

These objectives are accomplished within the framework of a workshop, simulating to the extent possible, and the real world industrial environment. During the workshops, groups of up to six students are given guidance and coaching (interactive learning) to assist in moving forward the design project. Each group of project engineers is assigned to a specific section head (Teaching Assistant).

CBE 3325A/B, CBE 3317A/B or the former CBE 3397, CBE 3323A/B, CBE 2220A/B, CBE 2224A/B, CBE 3315A/B, CBE 3322A/B.

Prerequisites

CBE 4497 Course Outline 2 Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites.

Business Administration 2299 or registration in Option C of the Chemical Engineering program. Corequisites

CEE 4441, ECE 4416, MME 4419, MME 4499, SE 4450, ES 4499. Antirequisites

1 lecture hour, 6 tutorial hours, 1.0 course. Contact Hours

Dr. A. Prakash (TEB 441) Telephone: 519-661-2111 ext: 88528 email: Instructors

[email protected] Dr. S. Barghi (TEB 447) Telephone: 519-661-2111 ext: 81275 email: [email protected] Dr. A. Margaritis (TEB 377) Telephone: 519-66-2111 ext: 82146 email: [email protected]


[email protected]

Anil Jhawar, email: Teaching Assistants

[email protected] Matthew Klaas, email: [email protected] Maryam Mogagheghi, email: [email protected] Flora Parveen email: [email protected] Hammayon Pervez, email: [email protected] Kai Pisters, email: [email protected]

G. Towler and R. Sinnott “Chemical Engineering Design”, Elsevier, Inc. 2008. Recommended Text


Jones, D.S.J., “Elements of Chemical Process Engineering”, John Wiley and Sons, 1996. Reference Texts

Ludwigm E.E., “Applied Process Design for Chemical and Petrochemical Plants”, Vol. 1-3, 2nd and 3rd

Perry, R.H. and D.W. Green, “Perry’s Chemical Engineers Handbook”, 7 edition, Gulf Publishing Co., 1983, 1995.

th

Sinnot, R.K., “Coulson and Richardson’s Chemical Engineering”, Vol. 6, 3

edition, McGraw-Hill Inc., 1997.

rd edition Butterworth-Heinemann, 1992.











CBE 4497 Course Outline 3 Soares, C., “Process Engineering Equipment Handbook”, McGraw Hill, New York, 2002. Turton R., R.C. Bailie, W.B. Whiting, J.A. Shaeiwitz,”Analysis, Synthesis and Design of Chemical Processes”, 2nd

Ulrich, G.D., “A Guide to Chemical Engineering Process Design and Economics”, John Wiley & Sons, New York, 1984.

edition, Prentice hall PTR, 2003.

Walas, S.M., “Chemical Process Equipment Selection and Design”, Butterworth-Heinemann, 1990. Reference to other books and articles will be made at the appropriate time during the course

None Laboratory

SI units will be used in lectures and examinations. Units



Problem Analysis X Team Work X Economics and Project Management X



The course is organized to develop following professional and job related skills of students while they apply acquired knowledge of engineering concepts and principles to an independent study industrial design project.


Team Work and Time Management Students should be able to: • work in team as they become more familiar with dynamics of team work and learn to make

use of strengths of team members • divide a project into tasks and sub-tasks with deadlines and milestones to allow scheduling

and resource allocation and utilization Information Collection, Analysis and Synthesis Students should be able to: • collect required information from different sources including literature, industry,

equipment suppliers, internet, specialists etc. • analyse sometimes conflicting information and learn to deal with it

CBE 4497 Course Outline 4 Critical Thinking (applied to design process) Students should be able to: • recognize existence of alternative solutions for the same problem. • compare alternatives based on selected criteria • ensure check calculations and consultations before making a recommendation

Engineering Judgment Students should be able to: • apply approximations in design calculations based on sound reasoning and documentation

• apply practical considerations to reduce downtime, improve safety and operability of a

system being designed

Communication Students should be able to: • present their work both orally and in written format as per acceptable standards

Progress will depend on a number of factors including complexity of the selected process, availability of process information, industrial contacts established by group, etc. Initiative and creativity is required from every student. This course draws on knowledge, skills and techniques learned in prerequisite and corequisite courses to solve practical engineering problems. It is a finishing course: students need to demonstrate sound design and professional capabilities before they can graduate. Evaluation The final course mark will be determined as follows: Project Stake Out 5% Participation in Design Workshops 6% Detailed Flow Plan with Description (grp. mark) 8% Short-cut Equipment Design 10% First Oral Presentation (50% ind. mark, 50% grp.) 9% Final Oral Presentation (60% ind. mark, 40% grp.) 12% First Design Report (50% ind. mark, 50% grp.) 20% Final Design Report (60% ind. mark, 40% grp.) 30% Note Students must secure a passing mark (>50%) in both the final oral presentation and final design report to pass this course. 1. Design Reports

A design report is due from each group at the end of each term culminating the efforts of the group. The reports will be submitted to the Undergraduate Assistant in TEB 477. Format for design report is given in course guide book.


First Formal Report due: December 6, 2010 Final Formal Report due: April 4, 2011

2. Oral Presentations

Two oral presentations will be made by each design group, one in each term. Each student will take part in the presentations. Presentation schedule will be distributed in class about two weeks before presentation week.

First Formal Oral Presentation November 15-19, 2010 Final Formal Oral Presentation March 23, 2011

3. Detailed Flow Plan with Description

Each design team will hand in a detailed flow plan of the process drawn on a 60cmX90cm sheet together with a description of the process to its section Teaching Assistant by the due date (to be determined).

Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalised up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar).

CBE 4497 Course Outline 6 The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Attendance Attendance at all lectures, tutorials and laboratories is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class, or workshop/tutorial periods will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from making final oral presentation and submission of final design report. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted in front of chief instructor’s offices. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Complimentary Studies = 25% Engineering Design = 75% September 14, 2010 / af

The University of Western Ontario Faculty of Engineering DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING CBE 4499 - Chemical Engineering Design for Medical Students


Selected chemical, biochemical or pharmaceutical processes or processes for pollution abatement will be designed. Alternatively, the design of specific biomedical devices may be carried out. Chemical engineering principles will be employed. The design will include problem formulation, detailed design of equipment, environmental, economic and legal issues, and safety consideration.

Description

The student will learn to apply basic principles in chemical and biochemical engineering and economics learned in other courses in the curriculum towards the design of a medically relevant process or device. The general objectives are for the student to become able to:

Objectives

• apply engineering and professional judgement to propose solution to open-ended design

problems; • formulate problems and apply decision making to evaluate design alternatives,

demonstrate initiative in applying innovative solutions; • identify safety, environmental, social, legal, ethical and economic issues, and their impact

on design decisions; • develop strong technical communication skills in order to present and defend technical

information and design decisions in both written and oral format; and • recognize the need for continual (life-long) learning to keep abreast of new developments

and information that could affect decisions related to design, modifications and improvements.

These objectives are accomplished within the framework of a workshop, simulating to the extent possible, and the real world industrial environment. Each design project is conducted either individually or in small groups of up to three students. A coach (supervisor) will be identified for each project. During the workshops, students are given guidance and coaching (interactive learning) to assist in moving the design project forward.

Completion of third year of the Chemical Engineering program, Option E, and acceptance in concurrent degree program with Medicine.

Prerequisites

CBE 4499 Course Outline 2 Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. CorequisitesNone

None Antirequisites

6 laboratory hours Contact Hours

Dr. A. Prakash (TEB 441) Telephone: 519-661-2111 ext. 88528 email: [email protected] Coordinator

None Required Textbook

None Course Notes

Fung, Y.C., (Ed.) “Introduction to Bioengineering”, World Scientific, 2001. Reference Texts

Jones, D.S.J., “Elements of Chemical Process Engineering”, John Wiley and Sons, 1996. Perry, R.H. and D. W. Green "Perry’s Chemical Engineers Handbook", 7th

Seider, W.D., J.D. Seader, and D.R. Lewin, “Product and Process Design Principles”, John Wiley & Sons Inc. 1999.

edition, McGraw-Hill Inc., 1997.

Sinnot, R.K., “Coulson and Richardson’s Chemical Engineering", 3rd

Ulrich, G.D., “A Guide to Chemical Engineering Process Design and Economics”, John Wiley & Sons, New York, 1984.

edition Butterworth-Heinemann, 1993.

Reference to other books and articles will be made available at the appropriate time during the course.

None Laboratory




Knowledge Base Individual Work X Ethics and Equity

Problem Analysis X Team Work X Economics and Project Management X



The course is organized to develop professional and job related skills of students by applying the acquired knowledge of engineering concepts and principles to an independent study industrial process or device. Progress will depend on a number of factors including complexity of the selected process, availability of process information, industrial contacts established by group, etc. Initiative and creativity is required from every student. This course draws on knowledge, skills and techniques learned in prerequisite courses to solve practical engineering problems. Students need to demonstrate sound design and professional capabilities.


Students should be able to: Information Gathering, Analysis and Synthesis

• collect required information from different sources including literature, industry, equipment suppliers, internet, specialists etc.

• analyse sometimes conflicting information and learn to deal with it • synthesize information to meet desired objectives

Critical Thinking Students should be able to: • recognize existence of alternative solutions for the same problem • compare alternatives based on selected criteria for a given problem • ensure check calculations and consultations before making a recommendation

Engineering Judgment Students should be able to: • apply approximations in design calculations based on sound reasoning and documentation • apply practical considerations to reduce downtime, improve safety and operability in a cost

effective and environmentally friendly manner

Communication Students should be able to: • present and defend their work both orally and in written format as per acceptable

standards

CBE 4499 Course Outline 4 Team Work and Time and Resource Management (where applicable) Students should be able to: • work in team as they become more familiar with dynamics of team work and learn to make

use of strengths of each team member • divide a project into tasks and sub-tasks with deadlines and milestones to allow scheduling

and resource allocation and utilization Evaluation Progress Report 30% Final Design Report 50% Oral presentation 20% Note: Students must secure pass mark (50%) in both oral presentation and final design report to pass this course. 1. Progress Report

It will include: Abstract♦Introduction♦Need analysis based on demand♦Available options♦Configuration of proposed design♦Test plans (if applicable)♦Preliminary design calculations♦Conclusions and Recommendations♦References♦Appendix. The report will be submitted to the advisor.

2. Final Design Report Updates: Abstract, Introduction, Need analysis and Available options, Conclusions and Recommendations, References and Appendix from first term report Include: Results of testing ♦ Detailed design calculations ♦ Final design configuration with 2-D and 3-D drawings ♦Safety considerations♦Costing and Economic analysis

3. Oral Presentations (date to be determined) Each student will make an oral presentation before submission of final report in the second term.

