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The Teratology Society 7+ $118$/0((7,1* -XQH²-XO\ and The Neurobehavioral Teratology Society (NBTS) 22 nd Annual Meeting June 30 – July 3, 1999 and 11 th International Conference of the Organization of Teratology Information Services (OTIS) June 28 – July 1, 1999 .H\VWRQHUHVRUWDQGFRQIHUHQFHFHQWHU .H\VWRQHFRORUDGR

The Teratology Society 39th Annual Meeting Program and Abstracts

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Page 1: The Teratology Society 39th Annual Meeting Program and Abstracts

The Teratology Society��7+�$118$/�0((7,1*-XQH����²�-XO\��������

and

The Neurobehavioral Teratology Society (NBTS)22nd Annual MeetingJune 30 – July 3, 1999

and

11th International Conference of theOrganization of Teratology Information Services (OTIS)

June 28 – July 1, 1999

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Page 2: The Teratology Society 39th Annual Meeting Program and Abstracts

BLANK – PAGE 346

Page 3: The Teratology Society 39th Annual Meeting Program and Abstracts

TERATOLOGY 59:347–420 (1999)

The Teratology Society��7+�$118$/�0((7,1*-XQH����²�-XO\��������

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TERATOLOGY 59:347–420 (1999)

PAGE 348 -- BLANK

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TERATOLOGY SOCIETY PROGRAM 349

TERATOLOGY SOCIETY

Officers (1998-1999)

ANTHONY R. SCIALLIPresident

GEORGE P. DASTON ROBERT J. KAVLOCKVice President Vice President-Elect

ROBERT E. SEEGMILLER JOHN M. ROGERSSecretary Treasurer

BARBARA F. HALES (1996-1999) RICHARD H. FINNELL (1997-2000)

L. DAVID WISE (1998-2001)Council Members

Past Presidents OfThe Society

J. WARKANY1960-1961

D.G. TRASLER1972-1973

L.B. HOLMES1985-1986

J.G. WILSON1961-1962

J.R. MILLER1973-1974

A.G. HENDRICKX1986-1987

F.C. FRASER1962-1963

E.M. JOHNSON1974-1975

C.T. GRABOWSKI1987-1988

M.M. NELSON1963-1964

L.S. HURLEY1975-1976

M.S. CHRISTIAN1988-1989

D.A. KARNOFSKY1964-1965

J.L. SEVER1976-1977

E.F. ZIMMERMAN1989-1990

I.W. MONIE1965-1966

E.V. PERRIN1977-1978

C.A. KIMMEL1990-1991

S.Q. COHLAN1965-1966

A.R. BEAUDOIN1978-1979

R.K. MILLER1991-1992

M.N. RUNNER1966-1967

R.M. HOAR1979-1980

M. BARR, JR.1992-1993

R.L. BRENT1967-1968

C.R. SWINYARD1980-1981

J.W. HANSON1993-1994

T.H. SHEPARD1968-1969

W.J. SCOTT, JR.1981-1982

J.M. DESESSO1994-1995

R.W. MILLER1969-1970

D.M. KOCHHAR1982-1983

K.K. SULIK1995-1996

J. LANGMAN1970-1971

R.E. STAPLES1983-1984

J.F. CORDERO1996-1997

A. PRUZANSKY1971-1972

G.P. OAKLEY, JR.1984-1985

PHILIP E. MIRKES1997-1998

TONIA MASSONExecutive SecretaryTeratology Society

1767 Business Center Drive, Suite 302Reston, VA 20190

TEL: (703) 438-3104 • FAX: (703) 438-3113 • E-mail: [email protected]

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350 TERATOLOGY SOCIETY PROGRAM

Committees Of TheTeratology Society(1998 – 1999)

(Date indicates year of expiration of term or office)

Nomination And ElectionsCommittee (5)

Thomas J. Flynn, Chair (1999)T: (301) 594-5884 F: (301) 594-0517

E-mail: [email protected] Harris (1999)Dana Shuey (1999)Martha Werler (1999)Phil Mirkes (Past President)L. David Wise (Council Liaison)

Constitution And BylawsCommittee (3)

Pia Lindstrom, Chair (1999)T: (919) 941-7031 F: (919) 941-2204

E-mail: [email protected] K. Hansen (2000)Maureen Feuston (2001)Barbara F. Hales (Council Liaison)Anthony R. Scialli (ex officio)

Membership Committee (3)