Use of English In accordance with Senate and Faculty Policy, students may be penalised up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Cheating University policy states that cheating, including plagiarism is a scholastic offence. The commission of a scholastic offence is attended by academic penalties that might include expulsion from the program. If you are caught cheating, there will be no second warning.

CBE 4499 Course Outline 5 Attendance Any student who, in the opinion of the instructor, is absent too frequently from class, or workshop/tutorial periods will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from making final oral presentation and submission of final design report. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted in front of chief instructor’s office. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Complimentary Studies = 25% Engineering Design = 75% September 8, 2010 / af

The University of Western Ontario Faculty of Engineering DEPARTMENT OF CHEMICAL AND BIOCHEMICAL ENGINEERING

GPE 4484A – Green Fuels and Chemicals


This course describes what are green fuels and chemicals and the main current or potential processes used to produce green fuels and chemicals. The general objectives are for the student to:

Description

• Be aware of the issues associated with the production of fuels and chemicals from fossil

resources • Develop a good knowledge of the current processes that are used on a commercial scale to

produce green fuels and chemicals, their advantages and drawbacks • Be introduced to the possible future processes to produce green fuels and chemicals, their

advantages and drawbacks • Gain knowledge to integrate various processes in a bio-refinery • Be aware of the socio-economic and environmental impacts of the various processes

CBE 2207A/B or GPE 2214A/B; CBE 2224A/B or GPE 2218A/B; CBE 3315A/B or GPE 3315A/B. Prerequisites


None Corequisites

CBE 4467A/B. Antirequisites


Dr. F. Berruti (CMLP 2331) Telephone: 519-661-2111 ext: 88771 email: Instructors

[email protected] Dr. C. Briens (CMLP 2333) Telephone: 519-661-2111 ext: 88865 email: [email protected]



GPE 4484A Course Outline 2


[email protected]

Feng Li, email: Teaching Assistant

[email protected]

None Required Text

Course notes will be available on WebCT. Course Notes

None Reference Text




Problem Analysis x Team Work Economics and Project Management x

Investigation x Communication Life-Long Learning Design x Professionalism x



At the end of this topic, students should: Introduction: Why we need Green Fuels and Chemicals. Biomass resources (Cedric Briens)

• be aware of the environmental and political drivers behind the development of green fuels and chemicals

• have a general knowledge of the processes used for the production of fuels and chemicals from fossil resources

• be aware of the environmental problems associated with these processes

At the end of this topic, students should: Biomass/BioFuels Combustion (Cedric Briens)

• know the processes used for the combustion of wood and residues from agricultural, food processing and municipal waste operations, as well as the processes for the combustion of fuels derived from these feedstocks



GPE 4484A Course Outline 3 • be aware of the environmental and logistic problems associated with these processes

At the end of this topic, students should: Biomass Gasification (Cedric Briens)

• know the processes used for the gasification of wood and residues from agricultural, food processing and municipal waste operations

• be aware of the environmental and logistic problems associated with these processes

At the end of this topic, students should: Pyrolysis to biochar, bio-oil and biogas (Cedric Briens)

• understand the processes that are used to pyrolyze biomass • be aware of the technical and environmental problems associated with the use of raw bio-

oils and biochar

At the end of this topic, students should: Processing and refining of bio-oils and biochar (Cedric Briens)

• understand how bio-oil can be stabilized and cleaned • know how bio-oil can be upgraded to a transportation fuel • understand the various applications for bio-char • know how to transform bio-char in higher value products

At the end of this topic, students should: Biodiesel (Cedric Briens)

• know the processes that are used to produce biodiesel, including biochemical and thermochemical methods

• understand the social, economical and political problems associated with the various production schemes

At the end of this topic, students should: Bioethanol and biobutanol (Franco Berruti)

• know the processes that are used to produce bioethanol, including biochemical and thermochemical methods

• know the processes that are used to produce biobutanol, including biochemical and thermochemical methods

• understand the social, economical and political problems associated with the various production schemes

At the end of this topic, students should: Biogas by fermentation (Franco Berruti)

• know the various fermentation processes that can be used to transform agricultural, industrial and municipal waste into biogas

• understand the various issues associated with the purification and use of biogas


At the end of this topic, students should:

Syngas and hydrogen production. Syngas conversion to clean fuels and chemicals (Franco Berruti)

• understand the processes that are used to generate syngas • know the processes that are used for hydrogen production from syngas • know the processes that are used to convert syngas to fuels • know the main processes that are used to convert syngas to chemicals

At the end of this topic, students should: Product Separation and Purification (Franco Berruti)

• understand the processes that are used to extract and purify products, with a stress on green processes

At the end of this topic, students should: Extraction and Purification of Green Chemicals from Renewable Resources (Franco Berruti)

• know the major green chemicals that are obtained from renewable resources • understand the processes that are used to produce chemicals from renewable resources Economics and Social Impact. Government At the end of this topic, students should:

Policies (Franco Berruti)

• know how to evaluate the economics and social impact of green fuels and chemicals • be aware of the major, relevant government policies


Assignments 30% Final Exam 70% Exam will be closed book. Programmable calculators not allowed. Students will be provided with a list of potential questions from which the exam questions will be selected. Questions will refer both to the course lectures and the assignments.

1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark.

Notes

2) Assignments are to be handed into GPE 4484A locker (#458) located in TEB on the specified due date provided by the Instructor.





Use of English

Attendance Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course.

Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar).

Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department

GPE 4484A Course Outline 6 Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 70% Engineering Design = 30% September 8, 2010 / af



CBE 4403B - BIOCHEMICAL SEPARATION PROCESSES

COURSE OUTLINE 2010-2011

The main objective of this course is to introduce the student to the basic fundamentals of downstream separation and purification processes such as membrane separation processes, protein separation and purification and other separation processes of economic importance to the fermentation industry.

Description

CBE 2290A/B or Biology 1222 or Biology 1223. Prerequisites

Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites.

None. Corequisites

None. Antirequisites


Dr. W.K. Wan (TEB 433) Telephone: 519-661-2111 ext: 88440 email: Instructor

[email protected]

Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: Undergraduate Assistant

[email protected]

J. Krijgsman, “Product Recovery in Bioprocess Technology”, Butterworth-Heinemann, 1992. Will be available at the University Bookstore (©M# 4933).

Required Text

M.L. Schuler, F. Kargi, “Bioprocess Engineering: Basic Concepts”, Prentice Hall, 1992. Reference Text

CBE 4403B Course Outline 2


None. Laboratory Notes

None. Laboratory

SI units will be used. Units


Knowledge Base Individual Work Ethics and Equity

Problem Analysis Team Work Economics and Project Management

Investigation Communication Life-Long Learning Design Professionalism

Engineering Tools Impact on Society

This course deals with downstream separation and purification unit operations of a bioprocess, and complements the other three Biochemical Engineering courses: CBE 2290a - Fundamentals of Biochemcial and Environmental Engineering, CBE 3301a - Biochemical Reaction Engineering, and CBE 3320b - Bioprocess Engineering. Completion of all four Biochemical Engineering courses will provide information and background which will be useful in the design of a typical bioprocess.


In many commercial bioprocesses, separation and purification of the final product represent the major component of the total production cost. The objectives of this course are to enable the student to identify appropriate combinations of separation and purification technologies for various types of bioproducts and to apply fundamental principels to the design of these unit operations. Specific Learning Objectives:

At the end of this topic, students should be able to: Introduction

• Distinguish bioproduct market sectors. • Describe general stages in bioproduct recovery processes. • Calculate yield, and purification and separation factors. • Select prospective unit operations based on bioproduct size and recovery stage. • Ask critical questions relevant to recovery process design.


At the end of this topic, students should be able to: Release of Intracellular Components

• Compare morphology and cell wall structure of cell types representative of fermentation broths.

• Describe operations used to prepare cells for disruption. • Identify various non-mechanical methods of cell disruption. • Describe the principles of operation for bead mills and high-pressure homogenizers. • Describe how various factors influence performance of bead mills and homogenizers. • Calculate parameters describing bioproduct release kinetics. • Quantitatively analyze various processing modes (multi-pass, batch recycle and continuous

recycle) for cell disruption.

At the end of this topic, students should be able to: Solid-liquid Separation

• Describe common broth pre-treatment methods employed prior to solid-liquid separation. • Determine specific cake resistance and medium resistance for constant-pressure filtration. • Calculate parameters describing compressible filter cakes, given V vs. t data. • Describe the principles of operation of common types of process filters. • Calculate required filter area for given processing rate using rotary vacuum filtration. • Calculate centrifugal acceleration, G-factor and drift velocity. • Describe the principles of operation of common types of process centrifuges. • Use sigma concept to scale up tubular and disc-stack centrifuges. • Describe laboratory and pilot scale testing methods for centrifugal separations.

At the end of this topic, students should be able to: Concentration of Bioproducts - I (Membrane Separation)

• Distinguish micro-, ultra- and hyper-filtration according to particle size and pressure difference.

• Compare and contrast cross-flow vs. dead-end filtration. • Describe the principles of operation of common types of cross-flow filtration modules. • Define rejection co-efficient, concentration factor, permeate yield and non-permeate yield for

batch and continuous modes of operation. • Calculate mass-transfer coefficient and permeate flux from both experimental data and

dimensionless correlations. • Determine final concentration and required membrane area for various operating modes

(batch recycle, and single and multi-stage feed-and-bleed). • Quantitatively describe continuous- and discrete-batch diafiltration processes.


At the end of this topic, students should be able to: Concentration of Bioproducts - II

• Describe the principles of operation of aqueous two-phase extraction. • Describe how the electric double layer surrounding a protein molecule influences

precipitation. • Describe the principles of operation of common precipitation methods (salting-out, isoelectric pH, organic solvents, non-ionic polymers, polyelectrolytes, and affinity interactions). • Quantitatively describe the kinetics of orthokinetic protein aggregation. • Specify the operating limits of a precipitate aging process.

At the end of this topic, students should be able to: Sorption Processes

• Fit adsorption data to Langmuir, Freundlich or linear isotherms. • Calculate bioproduct recovery in batch adsorption process, given operating and equilibrium

data. • Explain how various factors could influence the design of a continuous stirred-tank adsorption

process. • Predict the behaviour of breakthrough curves for various types of adsorption isotherms. • Calculate breakthrough time and fraction of bed used from supplied data. • Use the concept of transfer units or theoretical plates to determine the rate-controlling step

from column adsorption experiments. • Calculate peak resolution and selectivity, and column efficiency, from given chromatographic

results. • Size chromatographic separation process via productivity analysis of given operating

parameters. • Identify important engineering properties of chromatographic media. • Describe the principles of operation of ion exchange and common types of affinity

chromatography. • Calculate chromatographic distribution coefficient from equilibrium data, and use it to

estimate elution volume from column void volume. • Describe the principles of operation of size exclusion chromatography, and use the concept of

available distribution coefficient (Kav) to select appropriate media and predict elution volume. • Apply resolution-related criteria to scale up of chromatographic processes. • Contrast important requirements of pilot- vs. production-scale chromatographic systems. • Describe fundamental equipment requirements and basic configuration and operation of

chromatographic systems.


At the end of this topic, students should be able to: Polishing and Formulation

• Apply mass and enthalpy balances to calculate bioproduct yield and cooling load of crystallization processes.

• Describe common methods of creating supersaturated solutions. • Identify principle design considerations in batch crystallization. • Describe, using suitable examples, the various objectives commonly encountered in

bioproduct formulation. • Describe the formulation stages in the production of various types of bioproduct.


Assignments 20 % Mid-term Examination 30 % Final Examination 50 % The mid-term and final examinations will be open-book examinations.

1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned the aggregate mark, as determined above, or the examination mark, whichever is less.

Note

2) Assignments are to be handed in to the CBE 4403B locker (#462) in TEB on the specified due date provided by the Instructor.




Use of English


Attendance Attendance to all lectures, tutorials and laboratories is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offense. The commission of a scholastic offense is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage of text from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors.


Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 100% October 1, 2010/ch




COURSE OUTLINE 2009-2010 CBE 4409B – WASTEWATER TREATMENT

Description This course introduces a basic understanding of municipal wastewater treatment processes. The course reviews pertinent environmental regulations, and general wastewater quality parameters. Processes and unit operations in wastewater treatment are introduced with particular emphasis on process design. Considerations in integrating unit processes and operations into a treatment system are presented. Prerequisites CBE 2290a/b or Chemistry 2210a/b. Unless you have either the requisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Corequisites None. Antirequisites CBE 3363a/b. Contact Hours 3 lecture hours, 1 tutorial hours, 0.5 course. Instructor Dr. G. Nakhla (SEB 3037) Telephone: 519-661-2111 ext: 85470 email:

[email protected]

Undergraduate Assistant Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: [email protected] Required Texts Ronald L. Droste, "Theory and Practice of Water and Wastewater Treatment", John Wiley and Sons, 1997.



CBE 4409B Course Outline 2 Reference Texts Metcalf and Eddy Inc., "Wastewater Engineering: Origins, Characteristics, Treatment", 3rd edition, McGraw Hill, 1991. Course Notes “Water Pollution”, #M7913 will be available in the University Bookstore. Laboratory Notes None. Laboratory None. Units SI units will be used. General Learning Objectives

Knowledge Base √ Individual Work √ Ethics and Equity x

Problem Analysis √ Team Work x Economics and Project Management

x

Investigation x Communication √ Life-Long Learning √ Design √ Professionalism √

Engineering Tools √ Impact on Society x

Specific Learning Objectives What is Water Pollution? • Fundamentals • Legislation • Discharge limits in the environment At the end of this topic, students should be able to gain: • A fundamental understanding of water pollution. • An understanding of discharge limits, for pollutants. • An understanding of the environmental legislation. Water Pollution Control • Overview. • Objectives. At the end of this topic, students should be able to: • Describe basic concepts involved in water pollution control. Physical, Chemical, Biological Characteristics of Pollution

CBE 4409B Course Outline 3 • BOD, NOD. • COD, TOC, THOD. • VSS, TSS. • MLSS. • MPN. • Toxicity carcinogens. • Coliforms. At the end of this topic, students should be able to: • Gain an understanding and describe physical, chemical and biological characteristics for water

pollution. Preliminary Treatment Primary Treatment Biological Treatment Tertiary Treatment and Disinfection Natural Treatment, Lagoons Sludge Treatment and Anaerobic Digestion At the end of topics 4-9, students should be able to: • Describe water and wastewater treatment systems for municipalities and industry. • Suggest and provide initial design of suitable solutions for commercial wastewater pollution

problems.

Evaluation The final course mark will be determined as follows: Mid Term Examination 25% Assignments 25% Final Examination 50% Both mid-term and final examinations are open book. Note 1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark. 2) Assignments are to be handed into CBE 4409 (locker # C460) located in the Thompson Engineering building on the specified due date provided by the Instructor.

CBE 4409B Course Outline 4 Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission.

Attendance Attendance at all lectures, tutorials and laboratories is mandatory. Any student, who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course

Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea, or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others.

CBE 4409B Course Outline 5 Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented (see attached). The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor.

Accreditation (AU) Breakdown Engineering Science = 70% Engineering Design = 30% October 4, 2010/ch



CBE 4413B - INTRODUCTION TO NANOBIOTECHNOLOGY

COURSE OUTLINE 2010-2011 Description Nanobiotechnology is an emerging frontier in nanotechnology. It integrates materials science, chemical engineering, physics and life science toward the biological and biochemical applications. This course introduces the fundamental concepts of nanobiotechnology and the up-to-date application of nanotechnology to life science. In this course, nanofabrication and the interaction between nanostructured materials and biological system are addressed. Through introducing the vital information on application of nanotechnology, this course presents how to design and develop nano-devices for the applications of pharmaceuticals and healthcare. Typical applications include nano-biosensor, target delivery, and tissue engineering. Students will have chance to present and discuss individual application through team project. Course Goals

1. This course aims to strengthen and broaden the skill and knowledge of senior undergraduate in modern chemical and biochemical engineering.