Joseph C. Rutledge (1999)T: (206) 526-2103 F: (206) 527-3840

E-mail: [email protected] E. Dearlove (2000)Sid Hunter (2001)Robert E. Seegmiller (Council Liaison)

Publications Committee

William Slikker, Jr., Chair (1999)T: (870) 543-7203 F: (870) 543-7745

E-mail: [email protected] W. Tyl (2002)Karen Augustine (2003)Thomas E. Kwasigroch (ad hoc)

Section EditorsRudi Balling (1998)Robert L. Brent (1998)Richard H. Finnell (1998)Jan M. Friedman (1998)Kenneth L. Jones (1998)Muin J. Khoury (1998)Richard G. Skalko (1998)William Slikker, Jr. (1998)Deborah K. Hansen (1999)Thomas M. Burbacher (2000)David D. Weaver (2001)Frank A. Welsch (2001)

Ex Officio MembersLewis B. Holmes, Editor-in-Chief (2002)Nigel A. Brown (Liaison European Teratology Society)Mineo Yasuda (Liaison Japanese Teratology Society)Nancy Olson (Wiley-Liss)Anthony R. Scialli (President)Barbara F. Hales (Council Liaison)

Public Affairs Committee (12-14)

Kenneth L. Jones, Chair (2001)T: (619) 294-6217 F: (619) 291-8938

E-mail: [email protected] M. Friedman (Past-Chair)J. Edward Fisher, Jr. (1999)Jeanne M. Manson (1999)Anne L. Pastuszak (1999)Harpal S. Buttar (2000)John M. Graham, Jr. (2000)Bernard A. Schwetz (2000)Christina Chambers (2001)Tom Collins (2001)Sandra Kweder (2001)Joe Mitala (2001)Richard H. Finnell (Council Liaison)George P. Daston (Vice President)

Education Committee (6)

Melissa S. Tassinari, Chair (1999)T: (860) 441-6033 F: (860) 441-5499

E-mail: [email protected] Abbott (2000)Michael D. Collins (2000)JoLynda Jones, Secretary (2000)Kok-Wah Hew (2001)Ida Smoak (2001)Narsingh D. Agnish (ad hoc)George P. Daston (Council Liaison)

Finance Committee (3)

John R. Rogers, ChairT: (919) 541-5177 F: (919) 541-4017

E-mail: [email protected] ChmielewskiGeorge ClemensCarl KeenElaine Z. Francis (Past Treasurer)

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TERATOLOGY SOCIETY PROGRAM 351

Committees (Cont.)

Student Affairs Committee (3)

Robert M. Parker, Chair (1999)T: (215) 443-8710 F: (215) 443-8587

E-mail: [email protected] A. Keller (2000)Craig Harris (2001)Terrence Ozolins (ad hoc)Wafa Harrouk (Student Member)Judith Wubah (Student Member)George P. Daston (Council Liaison)

Strategic Planning Committee(Ad Hoc)

Philip E. Mirkes, ChairT: (206) 543-3373 F: (206) 543-3184

E-mail: [email protected] AdamsRobert L. BrentAdolfo CorreaMichael L. CunninghamGeorge P. DastonRichard H. FinnellCraig HarrisJohn HarrisLewis B. HolmesJoseph HolsonDiana M. JuriloffRobert J. KavlockCarole A. KimmelThomas B. KnudsenEdward J. LammerPatricia RodierBernard A. SchwetzDaniel M. SheehanDana ShueyMelissa S. TassinariRochelle W. TylPatrick Wier

History Committee (Ad Hoc)

Thomas H. Shepard, ChairT: (206) 543-3373 F: (206) 543-3184

E-mail: [email protected] Barr, Jr.Robert L. BrentAndrew HendrickxDevendra M. KochharGodfrey P. OakleyWilliam J. Scott, Jr.

Web Site Committee (Ad Hoc)

L. David Wise, Chair (Council Liaison)T: (215) 652-6974 F: (215) 652-3423

E-mail: [email protected] BatesTheresa FicoJohn KrayerRobert ParkerRobert VenezialeRobert Vinson (Student Member)

Future Site Selection Committee(Ad Hoc)

Robert H. Kavlock, ChairT: (919) 541-2326 F: (919) 541-1499

E-mail: [email protected] F. HalesGeorge P. DastonExecutive Secretary (ex officio)

Program Committee (Ad Hoc)

George P. Daston, ChairT: (513) 627-2886 F: (513) 627-1908

E-mail: [email protected] DuffyWilliam J. Scott, Jr.Melissa S. Tassinari (Education Course)Robert Parker (Student Awards)

Newsletter Editor

Robert E. Seegmiller, EditorT: (801) 378-2303 F: (801) 378-7423

E-mail: [email protected]

Placement Committee (Ad Hoc)

Alan M. Hoberman, ChairT: (215) 443-8710 F: (215) 443-8587

E-mail: [email protected] RogersL. David Wise

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352 TERATOLOGY SOCIETY PROGRAM

Committees (Cont.)