2. Students will work with each other through team-based activities to facilitate interdisciplinary collaborations.

Prerequisites Completion of 3rd

year of Engineering in Chemical, Electrical, Civil and Mechanical & Materials Engineering.

Unless you have either the prerequisites for this course or written special permission from your Dean to enroll in it, you may be removed from this course and it will be deleted from your record. This decision may not be appealed. You will receive no adjustment to your fees in the event that you are dropped from a course for failing to have the necessary prerequisites. Antirequisites None. Contact Hours 3 lecture hours, 1 tutorial, 0.5 course. Instructor Dr. J Zhang (TEB 465) Telephone: 519- 661-2111 ext: 88322 email: [email protected]



Undergraduate Assistant Marilyn Tudhope (TEB 477) Telephone: 519-661-2111 ext: 82131 email: [email protected] Required Text None. Reference Texts “Nanotechnology”, edited by Gregory Timp, editor. (1999) David S. Goodsell, “Bionanotechnology: lessons from nature”. (2004) Hoboken: Wiley-Liss, Inc.

New York: AIP Press.

“Nanobiotechnology: concepts, applications and perspectives”, edited by Christof M. Niemeyer and Chad A. Mirkin.

(2004) Weinheim: Wiley-VCH.

Course Notes Course notes will be available on the course website. Laboratory None. Units SI and other engineering units will be used. General Learning Objectives


Problem Analysis X Team Work X Economics and Project Management

X

Investigation X Communication X Life-Long Learning X Design X Professionalism


Learning Objectives

• Understand the fundamental concepts of nanotechnology and nanobiotechnology • Analyze and apply nanofabrication processes • Interpret the interaction between nanostructured materials and biological system • Generalize how to apply nanotechnology in the fields of pharmaceuticals and healthcare • Evaluate regulatory and ethical concerns on nanotechnology used in life science

Topics Introduction: From Nanotechnology to Nanobiotechnology

Evolution of nanotechnology Emerging field: Nanobiotechnology



Nanostructured Materials (Nanomaterials) Basic principles of nanotechnology Quantum size effect in nanomaterials Property changes due to nanostructuring

Interaction between Nanomaterials and Biological System

Biological system Protein-based nanostructures DNA-based nanostructures Cell-nanostructure interactions

Nanofabrication and Materials Characterization Chemical and physical techniques Nano self-assembly Nanolithography X-ray diffraction (XRD) Electron microscopy (SEM & TEM) Atomic force microscopy (AFM) Scanning Tunneling Microscope (STM)

Nanotechnology in Biological and Biomedical Applications Nanobiosensor Nanocrystals used in biological imaging Nanodevice for drug delivery Design- nanobiosensor devices

Nanotechnology in Tissue Engineering

Applying nanotechnology in scaffolds Advantages of nanomaterials used for Implants Design: biocompatible scaffold by applying nanotechnology

Assessing Potential Risks Perspective Commercializing Nanobiotechnology Future Nanotechnology used in Life Science Evaluation The final course mark will be determined as follows: Assignments and test 25% Design

Final exam 55% 20%

Undergraduate students need to finish one design project. All tests and final examination will be limited-opened book. Only non-programmable pocket calculators will be permitted.


Note 1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark. 2) Assignments are to be handed into the CBE 4413B course locker (#458) located in TEB on the specified due date provided by the Instructor. Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission.

Attendance Attendance at all lectures, tutorials and laboratories is mandatory. Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with permission of the Dean, the student will be debarred from taking the regular examination in the course.

Cheating University policy states that cheating is a scholastic offense. The commission of a scholastic offense is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning. Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking.


Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Office hours will be posted. Individual consultation may be arranged by appointment with the instructor.

Accreditation (AU) Breakdown Engineering Design = 20% Engineering Science = 80% October 1, 2010/ch



CBE 4420B - COMPUTER PROCESS CONTROL


The course covers more advanced topics in process control such as Feedforward, Cascade, and Multivariable Control. Design of multivariable control systems using continuous State Space Methods is covered. Use of Real Time Process Control Computers for data acquisition and control are introduced. Discrete Process Control Theory using Z-Transformations is covered in detail for single input single output processes.

Description

The general objectives of this course are for students to be able to: • Design process control strategy for variety of industrial applications • Develop computational abilities to analyse feedback control systems in a variety of

configurations • Develop tools for testing stability of feedback systems • Understand the dynamics of Multivariate (MV) systems • Design feedback control for MV systems based on decoupling • Develop understanding of Modern State Space Control methods • Apply feedback control to a real time computer control system

CBE 3310A/B, GPE 3310A/B or the former CBE 4410A/B. Prerequisites


None. Corequisites


3 lecture hours, 1 laboratory hour, 0.5 course. Contact Hours


2

Dr. S. Rohani (TEB 457) Telephone: 519-661-2111 ext: 84116 email: Instructor

[email protected]


[email protected] Required Text “Process Dynamics and Control”by Seborg, Edgar, Mellichamp, Doyle, 3rd

Edition. Wiley 2011.

Reference Texts “Feedback Control of Dynamic Systems”, G.F. Franklin et al, 4th

“Process Dynamics and Control” Seborg, Edgar and Mellichamp, John Wiley & Sons, New York 2003, 2

edition, Addison Wesley, 2002.

nd

edition.

Course Notes Course notes will be available for download through the course website. Hand outs will be provided in class. Laboratory The laboratory for this course will take the form of a real time computer control group project. Students will be arranged into teams and assigned a single project per term. Control Design Project Students will be required to implement the control design strategies onto the assigned industrial process from CBE 4497 course. In-class presentation and a written report of their project will be mandatory. Units SI and British units will be used. General Learning Objectives

Knowledge Base Individual Work x Ethics and Equity

Problem Analysis x Team Work x Economics and Project Management

x

Investigation x Communication Life-Long Learning Design x Professionalism x

Engineering Tools Impact on Society




3

General Learning Objectives The general objectives of this course are for students to be able to: • Design process control strategy for variety of industrial applications • Develop computational abilities to analyse feedback control systems in a variety of

configurations • Develop tools for testing stability of feedback systems • Understand the dynamics of Multivariate (MV) systems • Design feedback control for MV systems based on decoupling • Develop understanding of Modern State Space Control methods • Apply feedback control to a real time computer control system Specific Learning Objectives Process Control Design At the end of this topic, students will be able to: • Define the control problem. • Select Instrumentation. • Select Controlled and Manipulated Variables . • Provide sensors for monitoring. • Implement control for safety. Closed Loop Systems At the end of this topic, students will be able to: • Understand how to manipulate closed loop block diagrams to calculate overall transfer

functions. • Understand PID control and role integration in offset removal. • Tune a PID controller by trial and error as well as by using other analytical methods. • Use Simulink/Matlab tools to develop closed loop tuning simulations. Stability in Laplace Domain At the end of this topic, students will be able to: • Understand the concept of characteristic equation and be able to calculate it for closed loop

systems. • Apply Routh criteria to analyse the stability of systems without dead time.

Stability in Frequency Domain At the end of this topic, students should be able to: • Use Matlab to plot various frequency functions (Bode/Nyquist) for both dead time and non-

dead time systems. • Apply Bode/Nyquist stability criteria to dead time chemical processes. • Use frequency methods to tune controllers. • Use Matlab commands to analyse stability of complex systems.


4

Feedforward and Ratio Control Advanced Single-Loop Controllers At the end of this topic, students will be able to:

• Cascade Control. • Fuzzy Logic Control. • Inferential Control. • Selective Control/Override Systems. • Adaptive Control Systems.

Multi Variable (MV) Transfer Functions At the end of this topic, students will be able to: • Develop a MV Transfer Function Matrix for a MV process. • Understand Relative Gain Array (RGA) for MV systems. • Design Decoupling Controllers. Model Predictive and Real-Time Optimal Control State Space (SS) and Discrete Systems At the end of this topic, students will be able to: • Understand the concept of State Space (SS) Model. • Conversion between model forms. • Design of (SS) Controllers using pole placement. • Design of State Estimators. • Use of Matlab Control Toolbox for SS and discrete design. Evaluation The Computer Process Control Laboratory has a number of processes interfaced to real time computers. A series of goals will be set for the group and a comprehensive project report will be used to assess the group and individual performance. Simulation projects using Matlab + Simulink are also available. The final course mark will be determined as follows: Laboratory 15% Assignments 10% Control Design Project 10% Mid-term Examination 15% Final Examination 50% Examinations will be closed book. A formula sheet is allowed. Calculators of any kind will be permitted during examinations. The memory of the calculators should be purged before the examination.


5

Notes 1) Students must pass the final examination to pass this course. Students who fail the final examination will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark. 2) Students must turn in all laboratory reports, and achieve a passing grade in the laboratory component, to pass this course. 3) Assignments are to be handed in the CBE 4420 locker (#456) located in TEB on the specified due date provided by the Instructor. Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment, control design project, or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Attendance in all lectures, tutorials and laboratories is mandatory. Any student, who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar). Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking.


6

Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Undergraduate Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Undergraduate Chair regarding how best to deal with the problem. Failure to notify the Instructor or Undergraduate Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific questions regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructor in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultation can be arranged by appointment with the appropriate instructor. Accreditation Unit (AU) Content Engineering Science = 60% Engineering Design = 40% October 1, 2010/ch



CBE 4432B - OIL REFINING AND PROCESSING


An introduction to petroleum refining processes, operations, feedstocks and products. Configurations of refinery processes and their evolution will be discussed in view of environmental efficiency and economic considerations. Current trends and future of the industry will be addressed.

Description

CBE 2206A and CBE 2207B or the former 2216 or Chemistry 2213A/B and 2223B, or GPE 2213A/B and GPE 2218A/B, CBE 2224A/B or the former CBE 314A/B, CBE 3315A/B.

Prerequisites


None. Corequisites



Dr. S. Barghi (TEB 447) Telephone: 519-661-2111 ext: 81275 email: Instructor

[email protected]


[email protected]

None. Required Text

J.H. Gary and G. E. Handwerk “Petroleum Refining Technology and Economics”, 4Reference Text

th Ed.Marcel Dekker, Inc., 2001.




CBE 4432a/b Course Outline 2

Course notes will be available for download through the course web site. Handouts will be provided in class.

Course Notes

None. Lab Notes

None. Laboratory

SI units will be used in reports with British Engineering units between brackets. Units


Knowledge Base x Individual Work x Ethics and Equity

Problem Analysis Team Work Economics and Project Management

Investigation Communication x Life-Long Learning x Design x Professionalism x

Engineering Tools x Impact on Society

The general objectives are for the students to be able to: General Learning Objectives

• Become knowledgeable in composition, properties and classification of crude oil or petroleum. • Become familiar with operations and processes in petroleum processing as well related

chemistry and catalysis. • Become knowledgeable about impurities in crude oil and how to remove them from products. • Develop understanding of refinery products and their specifications. • Develop understanding of safety and environmental issues in petroleum refining. • Search the academic and technical literatures for information on the selected process area to

present in formal report. Specific Learning Objectives

At the end of this section, students should be familiar with: Introduction to the Petroleum Industry

• History and origin and occurrence of crude oil. • Exploration, recovery and transportation of crude oil.