Exhibitor Liaison Committee(Ad Hoc)

Charles H. Frith, Chair (ISIS BioComp)T: (501) 224-5939 F: (501) 224-5939

E-mail: [email protected] Boyle (SNBL USA)Richard E. Butcher (San Diego Instruments)Loretta Lawrence (INSTEM-Apoloco)Nancy Mutch (Hamilton Thorne Research)Peggy Seymour (LABCAT)George P. Daston (Council Liaison)

Liaison Representatives

AAALACB.R. SonawaneT: (202) 260-1495 F: (202) 260-8719

American Academy of PediatricsRobert L. BrentT: (302) 651-6880 F: (302) 651-6888

American Cleft Palate-Crainofacial AssociationMichael L. CunninghamT: (206) 543-3373 F: (206) 543-3184

American College of Obstetrics & Gynecologists (ACOG)Christine F. ColieT: (202) 687-8207 F: (202) 687-4018

American College of ToxicologyMildred S. ChristianT: (215) 443-8710 F: (215) 443-8587

American Institute of Ultrasound in MedicineKaren FilkinsT: (310) 206-4039 F: (310) 794-1290

American Society of Human GeneticsJohn M. Graham, Jr.T: (310) 855-2211 F: (213) 651-5381

Committee of Regional Networks for Genetics (CORN)Jaime L. FriasT: (813) 272-2960 F: (813) 272-2962

Council of Medical Genetics OrganizationJames W. HansonT: (301) 496-5099 F: (301) 402-2085

Liaison Representatives (Cont.)

Healthy Mothers, Healthy BabiesJosé F. CorderoT: (404) 639-8200 F: (404) 639-8626

International Federation of Teratology Societies (IFTS)Mason Barr, Jr.T: (313) 764-9511 F: (313) 763-4208

March of DimesAnthony R. ScialliT: (202) 687-8259 F: (202) 687-4018

MARTAJoseph MitalaT: (908) 704-4404 F: (908) 704-4950

MTAJudy W. HenckT: (313) 996-7127 F: (313) 998-5718

Neurobehavioral Teratology Society (NBTS)Mark StantonT: (919) 541-7783 F: (919) 541-4849

OTISKathie JohnsonT: (619) 543-2062 F: (619) 543-2066

Society of Perinatal ObstetriciansKaren FilkinsT: (310) 206-4039 F: (310) 794-1290

Society of ToxicologyLori A. DostalT: (313) 996-7524 F: (313) 998-5718

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TERATOLOGY SOCIETY PROGRAM 353

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The Teratology Society thanks the following organizations fortheir generous support of the Teratology Society.

Argus Research Laboratories, Inc.Chevron CorporationCoca-Cola Company

Hoffmann-LaRoche, Inc.Huntington Life Sciences

Pfizer, Inc.Rhône-Poulenc Rorer

Sanofi ResearchSchering-Plough Research

SmithKline Beecham PharmaceuticalsSpringborn Laboratories, Inc.

Valent USA CorporationWIL Research Laboratories

6XVWDLQLQJ�PHPEHUVAmerican Petroleum Institute

Bayer CorporationBristol Myers Squibb Company

Dow Corning CorporationEli Lilly and Company

Mitretek SystemsProcter & Gamble Company

R.W. Johnson Pharmaceutical Research InstituteWarner Lambert Company

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354 TERATOLOGY SOCIETY PROGRAM

�����DQQXDOPHHWLQJ�VSRQVRUVThe Teratology Society thanks the following sponsors:

(As of April 23, 1999)

American Petroleum InstituteBurroughs Wellcome FundCovance Laboratories, Inc.

Eli Lilly & CompanyElsevier Science, Inc.

March of DimesMerck Research Laboratories

NIEHSParke-Davis

Rhône-Poulenc RorerShin Nippon Biomedical Laboratories, Ltd.