Feedstocks and Products Composition, Properties and Specifications At the end of this section, students should become familiar with: • Composition and classification of crude oil. • Physical properties such as gravity, pour point and impurities level in petroleum. • Specifications of main products from petroleum refinery i.e. gasoline, diesel, kerosene, fuel oil

etc. Crude Distillation At the end of this section, students should become familiar with: • Typical fraction cuts and boiling ranges for atmospheric and vacuum still fractions. • Flow diagrams of atmospheric topping unit and vacuum distillation units. Catalytic Cracking and Hydrocracking At the end of this section, students should become familiar with: • Chemistry and catalysis of catalytic cracking and hydrocracking reactions. • Fluidized bed catalytic cracking (FCC) and hydrocracking unit configurations. • Process variables, heat recovery, yield estimation. Catalytic Reforming and Isomerization At the end of this section, students should become familiar with: • Chemistry and catalysis of catalytic reforming and isomerisation. • Catalytic reforming and isomerization processes with process variables and yields. Alkylation and Polymerization At the end of this section, students should develop understanding of: • Alkylation feedstocks, reactions, catalysts and products. • Various alkylation processes and their comparison. • Polymerisation processes to make high-octane gasoline product. Coking and Thermal Processes At the end of this section, students should be able to: • Process descriptions and review – delayed coking, flexicoking, fluid coking, visbreaking. • Process variables, products propertied and yields . Safety, Loss Prevention and Environmental Analysis At the end of this section, students should be able to: • Become knowledgeable about safety and health hazards in petroleum refinery i.e. fire and

explosion hazard, accidental release. • Develop understanding of fugitive emissions, loss prevention during storage and handling of

products. • Become familiar with acids gas removal, sulfur recovery processes, waste water treatment in

refinery.


Evaluation The final course mark will be determined as follows: Project Report 15% Presentation 10% Final Examination 75% Final Examination will be closed book. Note 1) Students must receive a passing grade on the final report to pass this course. Students who fail the final report will be assigned 48% if the aggregate mark is higher than 50%, or the aggregate mark. 2) A minimum mark of 50% is required for the safety examination. 3) Assignments are to be handed in to the CBE 4432B locker (#454) located in TEB on the specified due date provided by the Instructor. Repeating All Components of the Course In accordance with Senate and Faculty Policy, students who have failed an Engineering course (i.e. <50%) must repeat all components of the course. No special permissions will be granted enabling a student to retain laboratory, assignment or test marks from previous years. Previously completed assignments and laboratories cannot be resubmitted for grading by the student in subsequent years. Use of English In accordance with Senate and Faculty Policy, students may be penalized up to 10% of the marks on all assignments, tests, and examinations for the improper use of English. Additionally, poorly written work with the exception of the final examination may be returned without grading. If resubmission of the work is permitted, it may be graded with marks deducted for poor English and/or late submission. Attendance Any student who, in the opinion of the instructor, is absent too frequently from class or laboratory periods in any course, will be reported to the Dean (after due warning has been given). On the recommendation of the Department concerned, and with the permission of the Dean, the student will be debarred from taking the regular examination in the course. Cheating University policy states that cheating is a scholastic offence. The commission of a scholastic offence is attended by academic penalties, which might include expulsion from the program. If you are caught cheating, there will be no second warning (see Scholastic Offence Policy in the Western Academic Calendar).


Plagiarism Students must write their essays and assignments in their own words. Whenever students take an idea or a passage from another author, they must acknowledge their debt both by using quotation marks where appropriate and by proper referencing such as footnotes or citations. Plagiarism is a major academic offence (see Scholastic Offence Policy in the Western Academic Calendar). The University of Western Ontario has software for plagiarism checking. Students may be required to submit their work in electronic form for plagiarism checking. Conduct Students are expected to arrive at lectures on time, and to conduct themselves during class in a professional and respectful manner that is not disruptive to others. Sickness and Other Problems Students should immediately consult with the instructor or Department Chair if they have any problems that could affect their performance in the course. Where appropriate, the problems should be documented. The student should seek advice from the Instructor or Department Chair regarding how best to deal with the problem. Failure to notify the Instructor or Department Chair immediately (or as soon as possible thereafter) will have a negative effect on any appeal. Please contact the course instructor if you require material in an alternate format or if any other arrangements can make this course more accessible to you. You may also wish to contact Services for Students with Disabilities (SSD) at 661-2111 x 82147 for any specific question regarding an accommodation. Notice Students are responsible for regularly checking their Western email and notices posted on Instructors' doors. Consultation Students are encouraged to discuss problems with their teaching assistant and/or instructors in tutorial sessions. Office hours will be arranged for the students to see the instructor and teaching assistants. Other individual consultations can be arranged by appointment with the appropriate instructor. Accreditation (AU) Breakdown Engineering Science = 80% Engineering Design = 20% October 4, 2010/ch

Documents

The University Of Western Ontario - Zhejiang Universityche.zju.edu.cn/attachments/2011-09/07-1317289028-48655.pdf · The University Of Western Ontario . ... Downstream Processing