SmithKline BeechamWIL Research Laboratories

Wiley-Liss

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TERATOLOGY SOCIETY PROGRAM 355

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11:00 AM - 05:00 PM Registration – Shavano Foyer

12:00 PM - 06:00 PM Council IA Meeting – Ten Mile

01:00 PM - 05:00 PM Education Course – Torrey 2-4Organ System Maturation and Functional Postnatal Development

01:00 PM - 01:05 PM WELCOMESpeaker: Anthony Scialli, President, Teratology Society

01:05 PM - 01:15 PM INTRODUCTIONSpeaker: Melissa Tassinari, Pfizer Central Research

01:15 PM - 02:00 PM OVERVIEW: ASPECTS OF POSTNATAL GROWTH;ONTOGENY OF ORGAN SYSTEMSSpeaker: Joseph Holson, WIL Research Laboratories

02:00 PM - 02:45 PM GROWTH FROM BIRTH TO PUBERTY: DYNAMICSOF GROWTH AND SKELETAL DEVELOPMENTSpeaker: Rocky Tuan, Department of Orthopaedic Surgery,Thomas Jefferson University

02:45 PM - 03:15 PM BREAK

03:15 PM - 04:00 PM CARDIOVASCULAR SYSTEMSpeaker: John DeSesso, Mitretek Systems

04:00 PM - 05:00 PM CENTRAL NERVOUS SYSTEMSpeaker: Robert Holson, Department of Psychology,New Mexico Tech.

07:00 PM - 08:00 PM President’s Reception – Gallery/Lakeside(Sponsored by Elsevier Science, Inc.)

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356 TERATOLOGY SOCIETY PROGRAM

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07:00 AM - 12:00 PM Council IB Meeting – Ten Mile

07:30 AM - 05:00 PM Registration – Shavano Foyer

07:30 AM - 08:15 AM Education Course Continental Breakfast – Crestone 2-4 Foyer

08:00 AM - 12:00 PM Golf Tournament – Ranch Golf Course

08:15 AM - 12:00 PM Education Course (continued) – Crestone 2-4Organ System Maturation and Functional Postnatal Development

08:15 AM - 09:00 AM REPRODUCTIVE SYSTEMSpeaker: Kimberley Treinin, Schering-Plough ResearchSafety Evaluation Center

09:00 AM - 09:40 AM IMMUNE SYSTEMSpeaker: Dwayne Hill, University of Michigan

09:40 AM - 10:00 AM METABOLIC SYSTEMS—LIVER AND KIDNEYSpeaker: Jeffrey Peters, National Institutes of Health,Metabolism Laboratories

10:00 AM - 10:30 AM BREAK

10:30 AM - 11:10 AM PEDIATRIC SAFETY ASSESSMENTS—VIEW FROM ACLINICIANSpeaker: TBA

11:10 AM - 12:00 PM NON-CLINICAL SAFETY ASSESSMENTS—WHAT TODO AND WHENSpeaker: Melissa Tassinari, Pfizer Central Research

12:00 PM - 10:00 PM Exhibits Open – Shavano/Torreys

01:00 PM - 5:30 PM March of Dimes Symposium – Red Cloud PeakHIV Infection During Pregnancy: Biology, Developmental Effectsand Therapeutic InterventionsChairpersons: Richard K. Miller, Department of OB/GYN, University of Rochester,Rochester, New York and William Slikker, Jr., NCTR, Jefferson, Arkansas

01:00 PM - 01:05 PM INTRODUCTIONSpeaker: Richard K. Miller, University of Rochester

01:05 PM - 01:10 PM OVERVIEWSpeaker: Michael Katz, Scientific Director, March of Dimes

01:10 PM - 01:50 PM S1 BIOLOGY OF HIV—IMPACT OFCHEMOKINE RECEPTOR POLYMORPHISMON VERTICAL TRANSMISSIONLeonidas G. Kostrikis, Rockefeller University

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TERATOLOGY SOCIETY PROGRAM 357

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01:50 PM - 02:30 PM S2 THE ROLE OF THE PLACENTA IN HIVINFECTION FOR THE FETUSRichard K. Miller, University of Rochester

02:30 PM - 03:10 PM S3 NEURO-DEVELOPMENTAL INFECTION ANDOUTCOMELeon G. Epstein, Northwestern University

03:10 PM - 03:30 PM BREAK

03:30 PM - 04:10 PM S4 LONG TERM FOLLOW-UP OFCHILDREN—TOXICITY OF RETROVIRALSMary Glenn Fowler, CDC

04:10 PM - 04:50 PM S5 POTENTIAL TOXICITIES OF HIVTHERAPEUTICS ON THE DEVELOPINGINFANTWilliam Slikker, Jr., NCTR

04:50 PM - 05:20 PM ROUNDTABLE DISCUSSION

05:20 PM - 05:30 PM CONCLUSIONSSpeaker: William Slikker, Jr., NCTR

07:30 PM - 10:00 PM Poster Session (Posters 1-40) – Shavano/Torreys(Refreshments sponsored by Shin Nippon Biomedical Laboratories, Ltd.)

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07:00 AM - 07:45 AM Continental Breakfast – Shavano Foyer

07:30 AM - 05:00 PM Registration – Shavano Foyer

07:45 AM - 08:00 AM President’s Welcome and Introduction – Red Cloud PeakSpeaker: Anthony Scialli, President, Teratology Society

08:00 AM - 08:45 AM Warkany Lecture – Red Cloud PeakImproving the Science for Predicting Risks to Children’s HealthSpeaker: Carole Kimmel, USEPA

08:45 AM - 12:00 PM NIEHS Symposium – Red Cloud PeakOxidative Stress, Apoptosis and Abnormal DevelopmentChairpersons: Jerry Heindel, NIEHS, Research Triangle Park, North Carolina; AlanFantel, Central Embryology Laboratory, University of Washington, Seattle, Washington;and Thomas Knudsen, Department of Anatomy, Jefferson Medical College, Philadelphia,Pennsylvania

08:45 AM - 09:30 AM S6 FREE RADICALS, OXIDANTS ANDANTI-OXIDANTS: ORIGINS, TARGETS,CONSEQUENCESGarry Buettner, University of Iowa

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358 TERATOLOGY SOCIETY PROGRAM

7KXUVGD\��MXO\���������(continued)

9:30 AM - 10:15 AM S7 THE CAUSE-EFFECT OF OXIDATIVE STRESSAND APOPTOSISJames P. Kehrer, University of Texas at Austin

10:15 AM - 10:30 AM BREAK

10:30 AM - 10:55 AM S8 FREE RADICAL IMBALANCE IN LIMBREDUCTION DEFECTS: A NEWMECHANISTIC MODEL OF VASCULARDISRUPTIONAlan Fantel, University of Washington

10:55 AM - 11:20 AM S9 MITOCHONDRIAL TRANSDUCTION OFTERATOGENESIS: ROLE OF p53 AND BZRPGENESThomas Knudsen, Thomas Jefferson University

11:20 AM - 11:55 AM S10 ARSENIC FREE RADICALS ANDDYSMORPHOGENESISE. Sidney Hunter, USEPA

12:00 PM - 01:00 PM Past President’s Luncheon – Crestone Peak 2(By invitation only)

12:00 PM - 10:00 PM Exhibits Open – Shavano/Torreys

01:30 PM - 03:00 PM Platform I: OTIS/Teratology Society Joint Session – Red Cloud PeakChairpersons: Elisabeth Robert, Institut Européen des Génomutations, Lyon, France andKenneth Jones, Department of Pediatrics, Division of Dysmorphology and Teratology,University of California San Diego, La Jolla, California

01:30 PM - 01:45 PM 1 PREGNANCY OUTCOME IN WOMEN WHOUSE SERTRALINEC.D. Chambers, L.M. Dick, R.J. Felix, K.A.Johnson, and K.L. Jones, Department ofPediatrics, Division of Dysmorphology andTeratology, University of California San Diego,La Jolla, California

01:45 PM - 02:00 PM 2 NEUROBEHAVIORAL FOLLOW-UP OFCHILDREN PRENATALLY EXPOSED TOFLUOXETINES.N. Mattson, A.D. Eastvold, K.L. Jones, J.A.Harris, and C.D. Chambers, Center for BehavioralTeratology, SDSU, San Diego, California;Department of Pediatrics, Division ofDysmorphology and Teratology, UCSD, SanDiego, California; and the California BirthDefects Monitoring Program, Emeryville,California

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TERATOLOGY SOCIETY PROGRAM 359

7KXUVGD\��MXO\���������(continued)

02:00 PM - 02:15 PM 3 DISTRIBUTION OF MALFORMATIONSAMONG POPULATIONS LIVING AROUNDNUCLEAR PLANTS: A REGISTRY STUDYE. Robert, S.E. Vollset, J.C. Laborier, andO. Robert, Institut Européen des Génomutations,Lyon, France

02:15 PM - 02:30 PM 4 NEURODEVELOPMENT OF CHILDRENEXPOSED IN UTERO TO MATERNAL BINGEALCOHOL CONSUMPTION: A PROSPECTIVECONTROLLED STUDYI. Nulman, D. Kennedy, J. Rovet, J. Wolpin,C. Wasson, M. Loebstein, J. Gladstone, M. Levy,S. Freed, P. Pace-Asciak, and G. Koren

02:30 PM - 02:45 PM 5 A PROSPECTIVE CONTROLLEDMULTICENTRE STUDY OF LOPERAMIDE INPREGNANCYA. Einarson, P. Mastroiacovo, J. Arnon, A. Ornoy,A. Addis, A. Ritvanen, and G. Koren

02:45 PM - 03:00 PM 6 THE SAFETY OF DEXTROMETHORPHAN INPREGNANCY: A PROSPECTIVECONTROLLED STUDYA. Einarson, D. Lyszkiewicz, and G. Koren

03:00 PM - 04:15 PM Platform II: Epidemiology – Red Cloud PeakChairpersons: Martha Werler, Slone Epidemiology Unit, Boston University School ofPublic Health, Brookline, Massachusetts and Gary Shaw, California Birth DefectsMonitoring Program, Emeryville, California

03:00 PM - 03:15 PM 7 MULTIVITAMINS AND DIABETES-RELATEDBIRTH DEFECTSA. Correa, L. Botto, and J. Mulinare, Centers forDisease Control and Prevention, Atlanta, Georgia

03:15 PM - 03:30 PM 8 MATERNAL VITAMIN USE, INFANTMUTATION IN MTHFR AND CLEFT PALATERISKG.M. Shaw, R.H. Finnell, K. Todoroff, R. Rozen,and E.J. Lammer, California Birth DefectsMonitoring Program, Emeryville, California

03:30 PM - 03:45 PM 9 MATERNAL RED CELL FOLATE LEVELS,MTHFR GENOTYPE, AND RISK OFOROFACIAL CLEFT BIRTH DEFECTS IN THEPHILIPPINESR. Munger, H. Sauberlich, S. Wong, S. Daack-Hirshch, D. Trembath, S. O’Brien, J. Murray,D. Hendricks, N. West, F. Solon, and W. Magee,Utah State University, Logan, Utah

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360 TERATOLOGY SOCIETY PROGRAM

7KXUVGD\��MXO\���������(continued)

03:45 PM - 04:00 PM 10 PRECONCEPTION USE OF FOLIC ACIDAMONG WOMEN OF CHILDBEARING AGE:THREE NATIONAL SURVEYSD. Mattison, J. Petrini, C. Alter, K. Damus, andR.B. Johnston, Jr., March of Dimes Birth DefectsFoundation, White Plains, New York

04:00 PM - 04:15 PM 11 EFFECT OF PRENATAL EXPOSURE TOANTIEPILEPTIC DRUGS ON DERMAL RIDGEPATTERNS OF FINGERSA. Bokhari, B. Coull, and L.B. Holmes, Geneticsand Teratology Unit, Pediatric Service,Massachusetts General Hospital and Departmentof Biostatistics, Harvard School of Public Health,Boston, Massachusetts

04:30 PM - 06:00 PM Business Meeting – Red Cloud Peak(Teratology Society members only)

06:00 PM - 07:30 PM Reproductive Toxicology Editorial Board Meeting – Crestone 3-4

07:30 PM - 10:00 PM Poster Session (Posters 41-64 and NBTS) – Shavano/Torreys

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07:00 AM - 07:45 AM Continental Breakfast – Shavano Foyer

07:00 AM - 08:00 AM Exhibitor Breakfast – Torreys Peak 1(By invitation only)

07:45 AM - 10:30 AM Platform III: Student Plenary Session – Red Cloud PeakChairpersons: Robert Parker, Primedica Argus Research Laboratories, Horsham,Pennsylvania and Carole Kimmel, USEPA, Washington, D.C.

07:45 AM - 08:00 AM 12 CADMIUM-INDUCED STRESS SIGNALLINGPATHWAYS IN MOUSE EMBRYO MIDBRAINCELLS IN MICROMASS CULTUREK.M.W. Haberstroh and C.M. Kapron, WatershedEcosystems Graduate Program and Department ofBiology, Trent University, Peterborough, Ontario,Canada

08:00 AM - 08:15 AM 13 EXPOSURE OF MALE RATS TOCYCLOPHOSPHAMIDE (CPA) CHANGESCELL-CELL CONTACTS INPRE-IMPLANTATION EMBRYOSW. Harrouk, B. Robaire, and B. Hales,Department of Pharmacology & Therapeutics,McGill University, Montreal, Quebec, Canada